Article
Medicine, General & Internal
Min Ji Kwon, Jeong Nam Kim, Joon Park, Yun Tai Kim, Min Jae Lee, Byung Joo Kim
Summary: The anti-cancer effects of Alisma canaliculatum extracts (ACE) on AGS gastric cancer cells include inhibiting cell growth, inducing apoptosis, and regulating cell death through various signaling pathways.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Rentao Zhang, Zhongkun Zhou, Yunhao Ma, Kangjia Du, Mengze Sun, Hao Zhang, Hongyuan Tu, Xinrong Jiang, Juan Lu, Lixue Tu, Yuqing Niu, Peng Chen
Summary: This study investigated the effects of EPS from Lactiplantibacillus plantarum YT013 on gastric cancer cells. The results showed that EPS had the most significant inhibitory effect on AGS cells at a concentration of 1000μg/mL, followed by SGC-7901, PANC-1, and HCT116 cells, and had less inhibition on HepG2 cells. Cell cycle analysis demonstrated that EPS prevented AGS cells from transitioning from the S phase to the G(2)/M phase. Furthermore, flow cytometry results indicated that EPS promoted apoptosis in a concentration-dependent manner, possibly through the endogenous mitochondrial apoptotic pathway. The safety and effectiveness of lyophilized powder, cell-free culture supernatant, and EPS from Lactiplantibacillus plantarum YT013 were evaluated, and the results suggested that these components could serve as a basis for the development of natural anticancer active drugs.
FERMENTATION-BASEL
(2023)
Article
Chemistry, Medicinal
Tong Zhang, Yun-Hong Xiu, Hui Xue, Yan-Nan Li, Jing-Long Cao, Wen-Shuang Hou, Jian Liu, Yu-He Cui, Ting Xu, Ying Wang, Cheng-Hao Jin
Summary: Isoorientin induces autophagy in gastric cancer cells and inhibits cell migration by regulating multiple signaling pathways. It induces apoptosis in gastric cancer cells through a mitochondria-dependent pathway and increases ROS levels. The increase of ROS levels also leads to cell cycle arrest and the inhibition of cell migration.
Article
Biology
Myeong-Jin Kim, Hye-Won Kawk, Sang-Hyeon Kim, Hyo-Jae Lee, Ji-Won Seo, Chang-Yeol Lee, Young-Min Kim
Summary: Cancer metastasis is closely related to the survival rate of cancer patients. Ribes fasciculatum, a medicinal plant, has been confirmed to have anticancer potential and can inhibit cancer migration, reduce anoikis resistance, induce apoptosis, arrest the cell cycle, induce oxidative stress, and reduce cell mobility. The downregulation of proteins, such as epidermal growth factor receptor (EGFR), attenuates the resistance to anoikis. The anticancer effect of Ribes fasciculatum extract (RFE) is dependent on the increase in p53 expression and has been confirmed in both in vitro and in vivo experiments.
Article
Chemistry, Medicinal
Iwona Radziejewska, Katarzyna Supruniuk, Robert Czarnomysy, Kamila Buzun, Anna Bielawska
Summary: Afzelin demonstrates anti-inflammatory and anti-cancer properties. The study shows that it influences apoptosis, Bax, caspases, MUC1, cancer-related carbohydrate antigens, and enzymes participating in their formation. Afzelin can be considered a potential anti-cancer agent, supporting conventional cancer treatment.
Article
Food Science & Technology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Soo-Hyun Jung, Bum Seok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: The study demonstrates that oleanolic acid (OA) can inhibit cell viability, induce apoptosis and autophagy, thereby interfering with the proliferation and development of gastric cancer cells, reducing the phosphorylation levels of the PI3K/AKT/mTOR signaling pathway, exhibiting anti-cancer effects, and showing tumor-reducing effects in a mouse model.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Heying Zhou, Fengxia Li, Yanli Li
Summary: Gedunin, a phytochemical derived from Azadirachta indica, exhibits various pharmacological activities, including anti-tumor and anti-inflammatory effects. The study found that gedunin effectively inhibited the viability of gastric cancer cells, increased the generation of reactive oxygen species, and induced apoptosis, suggesting its potential as a therapeutic agent for gastric cancer.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ju Won Eom, Joo Weon Lim, Hyeyoung Kim
Summary: Anticancer agents induce apoptosis in gastric cancer cells by increasing reactive oxygen species (ROS) production, activating NADPH oxidase, and promoting DNA fragmentation.
Article
Biochemistry & Molecular Biology
Agnieszka Gornowicz, Roman Lesyk, Robert Czarnomysy, Serhii Holota, Yulia Shepeta, Bozena Poplawska, Magdalena Podolak, Wojciech Szymanowski, Krzysztof Bielawski, Anna Bielawska
Summary: Combining chemotherapy with immunotherapy is a promising strategy in treating gastric cancer with confirmed HER2 expression. Novel 4-thiazolidinone derivatives and anti-HER2 antibodies show potential in increasing the sensitivity of gastric cancer cells to treatment. The molecular mechanism of action involves apoptosis induction and decreased inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alka Ashok Singh, Sung-Han Jo, Anley Teferra Kiddane, Irvine Niyonizigiye, Gun-Do Kim
Summary: Indole-3-carbinol (I3C) is derived from cruciferous vegetables and has been extensively studied for its biological effects. However, its anticancer activity and molecular mechanisms in human adeno gastro carcinoma (AGS) cells have not been investigated. Our study demonstrated that I3C treatment significantly inhibited cell proliferation and induced apoptosis in AGS cells. The results revealed that I3C targeted components of cell-cycle control and showed a strong binding affinity for the apoptotic protein 3DCY.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Cell Biology
Luciano Ferrada, Maria Jose Barahona, Matias Vera, Brent R. Stockwell, Francisco Nualart
Summary: The combination therapy of imidazole ketone erastin (IKE) and oxidized form of vitamin C (DHAA) can restore sensitivity to ferroptosis in previously resistant tumor cells and induce lipid droplet peroxidation, leading to ferroptosis.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Gornowicz, Wojciech Szymanowski, Krzysztof Bielawski, Zbigniew Kaluza, Olga Michalak, Anna Bielawska
Summary: The study showed that the anti-MUC1 antibody in combination with OM-86II effectively reduced the viability of gastric cancer cells by promoting apoptosis and autophagy, while inhibiting proteins such as mTOR, sICAM1, and MMP-9.
Article
Plant Sciences
Yun-Hao Ma, Wan-Tong Ma, Zhong-Kun Zhou, Xiu Huang, Xin-Rong Jiang, Kang-Jia Du, Meng-Ze Sun, Hao Zhang, Hong Fang, Yi Zhao, Hong-Mei Zhu, Huan-Xiang Liu, Peng Chen, Ying-Qian Liu
Summary: Neocryptolepine derivatives, especially 8-Fluoroneocryptolepine (8FNC), have shown promising cytotoxic activity against gastric cancer cells (AGS) with greater selectivity and cytotoxicity compared to commonly used drugs. Structural modifications improved the cytotoxic effect and reduced toxicity to normal gastric cells (GES-1), making 8FNC a potential lead compound for the development of gastric cancer treatment. Mechanistic studies suggest that 8FNC inhibits AGS cell migration and induces apoptosis through the PI3K/AKT signaling pathway.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biotechnology & Applied Microbiology
Rongbo Wang, Keum-yun Ha, Sanjeevram Dhandapani, Yeon-Ju Kim
Summary: This study develops a novel drug delivery agent based on selenium nanoparticles, prepared from plant extracts and selenium salts. The results show that KP-SeNPs can induce both apoptosis and autophagic cell death in gastric cancer cells through the inhibition of the PI3K/Akt/mTOR pathway, thereby suppressing the progression of gastric cancer.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Integrative & Complementary Medicine
Ye Seul Park, Gun He Nam, Kyung Jo Jo, Hye Won Kawk, Sang Yung Kim, Young Min Kim
Summary: The study demonstrated that Zanthoxylum piperitum extract (ZPE) inhibits the growth of gastric cancer cells and induces apoptosis. ZPE modulates the expression of apoptosis-related proteins to impact cell apoptosis, providing a new direction and strategy for gastric cancer treatment.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.