Article
Biochemistry & Molecular Biology
Jiao Xiao, Yingjie Wang, Yanqiu Yang, Jingyu Liu, Bin Lin, Gang Chen, Ning Li
Summary: 16 alkaloids, including 11 new hasubanan alkaloids and five known alkaloids, were isolated from the alkaloidal extract of Stephania longa through 1H NMR-guided fractionation. The structures were determined by spectroscopic analysis, and the absolute configurations were established by comparing experimental and calculated ECD spectra. Compound 3 and compound 12 showed stronger antineuroinflammatory effects than minocycline against NO production on LPS-activated BV2 cells.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Tran Thi Thu Hien, Vinh Le Ba, Nguyen Quoc Huy, Nguyen Phuong Thao, Seo Young Yang, Le Thi Kim Van
Summary: Two new aporphine alkaloids (1 and 5) were discovered in the stems and leaves of Stephania dielsiana Y.C.Wu, along with six known alkaloids (2-4 and 6-8). Their structures were determined using spectroscopic techniques. Compound 2 showed strong cytotoxic activity against cancer cell lines HepG2, MCF7, and OVCAR8. Molecular docking simulations provided insights into the interactions and binding mechanisms of compound 2 with proteins. This study contributes to the understanding of secondary metabolites produced by S. dielsiana and provides a scientific basis for further investigation into the cytotoxicity of this medicinal plant.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiao Xiao, Yingjie Wang, Yanqiu Yang, Jingyu Liu, Gang Chen, Bin Lin, Yue Hou, Ning Li
Summary: Stephania epigaea, a folk medicine in southern China, has been found to contain alkaloids that can inhibit neuroinflammation. These alkaloids may have potential therapeutic effects for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Uriel Nava-Solis, Mario Rodriguez-Canales, Ana Bertha Hernandez-Hernandez, David Arturo Velasco-Melgoza, Brenda Paola Moreno-Guzman, Marco Aurelio Rodriguez-Monroy, Maria Margarita Canales-Martinez
Summary: This study investigated the antimicrobial activity of methanolic extract from Prosopis laevigata leaves against various bacteria and fungi, and analyzed its chemical composition. The results showed that the extract had strong antimicrobial activity, especially against certain pathogenic bacteria and fungi.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Applied
Haoran Ma, Xiaoqi Jin, Fuqian Wang, Jie Jiang, Lu Cheng, Song Hu, Geng Zhang, Hongfeng Xu
Summary: A new morphinan alkaloid and a new cularine alkaloid were isolated from the roots of Stephania cepharantha, both of which showed cytotoxic activities against human cancer cell lines. The structures of these compounds were determined by spectroscopic data analyses.
NATURAL PRODUCT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Fadia S. Youssef, Elham Alshammari, Mohamed L. Ashour
Summary: This review comprehensively explored the alkaloids isolated from different species of genus Aspergillus, revealing their important biological activities such as antiviral, antibacterial, antifungal, cytotoxic, antioxidant, and antifouling activities. In addition, both in vitro and in silico studies were conducted to investigate the anti-infection potential and mechanisms of action of these alkaloids. Furthermore, molecular docking was used to examine the inhibitory potential of compounds against Angiotensin-Converting Enzyme 2 (ACE2) as a key therapeutic target for combating COVID-19 infection and its complications, with Fumigatoside E showing promising results within the active sites of examined proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Beibei Qi, Liangbo Li, Rongshao Huang
Summary: The genus Stephania is a rich source of alkaloids and has been traditionally used in China for treating various ailments. However, there is limited understanding of the variation within the genus, which hinders its optimal utilization. This study evaluated the variation in alkaloid content in four commonly cultivated Stephania species in China. The results revealed significant variations in alkaloid abundance among the species, with the genotypes SY-xueteng and SY-hongteng showing relatively high alkaloid abundance. This study provides a foundation for the further utilization of ideal Stephania genotypes by clarifying alkaloid content variations within the genus.
Article
Agricultural Engineering
Hao Chen, Xuejiao Tian, Qunli Yu, Wei Hu, Jihong Chen, Libin Zhou
Summary: This study developed a novel strategy for extracting phenolic compounds from sweet sorghum, which significantly increased the total phenolic content and showed strong antioxidant and antimicrobial properties. It provides a new approach for the comprehensive utilization of sweet sorghum.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Applied
Li-Jun Yang, Zhong-Duo Yang, Zhi-Jie Li, Shu-Hong Yang, Zong-Mei Shu
Summary: Four undescribed bisbenzylisoquinoline alkaloids were isolated and identified from the roots of Stephania tetrandra, along with the isolation of N-trans-Feruloyltyramine for the first time from this plant. Stephtetrandrine C exhibited significant inhibitory effect on human hepatoma cell HepG2, while Limacine and 2'-N-chloromethyltetrandrine showed moderate monoamine oxidase inhibitory effects.
NATURAL PRODUCT RESEARCH
(2023)
Article
Cell Biology
Xinyi Li, Qishuang Li, Xiang Jiao, Hao Tang, Yatian Cheng, Ying Ma, Guanghong Cui, Jinfu Tang, Yun Chen, Juan Guo, Luqi Huang
Summary: In this study, two functional StNCSs genes were identified and characterized from the Menispermaceae family plant Stephania tetrandra. These genes could catalyze the formation of (S)-norcoclaurine and provide genetic components for synthetic biology-based production of BIAs in yeast. The study also contributes to understanding the phylogenetic relationships and structure-function relationship of NCS genes involved in the origin and production of BIAs.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Plant Sciences
Kicia Karinne Pereira Gomes-Copeland, Cinthia Gabriel Meireles, Joao Victor Dutra Gomes, Amanda Gomes Torres, Simone Batista Pires Sinoti, Yris Maria Fonseca-Bazzo, Perola de Oliveira Magalhaes, Christopher William Fagg, Luiz Alberto Simeoni, Damaris Silveira
Summary: The ethanol extract of Hippeastrum stapfianum leaves showed inhibitory effects on acetylcholinesterase enzyme, antioxidant activity, and selective activation of PPAR-alpha and PPAR-gamma. Major compounds identified were lycorine, 7-demethoxy-9-O-methylhostasine, and rutin, indicating its potential as a source of drugs for Alzheimer's disease.
Article
Chemistry, Inorganic & Nuclear
Yun Fang, Ci-Qing Hong, Fang-Rong Chen, Fang-Ze Gui, Yun-Xin You, Xiong Guan, Xiao-hong Pan
Summary: This study proposes a facile method for preparing silver nanoparticles using tea extract and evaluates its antimicrobial activity. The synthesized silver nanoparticles show good antibacterial effects on Escherichia coli and Pseudopestalotiopsis theae, broadening the application of nano silver in antimicrobial agents. The reactions between silver nanoparticles and bacteria/fungi may not be driven by electrostatic interactions, but rather by intermolecular forces.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Jianye Zeng, Dandan Chen, Chunli Lv, Kening Qin, Qin Zhou, Na Pu, Shanshan Song, Xiaomin Wang
Summary: The aqueous extract of Polygonum chinense L. has a significant bacteriostatic effect on Staphylococcus aureus and can destroy its cell wall as well as inhibit biofilm formation. Flow cytometry results show that the extract can disrupt the cell membrane and promote apoptosis. Confocal laser scanning microscopy images demonstrate the dose-dependent inhibition of biofilm formation by the extract.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Aurapa Sakulpanich, Siriluck Attrapadung, Wandee Gritsanapan
Summary: The ethanolic root extract of S. collinsiae has larvicidal activity against M. domestica and C. megacephala, causing irregular development and preventing the emergence of adult flies. This study suggests the potential use of S. collinsiae root extract as a natural fly control biopesticide.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Yothin Teethaisong, Piyasiri Chueakwon, Kulwara Poolpol, Intu-orn Ayamuang, Siriporn Suknasang, Chittadech Apinundecha, Griangsak Eumkeb
Summary: This study investigated the antibacterial potential of Stephania suberosa extract (SSE) and its synergism with ampicillin (AMP) or vancomycin (VAN) against AMP- and VAN-resistant Enterococcus faecium. The results showed that SSE inhibited the growth of E. faecium and exhibited synergistic interaction with AMP and VAN. These findings support that SSE could reverse the activity of AMP and VAN, and synergistically inhibit AMP- and VAN-resistant E. faecium.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.