Review
Pharmacology & Pharmacy
Fulvia Farabegoli, Marina Pinheiro
Summary: Chemoprevention is a strategy to reduce the risk and delay the development of cancer. EGCG, as a chemopreventive agent, shows potential but is limited by various factors. Lipid-based nanoparticles are proposed as a suitable delivery strategy for investigating the chemopreventive activity of EGCG.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
Iyyakkannu Sivanesan, Manikandan Muthu, Anusha Kannan, Suraj Shiv Charan Pushparaj, Jae-Wook Oh, Judy Gopal
Summary: This review discusses the analytical techniques for the key component Epigallocatechin-3-gallate (EGCG) in green tea and surveys its application in in vitro, in vivo, and biological sample analysis. The importance of exploring matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in this field is emphasized.
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Eman A. Mazyed, Doaa A. Helal, Mahmoud M. Elkhoudary, Ahmed G. Abd Elhameed, Mohamed Yasser
Summary: This study aimed to enhance the bioavailability of EGCG utilizing nanospanlastics, with the optimized formula (F4) showing prolonged drug release and improved characteristics compared to niosomes.
Article
Virology
Rackhyun Park, Minsu Jang, Yea-In Park, Yeonjeong Park, Woochul Jung, Jayhyun Park, Junsoo Park
Summary: Recent studies have shown that green tea polyphenols have an inhibitory effect on coronavirus replication, with significant results observed in a mouse model.
Article
Agriculture, Multidisciplinary
Huimin Yong, Huixia Hu, Zhihao Wang, Dawei Yun, Juan Kan, Jun Liu
Summary: By using acid-mediated coupling method, catechins were successfully conjugated onto dialdehyde starch to form stable dialdehyde starch-catechin conjugates. The conjugates exhibited improved thermal stability and enhanced stability of catechins in buffered solution. Furthermore, the conjugates showed higher antioxidant activity.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Food Science & Technology
Yangyang Chen, Min Zhang, Arun S. Mujumdar, Yaping Liu
Summary: This study evaluated the effects of epigallocatechin gallate (EGCG) and L-cysteine (L-cys) on Maillard browning of concentrated orange juice (COJ) during storage. The results showed that the combined use of EGCG and L-cys significantly reduced the production of 5-hydroxymethylfurfural (5-HMF) and preserved the sensory quality and material properties of COJ.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Oncology
Feng Li, Syeda Qasim, Dapeng Li, Q. Ping Dou
Summary: In-depth insights on cancer biology have highlighted the important roles of epigenetic mechanisms in tumorigenesis. Targeting the cancer epigenome with epi-drugs, including phytochemicals like EGCG, offers promising strategies for cancer chemoprevention and therapy. However, there are limitations to using EGCG as an epigenetic modulator in cancer treatment.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Chemistry, Medicinal
Pawel Bakun, Dariusz T. Mlynarczyk, Tomasz Koczorowski, Magdalena Cerbin-Koczorowska, Ludwika Piwowarczyk, Emil Kolasinski, Maciej Stawny, Joanna Kuzminska, Anna Jelinska, Tomasz Goslinski
Summary: Epigallocatechin gallate (EGCG), a polyphenol found in green tea, has potential anticancer and neurodegenerative disease protective effects. However, its bioavailability is limited due to chemical instability and poor absorption, resulting in its current use as a dietary supplement rather than medication.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fulvia Farabegoli, Andreia Granja, Joana Magalhaes, Stefania Purgato, Manuela Voltattorni, Marina Pinheiro
Summary: This study investigates the application of charged nanoparticles loaded with EGCG in breast cancer cells. The results demonstrate that these nanoparticles induce significant cytotoxicity in breast cancer cells at low concentrations, while having no effects on normal cells. These nanoparticles are suitable for in vitro studies and can improve the administration of EGCG in vivo.
Review
Biochemistry & Molecular Biology
Victor Valverde-Salazar, Daniel Ruiz-Gabarre, Vega Garcia-Escudero
Summary: Alzheimer's disease (AD) is a common form of dementia characterized by memory decline, cognitive impairment, and several pathological changes in the brain. Oxidative stress and inflammation play important roles in the development of AD. Green tea and its active compound EGCG have shown potential therapeutic effects in modulating AD through their antioxidative and anti-inflammatory properties. EGCG can regulate inflammatory processes, reduce protein aggregation, and promote neuronal survival pathways, making it a suitable candidate for the treatment of neurodegenerative disorders involving oxidative stress and inflammation.
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Wen-Ting Chen, Meei-Ju Yang, Yi-Wei Tsuei, Tsung-Chen Su, An-Ci Siao, Yow-Chii Kuo, Ling-Ru Huang, Yi Chen, Sy-Jou Chen, Po-Chuan Chen, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: This study investigates the effect of epigallocatechin gallate (EGCG) on the growth of white and beige preadipocytes by modulating the miR-let-7a and HMGA2 pathways. The results show that EGCG inhibits the growth of 3T3-L1 and D12 preadipocytes, upregulates miR-let-7a expression, and downregulates HMGA2 mRNA and protein levels. Overexpression of miR-let-7a and HMGA2 antagonizes the inhibitory effects of EGCG on cell growth. Therefore, EGCG acts on preadipocytes through the miR-let-7a/HMGA2 pathway to inhibit their growth.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Paulina Aguilera, Camilo Berrios-Pasten, Marcelo Veloso, Matias Galvez-Silva, Florian Turbant, Rosalba Lagos, Frank Wien, Veronique Arluison, Andres E. Marcoleta
Summary: Epigallocatechin gallate (EGCG), a green tea flavonoid, can interfere with the formation of MccE492 amyloid fibers, resulting in the formation of amorphous aggregates and small oligomers. Although the aggregation process is not completely prevented, EGCG is still an interesting inhibitor of MccE492 and other bacterial amyloids.
Article
Multidisciplinary Sciences
Pengpeng Zhang, Wei Wu, Chunyu Du, Xiang Ji, Yaling Wang, Qiu Han, Hiaxia Xu, Cencen Li, Yongjie Xu
Summary: In this study, primary WAT and BAT SVF cells were isolated and induced to adipogenic differentiation in the presence or absence of EGCG. RNA-seq was used to analyze the gene regulation by EGCG in these two distinct adipose tissues and identify the key differences. The findings of this study have significant implications for obesity-related clinical and basic research.
Article
Chemistry, Applied
Carolina Rojas-Garbanzo, Julia Winter, Maria Laura Montero, Benno F. Zimmermann, Andreas Schieber
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2019)
Article
Clinical Neurology
Johannes Levin, Sylvia Maass, Madeleine Schuberth, Armin Giese, Wolfgang H. Oertel, Werner Poewe, Claudia Trenkwalder, Gregor K. Wenning, Ulrich Mansmann, Martin Suedmeyer, Karla Eggert, Brit Mollenhauer, Axel Lipp, Matthias Loehle, Joseph Classen, Alexander Muenchau, Jan Kassubek, Florin Gandor, Daniela Berg, Silvia Egert-Schwender, Cornelia Eberhardt, Friedemann Paul, Kai Boetzel, Birgit Ertl-Wagner, Hans-Juergen Huppertz, Ingrid Ricard, Gunter U. Hoeglinger, Elisabeth Andre, Christiane Blankenstein, Monica Canelo, Marco Duering, Jens Ebentheuer, Christopher Fricke, Alexander Gerbes, Stefan Groiss, Doreen Gruber, Christian Hartmann, Thomas Kirchner, Daniel Kroneberg, Martin Kunz, Stefan Lorenzl, Alexia Moldovan, Anna Noda, Heidi Pape, Gesine Respondek, Eva Schaeffer, Alfons Schnitzler, Walter Schulz-Schaeffer, Johannes Schwarz, Cornelia Skowronek, Alexander Storch, Vera Tadic, David Vadasz, Benno Zimmermann, Martina Schneider
Article
Biochemistry & Molecular Biology
Michael Kaiser, Lisa Mueller-Ehl, Maike Passon, Andreas Schieber
Article
Nutrition & Dietetics
Sabine Ellinger, Andreas Reusch, Lisa Henckes, Christina Ritter, Benno F. Zimmermann, Joerg Ellinger, Rudolf Galensa, Peter Stehle, Hans-Peter Helfrich
Editorial Material
Nutrition & Dietetics
Benno F. Zimmermann, Sabine Ellinger
Article
Biochemistry & Molecular Biology
Mario Lorenz, Stephanie Lehmann, Ilija Djordjevic, Thomas Duesterhoeft, Benno F. Zimmermann, Karl Stangl, Verena Stangl
Article
Biochemical Research Methods
Maike Passon, Fabian Weber, Niklas Udo Jung, Dorothea Bartels
Summary: The study aimed to investigate the secondary plant metabolites of resurrection plants and a desiccation sensitive species. Results showed the presence of eight phenylethanoid glycosides and one flavone compound in the plants, with verbascoside being the predominantly synthesized phenylethanoid in all three plant species. The amount of verbascoside correlated with the degree of desiccation tolerance, suggesting a potential role as an antioxidant in the protective system.
PHYTOCHEMICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Sarah Strassmann, Tillman Brehmer, Maike Passon, Andreas Schieber
Summary: The study introduced a hemisynthesis method for methylated anthocyanins, successfully synthesizing cyanidin-3-O-glucoside derivatives with different degrees of methylation and identifying monomethylated derivatives. Dimethyl carbonate (DMC) was used as the methylation agent, and the influence of the catalyst DBU, temperature, and reaction time on product formation was examined. The identified conditions in this study led to a reduction in reaction time and minimized a side reaction known as carboxymethylation by using higher amounts of catalyst.
Article
Biochemistry & Molecular Biology
Sarah Strassmann, Maike Passon, Andreas Schieber
Summary: This study chemically converted cyanidin compounds to their sulfates and found that both the A ring and the B ring are sulfated by human enzymes, providing insights into the metabolism of anthocyanins.
Article
Chemistry, Multidisciplinary
Teresa Leszczynska, Barbara Pieklo, Aneta Kopec, Benno F. Zimmermann
Summary: This study compares the basic nutrients, steviol glycosides, antioxidants, and antioxidant activity in dried leaves of Stevia rebaudiana Bertoni from Poland, Paraguay, and Brazil. The findings show that leaves from Poland have higher dietary fiber content, while those from Brazil and Paraguay have lower steviol glycoside contents. Furthermore, dried leaves from Poland have higher vitamin C content but lower antioxidant activity compared to the other two countries.
APPLIED SCIENCES-BASEL
(2021)
Article
Clinical Neurology
Judith Bellmann-Strobl, Friedemann Paul, Jens Wuerfel, Jan Doerr, Carmen Infante-Duarte, Elmira Heidrich, Benedict Koertgen, Alexander Brandt, Caspar Pfuller, Helena Radbruch, Rebekka Rust, Volker Siffrin, Orhan Aktas, Christoph Heesen, Juergen Faiss, Frank Hoffmann, Mario Lorenz, Benno Zimmermann, Sergiu Groppa, Klaus-Dieter Wernecke, Frauke Zipp
Summary: In patients with RRMS, adding oral EGCG to GA did not show superiority over placebo in affecting MRI and clinical disease activity. Despite indications of EGCG bioavailability, it did not influence immune parameters. However, treatment with up to 800 mg of EGCG daily was safe and well tolerated.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Food Science & Technology
Rada Dinkova, Alexios Vardakas, Eva Dimitrova, Fabian Weber, Maike Passon, Vasil Shikov, Andreas Schieber, Kiril Mihalev
Summary: A new process for enzyme-assisted extraction of polyphenols from de-aromatized rose petals was developed, resulting in higher contents of individual flavonols compared to the control sample. The enzymatically extracted rose petal polyphenols enhanced the color intensity of strawberry spread when added, meeting the growing consumer demand for natural alternatives.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Flora M. Rezaeian, Benno F. Zimmermann
Summary: A simplified extraction method using ethanol + water for ultrasonication was found to be the quickest and simplest way to analyze flavanols in matcha tea. The method was successfully applied to various traditional matcha teas and green tea powders, demonstrating its time-saving and accurate capabilities in analyzing tea components.
Article
Nutrition & Dietetics
Elisabeth Khaikin, Sigrun Chrubasik-Hausmann, Sebahat Kaya, Benno F. Zimmermann
Summary: This study analyzed the TQ content of commercial black seed oils and black seed oil-containing capsules and found variations in TQ content. The highest TQ content was found in a bottled oil, which may be suitable for clinical studies without causing harm to health. It is recommended to regulate the TQ content of black seed products for consumers to purchase supplements with known ingredients.
Article
Food Science & Technology
Tania Paquignon, Mathias Scholz, Benno F. Zimmermann
Summary: Research has shown the positive health effects of EGCg3Me in Benifuuki tea, with the ISO 14502-2 method being suitable for its analysis. According to the study, brewing Benifuuki tea at recommended temperatures can provide effective doses of EGCg3Me.
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
