期刊
FOOD CHEMISTRY
卷 128, 期 2, 页码 495-499出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2011.03.059
关键词
Astilbe myriantha Diels; Triterpenoids; Antifungal activity
资金
- National Basic Research Program of China [2007CB108903]
- National Natural Science Foundation of China [20972062, 21002046]
- 111 Project
During a search for plant extracts that possess activity against the fungi that cause diseases in plants, a 95% ethanol extract from the roots of Astilbe myriantha Diets showed inhibitory activity against Colletotrichum gloeosporioides. Bioassay-guided fractionation of the 95% ethanol extract led to the isolation of seven triterpenoids (1-7). Their structures were elucidated by spectroscopy and by a comparison with literature data. Among these compounds, 3 beta,6 beta,24-trihydroxyurs-12-en-27-oic acid (7) was the most active inhibitor of C. gloeosporioides, with >68.0% inhibition at 100 mg/ml after 72 h. Moreover, compound 7 displayed broad-spectrum inhibitory activity against Rhizoctonia solani, Fusarium oxysporum f.sp. Niveum, Fusarium oxysporum f. sp. Cubens, C. gloeosporioides, Penicillium citrinum, Colletotrichum lagenarium, and Penicillium digitatum, with EC50 values ranging from 13.9 to 34.0 mu g/ml. The potential of compound 7 as a fungicide is therefore promising. In addition, compound 1 was found to be a new triter-penoid, 3 beta,6 beta-dihydroxyurs-12-en-7 alpha,27 alpha-olide, which possesses six rings. (C) 2011 Elsevier Ltd. All rights reserved.
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