期刊
FOOD CHEMISTRY
卷 120, 期 1, 页码 156-162出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2009.10.001
关键词
Taurine; Serum lipids; Hepatic lipids; Faecal lipids and bile acid; HMG-CoA reductase; CYP7A1; LDL receptor; GPT; GOT; Hepatic C-reactive protein
资金
- National Science Council, Taiwan (ROC) [NSC 96-2622-B-040-002-CC3]
Eight male hamsters per group were assigned randomly to one of the following diets: chow diet (Control); high-fat/cholesterol diet (HFCD); HFCD supplemented with 1% Tau (HFCD/1% Tau); HFCD supplemented with 2% Tau (HFCD/2% Tau). Tau supplementation improved (P<0.05) serum lipids and cholesterol profile in the high-fat/cholesterol-dietary hamsters. Although hepatic cholesterol/triacylglycerol in the high-fat/cholesterol-dietary hamsters were not (P > 0.05) changed by Tau supplementation, faecal cholesterol and bile acid outputs were increased (P < 0.05). Two percent Tau supplementation unregulated (P < 0.05) HMG-CoA reductase and cholesterol 7-alpha hydroxylase (CYP7A1) expressions in the high-fat/cholesterol-dietary hamsters. Besides, Tau supplementation also increased (P < 0.05) LDL receptor mRNA expressions in high-fat/cholesterol-dietary hamsters. Tau supplementation also reduced serum GPT and GOT values and C-reactive protein (CRP) levels in the high-fa t/cholesterol-dietary hamsters. Results clearly indicated that Tau Could alleviate blood lipids and hepatic damage induced by a high-fat/cholesterol-dietary diet. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据