期刊
FOOD CHEMISTRY
卷 114, 期 3, 页码 813-820出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2008.10.019
关键词
Antiproliferative; Cell-cycle; Cyclins; Fruit beverages; Polyphenols
资金
- CICYT, Spain [AGL2004-07657-C02-01]
- Generalitat Valenciana, Spain [GVARVIV2007-096]
- Fun-C-Food
- Consolider Ingenio 2010 [CSD2007-00063]
- Ministry of Science and Innovation (MICINN, Spain)
Three fruit beverages: Fb (grape-orange-apricot), FbFe (Fb + iron sulphate) and FbFeM (FbFe + skimmed milk) were subjected to in vitro gastrointestinal digestion. Addition of Fe and milk decreased the phenolic content of Fb by 13% and 55%, respectively. The digestion process decreased the phenolic content by 47%, 60%, and 70% in Fb, FbFe and FbFeM with respect to the initial, non-digested, Fb. Caco-2 cells were incubated for 4 h daily for four days or continuously for 24 h with bioaccessible fractions obtained after the digestion (digests). Polyphenols were not metabolised by Caco-2 cells. Fb digest (similar to 50 mu M total phenolics) was the sample that led to the highest inhibition of cell proliferation under the two experimental conditions. Fb digest did not induce apoptosis but ceased cell-cycle in the S-phase which is associated to a decrease in B1 and D1 cyclin levels upon incubation for 24 h. (C) 2008 Elsevier Ltd. All rights reserved.
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