Editorial Material
Chemistry, Multidisciplinary
Vikram Kestens, Vassili Bozatzidis, Pieter-Jan De Temmerman, Yannic Ramaye, Gert Roebben
JOURNAL OF NANOPARTICLE RESEARCH
(2017)
Article
Chemistry, Analytical
Hakan Emteborg, Doris Florian, Steven Choquette, Stephen L. R. Ellison, Maria Fernandes-Whaley, Lindsey Mackay, Pearse McCarron, Ulrich Panne, Sylvia G. Sander, Sook-Kyung Kim, Andrea Held, Thomas Linsinger, Stefanie Trapmann
ACCREDITATION AND QUALITY ASSURANCE
(2018)
Article
Engineering, Chemical
Thomas P. J. Linsinger, Tsvetelina Gerganova, Vikram Kestens, Jean Charoud-Got
Review
Chemistry, Applied
Brigitte Toussaint, Barbara Raffael, Alexandre Angers-Loustau, Douglas Gilliland, Vikram Kestens, Mauro Petrillo, Iria M. Rio-Echevarria, Guy Van den Eede
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2019)
Article
Chemistry, Multidisciplinary
Katrin Franks, Vikram Kestens, Adelina Braun, Gert Roebben, Thomas P. J. Linsinger
JOURNAL OF NANOPARTICLE RESEARCH
(2019)
Article
Biochemical Research Methods
Vikram Kestens, Tsvetelina Gerganova, Gert Roebben, Andrea Held
Summary: A new certified reference material for size and shape analysis of elongated nanoparticles has been developed by the European Commission's Joint Research Centre. The certified values, traceable to the unit of length in the International System of Units, range from 4 to 6% relative expanded uncertainties and can be used for quality assurance and calibration of electron microscopy methods for nanoparticle size and shape analysis, relevant for EU legislation related to nanomaterials.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Jesus Manuel Antunez Dominguez, Yannic Ramaye, Marta Dabrio, Vikram Kestens
Article
Chemistry, Physical
Yannic Ramaye, Marta Dabrio, Gert Roebben, Vikram Kestens
Summary: Zeta potential is a key factor in examining colloidal stability and can also be used for grouping and read-across of nanoforms. Two methods, electrophoretic light scattering and particle tracking analysis, have been validated for accurately measuring zeta potential of silica and polystyrene particles, with similar uncertainties in repeatability, intermediate precision, and trueness. These methods can be transferred to other laboratories or serve as a guide for validating their own methods.
Article
Chemistry, Medicinal
Kurt D. Benkstein, Gurusamy Balakrishnan, Ashwinkumar Bhirde, Pascal Chalus, Tapan K. Das, Ngoc Do, David L. Duewer, Nazar Filonov, Fook Chiong Cheong, Patrick Garidel, Nicole S. Gill, Adam D. Grabarek, David G. Grier, Judith Hadley, Andrew D. Hollingsworth, Wesley W. Howard, Maciej Jarzebski, Wim Jiskoot, Sambit R. Kar, Vikram Kestens, Harshit Khasa, Yoen Joo Kim, Atanas Koulov, Anja Matter, Laura A. Philips, Christine Probst, Yannic Ramaye, Theodore W. Randolph, Dean C. Ripple, Stefan Romeijn, Miguel Saggu, Franziska Schleinzer, Jared R. Snell, Jan Kuba Tatarkiewicz, Heather Anne Wright, Dennis T. Yang
Summary: This paper presents a study on the measurement variability of sub-micrometer polydisperse protein aggregates and particles in biotherapeutics. It includes an interlaboratory comparison involving 20 laboratories and different particle-counting instruments. The results show high variability between datasets from different laboratories and provide guidance for instrument performance assessment and the development of polydisperse reference materials.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hakan Emteborg, Jean Charoud-Got, John Seghers
Summary: The coupling of an infrared camera to a freeze dryer allows simultaneous monitoring of surface and vertical temperatures, providing high-resolution results for the freeze-drying process of a pharmaceutical formulation.
Article
Chemistry, Multidisciplinary
Hubert Rauscher, Andrej Kobe, Vikram Kestens, Kirsten Rasmussen
Summary: An updated definition, new harmonised measurement methods, and rules for systematically counting particles have been put in place in the European Union to support the identification and regulation of nanomaterials. These three essential elements provide EU legislators with the necessary tools to achieve regulatory convergence and create a level playing field for all stakeholders.
Article
Biochemical Research Methods
Hakan Emteborg, John Seghers, Silvia Garcia-Ruiz, Saioa Elordui-Zapatarietxe, Andreas Breidbach, Kamel Labibes, Jean Charoud-Got, Robert Koeber
Summary: Sufficient homogeneity of the certified parameter(s) over the whole fill series of a matrix reference material (RM) is a fundamental quality criterion. In this article, the authors report on the production of challenging matrix RMs using particle suspensions, and highlight the challenges in developing new CRMs in emerging fields. They propose strategies for collaboration between RM producers and analytical method developers, and suggest the development of a portfolio of inexpensive and well-homogenised common samples coupled with a reporting interface.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Caterina Minelli, Magdalena Wywijas, Dorota Bartczak, Susana Cuello-Nunez, Heidi Goenaga Infante, Jerome Deumer, Christian Gollwitzer, Michael Krumrey, Karen E. Murphy, Monique E. Johnson, Antonio R. Montoro Bustos, Ingo H. Strenge, Bertrand Faure, Peter Hoghoj, Vivian Tong, Loic Burr, Karin Norling, Fredrik Hook, Matthias Roesslein, Jovana Kocic, Lyndsey Hendriks, Vikram Kestens, Yannic Ramaye, Maria C. Contreras Lopez, Guy Auclair, Dora Mehn, Douglas Gilliland, Annegret Potthoff, Kathrin Oelschlagel, Jutta Tentschert, Harald Jungnickel, Benjamin C. Krause, Yves U. Hachenberger, Philipp Reichardt, Andreas Luch, Thomas E. Whittaker, Molly M. Stevens, Shalini Gupta, Akash Singh, Fang-hsin Lin, Yi-Hung Liu, Anna Luisa Costa, Carlo Baldisserri, Rid Jawad, Samir E. L. Andaloussi, Margaret N. Holme, Tae Geol Lee, Minjeong Kwak, Jaeseok Kim, Johanna Ziebel, Cedric Guignard, Sebastien Cambier, Servane Contal, Arno C. Gutleb, Jan Kuba Tatarkiewicz, Bartlomiej J. Jankiewicz, Bartosz Bartosewicz, Xiaochun Wu, Jeffrey A. Fagan, Elisabeth Elje, Elise Runden-Pran, Maria Dusinska, Inder Preet Kaur, David Price, Ian Nesbitt, Sarah O'Reilly, Ruud J. B. Peters, Guillaume Bucher, Dennis Coleman, Angela J. Harrison, Antoine Ghanem, Anne Gering, Eileen McCarron, Niamh Fitzgerald, Geert Cornelis, Jani Tuoriniemi, Midori Sakai, Hidehisa Tsuchida, Ciaran Maguire, Adriele Prina-Mello, Alan J. Lawlor, Jessica Adams, Carolin L. Schultz, Doru Constantin, Nguyen Thi Kim Thanh, Le Duc Tung, Luca Panariello, Spyridon Damilos, Asterios Gavriilidis, Iseult Lynch, Benjamin Fryer, Ana Carrazco Quevedo, Emily Guggenheim, Sophie Briffa, Eugenia Valsami-Jones, Yuxiong Huang, Arturo A. Keller, Virva-Tuuli Kinnunen, Siiri Peramaki, Zeljka Krpetic, Michael Greenwood, Alexander G. Shard
Summary: This study evaluates the repeatability and reproducibility of different measurement methods for the particle number concentration of colloidal nanoparticles. The results show that population-averaging methods have higher repeatability and reproducibility than particle-counting methods.
Article
Chemistry, Analytical
Vikram Kestens, Victoria A. Coleman, Jan Herrmann, Caterina Minelli, Alex G. Shard, Gert Roebben
Article
Environmental Sciences
D. Langevin, O. Lozano, A. Salvati, V. Kestens, M. Monopoli, E. Raspaud, S. Mariot, A. Salonen, S. Thomas, M. Driessen, A. Haase, I. Nelissen, N. Smisdom, P. P. Pompa, G. Maiorano, V. Puntes, D. Puchowicz, M. Stepnik, G. Suarez, M. Riediker, F. Benetti, I. Micetic, M. Venturini, W. G. Kreyling, M. van der Zande, H. Bouwmeester, S. Milani, J. O. Raedler, S. Muelhopt, I. Lynch, K. Dawson
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.