Article
Chemistry, Applied
Vinay Bharadwaj Tatipamula, Satya Sowbhagya Priya Annam, Ha Thi Nguyen, Haritha Polimati, Rajendra Prasad Yejella
Summary: Sekikaic acid (SA) shows strong antioxidant and antidiabetic effects in vitro and in vivo, with significant reductions in plasma glucose and lipid levels in diabetic rats, possibly due to the inhibition of digestive enzymes.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Physical
Antonios Kousaxidis, Anthi Petrou, Philippa Rouvim, Pavol Bodo, Milan Stefek, Ioannis Nicolaou, Athina Geronikaki
Summary: This study designed a series of novel benzothiazole-based 4-oxothiazolidin-2-yl-imino acetic acid derivatives as aldose reductase inhibitors. The compounds 5b and 5d showed potent inhibitory activity and optimal selectivity. Docking simulations were performed to explore the binding modes and the influence of fluorinated moieties on selectivity profiles.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Rosaria Ottana, Paolo Paoli, Mario Cappiello, Trung Ngoc Nguyen, Ilenia Adornato, Antonella Del Corso, Massimo Genovese, Ilaria Nesi, Roberta Moschini, Alexandra Nass, Gerhard Wolber, Rosanna Maccari
Summary: The study synthesized various ligands for diabetes treatment and focused on two enzymes, finding that some compounds exhibited dual AR/PTP1B inhibitory effects at low concentrations and insulin-sensitizing activity.
Review
Chemistry, Inorganic & Nuclear
Raj Kaushal, Mandeep Kaur
Summary: Chalcones and their metal complexes show significant therapeutic potential by interacting with various enzymes involved in diabetes, and possess promising activity against alpha-amylase, alpha-glucosidase, aldose reductase, and tyrosine phosphatase enzymes.
JOURNAL OF COORDINATION CHEMISTRY
(2021)
Article
Chemistry, Physical
Jayanth Jeevanandam, R. Madhumitha, N. T. Saraswathi
Summary: The study aims to identify efficient phytochemicals for inhibiting gamma-crystallin glycation. Among the screened compounds, Alizarin, Pseudobaptigenin, and Ellagic acid showed preferred druglike behavior and binding affinity for inhibiting glycation against gamma-crystallin protein, and could serve as prototypes for synthesizing new molecules against diabetic cataract.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Pharmacology & Pharmacy
Marcello Casertano, Massimo Genovese, Alice Santi, Erica Pranzini, Francesco Balestri, Lucia Piazza, Antonella Del Corso, Sibel Avunduk, Concetta Imperatore, Marialuisa Menna, Paolo Paoli
Summary: Type 2 diabetes mellitus (T2DM) is a complex disease characterized by impaired glucose homeostasis and serious long-term complications. The use of multitarget drugs, such as avarone, could be a potential strategy for the treatment of T2DM and its complications. Avarone, a compound obtained from the sponge Dysidea avara, has been found to inhibit PTP1B and aldose reductase, improving insulin sensitivity and mitochondrial activity in cells.
Review
Endocrinology & Metabolism
Sravya Jannapureddy, Mira Sharma, Gautham Yepuri, Ann Marie Schmidt, Ravichandran Ramasamy
Summary: Diabetes is a major risk factor for cardiovascular disease, and specific disease-modifying therapies are needed for diabetic patients. Research focusing on inhibiting the aldose reductase (AR) pathway to protect the cardiovascular system and the genetic polymorphisms associated with diabetic complications is ongoing to better understand and treat the consequences of diabetic cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Medicinal
Rosanna Maccari, Gerhard Wolber, Massimo Genovese, Gemma Sardelli, Valerij Talagayev, Francesco Balestri, Simone Luti, Alice Santi, Roberta Moschini, Antonella Del Corso, Paolo Paoli, Rosaria Ottana
Summary: Type 2 diabetes mellitus (T2DM) is a serious chronic disease with a growing prevalence worldwide. Current treatment relies on drug combinations, but recently there has been interest in developing multiple-targeted drugs for complex diseases like T2DM. In this study, the researchers designed new compounds that inhibit both PTP1B and AKR1B1, two enzymes crucially involved in the development of T2DM and its complications.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Bo Xue, Jinlong Tian, Yuehua Wang, Bo Jin, Haotian Deng, Ningxuan Gao, Xu Xie, Siyi Tang, Bin Li
Summary: The study revealed that M3G effectively inhibits PTP1B and alpha-glucosidase through reversible mixed inhibition and reversible non-competitive inhibition, respectively. M3G binding alters the secondary structures of these enzymes and regulates the microenvironment of specific amino acid residues.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Sonia Rocha, Mariana Lucas, Vera L. M. Silva, Pedro M. O. Gomes, Artur M. S. Silva, Alberto N. Araujo, Natalia Aniceto, Rita C. Guedes, M. Luisa Corvo, Eduarda Fernandes, Marisa Freitas
Summary: This study evaluated a library of 22 pyrazole compounds against human PTP1B activity, identifying two potent inhibitors and highlighting the importance of additional benzene rings in enhancing PTP1B inhibition. The most active compounds showed selectivity over TCPTP and molecular docking analyses revealed key residue contacts. This study represents a significant step in the design of novel PTP1B inhibitors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Food Science & Technology
Zhiqiang Wang, Zhaoyang Wu, Guanglei Zuo, Soon Sung Lim, Hongyuan Yan
Summary: The study found that defatted seeds of Oenothera biennis (DSOB) have excellent antioxidant, alpha-glucosidase inhibition, and aldose reductase inhibition properties, high content of polyphenols, carbohydrates, proteins, and minerals, making it suitable as an ingredient for functional foods for diabetes.
Article
Medicine, General & Internal
Nianting Tong, Liangyu Wang, Huimin Gong, Lin Pan, Fuxiang Yuan, Zhanyu Zhou
Summary: This study describes the clinical manifestations of supra-large range nonperfusion area (SLRNPA) in diabetic retinopathy (DR). The results show that SLRNPA patients are more likely to be male, younger, with earlier DR onset, a smoking history, other comorbidities, and a higher HbA1c level. SLRNPA in DR is associated with higher rates of neovascular glaucoma and diabetic keratopathy and is difficult to treat with poor prognosis.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Article
Chemistry, Medicinal
Massimo Genovese, Concetta Imperatore, Marcello Casertano, Anna Aiello, Francesco Balestri, Lucia Piazza, Marialuisa Menna, Antonella Del Corso, Paolo Paoli
Summary: The marine-derived phosphorylated polyketide phosphoeleganin was found to inhibit both PTP1B and AR enzymes, acting as a versatile scaffold for the synthesis of new designed multiple ligands.
Article
Biochemistry & Molecular Biology
Seon Min Ju, Md Yousof Ali, Seung-Mi Ko, Jung-Hye Ryu, Jae-Sue Choi, Hyun-Ah Jung
Summary: In this study, eight compounds were isolated from Morus bombycis leaves, and four of them showed strong anti-diabetic activity and antioxidant capacity, indicating that they could be potential therapeutic resources against diabetes and its complications.
Article
Chemistry, Medicinal
Md. Nurul Islam, Ran Joo Choi, Hyun Ah Jung, Sang Ho Oh, Jae Sue Choi
ARCHIVES OF PHARMACAL RESEARCH
(2016)
Article
Nutrition & Dietetics
Md Nurul Islam, Sung Hwa Choi, Hye Eun Moon, Jin Ju Park, Hyun Ah Jung, Mi Hee Woo, Hee Chul Woo, Jae Sue Choi
EUROPEAN JOURNAL OF NUTRITION
(2014)
Article
Food Science & Technology
Jae Sue Choi, Md. Nurul Islam, Md. Yousof Ali, Eon Ji Kim, Young Myeong Kim, Hyun Ah Jung
FOOD AND CHEMICAL TOXICOLOGY
(2014)
Article
Plant Sciences
Shusanto Roy, Mahbubah Jannat, Nadra Tabassum, Mohammad Nurul Islam
Summary: In this study, the variation among different lotus germplasm was evaluated based on external morphological characteristics, genetic variation, and molecular characterization. The morphological features showed a higher level of variation among the germplasm, and a dendrogram was constructed to assess the linkage among them. The molecular method "barcoding" was used to assess the genetic diversity and correct identification of lotus germplasm, and successful identification was achieved except for one germplasm. The study successfully established an efficient protocol for the identification and elite gene source of lotus germplasm.
BANGLADESH JOURNAL OF PLANT TAXONOMY
(2022)
Article
Plant Sciences
M. S. Bhuiyan, M. M. Hossain, Kazi Shakhawath Hossain, Mohammad Nurul Islam
Summary: Isolation and identification of mycorrhizal fungi from the roots of Rhynchostylis retusa confirmed the morphological features of the fungus as Rhizoctonia-like anamorphs of Ceratobasidium species, and further classification was achieved through molecular analysis. The study highlights the efficacy of these techniques in improving the isolation and accurate identification of mycorrhizal fungi, particularly in orchids.
BANGLADESH JOURNAL OF BOTANY
(2021)
Article
Plant Sciences
Shamim Shamsi, Mohammad Nurul Islam, Sarowar Hosen, Md Al-Mamun, Pranami Chowdhury, Mst Selina Momtaz, Najmun Naher, Zuhra Yeasmin, Sadia Sultana, Amina Khatun, Abu-Al-Islam, Md Abul Bashar
BANGLADESH JOURNAL OF PLANT TAXONOMY
(2019)
Article
Plant Sciences
Mohammad Nurul Islam, Aneesa Ansari, R. H. Sarker
BANGLADESH JOURNAL OF BOTANY
(2019)
Article
Plant Sciences
M. Oliur Rahman, Md. Zahidur Rahman, Sonia Khan Sony, Mohammad Nurul Islam
BANGLADESH JOURNAL OF PLANT TAXONOMY
(2017)
Article
Plant Sciences
Mihir Lal Saha, Sadia Afrin, Sonia Khan Sony, Mohammad Nurul Islam
BANGLADESH JOURNAL OF BOTANY
(2017)
Article
Plant Sciences
Anika Tabassum, Mihir Lal Saha, Mohammad Nurul Islam
BANGLADESH JOURNAL OF BOTANY
(2015)
Article
Plant Sciences
Mihir Lal Saha, Tahsin Khan, Md Mostafa Kamal, Mohammad Nurul Islam
BANGLADESH JOURNAL OF BOTANY
(2015)
Article
Chemistry, Medicinal
S. S. Chowdhury, M. N. Islam, H. A. Jung, J. S. Choi
RESEARCH IN PHARMACEUTICAL SCIENCES
(2014)
Article
Plant Sciences
Ashfaque Ahmed, Muminur Rashid, Sharmin Hasan, Md Nurul Islam, Parveen Rashid
BANGLADESH JOURNAL OF BOTANY
(2017)