期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 68, 期 -, 页码 234-238出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.03.024
关键词
Fucoidan; Molecular weight; Spleen cells; Viability; Immunostimulation
资金
- Bio-industry Technology Development Program, Ministry of Agriculture, Food and Rural Affairs
Fucoidan is an edible sulfated polysaccharide purified from brown algae that has multiple biological activities. However, the effects of fucoidans of different molecular weights on immune cells have not been determined. Thus, we treated spleen cells with low- and high-molecular-weight fucoidans (LMF and HMF, respectively). Viability assays demonstrated that HMF enhanced the viability and prevented the death of spleen cells. Furthermore, functional analysis revealed that HMF significantly increased the production of interferon-gamma and nitric oxide. In contrast, LMF had low activity and was relatively toxic to spleen cells. Taken together, these results indicate that HMF makes the greatest contribution to the immunostimulatory activity of fucoidan mixtures. Additionally, fucoidans with different molecular weights may have different effects on the viability and function of immune cells. This study increases our understanding of fucoidans, and may broaden their use in the basic research and clinical fields. (C) 2014 Elsevier Ltd. All rights reserved.
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