期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 74, 期 -, 页码 225-232出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2014.10.005
关键词
Berberine; Alcoholic liver disease; Oxidative stress; Steatosis
资金
- National Natural Science Foundation of China [81072679]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- College Students Innovation Project for the R&D of Novel Drugs [11030830]
Alcohol consumption is customary in many cultures and it is a common human behavior worldwide. Binge ethanol and chronic alcohol consumption, two usual drinking patterns of human beings, produce a state of oxidative stress in liver and disturb the liver function. However, a safe and effective therapy for alcoholic liver disease in humans is still elusive. This study identified the natural product berberine as a potential agent for treating or preventing ethanol-induced liver injury. We demonstrated that berberine attenuated oxidative stress resulted from binge drinking in liver by reducing hepatic lipid peroxidation, glutathione exhaust and mitochondrial oxidative damage. Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice. Either the total cytochrome P450 2E1 or the mitochondria-located cytochrome P450 2E1, which is implicated in ethanol-mediated oxidative stress, was suppressed by berberine. On the other hand, berberine significantly blunted the lipid accumulation in liver due to chronic alcohol consumption, at least partially, through restoring peroxisome proliferator-activated receptor alpha/peroxisome proliferator-activated receptor-gamma Co-activator-1 alpha and hepatocyte nuclear factor 4 alpha/microsomal triglyceride transfer protein pathways. These findings suggested that berberine could serve as a potential agent for preventing or treating human alcoholic liver disease. (C) 2014 Elsevier Ltd. All rights reserved.
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