期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 55, 期 -, 页码 637-644出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.01.060
关键词
Narirutin; Citrus unshiu; Alcoholic liver disease; Oxidative stress; Inflammation
This study aimed to demonstrate protective activities of the narirutin fraction from peels of Citrus unshiu against ethanol-induced hepatic damage through an animal study. Citrus narirutin fraction (CNF), contained 75% of narirutin, was obtained by an ultra-sonicated extraction and further purification. ICR mice were divided into four groups; normaldiet control, ethanol control (6.5 g ethanol/kg), low-CNF (ethanol + 150 mg CNF/kg) and high-CNF (ethanol + 300 mg CNF/kg) groups. Consumption of alcohol for 8 weeks induced severe liver damage with increases in prognostic indicators such as aspartate transaminase, alanine transaminase in serum whereas co-administration of CNF suppressed their increases. Excessive accumulations in liver TG and TC in ethanol control group were also suppressed by co-administration of CNF. Co-administration of CNF maintained SOD activity, GSH and malondialdehyde levels close to those of the normal diet group. Chronic consumption of alcohol also stimulated abrupt increases in pro-inflammatory cytokines such as nuclear factor (NF)-kappa B, tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta in liver otherwise co-administration of CNF effectively suppressed production of these cytokines dose-dependently. These results indicate that co-administration of CNF with alcohol can alleviate alcohol induced liver damage through preventing lipid formation, protecting antioxidant system and suppressing productions of pro-inflammatory cytokines. (C) 2013 Elsevier Ltd. All rights reserved.
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