期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 62, 期 -, 页码 349-354出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2013.08.083
关键词
Apiaceae; Volatile oil; Antimicrobial Inflammation; Aromatic plant; Cell viability
资金
- FCT - Fundacao para a Ciencia e a Tecnologia [PEst-OE/SAU/UI0177/2011]
- [SFRH/BD/40218/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/40218/2007, PEst-OE/SAU/UI0177/2011] Funding Source: FCT
The present study reports the chemical composition, antifungal, antioxidant and anti-inflammatory properties as well as the cytotoxicity of Oenanthe crocata essential oil and one of its main compounds. The essential oil was obtained from the aerial parts of the plant by hydrodistillation and analysed by GC and GC/MS. The oil was predominantly composed of monoterpene hydrocarbons (85.8%), being the main compounds trans-beta-ocimene (31.3%), sabinene (29.0%) and cis-beta-ocimene (12.3%). For the antifungal activity, the minimal inhibitory and minimal lethal concentrations (MICs and MLCs) were determined. The oil was particularly active against dermatophytes and Oyptococcus neoformans, with MIC values ranging from 0.08 to 0.16 mu L/mL. Regarding the anti-inflammatory activity, both the oil and sabinene demonstrated strong anti-inflammatory activity through nitric oxide (NO) production inhibition in lipopolysaccharide (LPS) plus interferon gamma (IFN-gamma)-triggered macrophages. Furthermore, the essential oil showed a potent NO scavenging effect and inhibited inducible NO synthase expression. Interestingly, and although we detected a cytotoxic effect in macrophages and keratinocytes for the highest concentrations tested of the oil and sabinene, we also disclosed bioactive and safe concentrations to be further explored for therapeutic proposes. Taking together, these results support the use of the oil and sabinene for the management of dermatophytosis and/or inflammatory-related diseases. (C) 2013 Elsevier Ltd. All rights reserved.
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