Article
Environmental Sciences
Maria Mooshammer, Wolfgang Wanek, Stephen H. Jones, Andreas Richter, Michael Wagner
Summary: Biological processes drive rapid turnover of cyanate in soils, serving as a nitrogen and energy source for soil microbes. Cyanate concentrations in soils are significantly lower than ammonium and nitrate, highlighting the unclear role of cyanate in biogeochemical cycles.
COMMUNICATIONS EARTH & ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Bei Shi Lee, Kiel Hards, Curtis A. Engelhart, Erik J. Hasenoehrl, Nitin P. Kalia, Jared S. Mackenzie, Ekaterina Sviriaeva, Shi Min Sherilyn Chong, Malathy Sony S. Manimekalai, Vanessa H. Koh, John Chan, Jiayong Xu, Sylvie Alonso, Marvin J. Miller, Adrie J. C. Steyn, Gerhard Gruber, Dirk Schnappinger, Michael Berney, Gregory M. Cook, Garrett C. Moraski, Kevin Pethe
Summary: The study highlights the value of a cytochrome bd oxidase inhibitor in a drug combination targeting oxidative phosphorylation for tuberculosis treatment. When combined with Q203, it can enhance efficacy and kill replicating and antibiotic-tolerant mycobacteria.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Rabia Ramzan, Amalia M. Dolga, Susanne Michels, Petra Weber, Carsten Culmsee, Ardawan J. Rastan, Sebastian Vogt
Summary: This study investigates the effects of ATP inhibition on cytochrome c oxidase (CytOx) in isolated rat heart mitochondria. The findings suggest that inhibiting CytOx activity with ATP leads to static respiration and decreased ROS production, highlighting the importance of ATP/ADP ratio for mitochondrial function.
Article
Cell Biology
Jia Shi, Yi Yang, Ya-Nan Wang, Qing Li, Xue Xing, An-Ying Cheng, Xiao-Na Zhan, Jie Li, Gang Xu, Fan He
Summary: This study reveals the association between metabolism and the progression of vascular calcification in chronic kidney disease (CKD). High phosphate and uremic serum enhance mitochondrial respiration capacity in vascular smooth muscle cells (VSMCs), while glycolysis level remains unchanged. Suppression of cytochrome c oxidase (COX) activity attenuates vascular calcification.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Kellye Cupp-Sutton, Michael T. Ashby
Summary: Lactoperoxidase catalyzes the oxidation of thiocyanate to produce hypothiocyanite, potentially involving an ordered sequential mechanism rather than the traditional halogen cycle as proposed.
Article
Chemistry, Multidisciplinary
Zebin Yang, Yu Luo, Yanan Hu, Kaicheng Liang, Gao He, Qian Chen, Qigang Wang, Hangrong Chen
Summary: By developing novel nanoparticles combined with photothermal and gas therapy, tumor growth can be inhibited in the tumor environment, opening up a new approach for the design of gas-mediated cancer treatment.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M. Pentimalli, Rene Juettner, Petar Glazar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Therese Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di Virgilio, Johannes A. Mayr, Saskia B. Wortmann, Josef Priller, Michael Gotthardt, Dean P. Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kuehn, Erich E. Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione
Summary: Leigh syndrome (LS) is a severe neurometabolic disorder lacking effective models. This study found that LS carrying mutations in SURF1 gene exhibit impaired neuronal morphogenesis due to metabolic deficiencies.
NATURE COMMUNICATIONS
(2021)
Editorial Material
Plant Sciences
Yongming Liu, Hussam Hassan Nour-Eldin, Ling Zhang, Zhanshuai Li, Alisdair R. Fernie, Maozhi Ren
Summary: The widespread occurrence of natural phytotoxins poses a challenge for crop consumption. To address this issue, we propose the use of biotechnological strategies to increase the harvest index without altering crop biomass or plant architecture.
TRENDS IN PLANT SCIENCE
(2023)
Article
Chemistry, Analytical
Ge Kang, Yijia Jing, Wendong Liu, Chenghui Zhang, Lixia Lu, Chuanxia Chen, Yizhong Lu
Summary: A novel colorimetric method for sensitive detection of thiocyanate (SCN-) has been developed based on its suppression of the oxidase-like activity of palladium square nanoplates on reduced graphene oxide. The method allows for both quantitative and visual detection of SCN-, and is sensitive enough for real sample detection.
Article
Multidisciplinary Sciences
Michael B. Powner, Glen Jeffery
Summary: Systemic glucose levels can be modulated through specific solar wavelengths that affect mitochondrial metabolism. Different wavelengths of light have opposing effects on mitochondrial respiration, with longer wavelengths increasing ATP production and shorter wavelengths suppressing metabolism. This study in a bumblebee model found that manipulating mitochondrial activity with specific wavelengths of light significantly altered circulating glucose concentration. This research contributes to our understanding of how light can affect systemic metabolism.
Article
Multidisciplinary Sciences
Agnes Moe, Justin Di Trani, John L. Rubinstein, Peter Brzezinski
Summary: Energy conversion in aerobic organisms involves electron transfer from low-potential donors to dioxygen through the membrane-bound respiratory chain. The formation of supercomplex CIII2CIV1/2 facilitates electron transfer by two-dimensional diffusion of cyt. c, increasing QH(2):O-2 oxidoreductase activity and suggesting a regulatory role for supercomplex formation in the respiratory chain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Sue Ellen Brand, Martha Scharlau, Lois Geren, Marissa Hendrix, Clayre Parson, Tyler Elmendorf, Earl Neel, Kaila Pianalto, Jennifer Silva-Nash, Bill Durham, Francis Millett
Summary: Cytochrome c (Cc) has undergone accelerated evolution from anthropoid primates to humans, with several amino acid changes occurring near the binding site of the Cc:CcO complex. These changes affect the dissociation constant and the role of phosphorylation in regulating mitochondrial electron transport and membrane potential.
Article
Microbiology
Sheng Zeng, Jingran Zhang, Mingwei Sun, Xiaofei Zhang, Gregory M. Cook, Tianyu Zhang
Summary: The branched electron transport chain of Mycobacterium tuberculosis allows it to resist the bactericidal action of cytochrome bc(1) inhibitors such as TB47. Combining cytochrome bc(1) inhibitors with nitric oxide donors like PMD can inhibit M. tuberculosis respiration and kill the bacteria, with the activity of the inhibitors enhanced by the presence of NO donors.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Wenshu Cong, Li Meng, Yuanjie Pan, Han Wang, Jiahui Zhu, Yuanyu Huang, Qingli Huang
Summary: Population aging is a global issue, and this study presents a novel approach using Pd-based single-atom nanozymes to improve mitochondrial function and attenuate aging. The nanozyme mimics enzyme activities in the mitochondrial respiratory chain and enhances mitochondrial activities and abundance. Additionally, it demonstrates excellent anti-aging and neuroprotective effects through the activation of the mitochondrial unfolded protein response (UPRmt) pathway.
Article
Veterinary Sciences
Steven V. Kubiski, Carmel Witte, Jennifer A. Burchell, Dylan Conradson, Alexandra Zmuda, Alberto Rodriguez Barbon, Jose G. Vilches-Moure, Stephen A. Felt, Bruce A. Rideout
Summary: Isospora infections are common in both wild and captive passerine species. The severity of the disease varies, making it a concern for institutions housing endangered species. The risk of severe isosporiasis due to mixed-species enclosures and non-host-adapted strains needs further research.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Shiv Kumar Yadav, Deo Kumar, Pravin Kumar, Pradeep Kumar Gupta, Rahul Bhattacharya
INTERNATIONAL JOURNAL OF TOXICOLOGY
(2018)
Article
Food Science & Technology
Rahul Bhattacharya, Pooja Rao, Poonam Singh, Shiv Kumar Yadav, Preeti Upadhyay, Sandhya Malla, Niranjan Laxman Gujar, Vinay Lomash, Satish Chandra Pant
FOOD AND CHEMICAL TOXICOLOGY
(2014)
Article
Medicine, Legal
Poonam Singh, Pooja Rao, Shiv K. Yadav, Niranjan L. Gujar, Ravindra M. Satpute, Rahul Bhattacharya
JOURNAL OF FORENSIC SCIENCES
(2015)
Article
Plant Sciences
Rahul Bhattacharya, Natarajan Gopalan, Anil Kumar Singh, Poonam Singh, Shiv Kumar Yadav, Pooja Rao, Saurabh Shrivastava
PHARMACEUTICAL BIOLOGY
(2014)
Article
Agriculture, Dairy & Animal Science
Vinod Kumar Yata, Dharmendra Kumar Gangwar, Vishal Sharma, Shivam Kumar Dubey, Shiv Kumar Yadav, Suman Choudhary, Sudarshan Kumar, Tushar Kumar Mohanty, Ashok Kumar Mohanty
ANIMAL REPRODUCTION SCIENCE
(2020)
Article
Medicine, Research & Experimental
Shiv Kumar Yadav, D. P. Nagar, Rahul Bhattacharya
Article
Public, Environmental & Occupational Health
Shiv K. Yadav, Gajanan P. Patil, Ankit Virmagami, Vandana Bijalwan, Kirti Devi, Aakriti Chauhan, Sanjeev K. Gupta, Shabarin Fathima, Chaoba D. Naorem, Suresh Yadav, Gyanendra Singh, SukhDev Mishra, Mahendra Bishnoi, Kamalesh Sarkar, Dhirendra P. Singh
Summary: Occupational lead exposure in lead-acid battery recyclers has adverse effects on cardiopulmonary functions, including increased blood lead levels, blood pressure, and small airways obstruction in lung function tests. It also impairs platelet indices, affects renal and liver function, and promotes oxidative stress and DNA damage.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Shiv K. K. Yadav, Vandana Bijalwan, Suresh Yadav, Kamalesh Sarkar, Santasabuj Das, Dhirendra P. P. Singh
Summary: This paper examines the male reproductive toxicity of Bisphenol A (BPA), including its impact on hormonal balance, sperm parameters, and reproductive organs. Furthermore, it highlights the role of non-monotonic dose-response (NMDR) in BPA exposure, providing a better understanding of the harmful effects of BPA on the male reproductive system.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dhirendra Pratap Singh, Shiv Kumar Yadav, Keya Patel, Shirali Patel, Gajanan Pratap Patil, Vandana Bijalwan, Gyanendra Singh, Rajendra Palkhade, Kanthi Kiran Kondepudi, Ravneet Kaur Boparai, Mahendra Bishnoi, Santasabuj Das
Summary: This study assessed the effects of short-term exposure to As(III) and Cr(VI) on key transcription factors and gut microbial abundances. The results showed that these exposures reduced beneficial bacteria, impaired gut wall integrity, inhibited adipogenesis and thermogenesis gene expression, and promoted oxidative stress and inflammation.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Agriculture, Dairy & Animal Science
Shiv Kumar Yadav, Dharmendra Kumar Gangwar, Jarnail Singh, Chiranjeev Kumar Tikadar, V. Vinoth Khanna, Sudha Saini, Sunny Dholpuria, Prabhat Palta, Radhey Shyam Manik, Manoj Kumar Singh, Suresh Kumar Singla
Article
Biochemistry & Molecular Biology
S. K. Yadav, D. Swami, P. Kumar, M. K. Meena, C. K. Maurya, P. K. Gupta, K. Ganesan, A. K. Jain, R. Bhattacharya
CELLULAR AND MOLECULAR BIOLOGY
(2014)
