Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Hui Liu, Chuankun Zhou, Dahu Qi, Yutong Gao, Meipeng Zhu, Tenghui Tao, Xuying Sun, Jun Xiao
Summary: MAGL plays a role in osteoclast differentiation through the MAPK and NF-kappa B pathways. JZL184 inhibits osteoclast differentiation and bone resorption, alleviating bone loss effects. Targeting MAGL may be a potential therapeutic strategy for osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Yo-Seob Seo, Hyang Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Hyun-Hwa Lee, Deuk-Sil Oh, Jae-Sung Kim
Summary: The purpose of this study was to evaluate the anti-osteoporosis effects of Osmanthus fragrans leaf ethanol extract (OFLEE) in both bone marrow-derived macrophages (BMM) and animals with osteoporosis. OFLEE was found to suppress the formation of osteoclasts and the activation of various factors involved in osteoclastogenesis. It also downregulated several inflammatory factors and prevented osteoporotic bone loss in animals. These findings suggest that OFLEE could be a potential treatment option for osteoporosis.
Article
Multidisciplinary Sciences
Yin Cheng, Haixia Liu, Jing Li, Yujie Ma, Changheng Song, Yuhan Wang, Pei Li, Yanjing Chen, Zhiguo Zhang
Summary: This study investigated the influence of different culture conditions on osteoclast differentiation in RAW264.7 cells. The results showed that RANKL treatment and cell density were important factors for osteoclast formation, while the addition of M-CSF had little effect. This research provides valuable insights into the optimal conditions for studying osteoclast function and mechanism.
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Guobin Qi, Zengxin Jiang, Wei Lu, Defang Li, Weibing Chen, Xiuying Yang, Lei Ding, Hengfeng Yuan
Summary: Berbamine, a natural product from Berberis amurensis Rupr, was found to have a protective effect against osteoporosis by inhibiting osteoclastogenesis and bone resorption without affecting osteogenesis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Mengbo Zhu, Wenbin Xu, Jiuzhou Jiang, Yining Wang, Yanjing Guo, Ruijia Yang, Yaqiong Chang, Bin Zhao, Zhenyu Wang, Jianfeng Zhang, Te Wang, Liqin Shangguan, Shaowei Wang
Summary: The study found that peiminine can inhibit the differentiation and function of OCs by regulating the levels of specific genes and proteins, with potential targets including NF-kappa B and ERK1/2 signaling pathways. In an animal model, peiminine can alleviate bone loss in ovariectomized mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Kebin Xu, Ziyi Chen, Jialong Hou, Chenlin Dong, Chengge Shi, Linglin Gao, Zhixian Huang, Ge Shen, Te Wang, Yan Zhou
Summary: The study showed that Praeruptorin B, a major component in the roots of Peucedanum praeruptorum Dunn, could suppress osteoporosis and alleviate symptoms in patients. This finding offers potential for using Praeruptorin B in the treatment of osteoporosis in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Cell Biology
Luodan Zhang, Fa Zeng, Minmin Jiang, Maozhen Han, Binbin Huang
Summary: This article reviews the potential role and therapeutic potential of osteoprotegerin in endocrine and metabolic diseases. It mainly focuses on the effects of osteoprotegerin through the RANKL/RANK/OPG system on various processes such as bone remodeling, vascular calcification, and beta-cell proliferation, providing a comprehensive understanding of osteoprotegerin as a potential drug for these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiaodi Zhang, Zhengfang Sun, Ying Zhang, Liuzhu Pan, Wei Jiang, Hui Dong, Zhengxin Jin, Jianning Kang, Ronghan Liu, Bin Ning
Summary: This study demonstrates that Periplocin can reduce inflammation and attenuate bone resorption in osteoporosis by inhibiting MAPK and NF-kappa B signaling pathways. It also exerts anti-inflammatory and anti-osteoclastic effects by binding to LRP4. These findings provide new possibilities for the treatment of osteoporosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qiang Xu, Guiping Chen, Huaen Xu, Guoming Xia, Meisong Zhu, Haibo Zhan, Bin Zhang, Min Dai, Hongxian Fan, Xuqiang Liu
Summary: Celastrol has shown promising potential in preventing aseptic prosthetic loosening and osteoporosis by inhibiting osteoclast formation and function, making it a potential treatment for osteolytic diseases induced by disrupted osteoclast function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xue Yang, Jiamin Liang, Ziyi Wang, Yuangang Su, Yunfei Zhan, Zuoxing Wu, Jing Li, Xuedong Li, Runfeng Chen, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Summary: This study found that sesamolin has the potential to treat osteoporosis by effectively inhibiting the formation of osteoclasts in vitro, attenuating bone loss through modulating multiple signaling pathways and gene expression, and demonstrating a preventive effect against bone loss induced by estrogen deficiency in vivo.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Yu, Leilei Zhong, Lutian Yao, Yulong Wei, Tao Gui, Ziqing Li, Hyunsoo Kim, Nicholas Holdreith, Xi Jiang, Wei Tong, Nathaniel Dyment, X. Sherry Liu, Shuying Yang, Yongwon Choi, Jaimo Ahn, Ling Qin
Summary: Our study identified marrow adipogenic lineage precursors (MALPs) as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Orthopedics
Yongyun Chang, Keyu Kong, Zhicheng Tong, Hua Qiao, Yi Hu, Runzhi Xia, Jingwei Zhang, Zanjing Zhai, Huiwu Li
Summary: Through in vitro and in vivo experiments, it has been found that aspirin has dual effects on bone metabolism, inhibiting the formation of osteoclasts and promoting the formation of osteoblasts, thus preventing osteoporosis. These findings indicate that aspirin has potential applications in the prevention and treatment of bone diseases.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Zhendong Lei, Lin Ding, Chenjie Yao, Fengfeng Mo, Chenchen Li, Yanan Huang, Xuelian Yin, Min Li, Jinliang Liu, Yong Zhang, Changquan Ling, Yanli Wang
ADVANCED MATERIALS
(2019)
Review
Oncology
Wan-Fu Lin, Mao-Feng Zhong, Qing-Hui Zhou, Yu-Ren Zhang, Huan Wang, Zhi-Hao Zhao, Bin-Bin Cheng, Chang-Quan Ling
CANCER MANAGEMENT AND RESEARCH
(2019)
Editorial Material
Biochemistry & Molecular Biology
Zi-fei Yin, Ya-ni Zhang, Shu-fang Liang, Sha-sha Zhao, Juan Du, Bin-bin Cheng
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2019)
Article
Oncology
Juan Du, Zhihao Zhao, Hetong Zhao, Dong Liu, Hui Liu, Jun Chen, Binbin Cheng, Xiaofeng Zhai, Zifei Yin, Yani Zhang, Changquan Ling
Article
Oncology
Shu Li, Wei Zhao, Zhimin Zhao, Binbin Cheng, Shuang Li, Chenghai Liu
MOLECULAR MEDICINE REPORTS
(2020)
Article
Integrative & Complementary Medicine
He-tong Zhao, Yong-bin Meng, Xiao-feng Zhai, Bin-bin Cheng, Sha-sha Yu, Man Yao, Hui-xia Yin, Xu-ying Wan, Yun-ke Yang, Hui Liu, Feng Shen, Chang-quan Ling
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2020)
Article
Integrative & Complementary Medicine
Wanfu Lin, Huan Wang, Maofeng Zhong, Shasha Yu, Shasha Zhao, Shufang Liang, Juan Du, Binbin Cheng, Wei Gu, Changquan Ling
Summary: Transcatheter arterial chemoembolization (TACE) is an effective treatment for hepatocellular carcinoma (HCC), but it may induce hypoxia and promote cytokine secretion, leading to tumor metastasis. This study explored the impact of Jiedu Recipe (JR), a traditional Chinese medicine, on TACE-induced cytokine upregulation and hypoxia-induced angiogenesis in HCC patients. Results showed that JR inhibited hypoxia-induced angiogenesis by suppressing IL-8/HIF-1α/PI3K and MAPK/ERK pathways.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Wanfu Lin, Shu Li, Yongbin Meng, Guokai Huang, Shufang Liang, Juan Du, Qun Liu, Binbin Cheng
Summary: This study found that ursodeoxycholic acid (UDCA) can inhibit hypoxic hepatocellular carcinoma (HCC) cell-induced angiogenesis by suppressing HIF-1 alpha/VEGF/IL-8-mediated intercellular signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Wentao Jia, Shufang Liang, Binbin Cheng, Changquan Ling
Summary: CAFs play a critical role in influencing tumor growth, invasion, and metastasis, with both tumor-supporting and tumor-suppressive effects. Traditional Chinese medicine, with its pleiotropic regulation properties, has potential in targeting CAFs for the treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Integrative & Complementary Medicine
Shufang Liang, Yong Zou, Jingdong Gao, Xiaolin Liu, Wanfu Lin, Zifei Yin, Juan Du, Ya'ni Zhang, Qunwei Chen, Shu Li, Binbin Cheng, Changquan Ling
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Man Yao, Shufang Liang, Binbin Cheng
Summary: Hepatocellular carcinoma (HCC) is typically associated with chronic liver inflammation and cirrhosis. Exosomes, nanometer-sized membrane vesicles, play a crucial role in the initiation and progression of HCC. They mediate cell-cell communication and regulate the tumor microenvironment by carrying proteins, DNAs, and various forms of RNA. Studies have shown that exosomes are involved in the communication between HCC cells and stromal cells, and they influence tumor proliferation, metastasis, immune evasion, and immunotherapy. Furthermore, exosomes can be utilized for the diagnosis and treatment of HCC, serving as biomarkers for early detection and drug delivery vehicles. Chinese herbal medicine, commonly used in HCC prevention and treatment in China, may regulate the release of exosomes and exosomes-mediated intercellular communication. This review summarizes the role of exosomes in HCC initiation, progression, and treatment, as well as the potential value of Traditional Chinese medicine in exosomes-mediated biological behaviors of HCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Wentao Jia, Jiaying Yuan, Binbin Cheng, Changquan Ling
Summary: This review discusses the potential mechanism of tumor-derived exosome (TDE)-mediated premetastatic niche (PMN) formation as a means of organotropic metastasis. Traditional Chinese medicine (TCM) has been successful in preventing and treating tumor metastasis, but the underlying mechanisms are still unclear. The review explores PMN formation through TDE biogenesis, cargo sorting, and alterations in recipient cells, which are crucial for metastatic outgrowth. It also examines the metastasis-preventive effects of TCM, which target the physicochemical materials and functional mediators of TDE biogenesis, regulate cargo sorting machinery and secretory molecules in TDEs, and target the TDE-recipient cells involved in PMN formation.
Article
Integrative & Complementary Medicine
Bing-jie Guo, Yi Ruan, Ya-jing Wang, Chu-lan Xiao, Zhi-peng Zhong, Bin-bin Cheng, Juan Du, Bai Li, Wei Gu, Zi-fei Yin
Summary: This study investigated the mechanism of Jiedu Recipe (JR) in hepatocellular carcinoma (HCC) treatment. The results showed that JR inhibits the proliferation, migration and invasion of HCC cells under hypoxia by blocking the Wnt/β-catenin pathway and reducing the expression of tumor stem cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Medicine, Research & Experimental
Maofeng Zhong, Xiaofeng Zhai, Wanfu Lin, Qun Liu, Man Yao, Yuyu Guo, Binbin Cheng, Changquan Ling
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2020)
Article
Medicine, Research & Experimental
Wanfu Lin, Maofeng Zhong, Yuren Zhang, Zhihong Chen, Jianfeng Xu, Cheng Wu, Qun Liu, Huan Wang, Shasha Zhao, Binbin Cheng, Changquan Ling
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2020)