Article
Environmental Sciences
Massimo Venditti, Mariem Ben Rhouma, Maria Zelinda Romano, Imed Messaoudi, Russel J. Reiter, Sergio Minucci
Summary: This study found that melatonin can alleviate the damage of cadmium on the adult rat testis, including decreased testosterone concentrations, altered sperm parameters, and disruption of the blood-testis barrier and germ cell structure. Melatonin can reduce oxidative damage caused by cadmium, reverse observed changes, and improve sperm quality.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Waseem Ali, Kai Deng, Jian Sun, Yonggang Ma, Zongping Liu, Hui Zou
Summary: Autophagy plays a critical role in spermatogenesis, but disruption of autophagic flux can lead to cell death. This study reveals that cadmium-induced autophagy might be involved in the regulation of spermiophagy and highlights the potential high risk to male fertility in the context of cadmium toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Massimiliano Peana, Alessio Pelucelli, Christos T. Chasapis, Spyros P. Perlepes, Vlasoula Bekiari, Serenella Medici, Maria Antonietta Zoroddu
Summary: Cadmium (Cd) is a toxic metal that can cause chronic exposure and increase the risk of various cancers. It is mainly released into the environment through human activities such as industrial processes, pollution, waste incineration, and electronic waste recycling. Cd-induced carcinogenesis mechanisms include oxidative stress, inhibition of antioxidant enzymes, lipid peroxidation, and interference with DNA repair systems. Proper treatments for Cd poisoning and preventive measures to counteract chronic exposure are summarized in this paper.
Article
Biochemistry & Molecular Biology
Lalrawngbawli Annie, Vanrohlu Nicy, Vanlal Rempuia, Chuckles Ch. Marak, Guruswami Gurusubramanian, Vikas K. Roy
Summary: Cadmium (Cd) is a heavy metal pollutant that causes toxicological effects on the testes. Morin hydrate, a plant-derived bioflavonoid, may have a protective effect against Cd-induced testicular impairment. In vivo and in vitro studies were conducted to investigate the role of Morin on Cd-mediated testicular toxicity. The results showed that Morin upregulated testicular visfatin and GCNA expression, improved testosterone levels, testicular histology, and sperm parameters in Cd-intoxicated mice. It also normalized the downregulation of visfatin and GCNA expression and suppressed testosterone secretion from testicular explants. Overall, Morin might play a protective role against Cd-induced testicular toxicity by upregulating testicular visfatin and GCNA expression.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Environmental Sciences
Ke Wang, Huina Hu, Wenbo Cui, Xuelian Zhang, Qi Tang, Nuan Liu, Xianyong Lan, Chuanying Pan
Summary: The study found that metformin has significant therapeutic effects on reproductive toxicity induced by triptolide, mainly by restoring the structural and functional stability of the testis through antioxidant stress.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Milena Andelkovic, Aleksandra Buha Djordjevic, Dragana Vukelic, Danijela Dukic-Cosic, Miodrag Acimovic, Nebojsa Bojanic, Daniela Bartolovic, Petar Bulat, Biljana Antonijevic, Zorica Bulat
Summary: Testis cancer (TC) is the most common malignancy of young men. Current evidence suggests a significant role of toxic metals, cadmium (Cd) and lead (Pb), in the origin and development of TC. This study investigated metal levels in blood, healthy, and tumor testis tissue and revealed hormone, oxidative status, and bioelements levels in TC patients. The study found significantly higher blood Cd levels in TC patients, but no significant difference in metal concentration between healthy and tumor testis tissue.
Article
Environmental Sciences
Guo-Xiang Zhou, Wei-Bo Liu, Li-Min Dai, Hua-Long Zhu, Yong-Wei Xiong, Dai-Xin Li, De-Xiang Xu, Hua Wang
Summary: Cadmium exposure impairs the blood-testis barrier by activating mitochondrial stress and related pathways in Sertoli cells, while melatonin can rescue this damage by blocking mitochondrial stress.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Lijuan Xiong, Bin Zhou, Jamie L. Young, Kupper Wintergerst, Lu Cai
Summary: Cadmium exposure can induce testicular damage through ferroptosis, possibly due to iron accumulation and decreased expression of Nrf2, HO-1, SOD2, and SLC7A11.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Plant Sciences
Lei Hou, Shengzhe Ji, Yao Zhang, Xiuzhe Wu, Li Zhang, Peng Liu
Summary: Cadmium is a highly toxic heavy metal element that poses a serious threat to food safety and agricultural production worldwide. Silicon, the second most abundant element in the Earth's crust, has been widely studied for its ability to promote plant growth and alleviate cadmium toxicity. This review summarizes the recent progress in understanding how silicon mitigates cadmium toxicity in plants, including its role in reducing cadmium uptake and transport, improving nutrient supply, regulating antioxidant systems, optimizing plant architecture, and enhancing water balance.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Optics
Hailang Dai, Hongrui Shan, Zhangchi Sun, Daopeng Dai, Yuxi Shang, Zhuangqi Cao, Xianfeng Chen
Summary: The paper introduces a novel fluorescence detection method to aid medical workers in early diagnosis and intervention of malignant tumors, leading to personalized cancer diagnosis and therapy.
PHOTONICS RESEARCH
(2021)
Article
Engineering, Environmental
Liwen Qiang, Nan Zhao, Kaizhen Liao, Xichao Sun, Qiang Wang, Hangbiao Jin
Summary: ENPs can resist heavy metal toxicity in plants, but their coexposure still exhibits toxicity to plants. This study aimed to investigate the toxic mechanism of nano TiO2 or TiO2-Cd on rice using transcriptomics and metabolomics. The findings showed that nano TiO2-Cd coexposure significantly decreased the plant height and root dry weight of rice. Nano TiO2 exposure induced regulation of DEGs and metabolites, while nano TiO2-Cd coexposure identified a greater number of DEGs and differential metabolites. The study highlights the importance of being cautious when using ENPs to combat heavy metal phytotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Yuanliang Li, Hanming Chen, Jianzhao Liao, Keli Chen, Muhammad Tariq Javed, Na Qiao, Qiwen Zeng, Bingxian Liu, Jiangnan Yi, Zhaoxin Tang, Ying Li
Summary: Copper exposure may result in testicular toxicity, decrease hormone concentrations, increase copper levels, and promote antioxidant responses such as cell apoptosis and autophagy, ultimately leading to testicular dysfunction.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Wenxuan Dong, Kanglei Zhang, Gang Liu, Yun Tan, Hui Zou, Yan Yuan, Jianhong Gu, Ruilong Song, Jiaqiao Zhu, Zongping Liu
Summary: Cadmium reduces lactic acid production in the testis of rats, while administration of puerarin restores lactate production and reduces cadmium toxicity to the testis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuxi Zhang, Qianghua Xue, Xuelian Yin, Lin Zhan, Junfeng Zhang, Murad Khan, Yinghua Wu, Jiale Ju, Yajie Li, Yajun Xu, Wen He, Yanli Wang, Chenchen Li
Summary: A new graphene-based fluorescent nanoprobe for tumor cell nucleus (GTTNs) was synthesized, showing potential for clinical applications in targeting cancer cell nucleus. Although acute and subacute toxicity studies have been conducted on GTTNs, evaluation of reproductive and offspring developmental toxicity is lacking.
MOLECULAR PHARMACEUTICS
(2023)
Review
Environmental Sciences
Fasih Ullah Haider, Cai Liqun, Jeffrey A. Coulter, Sardar Alam Cheema, Jun Wu, Renzhi Zhang, Ma Wenjun, Muhammad Farooq
Summary: This manuscript reviews the sources of Cd contamination, factors affecting Cd uptake in soil, toxicity of Cd in plants, and potential remediation strategies. It emphasizes the importance of interdisciplinary studies on Cd stress and essential strategies for overcoming Cd contamination in agricultural soils.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
