4.7 Article

Toxic hepatitis in a group of 20 male body-builders taking dietary supplements

期刊

FOOD AND CHEMICAL TOXICOLOGY
卷 50, 期 10, 页码 3826-3832

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2012.07.006

关键词

Athletes; Dietary supplements; Hepatitis; Toxic

向作者/读者索取更多资源

Dietary supplements have been used for decades for enhancing muscle growth. The harm caused by some of these products is well documented. We investigated and reported toxic hepatitis in 20 male athletes following self-prescribing of a number of dietary supplements which are lesser known. The patients' ages ranged from 24 to 32 with a mean of 28 years. They had taken three kinds of supplements for 1 year including testosterone optimizer agent T Bomb II, a creatine supplement Phosphagen and an amino acid based supplement Cell-Tech. Based on the history, clinical examination, and laboratory findings the cases were diagnosed as toxic hepatitis. After discontinuation of taking the supplements, clinical recovery and improvement of liver function tests were achieved within 30 days. Causality assessment with the CIOMS (Council for International Organization Medical Sciences) scale showed a possible grade of causality (+5 points) for these supplements. It can be concluded that these newer anabolic supplements may induce toxic hepatitis. Since the health risks of them may be severe, the use of these kinds of dietary supplements should be discouraged. (C) 2012 Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Cell Biology

The overview and perspectives of biosensors andMycobacterium tuberculosis: A systematic review

Kobra Salimiyan Rizi, Ehsan Aryan, Zahra Meshkat, Golnaz Ranjbar, Mojtaba Sankian, Kiarash Ghazvini, Hadi Farsiani, Hamid R. Pourianfar, Majid Rezayi

Summary: Tuberculosis (TB) is a fatal human disease that has been prevalent for thousands of years, and the rapid diagnosis of Mycobacterium tuberculosis (M. tb) is crucial for timely treatment and disease prevention. Biosensors, especially DNA electrochemical biosensors, have shown great potential and wide usage in the diagnosis of M. tb and its drug resistance, providing fast, valid, and cost-efficient diagnostic methods.

JOURNAL OF CELLULAR PHYSIOLOGY (2021)

Article Environmental Sciences

Bayesian Spatial Survival Analysis of Duration to Cure among New Smear-Positive Pulmonary Tuberculosis (PTB) Patients in Iran, during 2011-2018

Eisa Nazar, Hossein Baghishani, Hassan Doosti, Vahid Ghavami, Ehsan Aryan, Mahshid Nasehi, Saeid Sharafi, Habibollah Esmaily, Jamshid Yazdani Charati

Summary: This study aimed to examine the spatial variations of duration to cure and its associated factors in Iran. The results showed that factors such as gender, altitude, bacilli density, delayed diagnosis, nationality, and location significantly influenced the duration to cure, while pretreatment weight was associated with shorter duration to cure. The spatial log-logistic model with convolution prior demonstrated better performance in analyzing the duration to cure of PTB patients.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Immunology

The propagation of HSV-1 in high autophagic activity

A. Movaqar, A. Abdoli, E. Aryan, Z. Meshkat

Summary: The study demonstrates that autophagy activation can significantly reduce virus yield in neuroblastoma cells while decreasing HSV-1 propagation in HeLa cells. However, HSV-1 proliferation increases in both cell types and maintains its ability to propagate even under high autophagic activity. Overactivation of autophagy only slows down the rate of virus replication.

MICROBIAL PATHOGENESIS (2021)

Review Biochemistry & Molecular Biology

Development of detection methods for the diagnosis and analysis of highly toxic metal phosphides: A comprehensive and critical review

Arash Mohammadinejad, Kobra Salimiyan Rizi, Reza Kazemi Oskuee, Ehsan Aryan, Zahra Meshkat, Alizar Ulianas, Majid Rezayi

Summary: Metal phosphides and phosphine are commonly used as insecticides and rodenticides, with poisoning often caused by ingestion or inhalation. Early and accurate diagnosis is crucial for effective clinical treatment or determining the cause of death. Diagnosis methods for these compounds have significantly progressed in recent years, with techniques such as head-space gas chromatography and gas sensors showing promise for further advancement.

BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY (2022)

Article Chemistry, Analytical

Response surface methodology optimized electrochemical DNA biosensor based on HAPNPTs/PPY/MWCNTs nanocomposite for detecting Mycobacterium tuberculosis

Kobra Salimiyan Rizi, Behnaz Hatamluyi, Majid Rezayi, Zahra Meshkat, Mojtaba Sankian, Kiarash Ghazvini, Hadi Farsiani, Ehsan Aryan

Summary: In this study, a rapid, low-cost, and PCR-free DNA biosensor based on MWCNTs, PPy, and HAPNPs was developed for highly sensitive and specific recognition of Mycobacterium tuberculosis. The novel use of PB screening design and RSM based on CCD helped optimize the conditions for maximum biosensor performance. The biosensor exhibited a wide detection range and low detection limit for practical applications in clinical diagnosis.

TALANTA (2021)

Review Environmental Sciences

A systematic review on the metabolic effects of chlorpyrifos

Tahereh Farkhondeh, Omid Mehrpour, Mahmood Sadeghi, Michael Aschner, Hamed Aramjoo, Babak Roshanravan, Saeed Samarghandian

Summary: The study investigated the effects of CPF exposure on blood glucose, lipid profiles, and body weight in rodents and fish. Results showed that CPF exposure led to hyperglycemia, hyperlipidemia, decreased insulin levels, and body weight changes. Additionally, the metabolic alterations induced by CPF were dose- and time-dependent, indicating a potential link between CPF exposure and metabolic diseases that require further research to understand the underlying mechanisms.

REVIEWS ON ENVIRONMENTAL HEALTH (2022)

Review Chemistry, Medicinal

Potential benefits versus hazards of herbal therapy during pregnancy; a systematic review of available literature

Soudabeh Balarastaghi, Mohammad Delirrad, Abbas Jafari, Mohammad Majidi, Mahmood Sadeghi, Hadi Zare-Zardini, Gholamreza Karimi, Adel Ghorani-Azam

Summary: The use of herbal medicine has significantly increased worldwide over the past two decades, but some herbal medicines may have toxic effects on pregnant women and their fetuses, potentially leading to severe adverse effects, such as miscarriage and fetal developmental abnormalities.

PHYTOTHERAPY RESEARCH (2022)

Article Multidisciplinary Sciences

Pharmaceutical toxicity is a common pattern of inpatient acute poisonings in Birjand City, East of Iran

Kobra Naseri, Zahra Kiani, Zakieh Sadat Sajadi, Omid Mehrpour, Seyed Yoosef Javadmoosavi, Fatemeh Forouzanfar, Mahmood Sadeghi

Summary: This study analyzed cases of acute poisonings in a major poisoning center in Birjand city, Iran, and identified the characteristics of these cases, including the patients' age, season of poisoning, route of exposure, and types of toxicants. The results showed that pharmaceutical products and opioid abuse were the main causes of poisonings, particularly through oral ingestion and suicidal attempts at home. Therefore, it is recommended for national health authorities to strengthen drug distribution monitoring and to give significant attention to mental health in order to prevent suicide attempts.

SCIENTIFIC REPORTS (2023)

Article Medicine, General & Internal

A Comparative Study on Visual Detection of Mycobacterium tuberculosis by Closed Tube Loop-Mediated Isothermal Amplification: Shedding Light on the Use of Eriochrome Black T

Alireza Neshani, Hosna Zare, Hamid Sadeghian, Hadi Safdari, Bamdad Riahi-Zanjani, Ehsan Aryan

Summary: Closed tube LAMP was used for the visual detection of Mtb, comparing turbidimetric and two colorimetric methods. Turbidimetric method had the best analytical sensitivity, diagnostic sensitivity and specificity, but was prone to subjective error. EBT-LAMP showed the lowest potential for subjective error in reading the results.

DIAGNOSTICS (2023)

Article Integrative & Complementary Medicine

The significance of thymoquinone administration on liver toxicity of diazinon and cholinesterase activity; a recommendation for prophylaxis among individuals at risk

Gholam-Hassan Danaei, Arian Amali, Mohammad Karami, Mohammad-Bagher Khorrami, Bamdad Riahi-Zanjani, Mahmood Sadeghi

Summary: This study aimed to evaluate the protective effects of thymoquinone (TQ) against diazinon (DZN)-induced hepatotoxicity and found that the antioxidant and free radical scavenging properties of TQ may be associated with its ability to alleviate oxidative stress and enhance cholinesterase enzyme activity. In addition, it was observed that TQ could improve DZN-induced liver pathological alterations, increase the activity of acetylcholinesterase, butyrylcholinesterase, and superoxide dismutase enzymes, and reduce malondialdehyde levels.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2022)

Review Respiratory System

Mycobacterium simiae pulmonary infection: a case series and literature review

Hadi Lotfi, Mojtaba Sankian, Zahra Meshkat, Ahmad Khalifeh Soltani, Ehsan Aryan

Summary: The study investigated the clinical features of 20 patients with Mycobacterium simiae pulmonary infection in northeastern Iran, finding that the majority of patients were female with an average age of 55.1 years, and presenting symptoms mainly included severe cough and sputum production. Treatment primarily consisted of levofloxacin, clarithromycin, and co-trimoxazole.

RESPIROLOGY CASE REPORTS (2021)

Article Respiratory System

A case of multidrug-resistant Mycobacterium simiae in an elderly woman

Hadi Lotfi, Ehsan Aryan, Mojtaba Sankian, Zahra Meshkat, Ahmad Khalifeh Soltani, Amir Hooshang Alvandi, Hadi Farsiani

Summary: Mycobacterium simiae is an emerging pathogen in Iran with little data on drug susceptibility test available. A case study of multidrug-resistant M. simiae infection highlights the challenges in treatment. Antibiotic resistance testing is crucial for selecting appropriate treatment options.

RESPIROLOGY CASE REPORTS (2021)

Article Medicine, General & Internal

Mycobacterium szulgai pulmonary infection in a vitamin D-deficient patient: A case report

Hadi Lotfi, Mojtaba Sankian, Zahra Meshkat, Ahmad Khalifeh Soltani, Ehsan Aryan

Summary: It is important to pay closer attention to the vitamin D status of patients with mycobacterial diseases.

CLINICAL CASE REPORTS (2021)

Review Environmental Sciences

The effect of diazinon on blood glucose homeostasis: a systematic and meta-analysis study

Tahereh Farkhondeh, Michael Aschner, Mahmood Sadeghi, Omid Mehrpour, Kobra Naseri, Alireza Amirabadizadeh, Babak Roshanravan, Hamed Aramjoo, Saeed Samarghandian

Summary: The study established an association between DZN exposure and hyperglycemia in rodents and fish, which is dose- and gender-dependent.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH (2021)

Review Plant Sciences

Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19

Mohammad Reza Khazdair, Shoukouh Ghafari, Mahmood Sadeghi

Summary: The review suggests that N. sativa and TQ may reduce inflammatory mediators, enhance immune response, improve lung function tests, and have antiviral and anti-inflammatory properties that could be beneficial for the treatment or control of COVID-19. Randomized clinical trials are recommended to confirm the efficacy of N. sativa and TQ on COVID-19 patients.

PHARMACEUTICAL BIOLOGY (2021)

暂无数据