Article
Pharmacology & Pharmacy
Wenbin Pei, Xiaojian Huang, Bowei Ni, Rui Zhang, Guangyi Niu, Hongbo You
Summary: In this study, it was found that Alantolactone (ALT) could alleviate IL-1 beta-induced inflammatory responses, protect cartilage from damage, and promote impaired autophagy through inhibiting the STAT3 and NF-kappa B signal pathways, suggesting a promising therapeutic effect for osteoarthritis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Qiang Shen, Ji-Xia Kuang, Chun-Xiao Miao, Wan-Li Zhang, Yi-Wei Li, Xiong-Wen Zhang, Xuan Liu
Summary: The natural compound alantolactone (AL) showed significant effects in ameliorating muscle atrophy in a cancer cachexia model mainly through inhibiting the STAT3 pathway, making it a promising lead compound in the development of drug candidates for cancer cachexia therapy.
Article
Environmental Sciences
Wenli Luo, Li Li, Weina Xu, Jing Zhang, Jianxiong Xu
Summary: Treatment of BRL-3A cells with DHA (50, 100, and 200 μM) for 24 hours promotes cell apoptosis and inflammatory response, with involvement of the p38 MAPK, ERK, and NF-kappa B signal pathways.
Article
Medicine, Research & Experimental
Jiasheng Chen, Wancong Zhang, Chen Pan, Jufeng Fan, Xiaoping Zhong, Shijie Tang
Summary: This study demonstrates that GLA inhibits cell proliferation and induces apoptosis in melanoma cells via the NF-kappa B/p65 pathway. It also effectively suppresses tumor growth without causing toxicity to major organs.
Article
Cell Biology
Chenchen Zhou, Xueli Zhang, Cuiping Yang, Yuan He, Luo Zhang
Summary: The study reveals that PLEKHO2 acts as a novel inhibitor of apoptosis and necroptosis, playing a key role in regulating RIPK1 ubiquitination and activation. PLEKHO2 deficiency increases cell susceptibility to TNF-alpha induced apoptosis and necroptosis, affecting RIPK1 activation and NF-kappa B activation. Deficiency in PLEKHO2 leads to enhanced hepatotoxicity and lethality in mice after TNF alpha-induced hepatitis.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens
Summary: YB-1 is a RNA binding protein involved in various cellular processes, its activation is associated with NF-kappa B and can affect the inflammatory response and cell survival mechanisms.
Article
Biology
Wen-Ho Chuo, Yu-Tang Tung, Chao-Liang Wu, Nicole R. Bracci, Yu-Kang Chang, Hung-Yi Huang, Chi-Chien Lin
Summary: This study found that alantolactone can effectively alleviate psoriatic skin lesions by inhibiting inflammation, making it a potential candidate for future anti-psoriasis drug development.
Article
Biochemistry & Molecular Biology
Xue Liang, Jiping Yao, Danrui Cui, Weiyang Zheng, Yanning Liu, Guohua Lou, Bingjue Ye, Liyan Shui, Yi Sun, Yongchao Zhao, Min Zheng
Summary: This study investigated the dysregulation of TRAF2 in liver cancer and its biological function, aiming to validate TRAF2 as a promising therapeutic target for liver cancer.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Chemistry, Medicinal
Jingwen Feng, Songlin Li, Bing Zhang, Namin Duan, Rui Zhou, Shike Yan, Jeevithan Elango, Ning Liu, Wenhui Wu
Summary: FGFC1, an active compound isolated from marine fungi, has been found to possess anti-cancer, anti-oxidative, and anti-inflammatory activity. This study demonstrated that FGFC1 significantly inhibited proliferation and colony formation, induced cell cycle arrest and apoptosis in EGFR-mutant PC9 cells. Transcriptome analysis revealed that FGFC1 down-regulated genes related to the NF-kappa B pathway in PC9 cells. The inhibitory effects of FGFC1 were enhanced by the NF-kappa B inhibitor PDTC. Furthermore, intraperitoneal injection of FGFC1 inhibited xenograft growth and decreased the expression of Ki-67, p-p65, IL-6, and TNF-alpha in tumors. These findings suggest that FGFC1 exerts its anti-cancer activity in NSCLC through the inhibition of the NF-kappa B signaling pathway.
Article
Immunology
Tarun Minocha, Megha Das, Vipin Rai, Sumit Singh Verma, Nikee Awasthee, Subash Chandra Gupta, Chandana Haldar, Sanjeev Kumar Yadav
Summary: Melatonin exhibits dose-dependent anti-tumor effects on cervical cancer cells by inducing apoptosis, modulating cell cycle, and downregulating pro-inflammatory genes.
INFLAMMOPHARMACOLOGY
(2022)
Article
Oncology
Nana Xu, Mengmeng Lu, Jiaxin Wang, Yujia Li, Xiaotian Yang, Xiajie Wei, Jiaoyang Si, Jingru Han, Xiaojuan Yao, Juanmei Zhang, Junqi Liu, Yanming Li, Hushan Yang, Dengke Bao
Summary: The study demonstrated that ivermectin significantly inhibits the proliferation of ESCC cells and induces apoptosis. Mechanistically, ivermectin induces mitochondrial dysfunction and apoptosis pathway, leading to apoptosis of ESCC cells.
Article
Biochemistry & Molecular Biology
Matthew Martin, Aishat Motolani, Hyeong-Geug Kim, Amy M. Collins, Faranak Alipourgivi, Jiamin Jin, Han Wei, Barry A. Wood, Yao-Ying Ma, X. Charlie Dong, Raghavendra G. Mirmira, Tao Lu
Summary: Dysregulation of metabolic functions in the liver affects the development of diabetes and metabolic disorders. The study identifies lysine demethylase 2A (KDM2A) as a negative regulator of nuclear factor (NF)-kappa B in the liver, with a crucial role in liver function. Through a liver-specific Kdm2a knockout mouse model, it is shown that KDM2A deficiency leads to liver dysfunction and increased inflammation.
Article
Biology
Bin Li, Lisi Zheng, Jiayi Ye, Chenmin Zhang, Jie Zhou, Qiaojuan Huang, Yanhua Guo, Luqin Wang, Peng Yu, Shurong Liu, Qiao Lin, Yuxia Luo, Hui Zhou, Jianhua Yang, Lianghu Qu
Summary: This study identifies previously unknown mechanisms of CREB1 in colorectal cancer cell plasticity, including the regulation of lncRNA CCAT1 and NF-kappa B pathways. Knocking out CREB1 triggers epithelial-mesenchymal transition (EMT), inhibits cell proliferation, and enhances cell motility.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kaixin Ding, Xinzhi Li, Xiaomeng Ren, Na Ding, Li Tao, Xue Dong, Zheng Chen
Summary: GBP5 is identified as a major factor causing liver injury and inflammation. Its expression is regulated by the NIK signaling pathway and it induces hepatocyte apoptosis through the activation of multiple apoptotic signaling pathways, leading to liver injury and inflammation.
Article
Biochemistry & Molecular Biology
Stephanie Nuan-Aliman, Didier Bordereaux, Catherine Thieblemont, Veronique Baud
Summary: RelB NF-κB subunit plays a role in controlling oxidative metabolism in DLBCL, inhibiting RelB reduces DLBCL mitochondrial ATP production and increases sensitivity to antimetabolic drugs.
