Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Review
Endocrinology & Metabolism
Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa
Summary: Exposure to endocrine-disrupting chemicals (EDCs) in the environment can disrupt the maternal-fetal environment and lead to adverse pregnancy outcomes. Research focuses on the effects of EDCs, the role of environmental and lifestyle factors, related mechanisms, and future research directions.
Article
Environmental Sciences
Sherly Antony, Sham Antony, Sharrel Rebello, Sandhra George, Devika T. Biju, R. Reshmy, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, Raveendran Sindhu, Mukesh Kumar Awasthi
Summary: Endocrine Disrupting Chemicals (EDCs) pose a serious threat to the health and future of humans and the ecosystem. This review provides an overview of various EDCs, their toxic effects, and both conventional and modern remediation methods. The use of sustainable approaches like bioremediation has shown positive impacts in controlling EDC pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Yan Yan, Fengjun Guo, Kexin Liu, Rixin Ding, Yichao Wang
Summary: Endocrine-disrupting chemicals (EDCs) are naturally occurring or artificial substances released into the environment. Humans are exposed to EDCs through ingestion, inhalation, and skin contact, and they are found in everyday household items. EDCs have negative effects on health, including cancer, cardiovascular risk, and reproductive disorders, and the placenta is particularly sensitive to their impact. This review evaluates the effects of various EDCs on placental development and function, identifies knowledge gaps, and guides future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Agnethe Mehlsen, Laerke Hollund, Henriette Boye, Hanne Frederiksen, Anna-Maria Andersson, Signe Bruun, Steffen Husby, Tina Kold Jensen, Clara Amalie Gade Timmermann
Summary: This study suggests that high BPA exposure during pregnancy is associated with shorter duration of breastfeeding. Although the results were not statistically significant, estimates indicate an increased risk of early termination of breastfeeding with high exposure. Future studies should consider measuring BPA more than once.
ENVIRONMENTAL RESEARCH
(2022)
Review
Obstetrics & Gynecology
Akshaya Chandrakanth, Sana Firdous, Ramasamy Vasantharekha, Winkins Santosh, Barathi Seetharaman
Summary: Endometriosis is a reproductive disorder that affects women during their reproductive years, characterized by the presence of endometrial-like tissue outside the uterus. This comprehensive review examines the correlation between endocrine disruptors, microRNAs, and endometriosis, highlighting the connection between certain chemicals and altered gene expression. The review also emphasizes the importance of specific microRNAs in the onset and progression of endometriosis.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Leonardo Trasande, Robert M. Sargis
Summary: Rapidly advancing evidence indicates that synthetic chemicals in the environment contribute to disease and disability across the lifespan. Endocrine-disrupting chemicals (EDCs) have a substantial impact on chronic diseases in adulthood, especially metabolic, cardiovascular, and reproductive conditions. The mortality and economic costs of exposure to certain phthalates are significant. Low-income and minority populations are disproportionately affected by these exposures. Government action is necessary to limit hazardous exposures and screen new chemicals. Routine healthcare should include guidance to reduce EDC exposures.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
V. L. Marlatt, S. Bayen, D. Castaneda-Cortes, G. Delbes, P. Grigorova, V. S. Langlois, C. J. Martyniuk, C. D. Metcalfe, L. Parent, A. Rwigemera, P. Thomson, G. Van der Kraak
Summary: This review summarizes the current knowledge of the impacts of EDCs on reproductive success in wildlife and humans, with a focus on retrospective assessment and laboratory-based experiments. The evidence suggests that anthropogenic chemicals negatively impact reproduction by altering endocrine system function, particularly in aquatic species. Similar effects are observed in mammalian wildlife and humans in epidemiological studies. Further research is needed on the implications of chemical exposures during development and the potential for long-term reproductive effects. Field-based observations and long-term population level studies are key to addressing knowledge gaps.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Arash Derakhshan, Huan Shu, Maarten A. C. Broeren, Andreas Kortenkamp, Christian H. Lindh, Barbara Demeneix, Robin P. Peeters, Carl-Gustaf Bornehag, Tim I. M. Korevaar
Summary: This study investigated the association between concentrations of endocrine disrupting chemicals (EDCs) in urine and blood during pregnancy and serum human chorionic gonadotropin (hCG) concentrations. The results showed that higher exposure to bisphenol A was associated with lower hCG concentrations, while higher triclosan exposure was associated with higher hCG concentrations. Higher exposure to certain phthalates and polychlorinated biphenyls (PCBs) was also associated with lower hCG concentrations. These findings suggest that EDC exposure may have negative effects on placental hCG production and secretion, warranting further experimental studies.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Elikanah Olusayo Adegoke, Md Saidur Rahman, Yoo-Jin Park, Young Ju Kim, Myung-Geol Pang
Summary: EDCs are hormonally active compounds that can have significant impacts on the development and severity of comorbidities related to COVID-19. They are also known to play a role in the disruption of the body's immune system, which could further exacerbate the risks associated with COVID-19. Adopting comprehensive methodologies to study the role of EDCs in COVID-19 risk is important for understanding the full extent of their impact.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Toxicology
S. Dabeer, M. A. Afjal, S. Ahmad, M. Fatima, H. Habib, S. Parvez, S. Raisuddin
HUMAN & EXPERIMENTAL TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Prerna Agarwal, Darshana Singh, Sheikh Raisuddin, Raj Kumar
Article
Obstetrics & Gynecology
Shashi Nandar Kumar, Sheikh Raisuddin, Kh. Jitenkumar Singh, Banajit Bastia, Deepa Borgohain, Long Teron, Santanu Kumar Sharma, Arun Kumar Jain
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2020)
Article
Toxicology
Haroon Habib, Md Rafi Haider, Shikha Sharma, Mirza Masroor Ali Beg, Shahzad Ahmad, Sadaf Dabeer, Mohammad Shahar Yar, Sheikh Raisuddin
TOXICOLOGY MECHANISMS AND METHODS
(2020)
Article
Oncology
Farah Nawaz, Ozair Alam, Ahmad Perwez, Moshahid A. Rizvi, Mohd. Javed Naim, Nadeem Siddiqui, Jannat ul Firdaus, Shakilur Rahman, Mukund Jha, Aadil A. Sheikh
Summary: The study evaluated the EGFR kinase inhibitory and anti-proliferative activity of various pyrazole linked pyrazoline derivatives with carbothioamide on human cancer cell lines. Compounds 6h and 6j showed potent inhibitory effects on EGFR kinase and anti-proliferative activity on A549 cell line with KRAS mutation, inducing apoptotic activity. Further exploration is needed in cancer cell lines of different tissue origin and signaling pathways to confirm their potential anticancer activity.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Correction
Environmental Sciences
S. Sharma, S. Ahmad, M. A. Afjal, H. Habib, S. Parvez, S. Raisuddin
Article
Chemistry, Multidisciplinary
Mohd Amir Afjal, Poonam Goswami, Shahzad Ahmad, Sadaf Dabeer, Juheb Akhter, Mohd Salman, Anuradha Mangla, Sheikh Raisuddin
Summary: Tempol has been found to ameliorate cisplatin-induced nephrotoxicity and restore the levels of renal function markers. Additionally, it can attenuate the effects of cisplatin on genes and proteins related to kidney injury.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shashi Nandar Kumar, Kumar Vaibhav, Banajit Bastia, Vishwajeet Singh, Meenakshi Ahluwalia, Usha Agrawal, Deepa Borgohain, Sheikh Raisuddin, Arun Kumar Jain
Summary: This study found that occupational pesticide exposure during pregnancy may decrease AChE activity and cause in utero pathological changes accompanied by increased HIF-1 alpha expression, which contributes to placental insufficiency and fetal growth restriction.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Raghaba Sahu, Ranjan K. Mohapatra, Saud I. Al-Resayes, Debadutta Das, Pankaj K. Parhi, Shakilur Rahman, Lucia Pintilie, Manjeet Kumar, Mohammad Azam, Azaj Ansari
Summary: This study explores a novel synthesis route for crinipellin and investigates its pharmacological effects, suggesting the potential of these compounds as therapeutic agents for various diseases.
JOURNAL OF SAUDI CHEMICAL SOCIETY
(2021)
Review
Microbiology
Shubhrima Ghosh, Razi Ahmad, Kamalika Banerjee, Mohamed Fahad AlAjmi, Shakilur Rahman
Summary: The use of biogenic synthesis for nanoparticles presents a greener and promising approach with potential for large-scale production. Understanding the cellular, biochemical, and molecular mechanisms of nanoparticle biosynthesis in microorganisms allows for control over the shape, size, and monodispersity of the nanoparticles.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Environmental Sciences
Bhupendra Pratap Singh, Gaber E. Eldesoky, Pramod Kumar, Prakash Chandra, Md Ataul Islam, Shakilur Rahman
Summary: This study examines the impact of lockdowns on particulate matter and air quality. The results show a significant reduction in PM10 and PM2.5 concentrations during the lockdown period in India. However, the improvement in air quality in Riyadh was relatively smaller due to the predominance of natural factors.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Review
Food Science & Technology
Shubhra Pande, Sheikh Raisuddin
Summary: Sirtuins (SIRT) are a unique group of enzymes that can remove acyl groups from lysine residues using NAD+ as a co-substrate. The members of the SIRT family have distinct characteristics and biological functions, affecting various metabolic processes in different cellular locations. Understanding the distribution, specific biological roles, and effects of SIRT in human tissues is crucial for identifying molecular mechanisms and finding foods that can beneficially enhance SIRT activity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Shipra Pant, Astha Dimri, Renu Arora, Fouzia Siraj, Sheikh Raisuddin, Sangita Rastogi
Summary: This study investigated the expression of MMP-2, -9, -14/TIMP-1, -2, -3 in C. trachomatis-positive tubal EP patients. The results showed upregulated expression of MMP-2, -9, and -14, as well as downregulated expression of TIMP-1, -2, and -3 in C. trachomatis-positive patients compared to controls. The fold-change in MMP expression was significantly higher in C. trachomatis-positive patients, with MMP-2 showing the greatest upregulation. These findings suggest that dysregulation of MMPs/TIMPs, particularly enhanced MMP-2 expression, may play a role in the development of tubal EP in C. trachomatis-positive women.
MICROBIAL PATHOGENESIS
(2022)
Article
Environmental Sciences
Sadaf Dabeer, Sheikh Raisuddin
Summary: This study examined the intergenerational effect of parental exposure to an environmentally relevant dose of BPA on the hepatic health outcome of their offspring in a metabolically challenged population. The results showed that BPA exposure led to increased birth weight and rapid weight gain in the offspring, along with changes in liver function enzymes, histological changes in the liver tissue, and the onset of non-alcoholic fatty liver disease (NAFLD).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Polymer Science
Shambhvi Singh, Shikha Baghel Chauhan, Charu Gupta, Indu Singh, Annie Gupta, Shwetakshi Sharma, S. M. Kawish, Shakilur Rahman, Muzaffar Iqbal
Summary: The current study aimed to prepare and evaluate a microemulsion-based micro-emulgel loaded with citronella oil for the treatment of Candida albicans. The optimized formulation (F3) showed the highest drug content and release rate, and exhibited stronger antifungal activity compared to other formulations.