Article
Oncology
Jiachi Ma, Chensong Zhang, Wanqing Liang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Yuzhong Chen, Yuanpeng Wang
Summary: This study found that ω-6 PUFAs can enhance the metastatic potential of gastric cancer cells via the COX-2/PGE2 pathway, while ω-3 PUFAs inhibit the metastatic potential of gastric cancer cells through the COX-1/PGE3 signaling axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Borasio, Valentina De Cosmi, Veronica D'Oria, Silvia Scaglioni, Marie-Louise Eva Syren, Stefano Turolo, Carlo Agostoni, Marilena Coniglio, Massimo Molteni, Alessandro Antonietti, Maria Luisa Lorusso
Summary: The study investigates the associations between PUFA blood levels, nutritional status, and reading ability. Significant correlations were found between PUFA levels and reading scores, with fatty acids mediating the association between reading speed and nutritional status. Additionally, reading speed performances moderated the associations between blood PUFA levels and dietary intake. The findings suggest that reading skills are influenced by a complex interplay of factors, including fatty acids and nutritional status.
Article
Biochemistry & Molecular Biology
Mayra Montecillo-Aguado, Belen Tirado-Rodriguez, Gabriela Antonio-Andres, Mario Morales-Martinez, Zhen Tong, Jun Yang, Bruce D. Hammock, Rogelio Hernandez-Pando, Sara Huerta-Yepez
Summary: Lung cancer is the leading cause of cancer death worldwide, and the intake of omega-6 polyunsaturated fatty acids (PUFAs) in the diet is associated with increased cancer risk and progression. This study found that a diet rich in omega-6 PUFAs enhances the malignancy of tumor cells, promoting cell proliferation, angiogenesis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Yi Zhang, Hongbin Guo, Jieyu Liang, Wenfeng Xiao, Yusheng Li
Summary: This study examines the relationship between dietary levels of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) and sarcopenia. The results suggest that a higher dietary omega-3 PUFAs level is associated with a lower risk of sarcopenia, while the relationship between dietary omega-6 PUFAs level and sarcopenia is not significant.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Elise Grytten, Johnny Laupsa-Borge, Pavol Bohov, Bodil Bjorndal, Elin Strand, Jon Skorve, Jan Erik Nordrehaug, Rolf K. Berge, Espen Rostrup, Gunnar Mellgren, Simon N. Dankel, Ottar K. Nygard
Summary: The high-dose supplementation of n-3 (EPA + DHA) or n-6 (LA) PUFAs led to reductions in TAG- or cholesterol-related markers, respectively, indicating potential benefits for cardiometabolic risk reduction, even among individuals with normal TAG or LDL-C levels.
CLINICAL NUTRITION
(2021)
Article
Food Science & Technology
Dimitra Karageorgou, Ulrika Rova, Paul Christakopoulos, Petros Katapodis, Leonidas Matsakas, Alok Patel
Summary: This review summarizes the role of omega-3 and omega-6 fatty acids, determined by chain length, saturation degree, and position of double bonds, in human health. It highlights oleaginous microalgae as a reliable, economical, and sustainable source of these fatty acids. Humans cannot synthesize these fatty acids and need to absorb them through the diet. The demand for microbial omega-3 fatty acids is increasing due to the growing prevalence of cardiovascular diseases and changing dietary preferences. The importance of a healthy immune system, especially following the COVID-19 pandemic, has further strengthened the market for omega-3 fatty acids.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Oksana Maksymchuk, Angela Shysh, Dmytro Stroy
Summary: Long-term treatment with omega-3 PUFAs does not increase the risk of CYP2E1-dependent oxidative stress and development of liver pathology but prevents some diabetic ultrastructural damage to hepatocytes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Shuzhen Zhao, Dongzhen Jin, Shengyao Wang, Yanping Xu, Huihui Li, Yujie Chang, Yange Ma, Yixi Xu, Chengnan Guo, Fang Peng, Ruogu Huang, Mengyuan Lai, Zhezheng Xia, Mingzhu Che, Jingjing Zuo, Depeng Jiang, Chao Zheng, Guangyun Mao
Summary: This study shows an inverse relationship between omega-6/omega-3 polyunsaturated fatty acids ratio (PUFAR) and diabetic retinopathy (DR). PUFAR can serve as an ideal biomarker for distinguishing patients with DR from those without DR.
Review
Immunology
Zhi Chen, Qinyue Lu, Jiacheng Wang, Xiang Cao, Kun Wang, Yuhao Wang, Yanni Wu, Zhangping Yang
Summary: This article summarizes the impact of cadmium exposure on health and highlights the positive role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing and treating cadmium exposure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Fatma Al-Zahraa N. Al-Shahed, Hala H. Shoeb, Mohammad M. El-Shawwa
Summary: This study examined the histological and biochemical changes in rat testis following isotretinoin intake and evaluated the protective effects of omega-3 supplementation. The results showed that isotretinoin caused adverse changes in testicular histology and hormonal levels, which were effectively ameliorated by omega-3 supplementation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Nutrition & Dietetics
Jie Zhu, Peng-Cheng Xun, Marissa Kolencik, Ke-Feng Yang, Alyce D. Fly, Ka Kahe
Summary: Studies have suggested that the combined supplementation of B vitamins and omega-3 PUFAs may have additional benefits for preventing cardiovascular disease. However, the overall findings are inconsistent and inconclusive, and more well-designed trials are needed to draw firm conclusions.
Article
Multidisciplinary Sciences
Miaozhen Pan, Fei Zhao, Bintao Xie, Hao Wu, Sen Zhang, Cong Ye, Zhenqi Guan, Lin Kang, Yuqing Zhang, Xuan Zhou, Yi Lei, Qi Wang, Li Wang, Fan Yang, Chenchen Zhao, Jia Qu, Xiangtian Zhou
Summary: Research has shown that ω-3 PUFAs have an inhibitory effect on myopia, can slow down the progression of myopia, and alleviate the decrease in ChBP caused by near work.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Miriam Ouadih-Moran, Antonio Munoz-Hoyos, Luis D'Marco, Antonio Molina-Carballo, Isabel Seiquer, Ana Checa-Ros
Summary: This study found that ADHD patients had significantly increased levels of S100B, and that S100B concentrations gradually increased after triple therapy. These results support the hypothesis of a neuroinflammatory basis in ADHD and the damaging effect on glial function.
Article
Food Science & Technology
Paulinna Faccinetto-Beltran, Andrea R. Gomez-Fernandez, Norma E. Orozco-Sanchez, Esther Perez-Carrillo, Luis Martin Marin-Obispo, Carmen Hernandez-Brenes, Arlette Santacruz, Daniel A. Jacobo-Velazquez
Summary: The study demonstrated that milk chocolate can serve as a suitable vehicle for delivering Omega-3 PUFAs and probiotics, which are essential for enhancing cognitive development in children. The addition of probiotics and fish oil affected the physicochemical properties of chocolate, but did not impact overall consumer acceptability, with combined use showing improved acceptability. This highlights the potential of incorporating these nutrients into chocolate for their health benefits.
Article
Nutrition & Dietetics
Adelina Silvana Gheorghe, Serban Mircea Negru, Madalina Preda, Raluca Ioana Mihaila, Isabela Anda Komporaly, Elena Adriana Dumitrescu, Cristian Virgil Lungulescu, Lidia Anca Kajanto, Bogdan Georgescu, Emanuel Alin Radu, Dana Lucia Stanculeanu
Summary: This review highlights the relationship between gut microbiota and colorectal cancer, focusing on the metabolic impact of bacterial dysbiosis on cancer, particularly the biochemical mechanisms of butyrate, a SCFA with anti-inflammatory and anti-tumor properties. It also discusses the potential of omega-3 PUFAs in modulating gut microbiota to reduce the risk or progression of CRC.
Article
Pharmacology & Pharmacy
Yassine Chtourou, Hamadi Fetoui, Raoua Jemai, Ahlem Ben Slima, Mohamed Makni, Radhouane Gdoura
EUROPEAN JOURNAL OF PHARMACOLOGY
(2015)
Article
Pharmacology & Pharmacy
Assaad Sila, Zeineb Kamoun, Zohra Ghlissi, Mohamed Makni, Moncef Nasri, Zouhaier Sahnoun, Naima Nedjar-Arroume, Ali Bougatef
PHARMACOLOGICAL REPORTS
(2015)
Article
Pharmacology & Pharmacy
Yassine Chtourou, Ahlem Ben Slima, Mohamed Makni, Radhouane Gdoura, Hamadi Fetoui
PHARMACOLOGICAL REPORTS
(2015)
Article
Medicine, Research & Experimental
Mouna Chakroun, Bassem Khemakhem, Hazem Ben Mabrouk, Hanen El Abed, Mohamed Makni, Mohamed Bouaziz, Noureddine Drira, Naziha Marrakchi, Hafedh Mejdoub
BIOMEDICINE & PHARMACOTHERAPY
(2016)
Article
Food Science & Technology
Ben Ajmia Wafa, Mohamed Makni, Sonda Ammar, Lamia Khannous, Amal Ben Hassana, Mohamed Bouaziz, Nour Eddine Es-Safi, Radhouane Gdoura
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2017)
Article
Agriculture, Multidisciplinary
Ameny Farhat-Khemakhem, Monia Blibech, Ines Boukhris, Mohamed Makni, Hichem Chouayekh
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2018)
Article
Food Science & Technology
Redouan El-Haskoury, Walid Kriaa, Badiaa Lyoussi, Mohamed Makni
JOURNAL OF FOOD AND DRUG ANALYSIS
(2018)
Article
Biotechnology & Applied Microbiology
Mohamed Makni, Raoua Jemai, Walid Kriaa, Yassine Chtourou, Hamadi Fetoui
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Nutrition & Dietetics
Assaad Sila, Zohra Ghlissi, Zeineb Kamoun, Mohamed Makni, Moncef Nasri, Ali Bougatef, Zouheir Sahnoun
EUROPEAN JOURNAL OF NUTRITION
(2015)
Article
Toxicology
M. Makni, Y. Chtourou, E. M. Garoui, T. Boudawara, H. Fetoui
HUMAN & EXPERIMENTAL TOXICOLOGY
(2012)
Article
Food Science & Technology
Walid Kriaa, Hamadi Fetoui, Mohamed Makni, Najiba Zeghal, Nour-Eddine Drira
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2012)
Article
Food Science & Technology
Mohamed Makni, Anissa Haddar, Walid Kriaa, Najiba Zeghal
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2013)
Article
Food Science & Technology
Mohamed Makni, Anissa Haddar, Amor Ben Fraj, Najiba Zeghal
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2015)
Article
Agriculture, Dairy & Animal Science
Redouan El-Haskoury, Noori Al-Waili, Zeineb Kamoun, Mohamed Makni, Ahmed Al-Waili, Badiaa Lyoussi
Summary: This study aimed to investigate the antioxidant activity and the effect of ethanolic extract of propolis on carbon tetrachloride (CCl4)-induced oxidative stress on kidney and liver injury in rats. The results showed that propolis significantly alleviated liver and kidney function, improved antioxidant parameters, and decreased levels of oxidative agents.
Article
Medicine, Research & Experimental
Hanen El Abed, Mouna Chakroun, Imen Fendri, Mohamed Makni, Mohamed Bouaziz, Noureddine Drira, Hafedh Mejdoub, Bassem Khemakhem
BIOMEDICINE & PHARMACOTHERAPY
(2017)