Article
Biochemistry & Molecular Biology
Chou-Yuan Ko, Po-Chang Shih, Po-Wei Huang, Yi-Hsin Lee, Yen-Fu Chen, Ming-Hong Tai, Chi-Hao Liu, Zhi-Hong Wen, Hsiao-Mei Kuo
Summary: Sinularin was found to effectively inhibit the growth of hepatocellular carcinoma SK-HEP-1 cells at a concentration of 10 μM, inducing DNA fragmentation and apoptosis, as well as affecting cell migration and colony formation. Additionally, it altered the expression levels of various proteins related to cell signaling and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Trevor J. Mathias, Julia A. Ju, Rachel M. Lee, Keyata N. Thompson, Makenzy L. Mull, David A. Annis, Katarina T. Chang, Eleanor C. Ory, Megan B. Stemberger, Takashi Hotta, Ryoma Ohi, Michele Vitolo, Marie-Jo Moutin, Stuart S. Martin
Summary: This article discusses the recent discovery of the genetic identity of tubulin carboxypeptidase (TCP) and its role in breast epithelial cells and breast cancer cells. The study found that increased deTyr-Tub induces apoptosis in normal breast cells and enhances focal gelatin degradation in breast cancer cells. These findings provide important insights for further research and treatment of breast cancer.
Article
Biochemistry & Molecular Biology
Anuradha Kumari, Shweta S. Prassanawar, Dulal Panda
Summary: Indibulin, a microtubule-depolymerizing agent, shows minimal neurotoxicity and is less cytotoxic towards differentiated neuronal cells. It binds to beta-tubulin isotypes differently and has a lower affinity to beta-III tubulin. Depletion of beta-III tubulin increases the toxicity of indibulin and colchicine, while vinblastine is unaffected. Indibulin inhibits colchicine binding to tubulin and is a colchicine-site binder.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Vijay Laxmi Trivedi, Ruchi Soni, Praveen Dhyani, Priyanka Sati, Silvia Tejada, Antoni Sureda, William N. Setzer, Ahmad Faizal Abdull Razis, Babagana Modu, Monica Butnariu, Javad Sharifi-Rad
Summary: With the development of highly effective plant-based medications, the use of phytomedicines against complex diseases like cancer is increasing. This review focuses on the traits, roles, and mechanisms of the pentacyclic triterpenes known as boswellic acids (BAs) and their semi-synthetic derivatives in treating certain cancers. The review also explores the sources of BAs, their conservation, and the potential of biotechnology in improving BA production.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Plant Sciences
Rosa Tundis, Jayanta Kumar Patra, Marco Bonesi, Subrata Das, Rajat Nath, Anupam Das Talukdar, Gitishree Das, Monica Rosa Loizzo
Summary: Despite advancements in treatment strategies, cancer remains a leading cause of death globally. Therefore, the main focus should be on early cancer diagnosis, optimal therapeutic strategies, and the search for more effective molecules. This review comprehensively summarizes the potential anti-cancer properties of andrographolide, highlighting its mechanisms of action, pharmacokinetics, and potential side effects, while discussing future perspectives, challenges, and limitations of use.
Article
Biochemistry & Molecular Biology
Maria Ovejero-Sanchez, Gloria Asensio-Juarez, Myriam Gonzalez, Pilar Puebla, Miguel Vicente-Manzanares, Rafael Pelaez, Rogelio Gonzalez-Sarmiento, Ana Belen Herrero
Summary: This study synthesized and characterized a new microtubule-destabilizing agent, PILA9, which showed strong cytotoxicity against OC cells. Additionally, the combination of microtubule-destabilizing agents with Panobinostat synergistically enhanced cytotoxicity, potentially through inducing alpha-tubulin acetylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Samvel Sirakanyan, Erik Arabyan, Astghik Hakobyan, Tamara Hakobyan, Garri Chilingaryan, Harutyun Sahakyan, Arsen Sargsyan, Grigor Arakelov, Karen Nazaryan, Roza Izmailyan, Liana Abroyan, Zaven Karalyan, Elina Arakelova, Elmira Hakobyan, Anush Hovakimyan, Andre Serobian, Marco Neves, Joao Ferreira, Fernando Ferreira, Hovakim Zakaryan
Summary: This study identified three new compounds with anti-ASFV activity by targeting the colchicine binding site of tubulin. The most promising compound, 6b, showed dose-dependent reduction of ASFV replication with no cellular or animal toxicity. Compound 6b interfered with ASFV attachment, internalization, and egress, and had higher antiviral effects when added within 2-8 h post-infection. Additionally, compound 6b promoted tubulin polymerization, acting as a microtubule-stabilizing agent.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Oncology
Pavel Draber, Eduarda Draberova
Summary: The dysfunction of microtubule nucleation in cancer cells alters the cytoskeleton organization and cellular physiology, with a focus on dysregulation of the gamma-tubulin ring complex (gamma-TuRC) proteins. Recent research on the high-resolution structure of gamma-TuRC provides new insights into the mechanism of microtubule nucleation, potentially offering new drug targets for cancer chemotherapy.
Article
Chemistry, Multidisciplinary
Maria Stefania Sinicropi, Cinzia Tavani, Camillo Rosano, Jessica Ceramella, Domenico Iacopetta, Alexia Barbarossa, Lara Bianchi, Alice Benzi, Massimo Maccagno, Marco Ponassi, Domenico Spinelli, Giovanni Petrillo
Summary: This study reported the anticancer activity of a series of carbazole analogues, with 2-nitrocarbazole showing the best cytotoxic profile against two breast cancer cell lines. The compound demonstrated no interference with normal cell growth and was able to interfere with tubulin organization, leading to cell death through apoptosis.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
B. Shwetha, Sudhanva M. Srinivasa, G. S. Jagadeesha, N. R. Thimmegowda, Vivek K. Hamse, B. T. Sridhar, K. N. Thimmaiah, C. S. Ananda Kumar, Shobith Rangappa, K. S. Rangappa
Summary: The novel furan-2-carboxamide based small molecule exhibits strong anti-proliferative and anti-metastatic properties against cancer cell lines by stabilizing microtubules, leading to cell cycle arrest and cell death. Experimental results demonstrate the potent cytotoxic effect of SH09 against HeLa cells, inducing G2/M arrest and accumulation of subG1 population of cells.
BIOORGANIC CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Sheema Hashem, Tayyiba Akbar Ali, Sabah Akhtar, Sabah Nisar, Geetanjali Sageena, Shahid Ali, Sharefa Al-Mannai, Lubna Therachiyil, Rashid Mir, Imadeldin Elfaki, Mohammad Muzaffar Mir, Farrukh Jamal, Tariq Masoodi, Shahab Uddin, Mayank Singh, Mohammad Haris, Muzafar Macha, Ajaz A. Bhat
Summary: Cancer is a major cause of death and a burden to healthcare system. Natural products, with their accessibility, applicability, and reduced cytotoxicity, have been an important source of anticancer drugs. They play a major role in cancer treatment by modulating cancer microenvironment and different signaling pathways, mainly cell death pathways and embryonic developmental pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Maria Cecilia Gonzalez Garcia, Caroline Radix, Claude Villard, Gilles Breuzard, Pascal Mansuelle, Pascale Barbier, Philipp O. Tsvetkov, Harold De Pomyers, Didier Gigmes, Francois Devred, Herve Kovacic, Kamel Mabrouk, Jose Luis
Summary: In this study, we identified myotoxin-3, a peptide from the venom of the Northern Pacific rattlesnake, as a potential microtubule targeting agent. Myotoxin-3 increased tubulin polymerization and showed slight toxicity against glioblastoma and breast carcinoma cells. It also induced remodeling of the microtubule network and decreased microtubule dynamic instability. These effects were attributed to the direct interaction of myotoxin-3 with tubulin. Our findings suggest that exogenous peptides, such as myotoxin-3, could be promising candidates for the development of new anti-cancer drugs, and venom is a valuable source of pharmacologically active molecules.
Article
Immunology
Sai Zhang, Zhenglu Wang, Shunli Fan, Tao Liu, Sei Yoshida, Shuang Yang, Lei Liu, Wen Hou, Lei Cao, Jianxi Wang, Zhuolun Song, Shanni Li, Sirui Zhang, Hao Wang, Jianghong Li, Hong Zheng, Zhongyang Shen
Summary: Capacitabine is widely used in the treatment of digestive system tumors, and studies have shown its immunosuppressive effects through reduction of T cell proportions, pro-inflammatory cytokines, and induction of T cell apoptosis via TP expression, ERS induction, ROS production, and mitochondria-mediated apoptosis activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed A. Tantawy, Sameerah Shaheen, Shahad W. Kattan, Walla Alelwani, Ibrahim O. Barnawi, Gamal A. Elmgeed, Mohamed S. Nafie
Summary: This study provides new molecular insights into the antiproliferative activity of six 3 beta-acetoxy-5 alpha-androstane heterocycle compounds against non-small-cell lung carcinoma (NSCLC). Compound 4 shows potential cytotoxicity on NSCLC cells and acts as a dual inhibitor of IL6/JAK2/STAT3 and tubulin formation.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biology
Xiaoxiao Liu, Li Zhang, Pyone Myat Thu, Wenjian Min, Peng Yang, Ji Li, Ping Li, Xiaojun Xu
Summary: Sodium cantharidinate is identified as a potential anti-pancreatic cancer agent that activates p53 function, reducing cell viability and inducing apoptosis in pancreatic cancer cells. It perturbs the p53 signaling pathway and affects apoptosis-related protein expression, ultimately showing promising efficacy against pancreatic cancer.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Pawandeep Kaur, Arun Kumar Sharma, Debasish Nag, Amlan Das, Satabdi Datta, Arnab Ganguli, Vanshita Goel, Satyendra Rajput, Gopal Chakrabarti, Biswarup Basu, Diptiman Choudhury
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
Correction
Biochemistry & Molecular Biology
Satabdi Datta, Diptiman Choudhury, Amlan Das, Dipanwita Das Mukherjee, Moumita Dasgupta, Shreya Bandopadhyay, Gopal Chakrabarti
Article
Biochemistry & Molecular Biology
Amlan Das, Maruthi Kumar Narayanam, Santanu Paul, Pritha Mukhnerjee, Suvranil Ghosh, Debabrata Ghosh Dastidar, Subhendu Chakrabarty, Arnab Ganguli, Biswarup Basu, Mahadeb Pal, Urmi Chatterji, Sushanta K. Banerjee, Parimal Karmakar, Dalip Kumar, Gopal Chakrabarti
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Debabrata G. Dastidar, Amlan Das, Satabdi Datta, Suvranil Ghosh, Mahadeb Pal, Neeraj S. Thakur, Uttam C. Banerjee, Gopal Chakrabarti
Article
Plant Sciences
Santanu Paul, Subhendu Chakrabarty, Suvranil Ghosh, Debasish Nag, Amlan Das, Debabrata Ghosh Dastidar, Moumita Dasgupta, Naibedya Dutta, Mandavi Kumari, Mahadeb Pal, Gopal Chakrabarti
Article
Microbiology
Payel Paul, Poulomi Chakraborty, Ahana Chatterjee, Ranojit K. Sarker, Debabrata Ghosh Dastidar, Taraknath Kundu, Niloy Sarkar, Amlan Das, Prosun Tribedi
Summary: Staphylococcus aureus, a Gram-positive opportunistic microorganism, poses a major threat to public healthcare through biofilm formation. This study found that 1,4-naphthoquinone has significant antimicrobial and antibiofilm activity against Staphylococcus aureus, potentially offering a promising approach to inhibit biofilm formation caused by this pathogen.
ARCHIVES OF MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Poulomi Chakraborty, Payel Paul, Monika Kumari, Surajit Bhattacharjee, Mukesh Singh, Debasish Maiti, Debabrata Ghosh Dastidar, Yusuf Akhter, Taraknath Kundu, Amlan Das, Prosun Tribedi
Summary: Thymoquinone exhibited significant antibiofilm activity against Pseudomonas aeruginosa by accumulating ROS and inhibiting the expression of quorum sensing gene lasI. Combinatorial application of thymoquinone with other reported antibiofilm agents, such as tryptophan and tetrazine-capped silver nanoparticles, showed enhanced antibiofilm efficiency. The combination of these antibiofilm molecules resulted in ROS accumulation in cells, leading to the inhibition of biofilm formation with minimal cytotoxicity.
FOLIA MICROBIOLOGICA
(2021)
Article
Pharmacology & Pharmacy
Amlan Das, Inamul Haque, Priyanka Ray, Arnab Ghosh, Debasmita Dutta, Mohiuddin Quadir, Archana De, Sumedha Gunewardena, Indranil Chatterjee, Snigdha Banerjee, Scott Weir, Sushanta K. Banerjee
Summary: This study demonstrates that EGCG activates CCN5 to inhibit in vitro cell viability, reverse TNBC cells' stemness, and suppress tumor growth. Additionally, EGCG-loaded nanoparticles are found to be more effective in suppressing tumors compared to free-EGCG.
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2021)
Article
Microbiology
Payel Paul, Sharmistha Das, Sudipta Chatterjee, Aditya Shukla, Poulomi Chakraborty, Sarita Sarkar, Debasish Maiti, Amlan Das, Prosun Tribedi
Summary: The study investigated the impact of 1,4-naphthoquinone on pre-existing biofilm of Staphylococcus aureus, revealing the key role of extracellular DNA in biofilm integrity. The generation of reactive oxygen species was found to degrade the eDNA and lead to the disintegration of pre-existing biofilm.
ARCHIVES OF MICROBIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Meenu Mehta, Keshav Raj Paudel, Shakti Dhar Shukla, Venkata Sita Rama Raju Allam, Vinod Kumar Kannaujiya, Nisha Panth, Amlan Das, Vipan Kumar Parihar, Amlan Chakraborty, Md Khadem Ali, Niraj Kumar Jha, Dikaia Xenaki, Qian Peter Su, Peter Richard Wich, Jon Adams, Philip Michael Hansbro, Dinesh Kumar Chellappan, Brian Gregory George Oliver, Kamal Dua
Summary: NFicB is a significant player in respiratory diseases, and NFicB decoy ODNs have been utilized in the treatment of chronic inflammatory diseases. However, challenges such as poor pharmacokinetic profile of naked decoy ODNs exist. Structural modifications and nanotechnology offer potential solutions in enhancing the pharmacokinetic profiles of therapeutic substances.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biotechnology & Applied Microbiology
Payel Paul, Poulomi Chakraborty, Ranojit K. Sarker, Ahana Chatterjee, Debasish Maiti, Amlan Das, Sukhendu Mandal, Surajit Bhattacharjee, Debabrata Ghosh Dastidar, Prosun Tribedi
Summary: The study showed that tryptophan can effectively inhibit biofilm formation of Staphylococcus aureus by interfering with its quorum-sensing property and downregulating specific gene expression. Furthermore, tryptophan did not exhibit cytotoxicity at tested concentrations.
Article
Microbiology
Sharmistha Das, Payel Paul, Sudipta Chatterjee, Poulomi Chakraborty, Ranojit K. Sarker, Amlan Das, Debasish Maiti, Prosun Tribedi
Summary: Piperine, a plant-based alkaloid, has shown considerable antimicrobial activity against Staphylococcus aureus, inhibiting its biofilm formation at lower concentrations without compromising microbial growth.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Sudipta Chatterjee, Payel Paul, Poulomi Chakraborty, Sharmistha Das, Ranojit Kumar Sarker, Subhasis Sarkar, Amlan Das, Prosun Tribedi
Summary: The study demonstrated that cuminaldehyde has strong antibiofilm activity against Pseudomonas aeruginosa without showing antimicrobial activity. Cuminaldehyde treatment led to the accumulation of cellular reactive oxygen species, inhibiting microbial biofilm formation. Ascorbic acid exposure could restore the biofilm-forming ability of cuminaldehyde-treated cells.
Article
Multidisciplinary Sciences
Dipanjan Ghosh, Debabrata Ghosh Dastidar, Kamalesh Roy, Arnab Ghosh, Debanjan Mukhopadhyay, Nilabja Sikdar, Nidhan K. Biswas, Gopal Chakrabarti, Amlan Das
Summary: This study used computational analysis to predict the potential mechanism by which statin drugs inhibit SARS-CoV-2 pathogenesis. The researchers found that fluvastatin can bind to multiple target proteins of SARS-CoV-2 and exhibits strong antiviral efficacy.
SCIENTIFIC REPORTS
(2022)
