Article
Environmental Sciences
Han Jiang, Selvam Sathiyavimal, Liping Cai, Sandhanasamy Devanesan, Shaban R. M. Sayed, G. K. Jhanani, Junqing Lin
Summary: This study successfully synthesized cost-effective cobalt nanoparticles using the medicinal plant Tulsi, and evaluated their efficiency in removing methyl orange dye in wastewater treatment. The anti-inflammatory and anti-cancer properties of Tulsi-mediated cobalt nanoparticles were also examined for potential medical applications. The morphological analysis showed that the synthesized cobalt nanoparticles were crystal-shaped with an average particle size of 110 nm. In batch adsorption studies, the optimal conditions for removing methyl orange dye were found to be an incubation period of 5 hours, pH 2, temperature of 70 degrees C, and an adsorbent dosage of 125 μg/mL. Protein denaturation and nitric oxide scavenging assays demonstrated the anti-inflammatory properties of Tulsi-mediated cobalt nanoparticles, with the maximum response observed at a concentration of 250 μg/mL. MTT assays against MDA-MB-231 human breast cancer cells were used to evaluate the anti-cancer properties of the cobalt nanoparticles. This study explores the economical extraction of cobalt nanoparticles from Tulsi and their potential applications in wastewater purification and biomedical fields.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Izdebska, Wioletta Zielinska, Adrian Krajewski, Marta Halas-Wisniewska, Klaudia Mikolajczyk, Maciej Gagat, Alina Grzanka
Summary: Metastasis is a pressing issue in breast cancer patients, with ECM remodeling playing a key role in cell migration. High levels of MMPs, particularly MMP-9, have been linked to aggressive tumors. Research suggests that CP treatment can reduce breast cancer cell survival, with downregulation of MMP-9 enhancing this effect through apoptosis induction. Combination therapy targeting MMP-9 alongside CP might improve treatment effectiveness. Additionally, a relationship between MMP-9 levels and cytokeratin 19 (CK19) has been confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Kakali Baruah, Mahabul Haque, Leader Langbang, Sourav Das, Kripamoy Aguan, Atanu Singha Roy
Summary: This research demonstrates the biosynthesis of three different silver nanoparticles using tulsi extract and its flavonoids as reducing agents, and evaluates their antibacterial activity and protein interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Plant Sciences
Ayushi Mishra, Vipin Kumar, Anchal Singh
Summary: This study evaluated the anti-filarial activity of Ocimum sanctum and identified its bioactive compounds. The ethanol extract of O. sanctum significantly inhibited the motility of adult female Setaria cervi, and several bioactive compounds in O. sanctum showed high binding affinity towards filarial antioxidant proteins. This is the first report of the anti-filarial activity of O. sanctum.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Plant Sciences
M. Manjudevi, R. Thirugnanasampandan, B. Vishnupriya, M. Gogul Ramnath
Summary: This study aims to standardize the medium for shoot and callus induction in Ocimum species and perform RAPD analysis for identification of somaclonal variants. It also evaluates the free radical scavenging activity of eugenol and camphor and tests their MMP-9 inhibition using gelatin zymography. The results show the suitable cytokinins for shoot induction and favorable conditions for callus induction in different Ocimum species. The study reveals that eugenol is a potent free radical scavenging agent and both eugenol and camphor effectively inhibit MMP-9 in vitro.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaomin Deng, Bin Shi, Ziling Ye, Man Huang, Rong Chen, Yousheng Cai, Zhaolin Kuang, Xiang Sun, Guangkai Bian, Zixin Deng, Tiangang Liu
Summary: This study systematically screened and identified two sesquiterpenoid biosynthesis genes from Holy basil in India, successfully recognizing (-)-eremophilene and achieving high-yield bioproduction through a yeast system, while also confirming its insect-repelling effect.
METABOLIC ENGINEERING
(2022)
Review
Oncology
Saima Khatoon, Nida Kalam, Vinod R. M. T. Balasubramaniam, Mohd Farooq Shaikh, Mohammad Tahir Ansari
Summary: Ocimum sanctum, also known as Holy Basil, is a sacred herb of India with remarkable therapeutic efficacy. It contains polyphenols that have anti-cancer effects, but their poor bioavailability limits their clinical use. Nanonization has been implemented to improve their bioavailability and anticancer action.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wantida Chaiyana, Chanun Punyoyai, Suwannee Sriyab, Adchara Prommaban, Sasithorn Sirilun, Jakkrawut Maitip, Panuwan Chantawannakul, Waranya Neimkhum, Songyot Anuchapreeda
Summary: This study revealed the strong anti-inflammatory and antimicrobial activities of fermented Ocimum sanctum Linn. (FE), making it a potential natural agent for topical applications in the pharmaceutical and cosmetic industries.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Chemistry, Medicinal
Mohammed Salah Ayoup, Marwa M. Abu-Serie, Laila F. Awad, Mohamed Teleb, Hanan M. Ragab, Adel Amer
Summary: A novel series of quinoxaline-based dual MMP-9/MAO-A inhibitors were synthesized to suppress CRC progression. These compounds showed good anticancer potential against HCT116 cells while maintaining safety profiles on normal colonocytes. They exhibited strong inhibitory effects on CRC cell migration and invasion, with considerable selectivity against MAO-A. Experimental results suggested that these compounds may have significant therapeutic implications for CRC treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Integrative & Complementary Medicine
Pulkit Kumar, Dhaniket Patel
Summary: This review is a valuable resource for future researchers in the field of alternative medicine, providing a comprehensive analysis of the potential mechanisms of action of Ocimum sanctum in treating various types of cancer. The study aims to reintroduce traditional therapies that can be economically beneficial and have fewer adverse effects for cancer patients.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Agronomy
Mukund R. Shukla, Annaliese Kibler, Christina E. Turi, Lauren A. E. Erland, J. Alan Sullivan, Susan J. Murch, Praveen K. Saxena
Summary: Tulsi, a sacred plant in many cultures, is known for its medicinal and spiritual significance with antioxidant phytochemicals. This study screened a large seed population to select lines with high antioxidant potential and standardized protocols for phytochemically consistent crop production. The integrated approach of in vitro selection and propagation shows potential for developing safe, effective, and novel natural health products.
Article
Agricultural Engineering
Kajal Kumari, Sanjeev Kumar, Prashant, Amrit Kumar Jha, Nitish Kumar
Summary: This review paper discusses the application of biotechnological techniques for enhancing the production of secondary metabolites in O. sanctum. By using modern technology, the pharmaceutical yield of this plant can be improved, and studies on gene transfer and genome structure have been conducted.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Anjali Vijeata, Ganga Ram Chaudhary, Savita Chaudhary, Ahmad Umar, Sotirios Baskoutas
Summary: This study investigates the use of carbon dots (CDs) as a drug carrier for the antileprosy drug dapsone (Dap). The study provides important information about the physicochemical interaction between the drug and serum albumins, as well as the release behavior of Dap from the Dap-CDs complex at different pH conditions.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2022)
Article
Chemistry, Physical
Vinod Kumar Meena, Vijay Kumar, Shivani Karalia
Summary: The natural extract of Ocimum sanctum (OS) has been found to inhibit the aggregation of alpha-Synuclein (alpha-Syn), suggesting a potential therapeutic intervention against Parkinson's disease (PD) and other aggregation-related disorders. The study demonstrates the inhibitory and disaggregation effects of OS extract on alpha-Synuclein, as well as its protective effect on neuroblastoma cells against fibril-induced cytotoxicity. Docking studies also indicate the binding of OS extract with alpha-Synuclein, paving the way for further research on potential therapeutic strategies.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Biochemistry & Molecular Biology
Mohammad Raghibul Hasan, Bader Saud Alotaibi, Ziyad Mohammed Althafar, Ahmed Hussain Mujamammi, Jafar Jameela
Summary: In most cases, cancer develops due to abnormal cell growth and subsequent tumour formation. Because of limitations in current treatment options, natural compounds are being investigated as potential alternatives. Around 30 natural compounds are currently in clinical trials for cancer treatment. Tulsi, or Holy Basil, is an inexpensive and widely available medicinal plant with significant religious and medicinal importance in India. The essential oil of Tulsi contains bioactive compounds such as camphor, eucalyptol, eugenol, alpha-bisabolene, beta-bisabolene, and beta-caryophyllene, which are proposed to contribute to its antimicrobial properties. Tulsi leaves, rich in eugenol, have shown anticancer properties and are being evaluated in ongoing clinical trials.
Article
Computer Science, Hardware & Architecture
Jinwoo Kim, Yonggeon Choi, MyungWook Park, Sangwoo Lee, Sunghoon Kim
JOURNAL OF SUPERCOMPUTING
(2020)
Article
Mathematics, Applied
Kin Ming Hui, Sunghoon Kim
JOURNAL OF DYNAMICS AND DIFFERENTIAL EQUATIONS
(2020)
Article
Gastroenterology & Hepatology
Hyung-Don Kim, Seongyeol Park, Seongju Jeong, Yong Joon Lee, Hoyoung Lee, Chang Gon Kim, Kyung Hwan Kim, Seung-Mo Hong, Jung-Yun Lee, Sunghoon Kim, Hong Kwan Kim, Byung Soh Min, Jong Hee Chang, Young Seok Ju, Eui-Cheol Shin, Gi-Won Song, Shin Hwang, Su-Hyung Park
Article
Chemistry, Multidisciplinary
Myung-Yeon Cho, Sunghoon Kim, Ik-Soo Kim, Eun-Seong Kim, Zhi-Ji Wang, Nam-Young Kim, Sang-Wook Kim, Jong-Min Oh
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Chemistry, Applied
Hassnain Abbas Khan, Sunghoon Kim, Kwang-Deog Jung
Article
Pediatrics
Kara A. Rothenberg, Rebecca C. Gologorsky, Sunghoon Kim
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Pediatrics
Michael J. Zobel, Clifton Ewbank, Roberta Mora, Olajire Idowu, Sunghoon Kim, Benjamin E. Padilla
PEDIATRIC SURGERY INTERNATIONAL
(2020)
Article
Computer Science, Information Systems
Yongbon Koo, Sunghoon Kim, Young-guk Ha
Summary: Object detection is a technology used to recognize classes of objects and their location, with deep learning approaches outperforming traditional algorithms. Darknet is a popular deep learning object detection framework known for its speed and simplicity, but it requires Nvidia CUDA for acceleration. Our OpenCL-Darknet transforms Darknet into an open standard OpenCL backend, improving performance and supporting various architectures.
WORLD WIDE WEB-INTERNET AND WEB INFORMATION SYSTEMS
(2021)
Article
Food Science & Technology
Jung Hyun Kwak, Yoonji Kim, Soo In Ryu, Minho Lee, Hyo-Jeong Lee, Yong Pyo Lim, Jean Kyung Paik
FOOD SCIENCE & NUTRITION
(2020)
Article
Energy & Fuels
Sunghoon Kim, Jiyong Kim
Article
Chemistry, Multidisciplinary
Seon-Ok Lee, Yinzhu Xu, Hengmin Han, Seok-Tae Jeong, You-Kyung Lee, Jean Kyung Paik, Jin-Sol Cha, Hyo-Jeong Lee
APPLIED SCIENCES-BASEL
(2020)
Article
Biochemistry & Molecular Biology
Yinzhu Xu, Sooin Ryu, You-Kyung Lee, Hyo-Jeong Lee
Article
Chemistry, Multidisciplinary
Yinzhu Xu, Jin-Sol Cha, Seon-Ok Lee, Soo-In Ryu, You-Kyung Lee, Hengmin Han, Jung-Eun Kim, Min-Ho Lee, Eun-Ok Lee, Hyo-Jeong Lee
Summary: Heamatang (HMT) is a traditional medicinal formula used in Chinese and Korean medicine, mainly composed of herbal ingredients. Experimental results suggest that HMT exerts its anticancer effects by inhibiting PAK-1 expression, making it potentially useful in the development of functional health food and pharmaceuticals.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Min-Ho Lee, Sunyeong Park, Yinzhu Xu, Jung-Eun Kim, Hengmin Han, Jae-Hyeon Lee, Jean Kyung Paik, Hyo-Jeong Lee
Summary: This study analyzed the effect of Pinus koraiensis needle extract on fructose-induced cell culture and animal models. The extract was found to reduce triglyceride levels, inhibit lipid accumulation, and have anti-inflammatory and anti-tumor effects.
APPLIED SCIENCES-BASEL
(2022)
Article
Social Work
Jungmi Ha, Sunghoon Kim, Doolee Han
JOURNAL OF SOCIAL WORK PRACTICE
(2020)
