Review
Biochemistry & Molecular Biology
Babatunde Fasipe, Andre Faria, Ismail Laher
Summary: Alpha-lipoic acid (ALA) is a potent antioxidant used in the management of diabetic neuropathy and has potential applications in other diseases related to oxidative stress, inflammation, and metal overload. This review summarizes recent clinical trials and describes the uses of ALA in managing neuropathies. The unique pharmacological actions of ALA, combined with its low toxicity, have prompted trials on its potential therapeutic uses in diseases associated with increased oxidative stress, inflammation, and metal overload.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yunyang Wang, Mo Wang, Yunshan Liu, Hui Tao, Somesh Banerjee, Shanthi Srinivasan, Elizabeta Nemeth, Mark J. Czaja, Peijian He
Summary: Iron excess and deficiency can cause cellular stress and death through the common mechanism of impaired autophagic function.
Article
Environmental Sciences
Kexin Zhu, Richard W. Browne, Rachael Hageman Blair, Matthew R. Bonner, Mingmei Tian, Zhongzheng Niu, Furong Deng, Zeinab Farhat, Lina Mu
Summary: This study found that hydroxy metabolites derived from AA and LA are associated with air pollution and may interact with systemic inflammation in response to air pollution exposure.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Manuel Aureliano, Ana Luisa De Sousa-Coelho, Connor C. Dolan, Deborah A. Roess, Debbie C. Crans
Summary: Lipid peroxidation (LPO), induced by exposure to vanadium salts and compounds, is a process that affects human health. The LPO reaction involves the oxidation of alkene bonds in polyunsaturated fatty acids, resulting in the formation of radical and reactive oxygen species (ROS). Vanadium species have both direct and indirect effects on ROS formation, making the study of LPO arising from increased ROS challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anna Blazewicz, Andreas M. Grabrucker
Summary: Metals have been recognized to impact our body's physiology for hundreds of years. Recently, a link between abnormal metal levels and neuropsychiatric illnesses such as schizophrenia and autism spectrum disorders (ASDs) has been discovered. This review summarizes past and current research on the cellular and molecular mechanisms of toxic metals, focusing on ASD-related activities such as inflammation/immune activation, mitochondrial dysfunction, oxidative stress, impairment of axonal myelination, and synapse formation and function. The competition with essential metals may explain why both the presence of certain toxic metals and the absence of certain essential metals are risk factors for ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Ahmed Abdelraouf Salem, Kira Trares, Matthias Kohl, Eugene Jansen, Hermann Brenner, Ben Schottker
Summary: The study found a significant association between current smoking and increased levels of oxidative stress biomarker D-ROM, while there was no association with TTP levels. There is a dose-response relationship between smoking amount and D-ROM concentrations, indicating long-term effects of smoking on redox balance.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marta Martin-Fernandez, Victor Arroyo, Carmen Carnicero, Rebeca Siguenza, Reyes Busta, Natalia Mora, Beatriz Antolin, Eduardo Tamayo, Patricia Aspichueta, Irene Carnicero-Frutos, Hugo Gonzalo-Benito, Rocio Aller
Summary: This study found that elevated levels of lipid peroxidation (LPO) are significantly associated with a NASH score of >= 4 in NAFLD patients. LPO levels above 315.39 μM were identified as an independent risk factor. The model showed good discrimination ability in distinguishing NASH patients. Therefore, understanding the molecular mechanisms of basal inflammation may help identify biomarkers and therapeutic targets for NASH.
Review
Biochemistry & Molecular Biology
Heshu Chen, Chenyu Wang, Zemin Liu, Xinmiao He, Wenjie Tang, Liuqin He, Yanzhong Feng, Di Liu, Yulong Yin, Tiejun Li
Summary: Ferroptosis is a novel type of non-apoptotic cell death that can be triggered by specific modulators. It has potential implications in preventing inflammatory storms and cancer development. Ferroptosis may mediate biological processes such as oxidative stress and iron overload to treat cancer.
Review
Biochemistry & Molecular Biology
Ashley K. Putman, G. Andres Contreras, Lorraine M. Sordillo
Summary: Oxidative stress is associated with the generation of oxidized products such as IsoP, which are highly specific biomarkers of lipid peroxidation. Despite advancements in their detection and use, there is still limited knowledge about the biological activity and potential roles of IsoP in oxidative stress pathology, especially in veterinary medicine.
Article
Biochemistry & Molecular Biology
Yang Liu, Yuan Wang, Zhi Lin, Rui Kang, Daolin Tang, Jiao Liu
Summary: SLC25A22 acts as a metabolic repressor of ferroptosis by producing glutathione and monounsaturated fatty acids, providing a previously unrecognized defense pathway against ferroptotic cell death.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Toxicology
T. Kiremitli, S. Kiremitli, B. Akselim, B. Yilmaz, R. Mammadov, I. H. Tor, G. N. Yazici, M. Gulaboglu
Summary: This study investigated the preventive effects of CoQ10 on methotrexate-induced utero-ovarian damage and oxidative stress in rats. Results showed that CoQ10 has significant antioxidant effects, reversing the oxidative stress caused by MTX. CoQ10 may be useful for protecting ovarian and uterine tissue from injury caused by oxidative stress.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Linas Cerniauskas, Asta Mazeikiene, Egle Mazgelyte, Egle Petrylaite, Ausra Linkeviciute-Dumce, Neringa Burokiene, Dovile Karciauskaite
Summary: Cardiovascular diseases are the leading cause of mortality worldwide. This study aimed to evaluate oxidative lipid degradation biomarkers and antioxidant defense system components in healthy women and their relationships with age, anthropometric measures, and lipid metabolism biomarkers. The findings suggest that these indices could be useful biomarkers in the research of aging, obesity, and atherosclerosis pathogenesis.
Article
Biochemistry & Molecular Biology
Marlena Rademacher, Hartmut Kuhn, Astrid Borchert
Summary: GPX4, as the only enzyme capable of reducing complex lipid peroxides to the corresponding alcohols, plays a role in erythroid differentiation of mouse erythroleukemia cells, but heterozygous expression of a catalytically inactive Gpx4 is not sufficient to compromise erythropoiesis in vivo and ex vivo.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Vesna Sredoja Tisma, Stela Bulimbasic, Danica Galesic Ljubanovic, Kresimir Galesic, Jadranka Morovic-Vergles, Josko Mitrovic, Koji Uchida, Franz Tatzber, Neven Zarkovic, Morana Jaganjac
Summary: This study investigated the implication of oxidative stress in small-vessel vasculitis, focusing on acrolein immunohistochemistry in affected skin vessels and systemic stress response. It was found that systemic redox homeostasis and iron metabolism are altered in SVV patients, with possible biomarkers identified for evaluating oxidative status, disease activity, and prevalence. Furthermore, a strong correlation between the accumulation of acrolein-protein adducts in the skin and disease progression was revealed.
Article
Chemistry, Analytical
Xilei Xie, Guangzhao Liu, Yaxin Niu, Chenghui Xu, Yong Li, Jian Zhang, Xiaoyun Jiao, Xu Wang, Bo Tang
Summary: Alzheimer's disease (AD) involves multiple pathological factors, with Aβ plaques and ONOO- being two major factors. By designing a dual-functional fluorescent probe capable of discriminating and simultaneously profiling these two factors, their interaction and correlation during the progression of AD were demonstrated.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kashif Shakeel, Sheikh Raisuddin, Sadath Ali, Syed Sarim Imam, Md. Akhlaquer Rahman, Gaurav Kumar Jain, Farhan Jalees Ahmad
JOURNAL OF LIPOSOME RESEARCH
(2019)
Article
Obstetrics & Gynecology
Priya Prasad, Namita Singh, Banashree Das, Sheikh Raisuddin, Mridu Dudeja, Sangita Rastogi
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2019)
Article
Toxicology
S. Dabeer, M. A. Afjal, S. Ahmad, M. Fatima, H. Habib, S. Parvez, S. Raisuddin
HUMAN & EXPERIMENTAL TOXICOLOGY
(2020)
Article
Environmental Sciences
Shikha Sharma, Shahzad Ahmad, Mohd Amir Aijal, Haroon Habib, Suhel Parvez, Sheikh Raisuddin
Article
Neurosciences
Syed Suhail Andrabi, Heena Tabassum, Sabiha Parveen, Suhel Parvez
Article
Pharmacology & Pharmacy
Prerna Agarwal, Darshana Singh, Sheikh Raisuddin, Raj Kumar
Article
Obstetrics & Gynecology
Shashi Nandar Kumar, Sheikh Raisuddin, Kh. Jitenkumar Singh, Banajit Bastia, Deepa Borgohain, Long Teron, Santanu Kumar Sharma, Arun Kumar Jain
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2020)
Article
Toxicology
Haroon Habib, Md Rafi Haider, Shikha Sharma, Mirza Masroor Ali Beg, Shahzad Ahmad, Sadaf Dabeer, Mohammad Shahar Yar, Sheikh Raisuddin
TOXICOLOGY MECHANISMS AND METHODS
(2020)
Correction
Environmental Sciences
S. Sharma, S. Ahmad, M. A. Afjal, H. Habib, S. Parvez, S. Raisuddin
Article
Chemistry, Multidisciplinary
Mohd Amir Afjal, Poonam Goswami, Shahzad Ahmad, Sadaf Dabeer, Juheb Akhter, Mohd Salman, Anuradha Mangla, Sheikh Raisuddin
Summary: Tempol has been found to ameliorate cisplatin-induced nephrotoxicity and restore the levels of renal function markers. Additionally, it can attenuate the effects of cisplatin on genes and proteins related to kidney injury.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shashi Nandar Kumar, Kumar Vaibhav, Banajit Bastia, Vishwajeet Singh, Meenakshi Ahluwalia, Usha Agrawal, Deepa Borgohain, Sheikh Raisuddin, Arun Kumar Jain
Summary: This study found that occupational pesticide exposure during pregnancy may decrease AChE activity and cause in utero pathological changes accompanied by increased HIF-1 alpha expression, which contributes to placental insufficiency and fetal growth restriction.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Review
Food Science & Technology
Shubhra Pande, Sheikh Raisuddin
Summary: Sirtuins (SIRT) are a unique group of enzymes that can remove acyl groups from lysine residues using NAD+ as a co-substrate. The members of the SIRT family have distinct characteristics and biological functions, affecting various metabolic processes in different cellular locations. Understanding the distribution, specific biological roles, and effects of SIRT in human tissues is crucial for identifying molecular mechanisms and finding foods that can beneficially enhance SIRT activity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Shipra Pant, Astha Dimri, Renu Arora, Fouzia Siraj, Sheikh Raisuddin, Sangita Rastogi
Summary: This study investigated the expression of MMP-2, -9, -14/TIMP-1, -2, -3 in C. trachomatis-positive tubal EP patients. The results showed upregulated expression of MMP-2, -9, and -14, as well as downregulated expression of TIMP-1, -2, and -3 in C. trachomatis-positive patients compared to controls. The fold-change in MMP expression was significantly higher in C. trachomatis-positive patients, with MMP-2 showing the greatest upregulation. These findings suggest that dysregulation of MMPs/TIMPs, particularly enhanced MMP-2 expression, may play a role in the development of tubal EP in C. trachomatis-positive women.
MICROBIAL PATHOGENESIS
(2022)
Article
Environmental Sciences
Sadaf Dabeer, Sheikh Raisuddin
Summary: This study examined the intergenerational effect of parental exposure to an environmentally relevant dose of BPA on the hepatic health outcome of their offspring in a metabolically challenged population. The results showed that BPA exposure led to increased birth weight and rapid weight gain in the offspring, along with changes in liver function enzymes, histological changes in the liver tissue, and the onset of non-alcoholic fatty liver disease (NAFLD).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Meeting Abstract
Toxicology
S. Ahmad, S. Raisuddin
TOXICOLOGY LETTERS
(2019)
