Article
Medicine, Legal
Sihem Ait Atmane, Djedjiga Ait Eldjoudi, Zeynep Aksoylu Ozbek, Pelin Gunc Ergonul, Bachra Khettal
Summary: This study evaluated the oral safety of cold pressed oil of Pinus halepensis Mill. seeds (COPHS) through acute and 28-day repeated dose toxicities studies in mice and rats. The results demonstrated that COPHS is relatively non-toxic and has a large safety margin.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Mariana de M. Barbosa, Lidiane M. A. de Lima, Widarlane A. da S. Alves, Eucilene K. B. de Lima, Luzia A. da Silva, Thiago D. da Silva, Kahoana Postal, Mohammad Ramadan, Kateryna Kostenkova, Dayane A. Gomes, Giovana G. Nunes, Michelly C. Pereira, Wagner E. da Silva, Monica F. Belian, Debbie C. Crans, Eduardo C. Lira
Summary: This study provides the first toxicity evaluation of a mixed-valence polyoxovanadate (V15). The results demonstrate that V15 exhibits high cytotoxic activity, causing significant alterations in metabolic parameters related to the kidney and liver. The toxicity of V15 is attributed to oxidative stress and lipid peroxidation, making it inappropriate for biomedical applications.
Article
Pharmacology & Pharmacy
Hiba Natsheh, Elka Touitou
Summary: In this study, a phospholipid oily gel for nasal administration was designed and tested for its effectiveness in improving memory. The results showed significantly improved behavior in animals treated nasally, and enhanced delivery of fluorescent probes to the brain through nasal administration.
Article
Food Science & Technology
Nur Syamimi Zaini, Roselina Karim, Ahmad Faizal Abdull Razis, Nur Fazila Saulol Hamid, Norhasnida Zawawi
Summary: Kenaf seed beverage (KSB) shows potential as a novel plant-based beverage. It has different nutritional composition compared to soybean, with superior antioxidant properties. Toxicity evaluations in rats indicate that oral consumption of KSB does not cause adverse effects.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Na-Kyung Yoo, Su-Min Youn, Soo-Jin Choi
Summary: The synthesis methods of SAS can impact its oral toxicokinetics and tissue distribution, but not its oral toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Sineenart Sanpinit, Palika Wetchakul, Piriya Chonsut, Ngamrayu Ngamdokmai, Aktsar Roskiana Ahmad, Sakan Warinhomhoun
Summary: The objective of this study was to investigate the gastroprotective effects and subacute oral toxicity of black seed oil. The results indicated that the administration of black seed oil exerted gastroprotective effects by increasing the gastric wall mucus and decreasing gastric juice acidity. In addition, high-performance liquid chromatography detected 7.3 mg/mL of thymoquinone in black seed oil. These findings suggest that black seed oil may be a safe therapeutic drug for preventing gastric ulcers.
Article
Integrative & Complementary Medicine
Yu-En Lin, Meng-Hsuan Lin, Yi-Syuan Lai, Kuan-Hung Lu, Huai-Syuan Huang, Fu-Chuo Peng, Shing-Hwa Liu, Lee-Yan Sheen
Summary: Garlic essential oil (GEO) showed no mutagenicity or clastogenic effects in the experiments and demonstrated no adverse reactions in the subacute toxicity test on mice after oral administration for 28 days.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2022)
Article
Food Science & Technology
Ryota Ojiro, Hiromu Okano, Shunsuke Ozawa, Hiroshi Yamagata, Xinyu Zou, Qian Tang, Meilan Jin, Kazuaki Sasaki, Toshinori Yoshida, Tomoya Yoshinari, Makoto Shibutani
Summary: The study investigated the pharmacokinetics and repeated oral toxicity of enniatin B (ENNB) in mice. ENNB showed high bioavailability after oral dosing, with elimination half-life and fecal excretion. The 28-day toxicity study revealed no adverse effects in mice at a dose of 30 mg/kg BW/day.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Zhaoxu Yang, Sheng Wang, Yawen Hong, Renhua Gai, Wenxiang Hong, Bingbing Tang, Chunqin Lin, Xiaomeng Wang, Qiaojing Wang, Chao Chen, Jiajia Wang, Qinjie Weng
Summary: In this study, the repeated toxicity of curcumol, a natural product from traditional Chinese medicine, was evaluated. It was found that curcumol may have potential toxic effects on the blood system but did not cause any histopathological changes. These findings are important for the further study and application of curcumol as a new drug.
Article
Veterinary Sciences
Ling Wang, Jiongjie He, Lianghong Wu, Xueqin Wu, Baocheng Hao, Shengyi Wang, Dongan Cui
Summary: Postpartum uterine diseases in dairy cows, such as retained placenta (RP) and puerperal metritis (PM), can lead to decreased fertility. Antibiotics are commonly used to treat retained placenta, but their efficacy is low. Herbal medicines, such as Guixiong Yimu San (GYS), have been proposed as alternative approaches. This study evaluated the toxicity of GYS in mice and rats and found no adverse effects, suggesting that it could be a practical treatment for retained placenta.
VETERINARY SCIENCES
(2023)
Article
Food Science & Technology
Nazan Kutlu, Raciye Meral, Mehmet Mustafa Ekin, Yagmur Erim Kose, Zafer Ceylan
Summary: Pomegranate seed oil (PSO) is rich in bioactive materials and using it with nanotechnological methods can improve the microbial and oxidative stability of food samples. In this study, PSO-loaded nanomats showed great potential in reducing microbial contamination and improving oxidative stability in cheese and fish fillets during storage.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Medicine, Legal
Genoveva Murillo, Thomas Horn, William D. Johnson, Susan MacIntosh
Summary: Omega-3 fatty acids, particularly EPA and DHA, are mostly sourced from fish, but environmental factors and limited fishing quotas have led to the development of alternative sources like genetically engineered DHA canola by Nuseed. Safety assessments through animal studies support the safety of DHA canola oil and meal for food and feed purposes.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Zahra Karami, Sepideh Arbabi Bidgoli, Mohammadreza Saghatchi Zanjani, Peyman Arabshahi, Taraneh Gazori, Mehrdad Hamidi
Summary: In this study, acetaminophen nanosuspensions (APAP-NSs) were prepared to improve oral bioavailability and reduce toxicity. The APAP-NSs had a mean diameter of 124 +/- 3.8 nm and showed higher dissolution compared to coarse drug. In vivo study demonstrated increased AUC(0-inf) and C-max in APAP-NSs-receiving animals and no toxicity up to 100 mg/kg in a 28-day repeated oral dose toxicity study in mice.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Medicine, Legal
Hong-ju Du, Guo-hui Tong, Jun-yu Ning, Shan Gao, Qing Yang, Ying Feng, Peng Zhang, Wei Zhang, Hai-ming Jing, Guo-jun Li
Summary: This study investigated the potential toxicity of repeated oral doses of DHA-S in rats. The results showed that DHA-S at doses of 100 or 200 mg/kg BW caused reduced body weight and food consumption, affected hematological indexes and organ weight, especially in female rats. Moreover, DHA-S significantly influenced blood biochemical parameters at doses of 100 or 200 mg/kg BW. Female rats were more susceptible to the toxic effects of DHA-S. The no observed adverse effect level (NOAEL) of DHA-S in rats was determined to be 50 mg/kg BW/day.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hansol Won, Da Hye Jeong, Hyo-Sook Shin, Jin Hee Lee, Jeong Pyo Lee, Jun-Young Yang, Kikyung Jung, Jayoung Jeong, Jae Ho Oh
Summary: The study evaluated the genotoxicity and toxicity of BCP in Sprague-Dawley rats. BCP showed no genotoxic effects but caused mortality at high doses, with significant increases in cholesterol levels and treatment-related histopathological changes in the pancreas. The ALD of BCP was estimated to be over 1,000 mg/kg b.w., and the NOAEL was considered to be 250 mg/kg b.w. for male and female rats after repeated oral administration for 28 days.
FRONTIERS IN PHARMACOLOGY
(2021)