Article
Food Science & Technology
Maoru Li, Guoyong Xie, Yadong Ding, Ji Ma, Qiuyan Liu, Yuqin Wang, Zan Peng, Jianbo Sun, Jing Shang
Summary: Based on plant metabolomics and chemical composition analysis, differences in chemical ingredients and efficacy were found between Cichorium glandulosum Boiss. et Huet (CG) and Cichorium intybus L. (CI). CI extract exhibited stronger antioxidant activity, while CG extract showed stronger hypoglycemic activity. Furthermore, the study revealed chemical and biological differences between CG and CI, providing a basis for better quality control and development of more effective functional foods.
Article
Biochemistry & Molecular Biology
Ru Wang, Guijuan Zheng, Ting Dang, Pengfei Jin, Jia Yao, Linjie Su, Guangmin Yao, Dongmei Qin
Summary: A phytochemical investigation of the roots extract of Cichorium glandulosum resulted in the isolation and characterization of fourteen compounds, including sesquiterpene lactones, flavonoids, and lignans. Some of these compounds were isolated from this plant for the first time, showcasing the diversity of compounds present in C. glandulosum.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Serap Nigdelioglu Dolanbay, Seda Sirin, Belma Aslim
Summary: The alkaloid extracts of G. grandiflorum exhibit antioxidative effects and regulate oxidative stress induced by H2O2, suggesting their potential therapeutic role in neurodegenerative diseases.
APPLIED SCIENCES-BASEL
(2023)
Article
Multidisciplinary Sciences
Alyaa Farid, Valina Michael, Gehan Safwat
Summary: This study aimed to create Melatonin-loaded nanoparticles to alleviate liver damage caused by a chemical substance, CCL4. The nanoparticles exhibited good antioxidant, anti-inflammatory, and anticoagulant effects in vitro. Treatment with the nanoparticles improved histopathological changes in liver tissues, restored the levels of liver function enzymes, inflammatory cytokines, and matrix metalloproteinases to normal levels. These nanoparticles significantly protected the liver from the toxicity of CCL4.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Meng Chen, Xinyan Song, Jifang Jiang, Lei Xing, Pengfei Wang
Summary: The study found that galangin has a protective effect against CCl4-induced liver toxicity, possibly acting through the LKB1/AMPK-mediated pathway.
EUROPEAN JOURNAL OF INFLAMMATION
(2021)
Article
Environmental Sciences
Oktay Ozkan, Caner Ozbey, Gonca Donmez Arat, Asim Kart, Ismail Sari, Isil Aydemir
Summary: This study found that methanolic extract of Hypericum crenulatum Boiss significantly improved nimesulide-induced liver injury in mice. However, other serum and oxidative stress markers were not affected.
FRESENIUS ENVIRONMENTAL BULLETIN
(2022)
Article
Multidisciplinary Sciences
Zhao-Wei Tong, Hina Gul, Muhammad Awais, Salina Saddick, Falak Sher Khan, Muhammad Gulfraz, Umara Afzal, Khizar Nazir, M. Y. Malik, Sami Ullah Khan, M. Ijaz Khan
Summary: The study revealed the therapeutic potential of Dodonaea viscosa, specifically its flowers, in protecting against CCl4-induced toxicity in mice. The phytochemical analysis identified various compounds with antioxidant and anti-tuberculosis activities, showing the widespread medicinal value of this herbal medicine.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Sevil Albayrak
Summary: The study investigated the chemical composition, antioxidant and antimicrobial activities of the essential oil and methanolic extract of Dorystoechas hastata. Results showed that the methanol extract exhibited good total antioxidant, DPPH scavenging, cupric ions, and ferric ions reducing activities, suggesting potential as a natural antioxidant and antimicrobial agent.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dalia Mostafa Mohammed Domiaty
Summary: The study investigated the potential of pomegranate peel extract in treating liver damage caused by carbon tetrachloride in rats and its effects on the expression of the hMSH2 gene. The results showed that pomegranate peel extract attenuated the changes caused by carbon tetrachloride administration, indicating its potential for use in liver damage treatment.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND ALLIED SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hayat Ouassou, Mohamed Bouhrim, Nour Elhouda Daoudi, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Mohamed Aziz, Mohamed Bnouham
Summary: The study showed that the stem aqueous extract of Caralluma europaea has a significant hepatoprotective effect against carbon tetrachloride-induced liver damage, indicating its potential use in preventing liver intoxication.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2021)