Article
Plant Sciences
Min Jiang, Xiaoying Wang, Bin Lv, Yujie Lu, Xianghui Ma, Wenjuan Liu, Gang Bai, Xiumei Gao
Summary: The deposition of psoralen in the liver is the primary cause of liver damage, which is related to the inhibition of CYPs and GSTs activities leading to the depletion of GSH. Co-administration of GSH and psoralen is an effective approach to prevent liver injury in clinical settings.
Article
Oncology
Emma C. Hulshof, Mirjam de With, Femke M. de Man, Geert-Jan Creemers, Birgit A. L. M. Deiman, Jesse J. Swen, Saskia Houterman, Stijn L. W. Koolen, Sander Bins, Anna M. J. Thijs, Marjan M. J. Laven, Anke M. Hovels, Saskia A. C. Luelmo, Danny Houtsma, Katerina Shulman, Howard L. McLeod, Ron H. N. van Schaik, Henk-Jan Guchelaar, Ron H. J. Mathijssen, Hans Gelderblom, Maarten J. Deenen
Summary: This study aimed to determine the safety, feasibility, pharmacokinetics, and cost of UGT1A1 genotype-guided dosing of irinotecan. The results showed that UGT1A1 genotype-guided dosing significantly reduces the incidence of febrile neutropenia in UGT1A1 PM patients treated with irinotecan, results in a therapeutically effective systemic drug exposure, and is cost-saving.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Plant Sciences
Seth A. Strom, Aaron G. Hager, Jeanaflor Crystal T. Concepcion, Nicholas J. Seiter, Adam S. Davis, James A. Morris, Shiv S. Kaundun, Dean E. Riechers
Summary: The resistance of waterhemp to the herbicide S-metolachlor involves a combination of Phase I and Phase II metabolic activities, specifically the O-demethylation reaction conferring resistance. Greater activities of GSTs and P450s were observed in resistant populations compared to sensitive populations, leading to increased metabolism of S-metolachlor and the formation of resistant metabolites.
PLANT AND CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sangeeta Shrestha Sharma, Shishir Sharma, Jie Zhao, Matthias Bureik
Summary: Cytochromes P450 (CYPs) and UDP-glucuronosyltransferases (UGTs) are important human drug metabolizing enzymes, and this study explores their mutual interactions. The study used recombinant co-expression of 19 human UGTs with CYP enzymes in yeast and found that UGT co-expression had a significant effect on P450 activity in most cases. The study also observed varying degrees of influence of CYP co-expression on UGT activity.
Article
Pharmacology & Pharmacy
Seung-Bae Ji, So-Young Park, Subin Bae, Hyung-Ju Seo, Sin-Eun Kim, Gyung-Min Lee, Zhexue Wu, Kwang-Hyeon Liu
Summary: Resveratrol exhibited stereoselective inhibition on certain cytochrome P450s and uridine 5'-diphosphoglucuronosyl transferases, with different enantiomers showing varying levels of inhibition on different enzymes. Trans-resveratrol specifically demonstrated noncompetitive inhibition on CYP3A and UGT1A1 activities.
Article
Biochemistry & Molecular Biology
Safwat G. Sabra, Naeem Abbas, Abdulwahab M. Hafez
Summary: This study investigated the susceptibility of Myzus persicae field populations to different insecticides and explored the metabolic mechanisms of resistance. The findings revealed varying levels of resistance to different insecticides, with moderate resistance to bifenthrin and acetamiprid, low-to-moderate resistance to fosthiazate, and low resistance to spirotetramat. However, the populations were susceptible to afidopyropen and flonicamid. Carboxylesterases and cytochrome P450 monooxygenases were found to be involved in the resistance, but glutathione S-transferases were not implicated. The study suggests the potential of flonicamid and afidopyropen as alternative insecticides for controlling M. persicae.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Environmental Sciences
Derek Simonsen, Jacob Heffelfinger, David M. Cwiertny, Hans-Joachim Lehmler
Summary: The metabolism of the herbicide safener benoxacor in Rhesus monkey subcellular fractions was investigated in this study, with findings showing that the metabolism was primarily mediated by carboxylesterase and cytochrome P450 enzymes. Differences were observed in the metabolism between male and female monkeys, and enantioselective metabolism by glutathione-S-transferases and CYPs may have an impact on the toxicity of benoxacor.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patrick Maada Ngegba, Gaofeng Cui, Yun Li, Guohua Zhong
Summary: Spodoptera frugiperda is a major agricultural pest that threatens global food security. It is highly polyphagous, migratory, and fecund, making its management challenging. The insecticide chlorantraniliprole is commonly used to control S. frugiperda, but its overuse poses health risks, resistance development, toxicity to beneficial insects, and environmental contamination. This study investigates the synergistic effects of camptothecin with chlorantraniliprole in managing S. frugiperda resistance and associated challenges.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dries Amezian, Ralf Nauen, Gaelle Le Goff
Summary: The genus Spodoptera is known for being polyphagous and destructive agricultural pests, with detoxification genes playing a crucial role in overcoming plant defense mechanisms. Despite a significant amount of expression data produced in the past decade for Spodoptera larvae in response to xenobiotics, the scattered information makes it difficult to clearly identify candidate genes involved in host plant adaptation and insecticide resistance. This review highlights the importance of detoxification genes in the genus and reveals a lack of genetic and biochemical information in some species, suggesting a need for further research in this area.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Physiology
An-Jin Yang, Ning-Na Yin, Dan-Lu Chen, Yu-Ruo Guo, Yu-Jie Zhao, Nai-Yong Liu
Summary: This study investigated the detoxification mechanisms of the wood-boring beetle Pharsalia antennata through transcriptomics and gene identification. The results revealed differential expression of detoxification genes in different tissues and identified orthologous genes to other species. These findings provide valuable resources for understanding xenobiotic metabolism and odorant detection in P. antennata.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jaromir Petrtyl, Karel Dvorak, Jan Stritesky, Martin Lenicek, Alena Jiraskova, Vaclav Smid, Martin Haluzik, Radan Bruha, Libor Vitek
Summary: The study revealed dysregulated bilirubin metabolism in NAFLD patients, likely due to increased oxidative stress, with no effect on NAFLD development from major functional variants in the HMOX1 or UGT1A1 gene promoters.
Article
Entomology
XiaoYu Lu, MeiLing Nong, Kai Feng, Meng Xu, Fang Tang
Summary: The study found that Odontotermes formosanus showed significant responses in detoxifying enzyme genes (GSTs, UGTs, and CYPs) to Serratia marcescens infection, suggesting that these enzymes may play crucial roles in defense against bacterial infections and indicating that termites have evolved a complex immune response to potential pathogens.
Article
Biodiversity Conservation
Wen Li, Bin Yang, Naiyong Liu, Jiaying Zhu, Zongbo Li, Sangzi Ze, Jinde Yu, Ning Zhao
Summary: Bark beetles cause tree deaths and damage to mountain forest ecosystems. They detoxify plant metabolites through the cooperation of P450s, GSTs, and CCEs. The detoxification genes are broadly expressed in different tissues, providing a theoretical basis for insect resistance in mixed forests.
Article
Environmental Sciences
Jeonghoon Han, Yeun Park, Hyeryeong Jeong, Sang Bae Kim, Chan Min Yoo, Kiseong Hyeong, Kyun-Woo Lee
Summary: This study investigated the effects of fine particulate matter from hydrothermal ore on the physiological and molecular responses of Tigriopus japonicus, a marine copepod. The results showed that hydrothermal ore and its leachates significantly affected copepod survival, fecundity, and the transcriptional expression of detoxification, antioxidation, and development-related genes. This study is important for assessing the potential impacts of ore mining on marine organisms.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Biochemistry & Molecular Biology
Warin Rangubpit, Eukote Suwan, Danai Sangthong, Kannika Wongpanit, Roger W. Stich, Prapasiri Pongprayoon, Sathaporn Jittapalapong
Summary: In this study, molecular dynamics simulations were conducted to investigate the binding of GTX and GSH to RmGST. It was found that GSH binds tighter and sits rigidly inside the G-site, while GTX occupies both active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Medicine, Legal
Fabio Vivarelli, Donatella Canistro, Clara Babot Marquillas, Andrea Sapone, Moreno Paolini
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2015)
Article
Environmental Sciences
Andrea Sapone, Donatella Canistro, Fabio Vivarelli, Moreno Paolini
Article
Pharmacology & Pharmacy
Michela Novelli, Donatella Canistro, Manuela Martano, Niccola Funel, Andrea Sapone, Simone Melega, Matilde Masini, Vincenzo De Tata, Anna Pippa, Cecilia Vecoli, Daniela Campani, Rocco De Siena, Antonio Soleti, Moreno Paolini, Pellegrino Masiello
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Geriatrics & Gerontology
Donatella Canistro, Caterina Boccia, Rosanna Falconi, Barbara Bonamassa, Luca Valgimigli, Fabio Vivarelli, Antonio Soleti, Maria Luisa Genova, Giorgio Lenaz, Andrea Sapone, Francesco Zaccanti, Sherif Z. Abdel-Rahman, Moreno Paolini
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2015)
Article
Biotechnology & Applied Microbiology
Simone Melega, Donatella Canistro, Eleonora Pagnotta, Renato Iori, Andrea Sapone, Moreno Paolini
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2013)
Letter
Medicine, Legal
Fabio Vivarelli, Andrea Sapone, Donatella Canistro, Moreno Paolini
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2014)
Article
Cell Biology
Raffaella Fabbri, Andrea Sapone, Moreno Paolini, Fabio Vivarelli, Paola Franchi, Marco Lucarini, Gianandrea Pasquinelli, Rossella Vicenti, Maria Macciocca, Stefano Venturoli, Donatella Canistro
HISTOLOGY AND HISTOPATHOLOGY
(2015)
Article
Geriatrics & Gerontology
Luca Valgimigli, Andrea Sapone, Donatella Canistro, Massimiliano Broccoli, Luigi Gatta, Antonio Soleti, Moreno Paolini
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2015)