Article
Pharmacology & Pharmacy
Mirielle C. Nauman, Jeremy J. Johnson
Summary: The purple mangosteen is a popular fruit in Southeast Asia that contains xanthones, which have significant anti-cancer and anti-tumor activities. Alpha-mangostin, the most abundant xanthone, has been extensively studied for its anticancer effects, while other xanthones and mangosteen extracts also show promise but their mechanisms of action are not well understood. Clinical anticancer activity of mangosteen products has not been evaluated.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Restituto Tocmo, Bryan Le, Amber Heun, Jan Peter van Pijkeren, Kirk Parkin, Jeremy James Johnson
Summary: Xanthones from mangosteen exhibit anti-inflammatory and anti-oxidative effects. The study isolated seven prenylated xanthones from mangosteen fruit pericarp extracts, with Garcinone D (GarD) showing dual protection against intestinal epithelial barrier dysfunction through AhR and Nrf2 pathways.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Mirielle C. Nauman, Restituto Tocmo, Bhaskar Vemu, Jacob P. Veenstra, Jeremy J. Johnson
Summary: Xanthones from the purple mangosteen fruit have been shown to inhibit CDK2/CyclinE1 and dose-dependently inhibit the viability of prostate cancer and breast cancer cells. Gamma-mangostin and alpha-mangostin are the strongest inhibitors among the compounds evaluated.
NATURAL PRODUCT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nathamon Suksamran, Visaka Anantawat, Phanphen Wattanaarsakit, Chen Wei, Md. Atiar Rahman, Hideyuki J. Majima, Jitbanjong Tangpong
Summary: Mangosteen vinegar produced through steam distillation has higher antioxidant activity and contains abundant phenolic compounds. Compared to apple cider vinegar, mangosteen vinegar exhibited higher total phenolic content, total flavonoid content, and free radical scavenging activity. HPLC analysis revealed the presence of various phenolic compounds in mangosteen vinegar, which were found to be higher than those in apple cider vinegar. Mangosteen vinegar received higher acceptance in sensory evaluation.
Review
Biochemistry & Molecular Biology
Vasin Yuvanatemiya, Pao Srean, Wiyada Kwanhian Klangbud, Karthikeyan Venkatachalam, Jittimon Wongsa, Thanya Parametthanuwat, Narin Charoenphun
Summary: Xanthones are significant bioactive compounds and secondary metabolites in mangosteen pericarps, possessing various beneficial properties such as antioxidant, anti-inflammatory, and antimicrobial activities. Selecting an appropriate extraction procedure is crucial for obtaining high-quality and functionally enhanced xanthones from mangosteen pericarps.
Article
Food Science & Technology
Bianca R. Albuquerque, Maria Ines Dias, Jose Pinela, Ricardo C. Calhelha, Tania C. S. P. Pires, Maria Jose Alves, Rubia C. G. Correa, Isabel C. F. R. Ferreira, Maria Beatriz P. P. Oliveira, Lillian Barros
Summary: The ripe mangosteen pericarp contains seven organic acids, three tocopherol isomers, four fatty acids, and fifteen non-xanthone phenolic compounds. The most efficient extraction of phenolic compounds was achieved using hydroethanolic extract (MT80), followed by ethanolic extract (MTE), and then aqueous extract (MTW). Both MT80 and MTE extracts exhibited antioxidant and antibacterial activities. MTW did not show anti-inflammatory properties, while MTE and MT80 inhibited tumor cell lines.
Article
Energy & Fuels
Yves Iradukunda, Guoying Wang, Xin Li, Gaofeng Shi, Yawen Hu, Fenfang Luo, Kaiqiang Yi, Abdalazeez Ismail Mohamed Albashir, Xiuli Niu, Zhijun Wu
Summary: The study presented a new method for producing mangosteen peels activated carbons with excellent electrochemical performance, attributed to their well-structured micro/mesoporous features. The optimized MPAC-1 exhibited a high specific capacitance and retention rate, indicating potential applications for green energy production in the future.
JOURNAL OF ENERGY STORAGE
(2021)
Article
Nutrition & Dietetics
Oliver D. John, Peter Mouatt, Sunil K. Panchal, Lindsay Brown
Summary: The active compounds in the rind of purple mangosteen have significant therapeutic effects on rats with diet-induced metabolic syndrome, including weight loss, improved liver function, and enhanced cardiovascular parameters.
Article
Food Science & Technology
Xiaofang Li, Haoze Chen, Yan Jia, Jinming Peng, Chunmei Li
Summary: In this study, an efficient method for enriching polyphenols from mangosteen pericarp (MPPs) was developed, and its inhibitory effects on starch digestion were evaluated. The results showed that MPPs had inhibitory activity on alpha-amylase and could reduce blood glucose peak and glucose response AUC.
Review
Medicine, Research & Experimental
Aidin Mohammadi, Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Summary: This review evaluates the protective activities of mangosteen and its major components against natural and chemical toxicities. The protective effects are mediated through various mechanisms, including oxidative stress inhibition, modulation of inflammation, apoptosis and MAPK signaling pathways, and improvement of histological conditions.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Review
Ecology
T. L. Yao, M. Nazre, D. McKey, R. Jalonen, J. Duminil
Summary: This article reviews the origin of mangosteen and addresses errors of fact and interpretation. Field observations and examination of herbarium specimens support their interpretations. They propose a testable new evolutionary-ecological framework called Forest-Dusun Interface. Future studies are suggested to address knowledge gaps.
ECOLOGY AND EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Simona De Vita, Milena Masullo, Sabrina Grambone, Paloma Bermejo Bescos, Sonia Piacente, Giuseppe Bifulco
Summary: The Nrf2 pathway activation plays a crucial role in maintaining redox homeostasis and regulating inflammation. Xanthones isolated from Garcinia mangostana showed antioxidant properties by disrupting the interaction between Keap1 and Nrf2. Among these compounds, demethylcalabaxanthone exhibited an indirect antioxidant effect.
Article
Fisheries
Suwaree Kitikiew, Zheng-Xiang Chieng, Cheng-Ying Li, Hsin-Wei Kuo, Winton Cheng
Summary: This study aimed to investigate the effects of injecting mangosteen husk hot-water extracts (MHE) on immune and physiological factors in Macrobrachium rosenbergii. The results showed that higher doses of MHE led to significant increases in immune parameters, improved phagocytic activity, and clearance efficiency. However, certain parameters, such as phenoloxidase activity per granulocyte, plasma glucose, and lactate levels were decreased after injection. Prawns injected with MHE also exhibited changes in haemolymph dopamine and norepinephrine under hypothermal stress. In addition, prawns injected with MHE showed increased survival rates when challenged with Lactococcus garvieae, indicating enhanced resistance to the pathogen.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Thu Huong Tran, Van Thong Nguyen, Huyen Tram Le, Hoang Minh Nguyen, Thu Ha Tran, Thao Do Thi, Xuan Cuong Nguyen, Manh Tuan Ha
Summary: Xanthones isolated from Garcinia mangostana pericarps showed promising biological and pharmacological activities, with new compounds identified and characterized using NMR, HRESIMS, and ECD spectra. The compounds displayed significant DPPH scavenging capacity and moderate cytotoxic effects against human cancer cell lines in vitro.
Review
Biochemistry & Molecular Biology
Neha Verma, Soumya Pandit, Anil Kumar, Gulab Yadav, Shiv Kumar Giri, Dibyajit Lahiri, Zulhisyam Abdul Kari, Ram Prasad, KanuPriya
Summary: Mangosteen, also known as the Queen of Fruits in Malaysia, is a medicinal plant with biological properties like anticancer and antioxidant. Researchers aim to understand the mechanisms through which its compounds inhibit tumor cell growth.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
Francisco L. Ramirez-Cuapio, Monica A. Torres-Ramos, Marisol Orozco-Ibarra, Isaac Acosta, Ana L. Sosa-Ortiz
Summary: The study found that serum REST levels are not a viable blood-based biomarker for Alzheimer's disease, and are not associated with disease severity and comorbidities.
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2021)
Article
Neurosciences
Luis Fernando Rubio-Atonal, Norma Serrano-Garcia, Jorge Humberto Limon-Pacheco, Jose Pedraza-Chaverri, Marisol Orozco-Ibarra
Summary: This study demonstrated that CoPP induced hypophagia and weight loss in rats while also reducing the number of neurons in the Nucleus Accumbens Shell. Although CoPP did not alter anxiety-like behaviors and locomotor activity, the results could be relevant to diseases like anorexia. Further research is needed to explore the molecular mechanisms involved in the reduced food intake and weight loss caused by CoPP.
Article
Biochemistry & Molecular Biology
Alexis Paulina Jimenez-Uribe, Belen Bellido, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Jose Antonio Hernandez-Santos, Francisca Fernandez-Valverde, Estefani Yaquelin Hernandez-Cruz, Marisol Orozco-Ibarra, Jose Pedraza-Chaverri
Summary: This study evaluated the time course of mitochondrial mass and bioenergetics alterations induced by a unilateral ureteral obstruction (UUO), a widely used model to study kidney fibrosis induction and progression mechanisms. The results showed a marked reduction in mitochondrial oxidative phosphorylation (OXPHOS) and mitochondrial mass during days 7 to 28 of obstruction, suggesting a key role of mitochondrial biogenesis and mitophagy induction in the impairment of OXPHOS capacity during fibrotic progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Genetics & Heredity
Beatriz Hernandez-Ochoa, Fabiola Fernandez-Rosario, Rosa Angelica Castillo-Rodriguez, Alfonso Marhx-Bracho, Noemi Cardenas-Rodriguez, Victor Martinez-Rosas, Laura Morales-Luna, Abigail Gonzalez-Valdez, Ernesto Calderon-Jaimes, Veronica Perez de la Cruz, Sandra Rivera-Gutierrez, Sergio Meza-Toledo, Carlos Wong-Baeza, Isabel Baeza-Ramirez, Saul Gomez-Manzo
Summary: The study evaluated the expression of metabolic pathway-related genes in tumors and identified PKM and TPI1 as two novel genes suitable as reference genes. Results showed that genes involved in metabolic pathways were expressed differently in glioma samples of different CNS WHO grades, indicating a potential model for studying tumor development and finding molecular targets for glioma treatment.
Article
Cell Biology
Alexis Paulina Jimenez-Uribe, Tania Gomez-Sierra, Omar Emiliano Aparicio-Trejo, Marisol Orozco-Ibarra, Jose Pedraza-Chaverri
Summary: Fibrosis is characterized by pathological excessive deposition of extracellular matrix, involving a complex network of signal transduction pathways, with TGF-β playing a central role. Additionally, molecules not typically associated with fibrosis such as NOX4, mTOR, HDAC, and S1P have been found to be critical in its development.
CELLULAR SIGNALLING
(2021)
Article
Environmental Sciences
Teresita Guadalupe Lopez-Aceves, Elvia Coballase-Urrutia, Francisco Estrada-Rojo, America Vanoye-Carlo, Liliana Carmona-Aparicio, Maria Eugenia Hernandez, Jose Pedraza-Chaverri, Luz Navarro, Omar E. Aparicio-Trejo, Armando Perez-Torres, Omar N. Medina-Campos, Daniel Martinez-Fong, Vicente Sanchez-Valle, Noemi Cardenas-Rodriguez, Leticia Granados-Rojas, Evelyn Pulido-Camarillo, Veronica Rodriguez-Mata, Claudia del R. Leon-Sicairos
Summary: This study found that subacute exposure to Permethrin in rats led to increased lipoperoxidation and protein oxidation in brain regions, enhanced antioxidant enzyme activities, elevated pro-inflammatory cytokine expression, neuronal degeneration in the hippocampus, mitochondrial uncoupling, and decreased oxidative phosphorylation.
Article
Food Science & Technology
Y. Ramirez-Rodriguez, V Ramirez, K. Robledo-Marquez, N. Garcia-Rojas, P. Rojas-Morales, N. Arango, J. Pedraza-Chaverri, O. N. Medina-Campos, J. M. Perez-Rojas, R. Flores-Ramirez, R. Winkler, L. Riego-Ruiz, Joyce Trujillo
Summary: This study aimed to investigate the effect of pitaya juice concentrate (PJC) on cisplatin-induced nephrotoxicity. The results showed that PJC had a renoprotective effect by attenuating renal dysfunction, structural damage, apoptosis activation, and oxidative stress, and it was related to changes in the tumor necrosis factor-alpha and renal nitric oxide pathways.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Chemistry, Medicinal
Itzel Jatziri Contreras-Garcia, Noemi Cardenas-Rodriguez, Antonio Romo-Mancillas, Cindy Bandala, Sergio R. Zamudio, Saul Gomez-Manzo, Beatriz Hernandez-Ochoa, Julieta Griselda Mendoza-Torreblanca, Luz Adriana Pichardo-Macias
Summary: This study provides a comprehensive review of levetiracetam, discussing its clinical uses, structural properties, therapeutic targets, and various molecular, genetic, and systemic action mechanisms, highlighting its potential as a candidate for drug repurposing.
Article
Biochemistry & Molecular Biology
Omar Prado-Carrillo, Abner Arenas-Ramirez, Monserrat Llaguno-Munive, Rafael Jurado, Jazmin Perez-Rojas, Eduardo Cervera-Ceballos, Patricia Garcia-Lopez
Summary: This study established an imatinib-resistant CML cell line and found that overexpression of P-gp plays a significant role in imatinib resistance. Ketoconazole can reverse this resistance by inhibiting P-gp.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Cortes-Algara Alfredo, Cardenas-Rodriguez Noemi, Reyes-Long Samuel, Ortega-Cuellar Daniel, Ruz-Barros Rodrigo, Mondragon-Teran Paul, Escamilla-Tilch Monica, Correa-Basurto Jose, Lara-Padilla Eleazar, Alfaro-Rodriguez Alfonso, Cortes-Altamirano Jose Luis, Bandala Cindy
Summary: The study suggests that transdermal patches containing norelgestromin and ethinylestradiol could be a safe and effective treatment option for moderate and severe COVID-19 patients, as it showed significant improvement in hospital stay, oxygen requirements, and mechanical ventilation.
Review
Cell Biology
Berenice Franco-Juarez, Cristina Coronel-Cruz, Beatriz Hernandez-Ochoa, Saul Gomez-Manzo, Noemi Cardenas-Rodriguez, Roberto Arreguin-Espinosa, Cindy Bandala, Luis Miguel Canseco-Avila, Daniel Ortega-Cuellar
Summary: TFEB is a key transcription factor involved in autophagy and lysosomal biogenesis, and it may also regulate other important biological processes. The regulation of TFEB occurs at the post-translational level and is influenced by various signaling pathways. Understanding the mechanisms of TFEB regulation can help in the development of potential therapeutic strategies.
Article
Biochemistry & Molecular Biology
Ana Karina Aranda-Rivera, Alfredo Cruz-Gregorio, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Fernando Enrique Garcia-Arroyo, Isabel Amador-Martinez, Marisol Orozco-Ibarra, Francisca Fernandez-Valverde, Jose Pedraza-Chaverri
Summary: Sulforaphane (SFN) confers protection against unilateral ureteral obstruction (UUO)-induced kidney injury by targeting mitochondrial biogenesis and improving lipid metabolism.
Article
Neurosciences
Maria Teresa Ibarra-Gutierrez, Norma Serrano-Garcia, Marisol Orozco-Ibarra
Summary: Parkinson's disease (PD) is a neurodegenerative disorder diagnosed through motor symptoms, but it also presents numerous non-motor symptoms that appear years before motor symptoms. Experimental models have been used to replicate PD characteristics, but none have fully reproduced all the motor and non-motor symptoms, limiting PD research. The most commonly used models involve administering toxic compounds like MPTP, 6-OHDA, and rotenone, which mimic dopamine deficiency. This review focuses on the rotenone-induced PD model, highlighting its molecular characteristics beyond the inhibition of mitochondrial complex I.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Julieta Griselda Mendoza-Torreblanca, Noemi Cardenas-Rodriguez, Jazmin Carro-Rodriguez, Itzel Jatziri Contreras-Garcia, David Garciadiego-Cazares, Daniel Ortega-Cuellar, Valentin Martinez-Lopez, Alfonso Alfaro-Rodriguez, Alberto Nayib Evia-Ramirez, Ivan Ignacio-Mejia, Marco Antonio Vargas-Hernandez, Cindy Bandala
Summary: Dopamine and dopamine agonists have the potential to inhibit angiogenesis through the VEGF pathway. They can prevent important processes such as proliferation and migration by blocking the functions of VEGF and VEGFR2 through the D2 receptor. However, more research is needed to fully understand their mechanism and efficacy in diseases like cancer, endometriosis, and OA. This review aims to describe the antiangiogenic action of the DA-D2R/VEGF-VEGFR2 system and compile relevant findings from experimental studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ivan Ignacio-Mejia, Itzel Jatziri Contreras-Garcia, Julieta Griselda Mendoza-Torreblanca, Omar Noel Medina-Campos, Jose Pedraza-Chaverri, Mercedes Edna Garcia-Cruz, Antonio Romo-Mancillas, Saul Gomez-Manzo, Cindy Bandala, Maria Elena Sanchez-Mendoza, Luz Adriana Pichardo-Macias, Noemi Cardenas-Rodriguez
Summary: Epilepsy is a neurological disorder associated with oxidative stress. Some antiseizure drugs, including levetiracetam, have been found to have neuroprotective and antioxidant properties. This study evaluated the effects of levetiracetam on the oxidant-antioxidant status in the hippocampus of rats with temporal lobe epilepsy (TLE). The results showed that levetiracetam increased antioxidant enzyme activity, reduced hydrogen peroxide levels, and demonstrated scavenging activity against hydroxyl radicals.
