Article
Chemistry, Medicinal
Qian Yang, Yanhui Jiang, Shan Fu, Zhaopeng Shen, Wenwen Zong, Zhongning Xia, Zhaoya Zhan, Xiaolu Jiang
Summary: Polysaccharides from seaweed, especially Ulva lactuca polysaccharide extract (UPE), have been shown to have a significant ameliorative effect on renal injury induced by oxidative stress, demonstrating potential therapeutic benefits for oxidative damage diseases in the future.
Article
Biochemistry & Molecular Biology
Yihan Chen, Yuezhen Ouyang, Xuejin Chen, Ruoxin Chen, Qiling Ruan, Mohamed A. Farag, Xinhua Chen, Chao Zhao
Summary: Ageing-related type 2 diabetes is a significant public health problem that is increasing with population ageing. This study reveals that Ulva lactuca polysaccharide (ULP) can improve ageing-associated diabetes by modulating gut microbiota variation and regulating the expression levels of certain proteins. ULP shows potential as a nutraceutical for delaying or preventing the development of ageing-related type 2 diabetes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Multidisciplinary
Xiaoqing Li, Yihan Chen, Xiaoxiang Gao, Yijing Wu, Hesham Rushdy El-Seedi, Yong Cao, Chao Zhao
Summary: A novel polysaccharide from Ulva lactuca (ULP) was found to exhibit antihyperuricemic activity by regulating biochemical indexes, gene expressions, tissue pathology, and gut microbiota. It effectively reduced serum uric acid levels, improved renal injury, and showed potential in treating hyperuricemia-related diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed I. A. Ibrahim, Mohamed S. Amer, Hassan A. H. Ibrahim, Eman H. Zaghloul
Summary: In this study, a significant amount of ulvan was extracted from Ulva lactuca collected from Alexandria coastline, Egypt, using a simple extraction method. The extracted ulvan showed high sulfate content and demonstrated potent antimicrobial and anti-fouling properties.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Applied
Qiling Ruan, Yihan Chen, Jiahui Wen, Yinghui Qiu, Yajun Huang, Yi Zhang, Mohamed A. Farag, Chao Zhao
Summary: The antihyperglycemic effect of Ulva lactuca polysaccharide (ULP) was evaluated in aging diabetic mice by monitoring changes in the gut microbiota. The results showed that ULP alleviated type 2 diabetes by improving insulin tolerance, increasing SOD and CAT activities, and lowering blood glucose level. ULP also regulated the expressions of INSR and AMPK, while inhibiting the expressions of JNK, JAK, STAT3, p16, and p38 to improve glucose metabolism dysfunction. The abundance of Alloprevotella and Pediococcus might be the key factor for ULP's antihyperglycemic effectiveness in aging-related diabetes.
Article
Chemistry, Applied
Yazhong Ge, Huamai Qiu, Jianxian Zheng
Summary: The study found that polysaccharide extracted from Helvella leucopus can lower the levels of cholesterol, triglycerides, and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol in hyperlipidemic mice. It also regulates liver function and blood lipid metabolism. This suggests that Helvella leucopus polysaccharide could be a new complementary alternative strategy for managing hyperlipidemia.
Article
Biotechnology & Applied Microbiology
Jieteng Chen, Weishun Zeng, Jing Gan, Yunxue Li, Yifan Pan, Junyan Li, Hao Chen
Summary: The study investigated the effects of different extraction conditions on the yields, chemical composition, rheological properties, and antioxidant activities of ulvan. Enzyme and ultrasonic treatment improved extraction yields and affected the composition of ulvan, with enzyme-assisted extraction showing the highest DPPH radical scavenging ability. The physicochemical properties of ulvan were significantly influenced by extraction methods, highlighting potential applications in healthcare due to its antioxidative properties.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Chemistry, Medicinal
Yuzhou Wan, Lin Liu, Bo Zhang, Shaopeng Wang, Xiaoqian Wang, Kexu Chen, Yuxi Li, Tingting Zhao, Huimin Qi
Summary: This study elucidated the main structure of the high-sulfated derivative of Ulva pertusa polysaccharide (HU) and explored its therapeutic effect against nonalcoholic fatty liver disease (NAFLD). Results showed that HU effectively reduced blood lipid levels, improved liver function, decreased lipid droplets in the liver, and suppressed the abnormal enlargement of epididymal fat cells. HU appears to have a protective effect on the development of NAFLD.
Article
Biochemistry & Molecular Biology
Ragaa A. Hamouda, Mada A. Alharthi, Amenah S. Alotaibi, Asma Massad Alenzi, Doha A. Albalawi, Rabab R. Makharita, Keykavous Parang
Summary: This study focuses on the characterization and antibacterial activity of biogenic silver and copper nanoparticles and their composites produced by the marine green alga Ulva lactuca. The results show that UL/Ag2 O-NPS exhibited the greatest inhibition zones against multidrug-resistant bacterial strains, suggesting potential application as an antibacterial agent.
Article
Biochemistry & Molecular Biology
Enas E. Eltamany, Sameh S. Elhady, Marwa S. Goda, Omar M. Aly, Eman S. Habib, Amany K. Ibrahim, Hashim A. Hassanean, Usama Ramadan Abdelmohsen, Martin K. Safo, Safwat A. Ahmed
Summary: This study identified several new ceramides isolated from the edible green algae U. lactuca that demonstrated promising antiviral activity against SARS-CoV-2, particularly Cer-4 and Cer-5 inhibiting the virus from entering the human host. Furthermore, metabolites from U. lactuca were found to possess potential antiviral activity, indicating the potential of this algae as a source of safe antiviral compounds.
Article
Biochemistry & Molecular Biology
Wei Gao, Linzhang Zhang, Jianjun Wu, Yongbin Xu, Shenglan Qi, Wei Liu, Ping Liu, Songshan Shi, Huijun Wang, Qiaoyan Zhang, Yongli Wang, Shunchun Wang
Summary: Nonalcoholic steatohepatitis (NASH) is a chronic liver disease characterized by inflammation and hepatic steatosis that may coincide with fibrotic activity. A purified beta-glucan compound (PUP-W-1) from Polyporus umbellatus was found to prevent the development of NASH in a murine steatohepatitis model by suppressing inflammation, lipid accumulation, and fibrosis. These findings suggest that PUP-W-1 holds promise as a natural drug candidate or precursor for NASH treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Kajal Chakraborty, Shubhajit Dhara, Aswathy Elizabeth Mani
Summary: The ulvapyrone extracted from Ulva lactuca exhibits anti-inflammatory and antioxidant activities, inhibiting arachidonate 5-lipoxygenase. Compared to ibuprofen, ulvapyrone shows promising bioactivity and oral bioavailability.
NATURAL PRODUCT RESEARCH
(2022)
Article
Engineering, Environmental
Changxi Qi, Liping Li, Guodong Cheng, Bin Xiao, Yuxiao Xing, Xiaona Zhao, Jianzhu Liu
Summary: Platycodon grandiflorus polysaccharides (PGPS(t)) exhibit hepatoprotective effects in mice with acute liver injury induced by LPS/D-GalN, alleviating oxidative stress, reducing inflammatory cytokines, and enhancing the expression of anti-apoptotic proteins.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Chemistry, Medicinal
Yifan Wang, Han Ye, Leke Qiao, Chunying Du, Zhengpeng Wei, Ting Wang, Jingfeng Wang, Ruizhi Liu, Peng Wang
Summary: The study demonstrates that selenized polysaccharides from Ulva pertusa have alleviative effects on inflammatory bowel disease in mice by promoting intestinal mechanical and immune barrier functions, thus reducing intestinal inflammation levels.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Oncology
Maryam Pourhajibagher, Abbas Salehi-Vaziri, Mohammad Noroozian, Hossein Akbar, Farzaneh Bazarjani, Hassanali Ghaffari, Abbas Bahador
Summary: The study demonstrates that adding photo-activated Ulva lactuca to orthodontic acrylic resin at a concentration of 1% enhances its antibacterial and anti-biofilm activities without negatively impacting its flexural strength.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Environmental Sciences
Balan Rajan, Shanmugam Sathish, Subramanian Balakumar, Thiruvengadam Devaki
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2015)
Article
Biochemical Research Methods
Sheik Abdulazeez Sheriff, Shaikhussain Shaik Ibrahim, Thiruvengadam Devaki, Sandipan Chakraborty, Subhash Agarwa, Horacio Perez-Sanchez
JOURNAL OF PROTEOME RESEARCH
(2017)
Article
Cell Biology
Arumugam Madankumar, Sasivarnam Tamilarasi, Thandavamoorthy Premkumar, Mani Gopikrishnan, Natesh Nagabhishek, Thiruvengadam Devaki
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2017)
Article
Pharmacology & Pharmacy
Gokuladhas Krishnan, Jayakumar Subramaniyan, Pramila Chengalvarayan Subramani, Barath Muralidharan, Devaki Thiruvengadam
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2017)
Article
Plant Sciences
Arumugam Sathivel, Balavinayagamani, Balaji Raghavendran Hanumantha Rao, Thiruvengadam Devaki
PHARMACEUTICAL BIOLOGY
(2014)
Article
Cell & Tissue Engineering
Salma Baig, Ainnul Hamidah Syahadah Azizan, Hanumantha Rao Balaji Raghavendran, Elango Natarajan, Sangeetha Naveen, Malliga Raman Murali, Hui Yin Nam, Tunku Kamarul
STEM CELLS INTERNATIONAL
(2019)
Article
Biochemistry & Molecular Biology
Sathesh Kanna Velli, Jagan Sundaram, Manikandan Murugan, Gopalakrishnan Balaraman, Devaki Thiruvengadam
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Nirmala Subramaniam, Pugazhendhi Kannan, K. Ashokkumar, Devaki Thiruvengadam
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2019)
Article
Environmental Sciences
Palanisamy Krishnan, Jagan Sundaram, Sharmila Salam, Nirmala Subramaniam, Ashok Mari, Gopalakrishnan Balaraman, Devaki Thiruvengadam
ENVIRONMENTAL TOXICOLOGY
(2020)
Article
Integrative & Complementary Medicine
Ashok Mari, Gopikrishnan Mani, Sirpu Natesh Nagabhishek, Gopalakrishnan Balaraman, Nirmala Subramanian, Fathima Bushra Mirza, Jagan Sundaram, Devaki Thiruvengadam
Summary: Carvacrol significantly inhibited the proliferation of breast cancer MCF-7 cells and induced apoptosis by suppressing the PI3/AKT signaling pathway.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Oncology
Nirmala Subramaniam, Pugazhendhi Kannan, Jagan Sundaram, Ashok Mari, Sathesh K. Velli, Sharmila Salam, Palanisamy Krishnan, Gopalakrishnan Balaraman, Devaki Thiruvengadam
Summary: Boldine was found to protect the liver from reactive oxygen species, inhibit cell proliferation, regulate the cell cycle, and enhance detoxification processes, making it an effective chemopreventive agent in reducing the occurrence of diethylnitrosamine-induced hepatocellular carcinoma in Wistar albino rats.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Muhammad Rizwan, Krishnamurithy Genasan, Malliga Raman Murali, Hanumantha Rao Balaji Raghavendran, Rodianah Alias, Yi Ying Cheok, Won Fen Wong, Azura Mansor, M. Hamdi, Wan Jeffrey Basirun, Tunku Kamarul
Article
Nanoscience & Nanotechnology
Saktiswaren Mohan, Hanumantharao Balaji Raghavendran, Puvanan Karunanithi, Malliga Raman Murali, Sangeetha Vasudevaraj Naveen, Sepehr Talebian, Mohammad Mehrali, Mehdi Mehrali, Elango Natarajan, Chee Ken Chan, Tunku Kamarul
ACS APPLIED MATERIALS & INTERFACES
(2017)
Article
Biochemistry & Molecular Biology
Krishnan Gokuladhas, Subramaniyan Jayakumar, Balan Rajan, Ramasamy Elamaran, Chengalvarayan Subramani Pramila, Mani Gopikrishnan, Sasivarman Tamilarasi, Thiruvengadam Devaki
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2016)
Article
Integrative & Complementary Medicine
Pandi Anandakumar, Sattu Kamaraj, Sundaram Jagan, Gopalakrishnan Ramakrishnan, Selvamani Asokkumar, Chandrashekar Naveenkumar, Subramanian Raghunandhakumar, Manickam Kalappan Vanitha, Thiruvengadam Devaki
JOURNAL OF PHARMACOPUNCTURE
(2015)
