Article
Biochemistry & Molecular Biology
Johirul Islam, Alpa Shree, Haider Ali Khan, Sarwat Sultana
Summary: This study demonstrates the chemopreventive potential of Diosmin in lung carcinogenesis induced by B(a)P. Diosmin reduces lipid peroxidation, increases antioxidant proteins, and decreases levels of cancerous markers. It also inhibits the expression of inflammatory markers via the CREB/COX-2/PGE2 pathway. These findings suggest that Diosmin could be a promising agent for preventing lung cancer.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priti Bhardwaj, Manoj Kumar, Sunil Kumar Dhatwalia, Mohan Lal Garg, Devinder Kumar Dhawan
Summary: The study reveals that 3-acetyl-11-keto-beta-boswellic acid (AKBA) has chemopreventive potential against lung carcinogenesis induced by benzo(a)pyrene (BaP). BaP treatment caused oxidative stress and alterations in tumor biomarkers, but AKBA treatment significantly alleviated these changes.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Food Science & Technology
Junlin Ge, Rili Hao, Xue Rong, Q. Ping Dou, Xintong Tan, Guannan Li, Feng Li, Dapeng Li
Summary: The polyphenolic compound SDG found in flaxseed has been shown to protect mice from BaP-induced liver and kidney toxicity by regulating oxidative stress, inflammation, and apoptosis. SDG administration resulted in lower levels of liver and kidney damage markers and modulation of specific signaling pathways.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Qianyong Shen, Ranran Liu, Jingyi Chen, Guiying Li, Shengtao Ma, Yingxin Yu, Taicheng An
Summary: Occupational workers and residents near petrochemical industry facilities are exposed to multiple contaminants on a daily basis. However, little is known about the co-exposure effects of different pollutants based on biotransformation. This study investigated the changes in toxicity and co-exposure mechanism associated with different monoaromatic hydrocarbons (MAHs) when co-exposed with benzene, toluene, chlorobenzene, or nitrobenzene. The results showed that co-exposure to MAHs negatively affected the detoxification process of benzo[a]pyrene (BaP) and disturbed its metabolic pathways.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Krystian Mokrzynski, Grzegorz Szewczyk, Tadeusz Sarna
Summary: This study measured the quantum yield and action spectra of singlet oxygen photogeneration by benzopyrenes and their ability to generate superoxide anion. The results revealed the photochemical activity of benzopyrenes in producing singlet oxygen and superoxide anion. Furthermore, the cytotoxicity of benzopyrenes was demonstrated in skin model cells, with concentration-dependent and light-dependent effects, leading to damage to cell mitochondria and increased levels of intracellular reactive oxygen species.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Engineering, Environmental
Mukhtiar Ali, Xin Song, Qing Wang, Zhuanxia Zhang, Meng Zhang, Xing Chen, Zhiwen Tang, Xin Liu
Summary: In this study, it was found that the biodegradation rates of benzene and BaP co-contamination were significantly enhanced at elevated temperatures, with increased bioavailability and generation of ROS. The study also revealed that gram-positive bacteria exhibited higher enzymatic activities and PAH-RHD alpha gene expression, indicating their preference for long-term elevated temperatures. ROS species (O(2)(center dot-)and center dot OH) were detected and cleared by increased antioxidant enzyme activities. Soil properties were affected by temperature treatments, indicating metal-organic-associated reactions during TEB. Overall, the results highlight the importance of temperature in enhancing biodegradation under thermally enhanced biodegradation conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Hua Meng, Guyanan Li, Wei Wei, Yansen Bai, Yue Feng, Ming Fu, Xin Guan, Mengying Li, Hang Li, Chenming Wang, Jiali Jie, Xiulong Wu, Meian He, Xiaomin Zhang, Sheng Wei, Yangkai Li, Huan Guo
Summary: This study identified 15 CpG sites associated with BPDE-Alb adducts, with methylation levels at 5 sites mediating the association between BPDE-Alb adducts and lung cancer risk. The addition of these CpG sites improved the discrimination for lung cancer compared to traditional factors. These results highlight DNA methylation alterations as potential mediators in lung tumorigenesis induced by B[a]P exposure.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Naveenkumar Chandrashekar, Raghunandhakumar Subramanian, Devaki Thiruvengadam
Summary: Our study aims to explore the mechanisms of the growth inhibitory effect of baicalein in human lung carcinoma. The results show that baicalein treatment suppresses cell viability and induces cell apoptosis both in vitro and in vivo, through activating antioxidant pathways and regulating cell cycle-related proteins.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bozena Bukowska, Paulina Sicinska
Summary: Epigenetic changes play a crucial role in carcinogenesis, with Benzo(a)pyrene affecting DNA methylation and potentially leading to hypomethylation or hypermethylation depending on various factors. Exposure to BaP from sources like tobacco smoke can result in altered methylation status in offspring, and there is a potential link between BaP toxicity and disruption of biotin homeostasis pathway. Animal studies have shown that BaP toxicity can be passed down to the next generation, possibly through disturbance in circadian rhythm, and ancestral exposure to BaP can cause intergenerational effects like osteotoxicity in non-exposed offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Edina Reizer, Imre G. Csizmadia, Karoly Nehez, Bela Viskolcz, Bela Fiser
Summary: In this study, new reaction pathways leading to benzo(a)pyrene were explored using DFT methods to gain a deeper understanding of its carcinogenic effects. The research found that HAERA was the most exergonic reaction pathway, while DA was the least exergonic.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Engineering, Chemical
Xiaotian Ning, Xinlin Wang, Lei Zhang, Shanshan Yang, Shaoran Jia, Jianbing Wang, Chunquan Li, Zhiming Sun
Summary: This study explores the catalytic performance of CTAB-modified alpha-FeOOH/kaolinite material (Ca-FeOOH/K) and investigates the energetic effect of kaolinite on the structure of the synthesized composite. The results show that the C-alpha-FeOOH/K material exhibits excellent performance in activating peroxymonosulfate (PMS) for the degradation of benzo[a]pyrene (B[a]p). Furthermore, various radicals were detected through experiments, and potential degradation pathways of B[a]p were inferred based on liquid chromatography-mass spectrometry (LC-MS).
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Environmental Sciences
Marco Tarasco, Paulo J. Gavaia, Anabela Bensimon-Brito, Joao Cardeira-da-Silva, Srinath Ramkumar, Fabrice P. Cordelieres, Stefan Guenther, Maria J. Bebianno, Didier Y. R. Stainier, M. Leonor Cancela, Vincent Laize
Summary: Persistent and ubiquitous organic pollutants, like BaP, pose a major threat to aquatic organisms and human health, with adverse effects on fish bone formation and skeletal development. BaP induces activation of xenobiotic and metabolic pathways, impacting extracellular matrix formation, and regulating inflammation markers in larvae. BaP exposure negatively affects bone remodeling and may involve a role for neutrophils in inflammatory bone reduction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Yanwei Wang, Jiahui Zhao, Yipeng Xu, Cimin Tao, Jie Tong, Yingjie Luo, Yong Chen, Xuesong Liu, Tengfei Xu
Summary: This study integrated metabolomics and chemical proteomics approaches to comprehensively identify the potential target proteins affected by Bap in liver cells. The results showed that Bap weakened the antioxidant capacity by destroying the activities of SOD3 and GPX4, providing a new understanding of the mechanism of hepatotoxicity induced by Bap.
Article
Biochemistry & Molecular Biology
Yongzhan Mai, Songyao Peng, Haiyan Li, Yuan Gao, Zini Lai
Summary: The study found that exposure to BaP can induce physiological responses in the liver of zebrafish by altering associated genes, resulting in cellular abnormalities, oxidative stress, and dysregulation of immune response.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Zuotao Zhang, Jiao Sun, Xiaoqiang Gong, Chongyang Wang, Hui Wang
Summary: A new sulfate-reducing bacterium, Desulforamulus aquiferis strain DSA, was found to degrade high molecular weight polycyclic aromatic hydrocarbons (HMW-PAHs) pyrene and benzo[a]pyrene, while reducing sulfate to sulfide. The metabolic processes for anaerobic pyrene and benzo[a]pyrene degradation were proposed based on detecting intermediates and analyzing the genome. This study provides new guidance for anaerobic HMW-PAHs degradation under sulfate-reducing conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)