Article
Medicine, Research & Experimental
Peter S. Cunningham, Gareth B. Kitchen, Callum Jackson, Stavros Papachristos, Thomas Springthorpe, David van Dellen, Julie Gibbs, Timothy W. Felton, Anthony J. Wilson, Jonathan Bannard-Smith, Martin K. Rutter, Thomas House, Paul Dark, Titus Augustine, Ozgur E. Akman, Andrew L. Hazel, John F. Blaikley
Summary: Researchers proposed a method called ClinCirc to measure circadian rhythms in hospitalized patients, which is challenging due to infrequent sampling. Through comparisons with simulated and frequently sampled biological data, ClinCirc showed high accuracy and revealed important clinical associations in the ICU patients.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Rheumatology
Desiree Luis-Rodriguez, Javier Donate-Correa, Ernesto Martin-Nunez, Carla Ferri, Victor G. Tagua, Atteneri Perez Castro, Carmen Mora-Fernandez, Juan F. Navarro-Gonzalez
Summary: This study found that serum uric acid levels are associated with inflammation in asymptomatic hyperuricaemia (AHU) patients, and UA levels may be an inducer of subclinical inflammation. Therapeutic reduction of UA levels was associated with modulation of inflammatory characteristics.
Article
Polymer Science
J. F. A. Valente, P. Pereira, A. Sousa, J. A. Queiroz, F. Sousa
Summary: Gene therapy involves introducing functional genes into patients to correct specific mutations. In this study, different plasmids were complexed with chitosan (CH) or polyethyleneimine (PEI) polymers to evaluate their effectiveness in gene delivery systems. Chitosan polyplexes showed higher transfection efficiency and P53 protein expression compared to PEI polyplexes.
Article
Chemistry, Analytical
Yanyun Fang, Yawei Yan, Shiyi Bi, Yingfei Wang, Yue Chen, Peipei Xu, Huangxian Ju, Ying Liu
Summary: In this study, a photo detachable DNA-copolymer nanocage was designed to screen the activities of T cells for the success of T-cell therapy. The DNA-copolymer nanocage on the cell membrane encapsulated a single T cell and the secretion of cytokine interferon-gamma (IFN-gamma) was monitored to indicate individual T-cell activity. The selected active T cells showed improved capabilities for downstream cell activation and cancer cell killing.
ANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Zhongyu Xie, Wenhui Yu, Guan Zheng, Jinteng Li, Shuizhong Cen, Guiwen Ye, Zhaofeng Li, Wenjie Liu, Ming Li, Jiajie Lin, Zepeng Su, Yunshu Che, Feng Ye, Peng Wang, Yanfeng Wu, Huiyong Shen
Summary: Abnormal functions of mesenchymal stem cells (MSC) contribute to the pathogenesis of ankylosing spondylitis (AS). The authors demonstrate that high concentration of TNF-alpha induces enhanced migration of AS-MSC through METTL14 mediated m6A modification of the ELMO1 3 ' UTR.
NATURE COMMUNICATIONS
(2021)
Article
Virology
Anubama Rajan, Felipe-Andres Piedra, Letisha Aideyan, Trevor McBride, Matthew Robertson, Hannah L. Johnson, Gina Marie Aloisio, David Henke, Cristian Coarfa, Fabio Stossi, Vipin Kumar Menon, Harshavardhan Doddapaneni, Donna Marie Muzny, Sara Joan Javornik Cregeen, Kristi Louise Hoffman, Joseph Petrosino, Richard A. Gibbs, Vasanthi Avadhanula, Pedro A. Piedra
Summary: Respiratory syncytial virus (RSV) is a common cause of pediatric respiratory infection worldwide. This study characterized the infection of HEp-2 and A549 cells with four strains of RSV, including both major subgroups and historic and contemporary genotypes. The findings revealed differences in viral gene expression and host response between RSV subgroups, as well as the sensitivity of different cell lines to viral variation.
JOURNAL OF VIROLOGY
(2022)
Article
Endocrinology & Metabolism
Chaoyi Zhang, Anji Lian, Yue Xu, Quan Jiang
Summary: In this study, two distinct proglucagons and their receptors were identified in Nile tilapia, and it was found that GCGb can act at the pituitary level to stimulate SL release and gene expression via GCGRb through the activation of the AC/cAMP/PKA and PLC/IP3/Ca2+/CaM/CaMK-II cascades. These results provide evidence for the stimulatory role of GCGb in pituitary hormone regulation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
James M. Porter, Lea Guerassimoff, Francisco Rafael Castiello, Andre Charette, Maryam Tabrizian
Summary: Islet transplantation is a long-term cure for Type 1 Diabetes (T1D), and the study of INGAP-P variants shows potential for improving the insulin output of transplanted cells. A proof-of-concept study investigated novel molecular variants of INGAP-P and identified four peptide variants with statistically significant enhancements in insulin secretion and gene expression. This study highlights the potential of customized peptides for type 1 diabetes therapy and provides a foundation for future research.
Article
Sport Sciences
Hui-Ying Luk, Danielle E. Levitt, Casey Appel, Jakob L. Vingren
Summary: The study aimed to investigate the impact of resistance exercise-induced hormonal changes on intramuscular cytokine gene expression after muscle damage in untrained men and women. Results showed that men had a stronger response to factors like TGFB, IL-10, and TNFA compared to women, suggesting a gender difference in intramuscular cytokine response to muscle damage.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Psychiatry
Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, Takuya Hashimoto, Naomi Gamachi, Masaki Hata, Yuko Watanabe, Chiaki Yamanishi, Hideshi Yagi, Haruki Okamura, Hisato Matsunaga
Summary: IL18-deficient mice are more sensitive to acute stress and have a prolonged response. In addition, neural inflammation and augmentation of glucocorticoid signals caused by stress are more intense in IL18-deficient mice.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Materials Science, Multidisciplinary
Deqiang Miao, Ya Li, Zhongbing Huang, Yulin Wang, Min Deng, Xiaohui Li
Summary: Electroactive hydrogels have been found to guide nerve regeneration and promote functional recovery. An aniline pentamer-crosslinked chitosan (CS-AP) hydrogel, with better electroactivity and degradation, was created using the carbodiimide method and injected into the site of sciatic nerve damage. The CS-AP10 hydrogel showed improved capillary formation and repair of the sciatic nerve defect, resulting in better re-innervation of the gastrocnemius muscle. These findings suggest the potential application of CS-AP hydrogel in the regeneration and functional recovery of peripheral nerve injuries.
FRONTIERS OF MATERIALS SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Nadia Cherif, Fatma Amdouni, Boutheina Bessadok, Ghada Tagorti, Saloua Sadok
Summary: The study evaluates the in-vitro antiviral activity of chitosan extracted from the exo-skeleton of Parapenaeus longirostris, showing that chitosan can modulate the innate immune response and reduce virus load. This suggests chitosan as a potential suppressor of nodaviral infection in fish cell systems.
Article
Biochemistry & Molecular Biology
Alexandros Mavrommatis, Georgios Theodorou, Ioannis Politis, Eleni Tsiplakou
Summary: This study found that supplementing goats' diet with 20 g Schizochytrium sp. can downregulate the expression of pro-inflammatory transcripts, which could be a sustainable alternative strategy to improve immune function.
Article
Multidisciplinary Sciences
Masoumeh Saberpour, Shahin Najar-peeraye, Saeed Shams, Bita Bakhshi
Summary: This study evaluated the effects of mesenchymal stem cell conditioned media and chitosan nanoparticles on the expression of biofilm genes in V. cholerae and Toll-like receptors genes in Caco-2 cells. The findings suggest that these compounds can reduce the expression of biofilm genes and Toll-like receptors genes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Shou-Chen Lo, Chia-Yin Yang, Dony Chacko Mathew, Chieh-Chen Huang
Summary: The study found that Kluyveromyces marxianus grown with lactate as the sole carbon source showed optimal growth and released protein under different pH conditions. Lactate induced the autolysis of K. marxianus, leading to the release of proteins and peptides. These findings are crucial for future probiotic and kefir studies involving K. marxianus.
SCIENTIFIC REPORTS
(2021)
Review
Food Science & Technology
Yong Chen, Jing Wang, Liang Zou, Hui Cao, Xiaoling Ni, Jianbo Xiao
Summary: This review discusses the beneficial effects of dietary proanthocyanidins (PAC) on gastrointestinal functions. The findings suggest that PAC can directly act on the gastrointestinal tract through its antioxidant, antibacterial, anti-inflammatory, and anti-proliferative properties. PAC can also interact with carbohydrates, proteins, and lipids, reducing their digestion and absorption. Additionally, PAC has a prebiotic-like effect on the intestinal microbiota, which may contribute to the potential health benefits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Zebin Weng, Yuanrong Chen, Tingting Liang, Yajuan Lin, Hui Cao, Haizhao Song, Ling Xiong, Fang Wang, Xinchun Shen, Jianbo Xiao
Summary: Wheat germ protein is a promising source of bioactive peptides with various biological functions. However, there are still scientific issues that need further exploration in the basic research and industrialization process of WGBPs.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Chengye Zhao, Meichen Li, Yuqian Yang, Minni Qin, Ruojia Wang, Qing Zhu, Guangtong Chen, Andong Wang
Summary: In this study, a new flavonoid glycoside was isolated from the heartwood of Toxicodendron vernicifluum, together with four known compounds. The new compound showed significant cytotoxicity against A549 cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Chengye Zhao, Xunjia Qian, Minni Qin, Xinyang Sun, Qingqing Yu, Jianyu Liu, Qing Zhu, Andong Wang
Summary: This study reveals that Juglans mandshurica has various bioactive metabolites and shows multiple biological activities, including anti-inflammatory, anticancer, and antimicrobial properties. The traditional uses of this plant are also validated to some extent.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Nermeen Yosri, Sultan M. Alsharif, Jianbo Xiao, Syed G. Musharraf, Chao Zhao, Aamer Saeed, Ruichang Gao, Noha S. Said, Alessandro Di Minno, Maria Daglia, Zhiming Guo, Shaden A. M. Khalifa, Hesham R. El-Seedi
Summary: Arctium lappa, also known as burdock, is a medicinal edible plant that has been used in traditional Chinese medicine for centuries. It has demonstrated various pharmacological effects and has potential applications in nanomedicine.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Yan Geng, Jing Liu, Zichuan Wang, Tianzi Liu, Xintong Peng, Yan Huang
Summary: FAM83D is overexpressed in various cancers and may be associated with mutated TP53 and promoter DNA methylation. It is involved in progesterone-mediated oocyte maturation pathway, cell cycle regulation, and other signaling pathways. Therefore, differential expression of FAM83D could serve as a diagnostic and prognostic biomarker for various cancers.
Article
Clinical Neurology
Fan Zhang, Chuanyi Fu, Yidong Deng, Mao Zhang, Hao Peng, Wenan Li, Jian Zhong, Qing Zhou, Li Huang, Shuli Xiao, Jiannong Zhao
Summary: This study aimed to explore the association between CYP1B1 genetic variants and the risk of ischemic stroke (IS) in the Chinese Han population. The results showed that the genetic variants CYP1B1-rs10916 and CYP1B1-rs2855658 can increase the risk of IS in Chinese Han individuals aged 60 and above, smoking, or drinking alcohol.
CEREBROVASCULAR DISEASES
(2023)
Review
Biochemistry & Molecular Biology
Hidayat Hussain, Jianbo Xiao, Akbar Ali, Ivan R. Green, Bernhard Westermann
Summary: This review categorizes and discusses 180 new unusual cyclized triterpenoids, along with their demonstrated biogenetic pathways, syntheses, and biological effects, published between 2009 and 2021. The research showcases significant advances in the field of triterpenes, with a notable increase in the discovery of cyclized triterpenoids and significant progress in their synthesis and biological activities.
NATURAL PRODUCT REPORTS
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Review
Food Science & Technology
Yongbing Xu, Guilin Chen, Felix Wambua Muema, Jianbo Xiao, Mingquan Guo
Summary: Moringa oleifera Lam. (M. oleifera) is a fast-growing plant with high nutritional and medicinal values. It has been traditionally used to treat various health conditions. Phytochemical studies have revealed the presence of over 300 components in different parts of M. oleifera. Additionally, M. oleifera exhibits numerous pharmacological activities. This work aims to comprehensively review its nutritional components, chemical constituents, pharmacological activities, and applications in functional food products and medicines, providing valuable insights for future research.
FOOD REVIEWS INTERNATIONAL
(2023)
Review
Plant Sciences
Rosa Tundis, Jianbo Xiao, Ana Sanches Silva, Filipa Carreiro, Monica Rosa Loizzo
Summary: Citrus is a significant genus in the Rutaceae family, known for its medicinal and economic value, and including crops such as lemons, oranges, grapefruits, and limes. Citrus species are rich in carbohydrates, vitamins, dietary fiber, and phytochemicals, with various health-promoting properties. Citrus essential oils, mainly composed of monoterpenes and sesquiterpenes, have antimicrobial, antioxidant, anti-inflammatory, and anti-cancer properties. These oils are widely used in food, cosmetics, and pharmaceutical products.
Review
Food Science & Technology
Huanqi Wu, Shangyuan Sang, Peifang Weng, Daodong Pan, Zufang Wu, Junsi Yang, Lingyi Liu, Mohamed A. Farag, Jianbo Xiao, Lianliang Liu
Summary: Starch-based materials have suitable structural characteristics for 3D food printing inks and possess viscoelasticity, viscous film-forming, dough pseudoplasticity, and rheological properties. 3D food printing technology has significant advantages in customizing personalized and precise nutrition, expanding the range of ingredients, designing unique food appearances, and simplifying the food supply chain.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2023)
Review
Food Science & Technology
Fan Zhang, Shengxiong Chen, Jianguo Zhang, Kiran Thakur, Maurizio Battino, Hui Cao, Mohamed A. Farag, Jianbo Xiao, Zhaojun Wei
Summary: Asparagus is a perennial herb with valuable functional ingredients, which has been used as medicine and food since ancient times. Among its main chemical constituents, saponins play a crucial role in various health benefits and biological activities. This review focuses on the preparation methods, structure, classification, biological functions, food and non-food applications of asparagus saponins, with a special emphasis on their anti-cancer effects. It also highlights the challenges and limitations in current research and serves as a bridge between bioactive components and human health, aiding research on functional and health-promoting foods and medicinal applications of asparagus saponins.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Yaqian Geng, Yingfeng Xie, Wei Li, Yao Mou, Fang Chen, Jianbo Xiao, Xiaojun Liao, Xiaosong Hu, Junfu Ji, Lingjun Ma
Summary: Myricitrin, a flavonol compound extracted from plant resources, has shown great potential for various biological activities such as anti-inflammatory and anti-cancer effects. However, its practical application is constrained by low production, high cost, and environmental damage caused by extraction. Fortunately, innovative and sustainable extraction techniques as well as biosynthesis based on synthetic biology are emerging as alternatives to conventional techniques, providing new perspectives for large-scale production of myricitrin.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Food Science & Technology
Lu Li, Kexin Ji, Fengqi Du, Nini Jin, Christine Boesch, Mohamed A. Farag, He Li, Xinqi Liu, Jianbo Xiao
Summary: This systematic review suggests that flavonoid supplementation has beneficial effects on liver function, lipid profile, and inflammation in NAFLD patients, making it a promising drug regimen for the management of NAFLD and its associated complications.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
