Article
Plant Sciences
Laura Flores-Bocanegra, Zeinab Y. Al Subeh, Joseph M. Egan, Tamam El-Elimat, Huzefa A. Raja, Joanna E. Burdette, Cedric J. Pearce, Roger G. Linington, Nicholas H. Oberlies
Summary: This study evaluated the performance of MADByTE for compound dereplication and found that MADByTE is effective for detecting specific compound classes in complex mixtures and can successfully predict compound members in the sample set.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Organic
Krishnaiah Kumari, Tasqeeruddin Syed, A. M. S. Krishna, Subhashini Muvvala, Annpurna Nowduri, Chidara Sridhar, Abhishek Saxena
Summary: A novel synthetic route for the total synthesis of neocosmosin B from inexpensive and commercially available starting materials was described. This synthesis strategy, which utilizes alkylation of 1,3-dithiane, Sharpless dihydroxylation, and Yamaguchi macro-lactonization as key steps, could also be useful for the synthesis of other related resorcylic acid lactones.
Article
Biochemistry & Molecular Biology
Ying Gao, Jia Zhou, Xianggao Meng, Qianxi Ouyang, Yutian Gan, Hanli Ruan
Summary: Eleven previously undescribed radicicol-type resorcylic acid lactones were isolated and identified from a soil-derived fungus. Some of these compounds displayed immunosuppressive activities against T and B cell proliferation, suggesting the importance of the α,β-unsaturated ketone from C-8 to C-10. Further study revealed that one compound exerted anti-proliferative effect on T lymphocytes through Hsp90 inhibition.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ying Gao, Fangfang Duan, Jinling Chang, Xianggao Meng, Hanli Ruan
Summary: In this study, Podomycins A-L (1-12) were characterized from an endophyte harbored in the roots of Sanguisorba officinalis L. The structures of these compounds were determined through various methods, and their biological activities were evaluated. Compound 6, in particular, showed immunosuppressive activity by inducing apoptosis in activated T cells via the MAPKs/AKT pathway.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Sunghee Bang, Jaekyeong Kim, Jiwon Oh, Ji-Seok Kim, Seong-Ryong Yu, Stephen Deyrup, Yong-Sun Bahn, Sang Hee Shim
Summary: Six new beta-resorcylic acid derivatives were isolated from a fungus associated with a halophyte, along with four previously reported derivatives. The stereochemistry of one of the compounds was determined. The structures of the isolated compounds were elucidated using spectroscopic and chemical analysis. Two of the compounds showed potent antifungal activity against Cryptococcus neoformans.
Article
Chemistry, Multidisciplinary
Siwen Niu, Dong Liu, Zongze Shao, Jiang Huang, Aili Fan, Wenhan Lin
Summary: The study isolated eight compounds from a deep-sea-derived Spiromastix fungus, with compound 3 showing potent activities against Gram-positive pathogenic bacteria. The chemical diversity of chlorinated natural products from marine-derived fungi is extended by this research, providing a promising lead for the development of antibacterial agents.
Article
Plant Sciences
Jacob P. Walsh, David R. McMullin, Ken K-C Yeung, Mark W. Sumarah
Summary: Ilyonectria mors-panacis, formerly known as Cylindrocarpon destructans, is the main plant pathogen causing ginseng root rot, which significantly reduces crop yields. This study focused on the secondary metabolites produced by I. mors-panacis and their roles in the disease process. Results showed that pathogenic strains produce resorcylic acid lactones, while avirulent strains do not, indicating a potential link between these metabolites and disease severity.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Plant Sciences
Hong Chuan Song, Dan Qin, Hai Yang Liu, Jin Yan Dong, Chuan You, Yu Meng Wang
Summary: In this study, several new and known compounds were isolated from the endophytic fungus Penicillium ochrochloron SWUKD4.1850 from the medicinal plant Kadsura angustifolia. Penochrochlactone C demonstrated moderate cytotoxicity against HeLa tumor cells, while compounds 4-6 exhibited moderate antibacterial activities against various bacteria.
Article
Chemistry, Applied
Kalidasu Sheelam, Sridhar Chidara, Srilalitha Vinnakota, Gattu Sridhar, Ravikumar Polothi
Summary: An efficient and stereoselective total synthesis of (3R, 4S)-4-hydroxylasiodiplodin has been achieved starting from known starting materials. The key steps involved in this synthesis are Stille cross coupling, alkylation of 1,3-dithiane, and Yamaguchi macrolactonization.
NATURAL PRODUCT RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Shilpa Kuttikrishnan, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, Shahab Uddin
Summary: This review focuses on the structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms of natural RALs with cytotoxic activities.
DRUG DISCOVERY TODAY
(2022)
Article
Plant Sciences
Leslie N. Aldrich, Joanna E. Burdette, Esperanza Carcache de Blanco, Christopher C. Coss, Alessandra S. Eustaquio, James R. Fuchs, A. Douglas Kinghorn, Amanda MacFarlane, Brittney K. Mize, Nicholas H. Oberlies, Jimmy Orjala, Cedric J. Pearce, Mitch A. Phelps, Liva Harinantenaina Rakotondraibe, Yulin Ren, Djaja Doel Soejarto, Brent R. Stockwell, Jack C. Yalowich, Xiaoli Zhang
Summary: Research progress in the discovery of potential anticancer agents from various organisms has been summarized. Lead compounds with structural diversity have been obtained, and potential antitumor activities have been demonstrated. Further investigations are warranted for promising lead compounds.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Xiang Guo, Qinyu Meng, Siwen Niu, Jie Liu, Xingchen Guo, Zhaolun Sun, Dong Liu, Yucheng Gu, Jian Huang, Aili Fan, Wenhan Lin
Summary: Epigenetic manipulation of a deep-sea sediment-derived Spiromastix sp. fungus resulted in the isolation of nine new guaiane-type sesquiterpenes, with compound 5 demonstrating significant anti-neuroinflammatory activity by inhibiting NF-kappa B translocation and reducing pro-inflammatory cytokine levels in microglial cells. This study provides valuable insights into the cellular-level activity of guaiane-type sesquiterpenoids and suggests compound 5 as a promising candidate for further optimization as a multifunctional agent for anti-neuroinflammation.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Organic
Manmohan Reddy Depa, Suneetha Potla, Umesh C. Narkhede, Vinod D. Jadhav, Gattu Sridhar, Siddaiah Vidavalur
Summary: An alternative synthetic route to (-)-Neocosmosin A has been developed using commercially available (R)-propylene oxide and 4-Methoxysalicylic acid. The key steps in the synthesis involve alkylation of 1,3-dithiane and Yamaguchi macrolactonization.
SYNTHETIC COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Chen-Yu Chiang, Masao Ohashi, Yi Tang
Summary: This review highlights key examples in the integration of heterologous expression into genome mining and biosynthetic investigations in the last decade. By choosing appropriate heterologous hosts, prioritizing BGCs for structural novelty, and using shunt products from heterologous expression, important insights into the chemical logic of biosynthesis can be revealed. This study demonstrates the usefulness and limitations of heterologous biosynthesis in fungal natural product discovery.
NATURAL PRODUCT REPORTS
(2023)
Article
Plant Sciences
Agnieszka Ostrowska, Maciej T. Grzesiak, Tomasz Hura
Summary: Soil drought affects plant growth, and the study found that 5-ALA, ZEN, TRIA, and Si have different effects on water management and photosynthetic activity of maize under soil drought conditions. 5-ALA affects chlorophyll levels, gas exchange, and photochemical activity of PSII; ZEN induces stem elongation and limits dehydration; TRIA promotes leaf hydration and plant growth; silicon preparation induces changes in chlorophyll levels.
ACTA PHYSIOLOGIAE PLANTARUM
(2021)
Article
Chemistry, Applied
Chris M. Maragos, Mark Busman, Liang Ma, John Bobell
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2015)
Article
Food Science & Technology
Mark Busman, John R. Bobell, Chris M. Maragos
Article
Agriculture, Multidisciplinary
Susan P. McCormick, Takayuki Kato, Chris M. Maragos, Mark Busman, Veronica M. T. Lattanzio, Gianni Galaverna, Chiara Dall-Asta, David Crich, Neil P. J. Price, Cletus P. Kurtzman
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2015)
Review
Food Science & Technology
F. Berthiller, C. Brera, C. Crews, M. H. Iha, R. Krska, V. M. T. Lattanzio, S. MacDonald, R. J. Malone, C. Maragos, M. Solfrizzo, J. Stroka, T. B. Whitaker
WORLD MYCOTOXIN JOURNAL
(2015)
Article
Food Science & Technology
Chris M. Maragos
Article
Chemistry, Analytical
Chris M. Maragos
JOURNAL OF AOAC INTERNATIONAL
(2016)
Review
Food Science & Technology
F. Berthiller, C. Brera, C. Crews, M. H. Iha, R. Krska, V. M. T. Lattanzio, S. MacDonald, R. J. Malone, C. Maragos, M. Solfrizzo, J. Stroka, T. B. Whitaker
WORLD MYCOTOXIN JOURNAL
(2016)
Article
Food Science & Technology
Melanie Sanders, Daniel McPartlin, Kara Moran, Yirong Guo, Mia Eeckhout, Richard O'Kennedy, Sarah De Saeger, Chris Maragos
Article
Chemistry, Applied
Mark Busman, Jihong Liu, Hongjian Zhong, John R. Bobell, Chris M. Maragos
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2014)
Article
Food Science & Technology
Stefania Valenzano, Vincenzo Lippolis, Michelangelo Pascale, Agostino De Marco, Chris M. Maragos, Michele Suman, Angelo Visconti
FOOD ANALYTICAL METHODS
(2014)
Article
Chemistry, Multidisciplinary
Andrea Ventrella, Raffaella Verrone, Francesco Longobardi, Angela Agostiano, Vincenzo Lippolis, Michelangelo Pascale, Chris M. Maragos, Michael Appell, Lucia Catucci
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
(2013)
Article
Food Science & Technology
G. S. Shephard, F. Berthiller, P. A. Burdaspal, C. Crews, M. A. Jonker, R. Krska, V. M. T. Lattanzio, S. MacDonald, R. J. Malone, C. Maragos, M. Sabino, M. Solfrizzo, H. P. van Egmond, T. B. Whitaker
WORLD MYCOTOXIN JOURNAL
(2013)
Review
Food Science & Technology
F. Berthiller, P. A. Burdaspal, C. Crews, M. H. Iha, R. Krska, V. M. T. Lattanzio, S. MacDonald, R. J. Malone, C. Maragos, M. Solfrizzo, J. Stroka, T. B. Whitaker
WORLD MYCOTOXIN JOURNAL
(2014)
Article
Food Science & Technology
V. Lippolis, C. Maragos
WORLD MYCOTOXIN JOURNAL
(2014)
Article
Mycology
C. M. Maragos
MYCOTOXIN RESEARCH
(2014)