Article
Multidisciplinary Sciences
Iti Saraav, Luisa Cervantes-Barragan, Philipp Olias, Yong Fu, Qiuling Wang, Leran Wang, Yi Wang, Matthias Mack, Megan T. Baldridge, Thaddeus Stappenbeck, Marco Colonna, L. David Sibley
Summary: Oral infection with Toxoplasma gondii exacerbates damage to the colon caused by chemical irritant and impairs wound healing by suppressing stem cell regeneration. Enhanced tissue damage is due to inflammatory monocytes releasing inflammatory mediators.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Massumeh Saadatmand, Ghaidaa Raheem Lateef Al-Awsi, Abdullah D. Alanazi, Asghar Sepahvand, Mojtaba Shakibaie, Saeedeh Shojaee, Rasool Mohammadi, Hossein Mahmoudvand
Summary: The study demonstrated the prophylactic effects of synthesized ZnNPs against chronic toxoplasmosis in mice, showing a reduction in parasite load and even complete infection control. ZnNPs strengthened the innate immune system, leading to strong prophylactic effects, with increased expression of interferon-gamma and inducible nitric oxide synthase. Further in vivo and clinical studies are needed to confirm these results and explore other potential mechanisms behind these pharmacological properties.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Microbiology
Adelina Geanina Mocanu, Dana Liana Stoian, Emanuela Lidia Craciunescu, Ioana Mihaela Ciohat, Alexandru Catalin Motofelea, Dan Bogdan Navolan, Tatjana Vilibic-Cavlek, Vladimir Stevanovic, Dragos Nemescu, Marius Forga, Razvan Daniluc, Alexandra-Magdalena Ioana, Marius Craina
Summary: This study found no significant impact of latent toxoplasmosis on spontaneous abortion history, pregnancy complication rate, and neonatal outcome.
Review
Food Science & Technology
Pablo-Jesus Marin-Garcia, Nuria Planas, Lola Llobat
Summary: This article reviews the detection methods, prevalence, and control measures of Toxoplasma gondii in the food industry. T. gondii is a common parasite that causes infection through food contamination, but standardized detection methods are currently lacking in the industry. The main detection methods include bioassays, cell culture, molecular and microscopic techniques, and serological methods. Due to the high prevalence of T. gondii in many food products, standardized detection methods and control measures are necessary.
Article
Immunology
Mohammad Mahdi Jafari, Zahra Azimzadeh Tabrizi, Mohammad Saaid Dayer, Nazanin Atieh Kazemi-Sefat, Mahshid Mohtashamifard, Rahimeh Mohseni, Atefeh Bagheri, Saeed Bahadory, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar
Summary: Toxoplasma gondii infection is associated with immune response, which can be used as prognosis markers. Immunotherapy has become a new approach for toxoplasmosis treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Parasitology
Jiaofeng Huang, Jiaolong Zheng, Bang Liu, Lingling Lu, Haicong Wu, Su Lin, Dongliang Li
Summary: This study found that Toxoplasma gondii infection is associated with higher mortality in the general population, and this association is related to age and sex. This suggests that Toxoplasma gondii infection may be an important public health issue.
PARASITES & VECTORS
(2022)
Article
Multidisciplinary Sciences
Syrian G. Sanchez, Emilie Bassot, Aude Cerutti, Hoa Mai Nguyen, Amel Aida, Nicolas Blanchard, Sebastien Besteiro
Summary: Toxoplasma gondii is responsible for toxoplasmosis, a disease that can be serious when contracted during pregnancy, but can also be a threat for immunocompromised individuals. The study finds that targeting the apicoplast in bradyzoites, the latent form of the parasite, leads to a loss of long-term viability, suggesting the apicoplast as a potential therapeutic target.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Hira Mohyuddin, Blanca Laffon, Joao P. Teixeira, Solange Costa, Armanda Teixeira-Gomes, Eduardo Pasaro, Niel Constantine, Aline Dagdag, Heidi K. Ortmeyer, Boris Tizenberg, Liubov Afram, Poyu Yen, Christopher Marano, Christopher A. Lowry, Andrew J. Hoisington, Jill A. Rachbeisel, Vanessa Valdiglesias, Carlota Lema-Arranz, Natalia Fernandez-Bertolez, Ana Maseda, Jose C. Millan-Calenti, Elizabeth J. Kovacs, Johanna M. Gostner, Dietmar Fuchs, Lisa A. Brenner, Laura Lorenzo-Lopez, Teodor T. Postolache
Summary: This study revealed an association between Toxoplasma gondii and frailty, but further research is needed for validation. Certain biomarkers related to inflammaging were associated with both Toxoplasma gondii and frailty, but they did not fully mediate the association between the two.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Immunology
Amy C. Schumacher, Lina Elbadawi, Traci DeSalvo, Anne Straily, Daniel Ajzenberg, David Letzer, Ellen Moldenhauer, Tammy L. Handly, Dolores Hill, Marie-Laure Darde, Christelle Pomares, Karine Passebosc-Faure, Kristine Bisgard, Carlos A. Gomez, Cindy Press, Stephanie Smiley, Jose G. Montoya, James J. Kazmierczak
Summary: In 2017, an outbreak of toxoplasmosis was linked to undercooked venison served at a retreat in Wisconsin. Most of the attendees experienced illness, with laboratory results showing atypical features for toxoplasmosis. The strain of T. gondii found in the venison was a unique genotype, highlighting the potential risks of consuming undercooked game meat in North America.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Thais Cabral Monica, Fernanda Evers, Beatriz Souza Lima Nino, Fernanda Pinto-Ferreira, Jose Wander Bregano, Mariana Ragassi Urbano, Guita Rubinsky-Elefant, Roberta Lemos Freire, Italmar Teodorico Navarro, Regina Mitsuka-Bregano
Summary: The study examined the seroprevalence and risk factors of toxoplasmosis and toxocariasis in schoolchildren in Jataizinho, Parana, revealing associations with factors such as the mother's education level, age, presence of cats in the household, income, and presence of dogs. There was also an association between the two zoonoses, highlighting the importance of implementing control measures to reduce the incidence and risks of sequelae in children.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ragab M. Fereig, Yoshifumi Nishikawa
Summary: In this study, the cyto-nuclear and mitochondrial localization of TgPrx1 and TgPrx3 proteins in Toxoplasma gondii were revealed. Knocking out TgPrx1 and TgPrx3 genes in T. gondii resulted in decreased survival rate in mice infected with TgPrx3KO strain compared to TgPrx1KO and control strains. Additionally, TgPrx1KO and TgPrx3KO induced high levels of interferon gamma (IFN-gamma) and increased IL-6 and IL-12p40 production in infected mice and murine macrophages. These findings suggest that TgPrx3 may be a potential sub-unit vaccine candidate for controlling toxoplasmosis in susceptible humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lokman Galal, Frederic Ariey, Meriadeg Ar Gouilh, Marie-Laure Darde, Azra Hamidovic, Franck Letourneur, Franck Prugnolle, Aurelien Mercier
Summary: This study analyzes 156 genomes of Toxoplasma gondii and provides estimates of the parasite's mutation rate and generation time. It reveals that a specific haplotype is associated with the spread of the parasite through cats, indicating its role in sexual reproduction.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Rajib Acharjee, Keith K. Talaam, Endah D. Hartuti, Yuichi Matsuo, Takaya Sakura, Bundutidi M. Gloria, Shinya Hidano, Yasutoshi Kido, Mihoko Mori, Kazuro Shiomi, Masakazu Sekijima, Tomoyoshi Nozaki, Kousuke Umeda, Yoshifumi Nishikawa, Shinjiro Hamano, Kiyoshi Kita, Daniel K. Inaoka
Summary: Toxoplasma gondii is a protozoan parasite that infects a large portion of the global human population. A new potential drug target, TgMQO, has been identified in this study, and a novel expression system was developed to study its characteristics. Ferulenol, an MQO inhibitor, showed promising inhibitory effects on TgMQO, with distinct binding sites from other known inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Ningbo Xia, Nuo Ji, Longjiao Li, Yuan Huang, Congshan Yang, Xuefang Guo, Qinghong Guo, Bang Shen, Lihua Xiao, Yaoyu Feng
Summary: This study investigated the seroprevalence and risk factors of T. gondii infection in cats across China. The study found higher infection rates in Sichuan, Chongqing, and Hunan, and reported the seroprevalence in Qinghai, Anhui, Jiangxi, Shaanxi, and Ningxia for the first time. Age and lifestyle (stray or pet) of cats were identified as risk factors for T. gondii infection.
BMC VETERINARY RESEARCH
(2022)
Review
Infectious Diseases
Tahereh Mikaeili Galeh, Shahabeddin Sarvi, Seyed Abdollah Hosseini, Ahmad Daryani
Summary: Toxoplasmosis, caused by Toxoplasma gondii, is a common food-borne infection in humans. In rodent populations, atypical genotypes are dominant, while clonal strains circulate with low genetic diversity in this mammal species.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Cardiac & Cardiovascular Systems
Krzysztof Szwed, Wojciech Pawliszak, Magdalena Szwed, Marta Tomaszewska, Lech Anisimowicz, Alina Borkowska
Summary: Performing anaortic coronary artery bypass (ANA) significantly decreases the incidence of postoperative delirium and early postoperative cognitive dysfunction compared to conventional surgery, while using carbon dioxide surgical field flooding (CO2FF) does not show significant benefits in reducing these complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Infectious Diseases
Olga Zajac-Spychala, Jacek Wachowiak, Olga Gryniewicz-Kwiatkowska, Aneta Gietka, Bozenna Dembowska-Baginska, Katarzyna Semczuk, Katarzyna Fangrat, Krzysztof Czyzewski, Magdalena Dziedzic, Mariusz Wysocki, Patrycja Zalas-Wiecek, Anna Szmydki-Baran, Lukasz Hutnik, Michal Matysiak, Filip Pierlejewski, Wojciech Mlynarski, Zofia Malas, Wanda Badowska, Ninela Irga-Jaworska, Ewa Bien, Elzbieta Drozynska, Magdalena Bartnik, Tomasz Ociepa, Tomasz Urasinski, Pawel Wawrykow, Jaroslaw Peregud-Pogorzelski, Weronika Stolpa, Grazyna Sobol-Milejska, Jowita Fraczkiewicz, Malgorzata Salamonowicz, Bernarda Kazanowska, Alicja Chybicka, Liliana Chelmecka-Wiktorczyk, Walentyna Balwierz, Iwona Zak, Zuzanna Gamrot-Pyka, Mariola Woszczyk, Renata Tomaszewska, Tomasz Szczepanski, Marcin Plonowski, Maryna Krawczuk-Rybak, Agnieszka Urbanek-Dadela, Grazyna Karolczyk, Jakub Musial, Radoslaw Chaber, Jerzy Kowalczyk, Jan Styczynski
Summary: This study retrospectively analyzed bacterial infectious complications in pediatric cancer patients, revealing a higher risk of bacterial infections in patients with hematological malignancies and a higher proportion of multidrug-resistant strains, especially in hematological malignancy patients.
MICROBIAL DRUG RESISTANCE
(2021)
Article
Allergy
Olga Zajac-Spychala, Agnieszka Zaucha-Prazmo, Joanna Zawitkowska, Jacek Wachowiak, Jerzy R. Kowalczyk, Jowita Fraczkiewicz, Malgorzata Salamonowicz, Krzysztof Kalwak, Ewa Gorczynska, Alicja Chybicka, Krzysztof Czyzewski, Magdalena Dziedzic, Mariusz Wysocki, Patrycja Zalas-Wiecek, Jolanta Gozdzik, Jan Styczynski
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2020)
Letter
Cardiac & Cardiovascular Systems
Krzysztof Szwed, Marek Andryszczyk, Alina Borkowska
ANNALS OF THORACIC SURGERY
(2021)
Article
Biotechnology & Applied Microbiology
A. Badura, J. Krysinski, A. Nowaczyk, A. Bucinski
Summary: This study successfully used artificial neural networks to predict the biological activity of chemical compounds, with regression and classification models showing high predictive accuracy in determining antimicrobial properties. Three-dimensional models constructed with computational chemistry methods allowed the transformation of chemical information into useful numerical values, increasing experimental efficiency.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Adam Kokotkiewicz, Bozena Zabiegala, Pawel Kubica, Agnieszka Szopa, Adam Bucinski, Halina Ekiert, Maria Luczkiewicz
Summary: Microshoot cultures of Verbena officinalis in temporary immersion bioreactors were investigated for essential oil content and volatile fraction composition. Results showed variations in essential oil content and composition under different culture conditions.
PLANT CELL TISSUE AND ORGAN CULTURE
(2021)
Article
Medicine, General & Internal
Robert Bonek, Wojciech Guenter, Robert Jalowinski, Anna Karbicka, Anna Litwin, Maciej Maciejowski, Radoslaw Zajdel, Karolina Zajdel, Veronique Petit, Konrad Rejdak
Summary: The study found a high prevalence of anti-JCV antibodies in the Polish MS population, with increasing rates as patients age, and the highest values observed in patients treated with immunosuppressants.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
Jacek Czepiel, Marcela Krutova, Assaf Mizrahi, Nagham Khanafer, David A. Enoch, Marta Patyi, Aleksander Deptula, Antonella Agodi, Xavier Nuvials, Hanna Pituch, Malgorzata Wojcik-Bugajska, Iwona Filipczak-Bryniarska, Bartosz Brzozowski, Marcin Krzanowski, Katarzyna Konturek, Marcin Fedewicz, Mateusz Michalak, Lorra Monpierre, Philippe Vanhems, Theodore Gouliouris, Artur Jurczyszyn, Sarah Goldman-Mazur, Dorota Wultanska, Ed J. Kuijper, Jan Skupien, Grazyna Biesiada, Aleksander Garlicki
Summary: This study aimed to describe the clinical presentation, treatment, outcome, and factors associated with mortality in Clostridioides difficile infection (CDI) over a 90-day period. Older age, inadequate CDI therapy, cachexia, malignancy, Charlson Index, long-term care, elevated white blood cell count (WBC), C-reactive protein (CRP), bacteraemia, complications, and cognitive impairment were independently related with death during CDI. Additionally, factors such as older age, higher levels of WBC, neutrophil, CRP or creatinine, the presence of malignancy, cognitive impairment, and complications were strongly correlated with a shorter time from CDI diagnosis to death.
Article
Public, Environmental & Occupational Health
T. Bogiel, D. Depka, P. Zalas-Wiecek, M. Rzepka, E. Kruszynska, E. Gospodarek-Komkowska
Summary: This study compared the results of conventional culture investigation, BD Max GBS assay, and standard PCR protocols for detecting GBS carriage among pregnant women. The BD Max GBS assay had the highest percentage of positive results, showing statistically significant differences compared to other methods.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Chemistry, Multidisciplinary
Anna Badura, Jerzy Krysinski, Alicja Nowaczyk, Adam Bucinski
Summary: The study utilized artificial neural networks to investigate the antibacterial activity of imidazole derivatives against Staphylococcus aureus, resulting in the development of highly predictive regression and classification models. These models proved useful in determining the antibacterial properties of quaternary ammonium salts against S. aureus, showcasing the potential of ANNs in supporting synthesis design and the search for new antimicrobial substances.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Psychiatry
Ewa Betscher, Wojciech Guenter, Robert Bonek
Summary: The study found that memory impairment is common in patients with multiple sclerosis and affects employment status. Poor neurological status is the only clinical predictor of memory disturbances, and memory scores are significantly associated with employment status. Depression, anxiety, and fatigue are not directly related to memory status.
PSYCHIATRIA POLSKA
(2021)
Article
Medicine, General & Internal
Alicja Popiolek, Bartosz Brzoszczyk, Piotr Jarzemski, Aleksandra Chyrek-Tomaszewska, Radoslaw Wieczor, Alina Borkowska, Maciej Bielinski
Summary: PSA levels at a distant postoperative time and free T level after hormonal treatment may be biomarkers of cognitive function. There was a strong correlation between PSA levels and verbal memory and executive function tests, with a trend observed for visuospatial memory. Free T levels after hormonal treatment were significantly correlated with executive functions, with the impact of comorbid diabetes on these correlations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Wojciech Guenter, Ewa Betscher, Robert Bonek
Summary: This study reveals the relationship between 3VW and cognitive impairment in patients with multiple sclerosis, and demonstrates its predictive value after adjusting for demographic and clinical confounders.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Lukasz Wolowiec, Joanna Banach, Jacek Budzynski, Anna Wolowiec, Mariusz Kozakiewicz, Maciej Bielinski, Albert Jasniak, Agata Olejarczyk, Grzegorz Grzesk
Summary: The study aimed to assess the prognostic value of plasma catestatin concentration in patients with heart failure with reduced ejection fraction (HFrEF) in predicting unplanned hospitalization and all-cause death at a 2-year follow-up. The study included 122 hospitalized Caucasian patients in NYHA classes II to IV. Patients who died during the follow-up period had higher levels of CST, NT-proBNP, troponin T, creatinine, and glucose, and lower TAPSE, hemoglobin concentration, hematocrit, and platelet count compared to survivors. Plasma catestatin concentration was positively associated with NYHA class and blood NT-proBNP concentration. Higher plasma catestatin concentration increased the risk of all-cause death by more than five times. Plasma CST concentration is a valuable prognostic parameter in predicting death from all causes and unplanned hospitalization in patients with HFrEF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Milena Polumackanycz, Mateusz Kaszuba, Agnieszka Konopacka, Urszula Marzec-Wroblewska, Marek Wesolowski, Krzysztof Waleron, Adam Bucinski, Agnieszka Viapiana
