Review
Food Science & Technology
Wei Zhu, Patricia Oteiza
Summary: The prevalence of overweight and obesity is increasing worldwide, which is a major public health concern. Proanthocyanidins (PACs), which are widely distributed in nature, have been found to mitigate obesity-associated comorbidities. The mechanisms of PACs' anti-obesity effects include inhibiting digestive enzymes, modifying gut microbiota composition, modulating inflammation- and oxidative stress-triggered signaling pathways, and protecting the integrity of the gastrointestinal (GI) barrier. Further understanding of the mechanisms and biological activities of PACs at the GI tract can contribute to the development of nutritional and pharmacological strategies to mitigate the serious comorbidities of obesity.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Ecology
Scott Sugden, Colleen Cassady St Clair, Lisa Y. Stein
Summary: This study characterized the gut microbiota of wild coyotes using 16S rRNA gene sequencing and found differences between the microbial communities in the large and small intestines. Individual identity was more influential in shaping the microbiota than specific intestinal sites. Fecal samples were not a reliable proxy for studying upper intestinal environments.
Article
Biochemical Research Methods
Emma R. Guiberson, Christopher J. Good, Aaron G. Wexler, Eric P. Skaar, Richard M. Caprioli, Jeffery M. Spraggins
Summary: This study demonstrates a multimodal imaging workflow for mapping intestinal tissue and luminal content. The results highlight the differences in molecular and elemental distributions and abundances between tissue and luminal content.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2022)
Article
Medicine, Research & Experimental
Nimet Oner, Elif Celikel, Zahide Ekici Tekin, Vildan Gungorer, Tuba Kurt, Pakize Nilufer Tekgoz, Muge Sezer, Cuneyt Karagol, Serkan Coskun, Melike Mehves Kaplan, Merve Cansu Polat, Banu Celikel Acar
Summary: This study evaluated the outcomes of patients with immunoglobulin A vasculitis (IgAV) involving the gastrointestinal (GI) tract who received intravenous immunoglobulin (IVIG) treatment, and compared the differences between those who responded to IVIG and those who did not. The results showed that IVIG may be considered as a treatment option for IgAV patients who are resistant to steroids and/or immunosuppressive drugs, especially in cases with multi-organ/system involvement, comorbid inflammatory diseases, or resistance to standard treatment in pediatric patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Sajeen Bahadur Amatya, Sonja Salmi, Veera Kainulainen, Peeter Karihtala, Justus Reunanen
Summary: Microbial dysbiosis is considered one of the contributing factors to gastrointestinal tract cancer development and progression, with bacterial extracellular vesicles potentially playing a significant role. These vesicles have the ability to cross physiological barriers, selectively accumulate near tumor cells, and potentially alter the tumor microenvironment.
Article
Food Science & Technology
Chenyang Lu, Shasha Tang, Jiaojiao Han, Siqing Fan, Yumeng Huang, Zhen Zhang, Jun Zhou, Tinghong Ming, Ye Li, Xiurong Su
Summary: This study shows that AJOP exerts a protective effect on hyperuricemic mice by regulating uric acid metabolism, resulting in substantial heterogeneity in the GIT microbiota, and mediating the beneficial effects in a microbiota-dependent manner.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Microbiology
Alessandro Tanca, Marcello Abbondio, Giovanni Fiorito, Giovanna Pira, Rosangela Sau, Alessandra Manca, Maria Rosaria Muroni, Alberto Porcu, Antonio Mario Scanu, Paolo Cossu-Rocca, Maria Rosaria De Miglio, Sergio Uzzau
Summary: This pilot study utilizes metaproteomics to examine the relationship between gut microbiota and clinicopathological features of colon cancer. The results suggest that certain microbial taxa and functional features are associated with the stage and grade of colon cancer. This study provides valuable insights into the potential prognostic value of the gut microbiota in colon cancer progression.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Yaping Yan, Junfeng Wang, Shuai Qiu, Yanchao Duan, Wei Si
Summary: This study analyzed the intestinal microbiota composition of healthy rhesus monkeys in 6 GIT regions, providing important reference data for better understanding the regional organization and functions of gut microbial communities in humans.
MICROBIOLOGY SPECTRUM
(2022)
Review
Immunology
Yan-hao Wei, Ren-tang Bi, Yan-mei Qiu, Chun-lin Zhang, Jian-zhuang Li, Ya-nan Li, Bo Hu
Summary: The complex relationship between the brain and gastrointestinal tract has significant implications for ischemic stroke. Experimental evidence suggests that changes in the gastrointestinal microenvironment, including alterations in immune response, disruption of the gastrointestinal barrier, and modification of the gut microbiota, can contribute to the infiltration of immune cells and cytokines into the ischemic brain. Understanding the importance of brain-gastrointestinal crosstalk after stroke may offer potential therapeutic interventions for improving stroke prognosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Qi Zhang, Dian Zhong, Rui Sun, Yang Zhang, Ronald B. Pegg, Geng Zhong
Summary: Konjac glucomannan dietotherapy can improve the physiological state and microbiota diversity of constipated mice, bringing them closer to the normal group.
CARBOHYDRATE POLYMERS
(2021)
Review
Food Science & Technology
Qunran Xiang, Weiling Guo, Xin Tang, Shumao Cui, Feng Zhang, Xiaoming Liu, Jianxin Zhao, Hao Zhang, Bingyong Mao, Wei Chen
Summary: Long-term and high levels of capsaicin ingestion may cause gastrointestinal discomfort and affect gastrointestinal digestion, with a more pronounced impact on specific gastrointestinal disorders. Capsaicin can regulate visceral pain and immune response through mechanisms involving the TRPV1 receptor and neuropeptides, impacting oxidative stress and tissue permeability of the gastrointestinal tract. Probiotics have the potential to alleviate capsaicin-induced gastrointestinal discomfort based on their effects on gastrointestinal disorders and their correlation with TRPV1.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jiayuan Mo, Yujie Lu, Shan Jiang, Gang Yan, Tianqi Xing, Di Xu, Yaoyin He, Bingkun Xie, Ganqiu Lan, Baojian Chen, Jing Liang
Summary: This study found that feeding Lactobacillus delbrueckii subsp. bulgaricus (LDB) diets has positive effects on pig growth performance, gastrointestinal microbiota, and metabolites, supporting its potential as an antibiotic replacement in pig production.
Review
Microbiology
Yumeng Wang, Shixi Xu, Qiurong He, Kun Sun, Xiaowan Wang, Xiaorui Zhang, Yuqing Li, Jumei Zeng
Summary: This study evaluates the connection between GI tract biofilms and chronic mucosa diseases such as chronic gastritis, inflammatory bowel disease, and colorectal cancer. The representative biofilm makers including Helicobacter pylori, adherent-invasive Escherichia coli, Bacteroides fragilis, and Fusobacterium nucleatum in each disease are summarized. The study discusses the role of biofilms in causing inflammation and the pro-carcinogenic stage, as well as the typical resistance, persistence, and recurrence mechanisms seen in vitro. Biofilms may serve as a new biomarker for endoscopic and pathologic detection of gastrointestinal disease and suppression, which may be a useful addition to the present therapy strategy.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Patricia I. Oteiza, Eleonora Cremonini, Cesar G. Fraga
Summary: Anthocyanins, abundant flavonoids in our diet, have been associated with various health benefits. Their actions in the gastrointestinal tract can explain their local and systemic effects on health.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Elisa Cotozzolo, Paola Cremonesi, Giulio Curone, Laura Menchetti, Federica Riva, Filippo Biscarini, Maria Laura Marongiu, Marta Castrica, Bianca Castiglioni, Dino Miraglia, Sebastiano Luridiana, Gabriele Brecchia
Summary: Each animal hosts a diverse community of microorganisms, with the microbiota in the gastrointestinal tract playing a crucial role in health and immune development. This study focused on the bacterial populations present in different regions of the rabbit's digestive system, revealing distinct microbiota profiles along the digestive tract. Understanding the physiological microbiota of rabbits is vital for promoting host health, welfare, and productive performance.
Article
Environmental Sciences
Sumita Sahoo, Satyabrata Dash, Biswajit Rath, Keshab C. C. Mondal, Arpita Mandal
Summary: The purpose of this research is to change the traditional mindset of Indian farmers and rural Indian economy by using feather to produce nitrogen-rich liquid fertilizer. The fermented feather hydrolysate, containing abundant amino acids and thiol, has a significant impact on the growth and yield of moong beans in pot and field trials.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Agricultural Engineering
Subhadeep Mondal, Subham Rakshit, Kalyanbrata Pal, Sourav Santra, Debabrata Goswami, Saswati Parua Mondal, Suman Kumar Halder, Keshab Chandra Mondal
Summary: The aim of this study was to isolate a highly beneficial probiotic bacterium capable of producing glutathione. The isolated strain, Bacillus amyloliquefaciens KMH10, exhibited antioxidative activity (77.7 ± 2.56) and several other essential probiotic attributes. A consortium of lignocellulolytic enzymes was used to saccharify banana peel, resulting in the production of 65.71 g/L sugar to support optimal glutathione production of 181 ± 4.56 mg/L, which was 1.6 times higher than the control. Therefore, this probiotic bacteria could serve as an effective resource for glutathione and be used as natural therapeutics for the prevention/treatment of inflammation-related gastric ailments, as well as an effective producer of glutathione using valorized banana waste that has excellent industrial relevance.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Seba Das, Arindam Dey, Shilpa Maji, Asim Sahoo, Ananya Barman, Sourav Santra, Subhadeep Mondal, Keshab Chandra Mondal, Sandip Chattopadhyay
Summary: This study aimed to investigate the defensive impact of ferulic acid against sodium fluoride-induced hepatorenal dysfunction at the biochemical and antioxidative systems. Ferulic acid remarkably defended against oxidative damage, reduced lipid peroxidation, and normalized the serum biomarkers. In-silico and in-vitro experiments further validated the protective effects of ferulic acid on the activity of antioxidant enzymes.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Neurosciences
Amina Khatun, Titli Panchali, Sukhamoy Gorai, Ananya Dutta, Tridip Kumar Das, Kuntal Ghosh, Shrabani Pradhan, Keshab Chandra Mondal, Sudipta Chakrabarti
Summary: This study assessed the effects of syringic acid (SA) on obesity, neuroprotection, and neurogenesis in mice fed a high-fat diet. The results showed that SA treatment reduced metabolic abnormalities, memory loss, and neurodegeneration associated with obesity.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Chemistry, Medicinal
Surendra Patra, Sukhamoy Gorai, Soumitra Pal, Kuntal Ghosh, Shrabani Pradhan, Sudipta Chakrabarti
Summary: Phytoestrogens are plant secondary metabolites that resemble mammalian estrogens and have various health benefits in humans. They interact with nuclear estrogen receptor isoforms ER alpha and ER beta, acting as estrogen agonists or antagonists. This review highlights the botanical sources, identification techniques, classification, clinical implications, and safety issues of phytoestrogens.
PHYTOTHERAPY RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Abhi Mallick, Abhiparna Roy, Soma Sarkar, Keshab Ch. Mondal, Surojit Das
Summary: The acute crisis of carbapenem resistance hinders the use of carbapenems in medical emergencies, especially bloodstream infections. A low-cost in-house molecular diagnostics assay was developed to rapidly detect carbapenemase-producing carbapenem-resistant organisms (CP-CROs) in positive blood-culture broths. The assay has been validated and meets the minimal requirements of the WHO for multiplex-PCR.
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Subham Rakshit, Kalyanbrata Pal, Subhadeep Mondal, Arijit Jana, Keshab Chandra Mondal, Suman Kumar Halder
Summary: This study focuses on the enzymatic extraction of chitosan from chitin, avoiding the adverse effects of chemical treatment and reducing environmental pollution. A bacterial strain, Alcaligens faecalis CS4, was identified as a potent chitin deacetylase (CDA) producer. After optimization, a CDA production of 40.69 U/mL was achieved. The resulting chitosan exhibited desirable properties, including high solubility, degree of deacetylation, crystallinity index, molecular weight, and decomposition temperature. It also demonstrated antioxidant potential, antimicrobial activity, mucoadhesiveness, and cholesterol binding properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Virology
Smita Ghosh, Priyanka Kar, Sudipta Chakrabarti, Shrabani Pradhan, Keshab Chandra Mondal, Kuntal Ghosh
Summary: In this study, the efficacy of bacteriophage AHPMCC7 against A. hydrophila was evaluated, and it was found to have broad adaptability and can be used as a biocontrol agent in shrimp aquaculture.
Article
Biotechnology & Applied Microbiology
Priyanka Kar, Smita Ghosh, Pijush Payra, Sudipta Chakrabarti, Shrabani Pradhan, Keshab Ch. Mondal, Kuntal Ghosh
Summary: The bacteriophage VPMCC14 was characterized for its lytic ability against Vibrio harveyi, the causative agent of luminous vibriosis diseases in shrimp. VPMCC14 showed strong lytic activity against V. harveyi in liquid culture and was able to control V. harveyi infection and reduce shrimp mortality in aquariums.
INTERNATIONAL MICROBIOLOGY
(2023)
Article
Biology
Papan K. Hor, Kuntal Ghosh, Suman Kumar Halder, Subhadeep Mondal, Keshab Chandra Mondal
Summary: This study explored the possibility of introducing beneficial microbes into rice-based fermented foods using a herbal starter, demonstrating that the newly formulated fermented food is rich in various nutrients and has antioxidant properties against free radicals.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biology
Saswati Parua Mondal, Kuntal Ghosh, Papan K. Hor, Saptadip Samanta, Keshab Chandra Mondal
Summary: Gahana bori is an ornamental dumpling made from blackgram beans, which not only enhances the appearance of food but also has potential health benefits. It is rich in vitamins and antioxidants, and exhibits notable antibacterial activity.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biology
Kalyanbrata Pal, Subham Rakshit, Subhadeep Mondal, Arijit Jana, Keshab Chandra Mondal, Suman Kumar Halder
Summary: Fungal biomass, as an organic waste, has great potential as a source of protein, carbohydrate and minerals. This study explores the utilization of waste fungal biomass through both fermentation and enzymatic degradation, resulting in the production of valuable metabolites. The physicochemical conditions of these processes were optimized using statistical methods, providing a sustainable and environmentally friendly approach for the production of microbial metabolites.
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
