Article
Biophysics
Yohko Gotoh, Toshimasa Yamazaki, Yasuyuki Ishizuka, Hirohiko Ise
Summary: Cytoskeletal proteins desmin and vimentin are expressed on the surface of muscle, mesenchymal and cancer cells with N-acetyl-beta-D-glucosamine residue-binding properties. Through chemical modification, glycoconjugates composed of silk fibroin and N-acetyl-D-glucosamine were prepared and assessed by H-1-NMR measurements, demonstrating potential for tissue engineering applications. This study shows that immobilization of monosaccharide GlcNAc is a useful method for functionalizing SF and enhancing cell interactions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Immunology
Kai Deng, Zhanxue Xu, Mingxiao Chen, Xiaoxiang Liu
Summary: The study found that peptides within HCV glycoproteins could serve as potent immunogens for vaccine design, inducing antibodies with strong neutralizing activity. The high diversity of HCV sequences poses a challenge in vaccine development, but targeting conserved peptides may be a promising approach for achieving protection against multiple HCV genotypes.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Mahdi Saghari, Pim Gal, Hendrika W. Grievink, Erica S. Klaassen, Andrea Itano, Duncan McHale, Matthijs Moerland
Summary: The study aimed to investigate the immunomodulatory effects of L. lactis spp. cremoris on the immune response to KLH, but found no significant impact on antibody responses. However, exposure to L. lactis spp. cremoris in minitablet formulation did impact ex vivo whole blood LPS cytokine response. Further investigations are needed to determine the clinical significance of these effects.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anil Kumar Yerragopu, Chitra Vellapandian
Summary: Most chemotherapeutic agents can induce antitumor immunity and modulate the tumor infiltrating lymphocytes, affecting the therapeutic responses and prognosis in cancer patients. Combination therapy of caffeine and doxorubicin can inhibit tumor growth and enhance immunogenic cell death. Therefore, combining caffeine with ICD inducing drugs like doxorubicin may be a potential strategy.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Oncology
Ines Bouhlel Chatti, Yosr Krichen, Mouna Maatouk, Aida Lahmar, Sonia Ghoul Mazgar, Rim Kammoun, Sihem Safta Skhiri, Leila Chekir Ghedira, Mounira Krifa
Summary: In this study, an enriched total oligomers flavonoids (TOF) extract of R. alaternus was found to exhibit anticancer activity in melanoma cells, reducing proliferation, tumor volume, and weight, while enhancing the level of TH1 cytokine IL-2. This extract also decreased the level of pro-inflammatory cytokine IL-6 and induced macrophage activation in the tumor microenvironment.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Oncology
Fernanda Fernandes Miranda da Cunha, Angela Pedroso Tonon, Fabricio Machado, Luis Rodolpho Travassos, Nathalia Grazzia, Joao Fernando Possatto, Agnes Kobayashi Calvo de Sant'ana, Rayssa de Mello Lopes, Tiago Rodrigues, Danilo Ciccone Miguel, Fernanda Ramos Gadelha, Denise Costa Arruda
Summary: Astaxanthin exhibits cytotoxic effect in melanoma cells and inhibits cell migration and invasion.
JOURNAL OF CHEMOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ping Fan, Congling Yang, Li Wang, Qiling Wang, Yan Zhang, Jie Zhou, Jie Weng, Bo Feng
Summary: Studies have shown that zinc oxide nanoparticles have significant cytotoxicity to melanoma cells by inducing oxidative stress and release of apoptosis factors. ZnO NPs in a concentration range of 20-35 μg ml(-1) can effectively inhibit the growth of melanoma cells, while having minimal impact on fibroblasts. Overall, ZnO NPs demonstrate strong antitumor effects both in vitro and in vivo.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2021)
Correction
Immunology
J. Richter, V. Benson, V. Grobarova, J. Svoboda, J. Vencovsky, R. Svobodova, A. Fiserova
CLINICAL IMMUNOLOGY
(2015)
Review
Biochemistry & Molecular Biology
Daniel Rozbesky, Ljubina Ivanova, Lucie Hernychova, Valeria Grobarova, Petr Novak, Jan Cerny
Article
Oncology
Karel Valis, Pavel Talacko, Valeria Grobarova, Jan Cerny, Petr Novak
EXPERIMENTAL CELL RESEARCH
(2016)
Article
Plant Sciences
Valeria Grobarova, Karel Valis, Pavel Talacko, Barbora Pavlu, Lucie Hernychova, Jana Novakova, Eva Stodulkova, Miroslav Flieger, Petr Novak, Jan Cerny
JOURNAL OF NATURAL PRODUCTS
(2016)
Article
Oncology
Karel Valis, Valeria Grobarova, Lucie Hernychova, Martina Buganova, Daniel Kavan, Martin Kalous, Jiri Cerny, Eva Stodulkova, Marek Kuzma, Miroslav Flieger, Jan Cerny, Petr Novak
Article
Immunology
J. Richter, V. Benson, V. Grobarova, J. Svoboda, J. Vencovsky, R. Svobodova, A. Fiserova
CLINICAL IMMUNOLOGY
(2010)
Article
Immunology
Valeria Grobarova, Veronika Benson, Daniel Rozbesky, Petr Novak, Jan Cerny
IMMUNOLOGY LETTERS
(2013)
Article
Immunology
Veronika Benson, Valika Grobarova, Jan Richter, Anna Fiserova
INTERNATIONAL IMMUNOLOGY
(2010)
Article
Immunology
Katarina Hulikova, Jan Svoboda, Veronika Benson, Valeria Grobarova, Anna Fiserova
INTERNATIONAL IMMUNOPHARMACOLOGY
(2011)
Review
Toxicology
Luca Vannucci, Renata Stepankova, Valeria Grobarova, Hana Kozakova, Pavel Rossmann, Klara Klimesova, Veronika Benson, Petr Sima, Anna Fiserova, Helena Tlaskalova-Hogenova
JOURNAL OF IMMUNOTOXICOLOGY
(2009)
Article
Chemistry, Multidisciplinary
Laura Moore, Valeria Grobarova, Helen Shen, Han Bin Man, Julia Micova, Miroslav Ledvina, Jan Stursa, Milos Nesladek, Anna Fiserova, Dean Ho