Article
Plant Sciences
Yuanyuan Li, Chao Tian, Yufei Wei, Haoqi Liu, Na An, Ke Song, Yikun Sun, Yonghong Gao, Ying Gao
Summary: This study explored the pharmacological mechanism of Naoxueshu oral liquid in the treatment of intracerebral hemorrhage (ICH). It was found that Naoxueshu oral liquid suppressed the inflammatory response and accelerated hematoma absorption, possibly through the regulation of Nrf2/CD163/HO-1 pathway. The study suggests that Naoxueshu oral liquid could be a potential drug for ICH treatment.
Article
Cell Biology
Andrew Higham, James M. Baker, Natalie Jackson, Rajesh Shah, Simon Lea, Dave Singh
Summary: This study found that pulmonary iron levels are increased in chronic obstructive pulmonary disease (COPD) patients, which may play an important role in the pathophysiology of COPD. The dysregulation of the CD163-haptoglobulin axis in COPD was examined, and it was found that soluble CD163 levels were lower in COPD patients compared to controls, with a significant correlation to forced expiratory volume in 1 s (FEV1)% predicted. The study also revealed a correlation between macrophage CD163 expression and haptoglobin levels, supporting the role of CD163 in the cellular uptake of haptoglobin.
Article
Biochemistry & Molecular Biology
Laura Matuschik, Vladimir Riabov, Christina Schmuttermaier, Tatyana Sevastyanova, Christel Weiss, Harald Klueter, Julia Kzhyshkowska
Summary: Hyperglycemia amplifies inflammatory response via interactions between Hb-Hp complexes and the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kasper Munch Lauridsen, Marianne Hokland, Sinan Al-Karradi, Holger Jon Moller, Frede Donskov, Morten Norgaard Andersen
Summary: The levels of monocyte mCD163 were reduced and the levels of serum sCD163 were increased in mRCC patients compared to healthy controls. A negative correlation between mCD163 and sCD163 levels was observed. Intermediate levels of monocyte mCD163 were associated with the longest overall survival, while both lower and higher levels of mCD163 were associated with worse outcomes. Higher levels of sCD163 at diagnosis were associated with poor overall survival.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Elisha Siwan, Stephen M. Twigg, Danqing Min
Summary: This review systematically examined the expression of CD163 in diabetes complications and found that soluble CD163 was upregulated, suggesting its potential utility as an inflammation biomarker. The variable expression of CD163 on cell surfaces and its mRNA across different diabetes complications warrants further investigation.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2022)
Article
Transplantation
Yuki Yokoe, Naotake Tsuboi, Takahiro Imaizumi, Akimitsu Kitagawa, Munetoshi Karasawa, Takaya Ozeki, Nobuhide Endo, Yuriko Sawa, Sawako Kato, Takayuki Katsuno, Shoichi Maruyama, Kunihiro Yamagata, Joichi Usui, Michio Nagata, Ken-Ei Sada, Hitoshi Sugiyama, Koichi Amano, Yoshihiro Arimura, Tatsuya Atsumi, Yukio Yuzawa, Hiroaki Dobashi, Yoshinari Takasaki, Masayoshi Harigai, Hitoshi Hasegawa, Hirofumi Makino, Seiichi Matsuo
Summary: The detection of leukocyte-derived CD11b and CD163 in urine may reflect renal inflammation in ANCA-GN, and CD11b at diagnosis can predict the recovery rate after the treatment of ANCA-GN.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medical Laboratory Technology
Anne J. Nielsen, Marlene C. Nielsen, Henrik Birn, Per Ivarsen, Holger J. Moller, Claus V. B. Hviid
Summary: The study validated the potential of urine sCD163 as a biomarker for GN and established a reference interval. Urine sCD163 was found to be generally increased in GN patients, decreased upon treatment, but did not outperform urine albumin. The commercial assay had a higher detection limit, resulting in lower patient levels compared to the in-house assay.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Yang Liu, Xingjie Wu, Shan Jiang
Summary: This study investigates the role and regulatory mechanism of miR-141-3p in the pathogenesis of recurrent spontaneous abortion (RSA), and finds that miR-141-3p promotes inflammation in the decidual tissue of RSA mice by inhibiting CD163 and inhibiting the polarization of M2 macrophages.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Guangwei Han, Haotian Yang, Huiling Xu, Suya Zheng, Yingxiang Li, Zehui Liu, Fang He
Summary: Novel antiviral peptides derived from pCD163 were developed, which showed inhibitory effects on PRRSV of different lineages and modulated the NF-kappa B pathway. These findings deepen the understanding of the interaction between PRRSV and pCD163 receptor, and provide alternative universal antiviral strategies against PRRSV.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Dermatology
Wael M. Seoudy, Sara M. Mohy El Dien, Talal A. Abdel Reheem, Mona M. Elfangary, Moatasem A. Erfan
Summary: This study suggests that M1 and M2 macrophages play important roles in the pathogenesis of keloid formation. Keloid formation might be a result of an abnormal response to tissue injury with excessive entry of inflammatory cells, including macrophages, into the wound, and the incidence of keloid might be related to a decrease in M1 and an increase in M2.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Endocrinology & Metabolism
Rocio Escartin, Maria Font, Jose Miguel Gonzalez-Clemente, Joan Vendrell, Assumpta Caixas, Raquel Corripio
Summary: This study found that TWEAK and CD163 levels were associated with obesity in prepubertal children. After a 2-year intervention program, successful weight loss in obese children was associated with increased levels of TWEAK and a decreased CD163/TWEAK ratio.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mustafa Yilmaz, Esra Demir, Mervi Gursoy, Erhan Firatli, Ulvi Kahraman Gursoy
Summary: The aim of this study was to examine the relationship between healing response after non-surgical periodontal treatment and baseline gingival tissue levels of M2 macrophage activation-related proteins CD163, interleukin (IL)-10, interferon (IFN)-gamma, and tumor necrosis factor-like weak inducer of apoptosis (TWEAK), and the CD163/TWEAK ratio. The study found that IL-10, CD163, and TWEAK levels were higher in periodontally healthy tissues than in periodontitis tissues. Pocket closure at 12 weeks was associated with elevated baseline gingival CD163 levels and CD163/TWEAK ratio.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhuofan Deng, Shengkun Zhang, Meiqi Sun, Haotian Yang, Ying Lu, Maopeng Wang, Weihuan Fang, Fushan Shi, Fang He
Summary: In this study, a phage display VHH library was constructed to select nanoantibodies against porcine CD163 receptor. Seven CD163-specific nanoantibodies were identified and showed strong affinity to CD163 receptor and excellent antiviral activity. The nanoantibodies mainly exerted antiviral functions by interfering with virus attachment stage and decreasing the transcription of CD163. The findings provide insights into the biofunction of CD163 in antiviral infection and the development of broad-spectrum strategies against PRRSV.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Immunology
Jiexiong Xie, Nick Vereecke, Sebastiaan Theuns, Dayoung Oh, Nathalie Vanderheijden, Ivan Trus, Jannes Sauer, Philip Vyt, Caroline Bonckaert, Christian Lalonde, Chantale Provost, Carl A. Gagnon, Hans Nauwynck
Summary: Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) exhibits a highly restricted cellular tropism, with different cell lines showing varying susceptibility to infection. PK15(Sn-CD163) and PK15(S10-CD163) cells are more suitable for virus isolation and propagation compared to MARC-145/MARC-145(Sn) cells due to their close resemblance to target macrophages in vivo. Further studies on PRRSV protein residues potentially related to cell tropism are warranted.
Article
Biology
Maki Kusunoki, Yukio Fujiwara, Yoshihiro Komohara, Yuko Imamura, Ritsuo Honda, Takashi Ohba, Hidetaka Katabuchi
Summary: Endometriosis is a chronic inflammatory disease characterized by the presence of endometriotic cysts containing hemoglobin and infiltrated macrophages. The study found that macrophages were the predominant immune cells in the cysts, with CD163-positive macrophages mainly localized in the hemorrhagic and outer areas of the cyst wall. High levels of IL-6 and CCL2 were detected in the cystic fluids, and inflammatory cytokines were secreted from macrophages when stimulated by Hb, suggesting a potential mechanism for the development and carcinogenesis of endometriosis.
MEDICAL MOLECULAR MORPHOLOGY
(2021)
Article
Allergy
Krzysztof Kowal, Agnieszka Pampuch, Ewa Sacharzewska, Ewa Swiebocka, Zenon Siergiejko, Grzegorz Siergiejko, Maksymilian Chruszcz, Lawrence DuBuske
ALLERGY AND ASTHMA PROCEEDINGS
(2020)
Article
Allergy
Andras Bikov, Ipek Kivilcim Oguzulgen, Ilaria Baiardini, Marco Contoli, Alexander Emelyanov, Omar Fassio, Juan Carlos Ivancevich, Igor Kaidashev, Krzysztof Kowal, Marina Labor, Lies Lahousse, Stefan Mihaicuta, Silviya Novakova, Alicia Padilla Galo, Alexander Simidchiev, Angelica Tiotiu, Ignacio J. Ansotegui, Jonathan A. Bernstein, Louis Philippe Boulet, Giorgio Walter Canonica, Lawrence Dubuske, Nelson Rosario, Pierachille Santus, Fulvio Braido
WORLD ALLERGY ORGANIZATION JOURNAL
(2020)
Article
Medicine, Research & Experimental
Krzysztof Kowal, Agnieszka Pampuch, Grzegorz Siergiejko, Zenon Siergiejko, Ewa Swiebocka, Caleb R. Schlachter, Maksymilian Chruszcz, Alain Jacquet
ADVANCES IN MEDICAL SCIENCES
(2020)
Article
Allergy
Pascal Demoly, Jonathan Corren, Peter Creticos, Frederic De Blay, Philippe Gevaert, Peter Hellings, Krzysztof Kowal, Martine Le Gall, Natalia Nenasheva, Giovanni Passalacqua, Oliver Pfaar, Miguel Tortajada-Girbes, Carmen Vidal, Margitta Worm, Thomas B. Casale
Summary: The study evaluated the efficacy and safety of a 300 index of reactivity sublingual tablet for allergic rhinitis induced by house dust mites, showing significant improvement in symptoms and good tolerability. This treatment is proven to be effective and safe for patients with moderate to severe allergic rhinitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Environmental Sciences
Angelica I. Tiotiu, Plamena Novakova, Denislava Nedeva, Herberto Jose Chong-Neto, Silviya Novakova, Paschalis Steiropoulos, Krzysztof Kowal
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Allergy
Angelica Tiotiu, Plamena Novakova, Ilaria Baiardini, Andras Bikov, Herberto Chong-Neto, Jaime Correia- De-Sousa, Alexander Emelyanov, Enrico Heffler, Guillermo Guidos Fogelbach, Krzysztof Kowal, Marina Labor, Stefan Mihaicuta, Denislava Nedeva, Sylvia Novakova, Paschalis Steiropoulos, Ignacio J. Ansotegui, Jonathan A. Bernstein, Louis-Philippe Boulet, Giorgio Walter Canonica, Lawrence Dubuske, Carlos Nunes, Juan Carlos Ivancevich, Pierachille Santus, Nelson Rosario, Tommaso Perazzo, Fulvio Braido
Summary: This article addresses the issue of upper and lower airways diseases, advocating for challenging assumptions, fostering commitment, and bringing about change. It emphasizes the impact of UAD on patient health status and medical needs.
Article
Biochemistry & Molecular Biology
Andrea O'Malley, Swanandi Pote, Ivana Giangrieco, Lisa Tuppo, Anna Gawlicka-Chruszcz, Krzysztof Kowal, Maria Antonietta Ciardiello, Maksymilian Chruszcz
Summary: The study found that allergens from the nsLTP family have structural similarities and may trigger cross-reactive reactions with other nsLTP family proteins. These allergens may affect the surface regions where immunoglobulin E binds by binding ligands.
Article
Medicine, General & Internal
Andrzej Sieskiewicz, Tomasz Lyson, Marek Rogowski, Marek Bielecki, Ewa Gindzienska-Sieskiewicz, Ewa Olszewska, Pawel Bielecki
Summary: The study aimed to assess the anatomical and functional patency of lacrimal ducts after medial maxillectomy without additional procedures, and compare results from different assessment tests, indicating that a small fraction of patients may experience tear drainage disorders.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Respiratory System
Angelica Tiotiu, Herberto Chong Neto, Andras Bikov, Krzysztof Kowal, Paschalis Steiropoulos, Marina Labor, Ivan Cherrez-Ojeda, Hector Badellino, Alexander Emelyanov, Rocio Garcia, Guillermo Guidos
Summary: The COVID-19 pandemic has had a significant impact on the management and outcomes of patients with chronic noninfectious respiratory illnesses. Most chronic respiratory diseases, apart from asthma and cystic fibrosis, are associated with more severe COVID-19 and poor outcomes. The therapeutic management of these patients is similar to others, but there may be worse post-recovery courses leading to pulmonary fibrosis, bronchiectasis, and pulmonary hypertension. The pandemic has also affected medical activities by limiting access to diagnosis procedures and requiring the development of new monitoring methods and therapeutic strategies. The long-term consequences of these changes remain unknown.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Review
Orthopedics
Jakub Szczesiul, Marek Bielecki
Summary: The study compared the outcomes of patients undergoing total hip arthroplasty (THA) for femoral neck fracture (FNF) and osteoarthritis (OA). The results indicated that FNF patients were more fragile and required additional care and attention, while the primary reason for the need for hip replacement surgery was osteoarthritis.
ADVANCES IN ORTHOPEDICS
(2021)
Article
Allergy
Fulvio Braido, Angelica Tiotiu, Guillermo Guidos-Fogelbach, Ilaria Baiardini, Filippo Cosini, Jaime Correia de Sousa, Andras Bikov, Sylvia Novakova, Marina Labor, Igor Kaidashev, Denislava Nedeva, Krzysztof Kowal, Stefan Mihaicuta, Marilyn Urrutia Pereira, Dirceu Sole, Plamela Novakova, Herberto Chong-Neto, Laura Vrzy, Ignacio J. Ansotegui, Jonathan A. Bernstein, Louis-Philippe Boulet, Giorgio Walter Canonica, Lawrence Dubuske, Carlos Nunes, Juan Carlos Ivancevich, Pierachille Santus, Nelson Rosario, Alexander Emelyanov, Paschalis Steiropoulos
Summary: The article discusses the significant results of optimal drug combination for asthma management and Interasma's position on inhaled triple therapy. Through extensive literature research, the authors advocate for further studies on the benefits of inhaled corticosteroid, long-acting beta 2 agonist, and long-acting muscarinic antagonist combinations.
Review
Allergy
Kriti Khatri, Andrea O'Malley, Christina Linn, Krzysztof Kowal, Maksymilian Chruszcz
Summary: A significant portion of allergens bind with small molecular ligands, many of which are lipids. However, the role of these ligands in allergic sensitization or effector phases is mostly unknown.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Article
Respiratory System
Angelica Tiotiu, Andras Bikov, Francisco-Javier Gonzalez-Barcala, Silviya Novakova, Plamena Novakova, Herberto Chong-Neto, Pierachille Santus, Ignacio Ansotegui, Juan Carlos Ivancevich, Krzysztof Kowal, Stefan Mihaicuta, Denislava Nedeva, Gorgio Walter Canonica, Jonathan A. Bernstein, Louis Philippe Boulet, Fulvio Braido
Summary: Currently, there are no universally accepted criteria to measure the response to biologics available as treatment for severe asthma. However, an international panel of experts established four consensus criteria for evaluating the response to biologics after 4 months of treatment. These criteria include reducing systemic corticosteroid dose by ≥50%, decreasing the number of asthma exacerbations requiring systemic corticosteroids by ≥50%, minimal or no side effects, and achieving asthma control according to validated questionnaires. Overall, this study highlights the importance of establishing standardized criteria for evaluating the response to biologics in severe asthma. Rating: 10/10.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Review
Respiratory System
Denislava Nedeva, Krzysztof Kowal, Stefan Mihaicuta, Guillermo Guidos Fogelbach, Paschalis Steiropoulos, Herberto Jose Chong-Neto, Angelica Tiotiu
Summary: This article reviews the role of TSLP, IL-33, IL-25, and HMGB1 in the pathogenesis of asthma, COPD, idiopathic pulmonary fibrosis, and cystic fibrosis. It also summarizes the current evidence on the efficacy of anti-alarmin therapies in chronic respiratory diseases.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Article
Ophthalmology
Pawel Bielecki, Ewa Gindzienska-Sieskiewicz, Joanna Reszec, Bartosz Piszczatowski, Marek Rogowski, Otylia Kowal-Bielecka, Krzysztof Kowal, Andrzej Sieskiewicz
Summary: The expression of LIGHT and its receptors, HVEM and LT beta R, in lacrimal sac biopsies was significantly correlated with the intensity of fibrosis and disease duration. Only LIGHT showed a significant relationship with fibrosis in multivariate analysis, suggesting a potential role in fibrosis and synechiae formation in the lacrimal sac.
OPHTHALMOLOGY AND THERAPY
(2021)
