期刊
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
卷 47, 期 1, 页码 69-74出版社
VIA MEDICA
DOI: 10.2478/v10042-009-0015-1
关键词
3-dimensional; cytokines; multiple myeloma; bone marrow stromal cells
资金
- Ministry of Science and Higher Education [2 P05A 095 28]
We examined cytokine production by bone marrow stromal cells (BMSCs) of patients with multiple myeloma (MM) in response to contact with myeloma RPMI8226 cells in standard 2-dimensional (2D) cultures and in 3-dimensional (3D) cultures on a gelatine sponge scaffold. It was detected that BMSCs in the 3D cultures produced more IL-11 and HGF and less IL-10 than in the 2D cultures. Moreover, RPMI8226 cells after contact with BMSCs in 3D cultures produced more sIL-6R than in the classic 2D cultures. We concluded that 3D cultures of BMSCs with myeloma cells offered a promising model for in vitro examination of interactions between myeloma cells and the bone marrow stroma and for examination of potent antimyeloma agents.
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