期刊
FITOTERAPIA
卷 92, 期 -, 页码 252-259出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.11.012
关键词
Eurotium sp.; Variecolortides; Caspase-3 inhibitor
资金
- Ministry of Science and Technology of China [2012ZX09301002-003]
- Natural Science Foundation of China [81373306, 81202441]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]
- program for New Century Excellent Talents in University [NCET-10-0120]
7-O-methylvariecolortide A (1), variecolortide B (2), and variecolortide C (3), the rare variecolortides existing in racemic manner, were isolated from an endolichenic fungal strain Eurotium sp. (No. 17-11-8-1). With the chiral HPLC technology, (-)-(S)-7-O-methylvariecolortide A (1a), (+)-(R)-7-O-methylvariecolortide A (1b), (-)-(S)-variecolortide B (2a), (+)-(R)-variecolortide B (2b), (-)-(S)-variecolortide C (3a), and (+)-(R)-variecolortide C (3b) were successfully separated and obtained. Their absolute configurations were firstly assigned by ECD experiment and ECD calculation. According to the relation of isolated compounds, a plausible biosynthetic pathway for variecolortides was proposed. In caspase-3 enzymatic assay, compounds 1-3 showed inhibitory activity, with IC50 values of 1.7, 0.8 and 15.7 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved.
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