Article
Chemistry, Medicinal
Y. G. Cheng, P. Li, J. L. Li, F. X. Guo, Z. Qi, J. Y. Tan, Y. Wang, X. P. Kong, Y. L. Wang
Summary: In this study, phenylpropanoids were isolated and purified from Aster tataricus L. f. using column chromatographies, preparative HPLC, and other separation techniques. The structures of 16 compounds, including 6 flavonoids, a coumarin, and 9 lignans, were identified using MS and NMR techniques. One flavonoid glycoside was found to be a new compound, and 2, 7-16 were isolated from A. tataricus for the first time.
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Chemistry, Applied
Ting Chen, Peng Yang, Hai-jun Chen, Bin Huang
Summary: A new biflavonoid compound was isolated from Aster tataricus, exhibiting moderate cytotoxicity against cancer cells and specifically inhibiting A549 cancer cell proliferation through non-apoptotic mechanisms.
NATURAL PRODUCT RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ke-Jie Li, Yang-Yang Liu, Dong Wang, Pei-Zheng Yan, De-Chao Lu, Dong-Sheng Zhao
Summary: This article summarizes the available information on Radix Asteris (RA) in ancient Chinese medicine books and modern research literature, including its botanical properties, traditional uses, chemical composition, pharmacological activity, toxicity, and quality control. Studies have shown that RA has various pharmacological activities and is considered to be a promising medicinal plant. However, there is a lack of research on its toxicity and the consistency of its components, indicating the need for further in-depth studies.
Article
Biochemistry & Molecular Biology
Xin Li, Yuan-Xiang Gong, Li Feng, Xin-Jia Wang, Jing-Wen Wang, An-Xin Zhang, Ning-Hua Tan, Zhe Wang
Summary: Five undescribed alpha-pyrone derivatives were isolated from the endophytic fungus Neurospora dictyophora WZ-497 and named neuropyrones A-E. The structures of these compounds were determined by spectroscopic analysis and computational calculations. Neuropyrones A-C showed potent inhibitory effects on tyrosinase, comparable to the positive control kojic acid. Molecular docking study revealed the interaction between compound 3 and specific residues in tyrosinase.
Article
Chemistry, Analytical
Dongyue Yang, Songrui Wang, Xuhua Huang, Wenjuan Ma, Zixiang Xue, Lulu Zhao, Huizi Ouyang, Jun He
Summary: A sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry method was developed and validated to investigate the pharmacokinetic properties of 15 compounds in raw and honey-processed Aster tataricus. The study found that the areas under the curve (AUCs) of shionone, ferulic acid, and protocatechuic acid in honey-processed Aster tataricus were significantly lower than those in raw Aster tataricus.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Medicine, Research & Experimental
Hao Wu, Yijun Chen, Beibei Huang, Yingting Yu, Shujun Zhao, Jie Liu, Zhixin Jia, Hongbin Xiao
Summary: The study demonstrated that ethanol extract of Aster tataricus (ATE) could significantly promote small intestinal transit, reduce fecal amount, increase fecal water content, and alleviate colonic pathological damage. In vitro experiments showed that ATE could attenuate constipation by antagonizing acetylcholine binding to muscarinic receptors, inhibiting calcium influx, and anti-inflammatory effects in a concentration-dependent manner.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Luis Apaza Ticona, Karla Slowing, Andreea Madalina Serban, Marcos Humanes Bastante, Maria J. Hernaiz
Summary: This study evaluated the wound healing, anti-inflammatory, and anti-melanogenic activities of the aqueous extract of Semialarium mexicanum. Three compounds were isolated and characterized, which showed significant activities in inhibiting inflammation, melanin production, and promoting wound healing.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Songrui Wang, Zixiang Xue, Xuhua Huang, Wenjuan Ma, Dongyue Yang, Lulu Zhao, Huizi Ouyang, Yanxu Chang, Jun He
Summary: The components of Aster tataricus can show chemical profile differences based on different processing methods, and metabolomics methods combined with chemometrics are an effective strategy for analyzing these differences.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Plant Sciences
Kaixuan Jia, Xiaoling Zhang, Yijiang Meng, Shuqi Liu, Xiaoqing Liu, Taixin Yang, Chunxiu Wen, Lingdi Liu, Shujun Ge
Summary: This study measured the total flavonoid content of Aster tataricus roots at different developmental stages and conducted an integrated analysis of transcriptome and metabolome. The results identified flavonoid compositions and key genes involved in flavonoid biosynthesis in A. tataricus roots, providing valuable information for understanding the mechanism of flavonoid biosynthesis.
JOURNAL OF PLANT RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Vijay Laxmi Trivedi, Ruchi Soni, Praveen Dhyani, Priyanka Sati, Silvia Tejada, Antoni Sureda, William N. Setzer, Ahmad Faizal Abdull Razis, Babagana Modu, Monica Butnariu, Javad Sharifi-Rad
Summary: With the development of highly effective plant-based medications, the use of phytomedicines against complex diseases like cancer is increasing. This review focuses on the traits, roles, and mechanisms of the pentacyclic triterpenes known as boswellic acids (BAs) and their semi-synthetic derivatives in treating certain cancers. The review also explores the sources of BAs, their conservation, and the potential of biotechnology in improving BA production.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Morteza Yazdani, Anita Barta, Robert Berkecz, Orinamhe Godwin Agbadua, Attila Vanyolos, Judit Hohmann
Summary: Investigation of the edible mushroom Pholiota populnea led to the discovery of new bioactive lanostane-type triterpenes, including eight triterpenes, with the undescribed natural products pholiols E-K and the known (+)-clavaric acid. The compound pholiol F showed strong anti-inflammatory activity.
Article
Multidisciplinary Sciences
Lijuan Lv, Xiangpei Wang, Hongmei Wu, Ke Zhong, Feng Xu
Summary: Aster tataricus (AT) and honey-fried Aster tataricus (HAT) have significant effects on relieving cough and reducing sputum, likely due to their volatile components with potential anti-inflammatory properties. This study compared the qualitative and quantitative analysis of AT and HAT and explored their anti-inflammatory mechanisms using network pharmacology. The results showed significant differences in volatile compositions between AT and HAT, but they shared similar anti-inflammatory mechanisms. HAT had unique active ingredients and targets, indicating its potential superiority in clinical anti-inflammatory effects.
Article
Immunology
Yonas Bekele, Jay A. Berzofsky, Francesca Chiodi
Summary: HIV-1-infected individuals exhibit suboptimal response to HBV vaccines and poor maintenance of protective immunity, necessitating interventions based on factors such as CD4+ T cell counts, B cell response, vaccine formulation, and timing of administration. The initial response to HBV vaccination is crucial for sustaining antibody responses in both infected and uninfected individuals, highlighting the importance of regular follow-up and booster doses to prevent HBV transmission in HIV-1 infected people.
Article
Gastroenterology & Hepatology
Armando A. Roca A. Suarez, Enkhtuul Batbold, Birke Bartosch, Naranjargal Dashdorj, Barbara Testoni, Fabien Zoulim
Summary: Hepatitis delta virus (HDV) is a satellite RNA virus that requires hepatitis B virus (HBV) for replication. Co-infection with HDV/HBV leads to faster disease progression compared to HBV mono-infection. Developing antiviral therapies targeting HDV is crucial. Evaluating promising HDV-specific drugs and combination therapies, as well as exploring anti-HBV drugs with potential effects against HDV, are key areas of research.
LIVER INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Mohamed O. Radwan, Howaida I. Abd-Alla, Azhaar T. Alsaggaf, Hatem El-Mezayen, Mohammed A. S. Abourehab, Mohamed E. El-Beeh, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita
Summary: In the past decade, gypsogenin has gained attention for its strong potential as an anti-cancer agent. Despite being discovered relatively late, gypsogenin has shown itself to be a competitive player among other pentacyclic triterpenes in terms of anti-proliferative activity. This article presents the crucial reactions of gypsogenin and explores its anti-cancer activity and potential for rational design. It provides new insights and possibilities for utilizing gypsogenin as a lead compound in cancer chemotherapy.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.