期刊
FITOTERAPIA
卷 93, 期 -, 页码 126-131出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.12.022
关键词
Chaetomium globosum; Chaetomiaceae; Cytochalasans; Chaetoglobosins; Cytotoxicity
资金
- Ministry of Science and Technology of China [2012ZX09301002-003]
- National Natural Science Foundation of China [81373306, 81202441]
- Guangdong Natural Science Funds for Distinguished Young Scholar [S2013050014287]
- program for New Century Excellent Talents in University from the Ministry of Education of China [NCET-10-0120]
Chaetoglobosin Y (1), was isolated from the endolichenic fungal strain Chaetomium globosum (No. 64-5-8-2), along with related six known cytochalasans, chaetoglobosin Fex (2), chaetoglobosin E (3), isochaetoglobosin D (4), chaetoglobosin G (5), cytoglobosin B (6), and cytoglobosin C (7). Their structures were determined by detailed spectroscopic analyses and comparison with those of the closely related compounds previously reported. The cytotoxicity to HCT-116 cell line of 2-7 was evaluated in vitro with doxorubicin as positive control. (C) 2014 Elsevier B.V. All rights reserved.
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