Article
Chemistry, Multidisciplinary
Ebru Erol, Muge Didem Orhan, Timucin Avsar, Atilla Akdemir, Emine Sukran Okudan, Gulbahar Ozge Alim Toraman, Gulacti Topcu
Summary: This study is the first chemical investigation of Caulerpa cylindracea Sonder in the Dardanelles, resulting in the isolation of four compounds. Two of these compounds showed significant inhibition against SARS-CoV-2 virus infection and higher cytotoxicity against breast cancer cells.
Article
Chemistry, Applied
Daichun Li, Xiaojian Liao, Shihai Xu, Bingxin Zhao
Summary: A new pair of alpha-tocopheroid isomers and several other compounds were isolated from green algae and their structures were determined. These compounds showed potential antibacterial activities, although none of them exhibited significant activity.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Tian-Yun Jin, Ping-Lin Li, Ci-Li Wang, Xu-Li Tang, Mei-Mei Cheng, Yuan Zong, Lian-Zhong Luo, Hui-Long Ou, Ke-Chun Liu, Guo-Qiang Li
Summary: The study isolated new racemic and dimeric indole alkaloids from a cultured sponge, with one of the compounds, (+)-spondomine, showing cytotoxicity against K562 cell line and stronger signaling inhibitory activity. All stereoisomers significantly promoted angiogenesis and exhibited moderate anti-inflammatory effects. Quantum chemical calculations and deuteration experiments were used to guide the synthesis of the target compounds.
CHINESE JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Rudy Kurniawan, Fahrul Nurkolis, Nurpudji Astuti Taslim, Dionysius Subali, Reggie Surya, William Ben Gunawan, Darmawan Alisaputra, Nelly Mayulu, Netty Salindeho, Bonglee Kim
Summary: This study aimed to investigate the carotenoid profile and biological activities of Caulerpa racemosa. The results showed that the detected carotenoids were mainly xanthophylls, including beta-carotene, lutein, astaxanthin, canthaxanthin, zeaxanthin, beta-cryptoxanthin, and fucoxanthin. The carotenoid extract of C. racemosa exhibited significant antidiabetic, anti-obesity, anti-oxidative, anti-inflammatory, and cytotoxic activities, making it a potential candidate for drug development or functional food.
Article
Chemistry, Medicinal
Ratih Pangestuti, Monjurul Haq, Puji Rahmadi, Byung-Soo Chun
Summary: The study demonstrates the potential of underexploited tropical green seaweed resources, such as Caulerpa racemosa and Ulva lactuca, as sources of antioxidants for nutraceutical and cosmeceutical products. Subcritical water extraction shows higher extraction yield and higher content of bioactive compounds compared to conventional hot water extraction, indicating its potential for producing high-quality seaweed hydrolysates.
Article
Chemistry, Medicinal
Sivagaami Palaniyappan, Arun Sridhar, Zulhisyam Abdul Kari, Guillermo Tellez-Isaias, Thirumurugan Ramasamy
Summary: The present study investigated the bioactive metabolites of green seaweed Caulerpa racemosa from the perspective of wider applications. The methanolic extract showed higher phenolic, tannin, and flavonoid content compared to other extracts. It also exhibited strong antioxidant activity. GC-MS analysis identified major compounds such as 3,7,11,15-Tetramethyl-2-hexadecen-1-ol, 3-hexadecene, and Phthalic acid. The seaweed showed promising antibacterial potential against aquatic pathogens. Further studies are needed to explore the novel bioproperties and applications of C. racemosa.
Article
Chemistry, Applied
Hui-Na Yao, Zhi-Tian Peng, Yun-Feng Zhang, Di-Fa Liu, Bing-Feng Huang, Peng-Fei Tu, Yun-Fang Zhao, Hui-Xia Huo, Jun Li
Summary: Two new isoquinoline alkaloids and fourteen known alkaloids were isolated from Corydalis racemosa, and their structures were elucidated by analyzing spectroscopic data and comparing with literature values. The inhibitory activity against AChE was evaluated, with several compounds showing potential as inhibitors.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Physical
V Jayakumar, S. Govindaradjane, M. Rajasimman
Summary: The sorption efficiency of marine green macro algae Caulerpa scalpelliformis for heavy metal zinc from aqueous and industrial wastewater was explored in this study. The characteristics of the sorbent prepared, optimum operating conditions, and equilibrium studies were investigated. Results showed that the sorption mechanism followed pseudo-second order kinetics, with the Langmuir isotherm model fitting the data well and showing a maximum uptake of 83.3 mg/g of zinc. Overall, the sorption of zinc on green biomass was found to be feasible, spontaneous, and endothermic.
SURFACES AND INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Ryuta Terada, Moe Takaesu, Iris Ann Borlongan, Gregory N. Nishihara
Summary: The cultivated Japanese green alga Caulerpa lentillifera showed strong adaptability to temperature, irradiance, and desiccation, with the optimal temperature being 30.7 degrees Celsius and the highest net photosynthetic rates and saturation irradiance occurring at 32 degrees Celsius.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Chemistry, Medicinal
Jei Ha Lee, Set Byul Lee, Heabin Kim, Jae Min Shin, Moongeun Yoon, Hye Suck An, Jong Won Han
Summary: Bryopsis plumosa lectin BPL2 exhibits high anticancer activity against lung cancer cells, while showing weak toxicity to non-cancerous cells. BPL2 also inhibits cancer cell invasion and migration, and induces downregulation of epithelial-to-mesenchymal transition-related genes. Combination therapy with gefitinib shows a synergistic effect.
Article
Biology
Pradtana Choosuwan, Jantana Praiboon, Korawinwich Boonpisuttinant, Anirut Klomjit, Narongrit Muangmai, Rapeeporn Ruangchuay, Anong Chirapart
Summary: This study evaluated the effects of ethanolic extracts from twelve seaweeds on tyrosinase inhibition and melanin synthesis. The results showed that the ethanolic extracts of Caulerpa racemosa, Ulva intestinalis, and Lobophora challengeriae had inhibitory effects on melanin production and intracellular tyrosinase levels. These seaweeds can be potential sources of natural tyrosinase inhibitors for therapeutic or cosmetic applications in the future.
Article
Biochemistry & Molecular Biology
Xiaoqi Jin, Jiangyang Chi, Yixuan Zhao, Rui Jiang, Jiangchun Wei, Nianguo Dong, Zhengxi Hu, Yonghui Zhang
Summary: This study isolated eleven new indoloquinazoline alkaloids, named aspergilloids A-K (1-11), from the fungus Aspergillus clavatonanicus, which was obtained from the gut of a centipede. The structures of these compounds were determined through spectroscopic analyses. The cardiomyocyte protective activity assay showed that compounds 1, 2, 5, 12-14, and 16 improved cold ischemic injury, and compounds 1, 5, and 14 prevented cold ischemia-induced Ser9 dephosphorylation of GSK3 beta. This study highlights the potential of indoloquinazoline alkaloids as cardiomyocyte protective agents for heart transplantation medicine.
BIOORGANIC CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Grace Sanger, Djuhria Wonggo, Nurmelita Taher, Verly Dotulong, Aurielle Annalicia Setiawan, Happy Kurnia Permatasari, Sidik Maulana, Fahrul Nurkolis, Apollinaire Tsopmo, Bonglee Kim
Summary: This study aimed to investigate the anticancer activity of C. racemosa extracts in breast cancer cells, identify compounds, and determine the mechanism. The results showed that C. racemosa extracts exhibited significant cytotoxicity against breast cancer cells and had antioxidant activity. LC-ESI-QTOF-MS analysis identified 21 compounds with potential anticancer activity against HER2 protein.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2023)
Article
Environmental Sciences
Hanaa H. Morsi, Sabha M. El-Sabbagh, Ahlam A. Mehesen, Ahmed D. Mohamed, Maha Al-Harbi, Amr Elkelish, Mostafa M. El-Sheekh, Abdullah A. Saber
Summary: Finding alternative antibacterial drugs is crucial due to bacterial resistance. Algae, such as Rhizoclonium hieroglyphicum, have bioactive constituents with antibacterial implications. In this study, extracts of R. hieroglyphicum were tested against pathogenic bacteria, showing potent antibacterial activity. The ethanolic extract exhibited the strongest effect, mainly due to the presence of fatty acids. R. hieroglyphicum could be a promising source for the development of antibacterial agents.
Article
Chemistry, Inorganic & Nuclear
Yang Liu, Jun Guo, Zhou Zhou, Qingke Wu, Xin Jin, Tao Wang
Summary: The formulation and characterization of novel cardiovascular supplements and drugs without any side effects are research priorities in both developed and developing countries. In this study, gold nanoparticles containing Silybum marianum were used to formulate a modern cardioprotective drug and evaluated in a mouse model of isoproterenol-induced myocardial ischemia. The gold nanoparticles exhibited antioxidant properties and reduced inflammation, leading to improved cardiac function and decreased mortality rates in the mice.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Modjtaba Ghorbani, Mardjan Hakimi-Nezhaad, Lihua Feng
MATCH-COMMUNICATIONS IN MATHEMATICAL AND IN COMPUTER CHEMISTRY
(2022)
Article
Plant Sciences
Yufan Wang, Yanling Hu, Fangyi Gong, Yarong Jin, Yingjie Xia, Yu He, Yun Jiang, Qiang Zhou, Jingshu He, Lihua Feng, Guoyue Chen, Youliang Zheng, Dengcai Liu, Lin Huang, Bihua Wu
Summary: Stripe rust, caused by Puccinia striiformis f. sp. tritici, is a damaging disease of wheat globally, and breeding resistant cultivars is the best control strategy. This study aimed to identify and map quantitative trait loci (QTL) for resistance to stripe rust in a population of 154 recombinant inbred lines (RILs) derived from a cross between cultivars Taichang29 (TC29) and Shumai126 (SM126). Six QTL were mapped on chromosomes 1BL, 2AS, 2AL, 6AS, 6BS, and 7BL, respectively, with QYr.sicau-1BL and QYr.sicau-2AS having major effects.
Article
Computer Science, Theory & Methods
Qinglin Wang, Yingzhi Tian, Lihua Feng
Summary: In this paper, the relationship between the connectivity of hypergraphs and the number of edges is studied. By conjecture and proof, an upper bound for the hypergraphs is obtained, which is related to the vertex connectivity and the number of edges.
JOURNAL OF INTERCONNECTION NETWORKS
(2022)
Article
Engineering, Environmental
Yong Liao, Lei Jiang, Xuekang Cao, Hao Zheng, Lihua Feng, Qian Zhang, Qiushi Shen, Fangying Ji
Summary: In this study, a biochar regeneration tidal flow constructed wetland (BR-TFCW) was constructed and its performance in removing pollutants, microbial community characteristics, pollutant removal mechanisms, and biochar in-situ regeneration mechanisms were explored. The results showed that the BR-TFCW had a high removal rate of chemical oxygen demand (COD) and the biochar could maintain its adsorption capacity through the cycle of adsorption and biological regeneration.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Plant Sciences
Wenyang Wang, Wenjun Ji, Lihua Feng, Shunzong Ning, Zhongwei Yuan, Ming Hao, Lianquan Zhang, Zehong Yan, Bihua Wu, Dengcai Liu, Lin Huang
Summary: In this study, 35 novel low molecular weight glutenin subunit (LMW-GS) genes were obtained from Aegilops umbellulata using allelic-specific PCR. These LMW-GS genes shared the same primary structure as other known LMW-GSs. One specific gene had more cysteine residues than others, which could have positive effects on dough properties. Extensive variations were found among the LMW-GS genes in Ae. umbellulata, mainly resulting from single-nucleotide polymorphisms (SNPs) and insertions and deletions (InDels). This study highlights the potential value of the novel LMW-GS alleles from Ae. umbellulata for improving wheat quality.
PLANT GENETIC RESOURCES-CHARACTERIZATION AND UTILIZATION
(2022)
Article
Pharmacology & Pharmacy
Yubiao Lin, Kaida Huang, Zhezhen Cai, Yide Chen, Lihua Feng, Yingqin Gao, Wenhui Zheng, Xin Fan, Guoqin Qiu, Jianmin Zhuang, Shuitu Feng
Summary: This study provides assistance for personalized therapy for gastric cancer through exosome-based classification. The results show that exosome-relevant phenotype B has a poorer prognosis, an inflamed tumor microenvironment, and higher responses to the anti-CTLA4 inhibitor. The exosome-based gene signature can independently and accurately predict gastric cancer prognosis, which is linked to stromal activation and immunosuppression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mathematics, Applied
Lihua Feng, Weijun Liu, Lu Lu, Wei Wang, Guihai Yu
Summary: This paper investigates the maximum and minimum access times in the set of trees T(s,t), and obtains sharp upper and lower bounds, as well as corresponding extremal graphs. Additionally, it is proven that the path Pn and the star K-1,K-n-1 have the maximum and minimum average access times, respectively, among all trees.
APPLIED MATHEMATICS AND COMPUTATION
(2022)
Article
Mathematics
Zhouyang Chen, Lihua Feng, Weijun Liu, Lu Lu
Summary: In this paper, the authors investigate the spectral radius of the signless p-Laplacian matrix of a graph and obtain the graphs that maximize this spectral radius under specific conditions.
LINEAR & MULTILINEAR ALGEBRA
(2023)
Article
Mathematics
Zhouyang Chen, Lihua Feng, Wei Jin, Lu Lu
Summary: This paper investigates the spectral radius of the signless p-Laplacian of a graph, which extends the quadratic form of the signless Laplacian matrix for p = 2. It considers a non-increasing sequence of positive integers pi and the set of graphs with degree sequence pi, denoted as G(pi). The paper provides transformations for graphs in G(pi) that maintain or increase the largest eigenvalue of the signless p-Laplacian. It also identifies the graph in G(pi) that maximizes the signless p-Laplacian spectral radius under certain conditions.
BULLETIN OF THE MALAYSIAN MATHEMATICAL SCIENCES SOCIETY
(2023)
Article
Environmental Sciences
Yong Liao, Zhigang Wan, Xuekang Cao, Lei Jiang, Lihua Feng, Hao Zheng, Fangying Ji
Summary: This paper investigated the effects of the rest phase of tidal flow constructed wetlands (TFCW) on pollutant removal and microbial communities, and analyzed the mechanism of TFCW in removing pollutants from grey water. The results showed that enhancing the rest phase of TFCW led to better aerobic removal of organic matter in the microbial community, while limiting the rest phase had the opposite effect. The microbial community in TFCW did not have the ability to nitrify, but it was able to remove phosphorus.
Article
Mathematics
Xinru Yan, Xiaocong He, Lihua Feng, Weijun Liu
Summary: This paper investigates graphs G that do not contain the 2-power of a Hamilton cycle and identifies certain graphs that satisfy specific conditions. Using these results, we establish a spectral condition for graphs containing a specific Hamilton cycle. This is of great importance in graph theory research.
DISCRETE MATHEMATICS
(2023)
Article
Microbiology
Xuhui Huang, Xueli Jin, Xiaojie Ren, Wenxuan Wu, Wenjun Ji, Lihua Feng, Bo Jiang, Ming Hao, Shunzong Ning, Zhongwei Yuan, Lianquan Zhang, Bihua Wu, Dengcai Liu, Zhen-Zhen Wei, Lin Huang
Summary: In this study, three novel haplotypes (HapI-HapIII) of the Pm60 locus were discovered. HapI and HapII were found in domesticated tetraploid wheats, while HapIII was identified in wild tetraploid wheat T. araraticum. HapII was more closely related to the functional haplotype MlIW172 and showed partial resistance to Bgt#GH, while HapI was susceptible.
Article
Green & Sustainable Science & Technology
Hao Zheng, Yong Liao, HongXiang Chai, Liuwei Zhao, Xuekang Cao, Lihua Feng, Fangying Ji
Summary: A falling water enhanced tidal flow constructed wetlands (F-TFCW) was constructed to solve the problems of insufficient oxygen supply and low pollutant removal efficiency in traditional constructed wetlands (CW). The effects of falling water reoxygenation, tidal operation, and flood rest ratio (F/R) on the pollutant removal performance of F-TFCW were examined. The results showed that F-TFCW exhibited high removal rates for COD, NH4+-N, and TP, and the microbial analysis revealed the pollutant removal mechanism of F-TFCW.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Mathematics, Applied
Jing Yang, Yongjiang Wu, Lihua Feng, Weijun Liu
Summary: In this paper, the closed-form formulae for the hitting time, resistance distance and Kirchhoff index of Cayley graphs over dicyclic and semi-dihedral groups are derived using eigenvalues and eigenvectors.
APPLIED MATHEMATICS AND COMPUTATION
(2023)
Article
Mathematics
Xiaocong He, Lihua Feng, Dragan Stevanovic
Summary: The (k+1)-core of a graph G is obtained by repeatedly removing any vertex of degree less than or equal to k. Ck+1(G) is the unique induced subgraph of minimum degree larger than k with a maximum number of vertices. In this paper, we prove that Rn,k,m obtains the maximum spectral radius and signless Laplacian spectral radius among all n-vertex graphs whose (k+1)-core has at most m vertices. Our result extends a recent theorem proved by Nikiforov in 2014 and we also present the bipartite version of our result.
ELECTRONIC JOURNAL OF LINEAR ALGEBRA
(2023)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
