期刊
FITOTERAPIA
卷 85, 期 -, 页码 114-118出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.01.010
关键词
Pestaloficiol; Cytotoxic activity; Endophytic fungus; Structure elucidation
资金
- Key Program of National Hi-Tech Research and Development [2012AA021703]
- National Natural Science Foundation of China [21002120]
- Chinese Academy of Sciences [KSCX2-EW-G-6]
- Ministry of Science and Technology of China [2010ZX09401-403, 2012ZX09301-002-003]
- Youth Innovation Promotion Association of Chinese Academy of Sciences
Two new isoprenylated chromone derivatives, pestaloficiols Q (1) and R (2), and one new benzofuran derivative, pestaloficiol S (3), along with three known metabolites, anofinic acid (4), siccayne (5), and pyrenophorol (6) were isolated from solid cultures of the plant endophytic fungus Pestalotiopsis fici. Their structures were elucidated primarily by NMR spectroscopy, and the absolute of the C-6 secondary alcohol in 1 was deduced on the basis of circular dichroism (CD) data. Compound 5 showed cytotoxic activity against the human cancer cell lines, HeLa and HT29, with IC50 values of 48.2 and 33.9 mu M, respectively. (C) 2013 Elsevier B.V. All rights reserved.
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