Article
Biochemistry & Molecular Biology
Jie Dong, Mi Zhou, Da-bo Pan, Qian-yu Qin, Ting Li, Xin-sheng Yao, Hai-bo Li, Yang Yu
Summary: In this study, 38 sesquiterpenoids were isolated from the fruits of Alpinia oxyphylla, including six previously undescribed compounds and six new compounds. These compounds exhibited moderate to strong anti-inflammatory activity and could regulate the expression and phosphorylation of related proteins. These findings are of great significance for further development and utilization of A. oxyphylla.
Article
Biochemistry & Molecular Biology
Jie Dong, Mi Zhou, Qianyu Qin, Ting Li, Xinsheng Yao, Jianliang Geng, Yang Yu
Summary: The fruits of Alpinia oxyphylla were found to contain 40 structurally diverse sesquiterpenoids, including 17 new eudesmane sesquiterpenoids and 23 known analogues. Some of these compounds were unusual rearranged eudesmane sesquiterpenoids with rare carbon skeletons. The structures of these compounds were elucidated through comprehensive spectroscopic data analysis and calculations. Furthermore, some of these compounds showed anti-inflammatory activity by inhibiting nitric oxide production and reducing the secretion of TNF-alpha and IL-6.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Chengxing Qiu, Liping Mu, Ji Wang, Ran Tang, Bo Hou, Weiyan Hu, Rongping Zhang, Xinglong Chen
Summary: The purpose of this study was to identify sesquiterpenoids from Alpinia oxyphylla Miq. fruits using LC-MS and evaluate their neuroprotective effects on H2O2-induced SH-SY5Y cells. A total of 35 sesquiterpenoids, including 10 previously unreported ones, were isolated from A. oxyphylla fruits. The results showed that certain compounds demonstrated neuroprotective effects by improving cell viability and reducing oxidative stress markers.
Article
Chemistry, Applied
Weirong Bai, Tuanjie Wang, Xiaoming Yang, Zhenzhong Wang, Haibo Li, Jianliang Geng
Summary: Two undescribed sesquiterpenoids, including one nor-eudesmane type (1) and one guaiane type (2), were isolated and identified from the fruits of Alpinia oxyphylla. Their structures were determined by extensive spectroscopic analyses and NMR calculations. The anti-inflammatory activities of these compounds were evaluated by measuring their inhibitory effects on PGE(2) production in LPS stimulated macrophages.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Xiaomin Deng, Ziling Ye, Jingyu Duan, Fangfang Chen, Yao Zhi, Man Huang, Minjian Huang, Weijia Cheng, Yujie Dou, Zhaolin Kuang, Yanglei Huang, Guangkai Bian, Zixin Deng, Tiangang Liu, Li Lu
Summary: The complete biosynthetic pathway of (+)-nootkatone in Alpinia oxyphylla has been identified and successfully reconstructed in Saccharomyces cerevisiae. This study has important implications for understanding the molecular mechanism of (+)-nootkatone formation in plants and for bioengineering production. The highly efficient yeast chassis screening method can also be used to elucidate the biosynthetic pathways of other valuable plant natural products in the future.
Article
Geriatrics & Gerontology
Peng Zeng, Yuan-Cheng Liu, Xiao-Ming Wang, Chao-Yuan Ye, Yi-Wen Sun, Hong-Fei Su, Shuo-Wen Qiu, Ya-Nan Li, Yao Wang, Yan-Chun Wang, Jun Ma, Man Li, Qing Tian
Summary: The dried and ripe fruits of Alpinia oxyphylla have been widely used in treating dementia. This study investigated the targets of Alpinia oxyphylla in tonifying kidney-essence and nourishing intelligence and identified key phytochemicals that regulate the pathogenesis of neurodegenerative dementia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Plant Sciences
Chunlian Li, Xiaobin Lin, Qiuyang Cai, Weicheng Zhang, Xianyi Wu, Zekai Tan, Lewen Yao, Shiyuan Huang, Yanghe Yuan, Lanyue Zhang
Summary: The essential oil of Alpinia oxyphylla has antioxidant and antibacterial activities, as well as anti-inflammatory effects on TPA-induced ear edema. Its potential distribution in China includes over 12 provinces, with the most extensive in Hainan province.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2022)
Article
Plant Sciences
Kun Pan, Shuiping Dai, Jianping Tian, Junqing Zhang, Jiaqi Liu, Ming Li, Shanshan Li, Shengkui Zhang, Bingmiao Gao
Summary: This study investigated the formation mechanism of high-quality Alpinia oxyphylla using a multi-omics approach. The results showed a high-quality chromosome-level genome assembly with abundant genes and a significant genome duplication event. Moreover, the chemical composition of A. oxyphylla varied significantly among different provinces, with a distinct difference in nootkatone content in Hainan. These findings provide valuable insights into germplasm conservation, geo-herbalism evaluation, and functional genomic research for A. oxyphylla.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Can Cui, Sheng-Li Wu, Ji-Jun Chen, Pianchou Gongpan, Min Guan, Chang-An Geng
Summary: In this study, multiple sesquiterpenoids with diverse activities were isolated from the fruits of Alpinia oxyphylla. The compounds exhibited significant GLP-1 stimulation and inhibitory activity against alpha-glucosidase and PTP1B. The GLP-1 stimulative effects of compounds 6 and 13 were closely related to Ca2+/CaMKII and PKA pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Kun Pan, Xiaodan Yu, Shujuan Wang, Jie Hou, Yuchao Luo, Bingmiao Gao
Summary: The study investigated the changes in metabolites and transcription levels during fruit development of Alpinia oxyphylla and found that different metabolic pathways and key components were enriched at different developmental stages.
JOURNAL OF PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Se Yeong Jeon, Su Hyun Yu, Bo Su Lee, Hyun Jin Kim, Chang Geon Kim, Eun-Ju Jang, Jeong Jun Lee, Dong-Seon Kim, Mi Ran Kim
Summary: Alpinia oxyphylla ethanol extract showed chondroprotective effect by inhibiting collagen degradation through regulating matrix metalloproteinases, tissue inhibitor of metalloproteinase, and inflammatory mediators.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Seo Woo Shin, Young Sun Hwang
Summary: Oral microbes are closely related to oral and systemic diseases. This study investigates the effect of Alpinia Katsumadai seed extract on dental plaque bacteria-induced inflammation and bone resorption. It is found that the extract suppresses bacterial growth, reduces inflammation and inhibits bone resorption.
Article
Biotechnology & Applied Microbiology
Yoon-Young Sung, Dong-Seon Kim
Summary: This study discovered that the combined use of Alpinia oxyphylla seed extract (AE) and allopurinol can effectively decrease urate concentrations and improve kidney function in rats with hyperuricemia. This finding suggests potential clinical efficacy in treating hyperuricemia.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Punam Thapa, Yoo Jin Lee, Tiep Tien Nguyen, Donglan Piao, Hwaryeong Lee, Sujin Han, Yeon Jin Lee, Ah-Reum Han, Hyukjae Choi, Jee-Heon Jeong, Joo-Won Nam, Eun Kyoung Seo
Summary: Alpinia oxyphylla contains compounds that show protective effects against oxidative stress-induced damage in stem cells, with compounds 11 and 12 being particularly effective in improving cell viability.
Article
Plant Sciences
Yung-Ming Chang, Marthandam Asokan Shibu, Chih-Sheng Chen, Shanmugam Tamilselvi, Chuan-Te Tsai, Chin-Chuan Tsai, Kannan Ashok Kumar, Hung-Jen Lin, B. Mahalakshmi, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study investigated the effect of the anti-aging herbal medicine AoF on enhancing the cardiac restorative function of adipose-derived mesenchymal stem cells (ADMSCs) in aging conditions, and found that AoF has potential therapeutic properties in improving heart function in aging individuals.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xuguang Zhang, Zhenrui Xie, Xun Chen, Junqiang Qiu, Yinfeng Tan, Xiaoliang Li, Hailong Li, Junqing Zhang
Summary: Alpinia officinarum alters the pharmacokinetic parameters of indomethacin, reducing its systemic exposure and increasing elimination. Co-administration of A. officinarum does not reduce indomethacin accumulation in target tissues, but accelerates excretion of indomethacin and its metabolites. This suggests that A. officinarum may have a gastrointestinal protective effect through interactions with indomethacin in rats.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Review
Pharmacology & Pharmacy
Chunqi Pan, Mengyun Zhou, Ying Jian, Yuanyuan Zeng, Mingwei Wang, Feng Chen
Summary: CA125 is not only a significant tumor marker in ovarian cancer, but also shows potential as a surrogate for heart failure. In patients with heart failure, CA125 levels can reflect disease severity and help predict prognosis. Continuous monitoring of CA125 combined with other biomarkers can provide more accurate prognostic value.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Pediatrics
Ze-Yue Xu, Hong-Li Guo, Ling Li, Min Zhang, Xia Jing, Ze-Jun Xu, Jin-Chun Qiu, Xiao-Peng Lu, Xuan-Sheng Ding, Feng Chen, Jing Xu
Summary: This study evaluated the factors contributing to plasma trough concentration-to-dose ratio of valproic acid in pediatric patients with epilepsy. The study found that dosage forms significantly affected the ratio, while genetic variants did not show significant association. The results suggest cautious consideration when switching between solution and sustained-release tablet forms of the medication.
FRONTIERS IN PEDIATRICS
(2021)
Review
Pharmacology & Pharmacy
Hong-Li Guo, Ling Li, Ze-Yue Xu, Xia Jing, Ying Xia, Jin-Chun Qiu, Xing Ji, Feng Chen, Jing Xu, Fei Zhao
Summary: Steroid-resistant nephrotic syndrome is a common cause of chronic kidney disease in children, with complex etiology and lack of standardized treatment. Recent genomic research has shed light on the molecular mechanisms and genetic polymorphisms of the disease, aiming to improve the management of children with this syndrome.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Chemistry, Organic
Xue Cui, Xueying Zhang, Wei Wang, Xia Zhong, Yinfeng Tan, Yan Wang, Jianlan Zhang, Youbin Li, Xuesong Wang
Summary: A methodology has been developed for the synthesis of diverse carbonyl-substituted 1,2,3-triazoles via C-C bond cleavage, featuring excellent regioselectivity, wide functional group tolerance, and mild conditions. The key steps involve Regitz diazo transfer and C-C bond cleavage.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Shuang-Qing Zhang, Feng Chen
CURRENT DRUG METABOLISM
(2021)
Article
Multidisciplinary Sciences
Rangru Liu, Hailong Li, Na Wei, Yinfeng Tan
Summary: This study established a UFLC-MS/MS analytical method to simultaneously determine the concentrations of two glucuronidated metabolites of galangin in rat plasma, and successfully applied it to evaluate in vivo metabolism.
Article
Biochemical Research Methods
Zhen-miao Qin, Yong-hui Li, Yin-feng Tan, Hai-long Li
Summary: This study developed a rapid, sensitive, and specific LC-tandem mass spectrometry method for the determination of nootkatone in rat plasma. The method was successfully applied to pharmacokinetic study, showing low bioavailability of nootkatone. The method demonstrated acceptable precision and accuracy values in quantification.
BIOMEDICAL CHROMATOGRAPHY
(2021)
Article
Chemistry, Organic
Jianting Ma, Xue Cui, Junyu Xu, Yinfeng Tan, Yan Wang, Xuesong Wang, Youbin Li
Summary: A one-pot strategy using ynamides as coupling reagents has been developed for the formation of alpha-keto amide bonds under extremely mild reaction conditions. Diversely structural alpha-ketoamides were obtained in up to 98% yield for 36 examples. This reaction offers practical coupling procedure, wide functional group tolerance, and extremely mild conditions, with potential applications in synthetic and medicinal chemistry.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Hua Wang, Yinfeng Tan, Hao Jia, Danqi Liu, Rangru Liu
Summary: In this study, it was found that Posaconazole (POS) has potential antitumor activity against glioblastoma (GBM) and its molecular mechanisms were elucidated. POS can weaken the stemness of CSCs and promote autophagy induction. It was also revealed that POS targets survivin and suppresses the Wnt/β-catenin signaling pathway in GBM. This study provides an experimental foundation for the development of POS as a CSCs-targeting antitumor drug for GBM treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Organic
Jianting Ma, Yinfeng Tan, Yao Tang, Xue Cui, Junyu Xu, Youbin Li, Xuesong Wang
Summary: An efficient base-promoted approach for the synthesis of pyrido[1,2-a]pyrimidinones from ynones and 2-methylpyrimidin-4-ols has been developed. The reaction exhibited practical tandem procedure, wide functional group tolerance, and metal-free conditions, making it potentially applicable in synthetic and medicinal chemistry.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemical Research Methods
Zhenmiao Qin, Geng Lv, Tong Wang, Hailong Li, Beicheng Zhao, Meili Chen, Hou Gang, Yinfeng Tan, Huanhuan Jia
Summary: A sensitive and reliable LC-MS/MS method was developed and validated to measure the concentration of celecoxib in cynomolgus monkey serum. The pharmacokinetic process after administration of different forms of celecoxib was investigated. The results showed that the preparation of nanoparticles and modification of hyaluronic acid improved the bioavailability and circulation of celecoxib in vivo.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Correction
Plant Sciences
Zhang Yong, Wang Ruiqi, Yang Yanan, Ma Ning, Zhou Zhi, Tan Yinfeng, Dong Lin, Li Yiying, Lu Weiying, Wu Chongming, Xiaopo Zhang
Article
Integrative & Complementary Medicine
Han Xu, Sicong Xu, Liyan Li, Yuhuang Wu, Shiying Mai, Yiqiang Xie, Yinfeng Tan, Ailing Li, Fengming Xue, Xiaoning He, Yonghui Li
Summary: This study integrated metabolomics, network pharmacology, and biological verification to investigate the potential mechanism of Nauclea officinalis Pierre ex Pitard (DM) in treating acute lung injury (ALI). The results showed that DM improved the lung histopathological characteristics and inflammatory response in LPS-induced ALI by regulating inflammatory response and cell apoptosis, potentially through the PI3K/Akt pathway. This integrated analysis provides new strategies and ideas for the study of traditional Chinese medicines in the treatment of ALI.
Article
Plant Sciences
Yanan Yang, Wenquan Su, Chenchen Zang, Yinfeng Tan, Yong Zhang, Zhi Zhou, Weiying Lu, Shengxian Wu, Xiaopo Zhang, Chongming Wu
Summary: This study evaluated the co-regulatory effects of different traditional Chinese medicines (TCMs) on gut microbiota when combined with Coptis chinensis (HL) and assessed the relationship between gut microbiota and the meridians of TCMs. The results showed that HL significantly disrupted the gut microbiota, but specific meridian-related TCMs gradually restored the gut microbial community to normal. These TCMs not only reduced the toxicity of HL when co-administered, but also preserved its beneficial effects on certain beneficial bacteria.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.