期刊
FITOTERAPIA
卷 89, 期 -, 页码 15-19出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2013.05.013
关键词
Rehmannia glutinosa; Scrophulariaceae; Ursane-type triterpenes; Cytotoxic activity
资金
- Key Projects in the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period [2011BAI06B02]
Three new ursane-type triterpenes, glutinosalactone A-C (1-3), were isolated from the 50% aqueous acetone extract of the leaves of Rehmannia glutinosa. Their structures were elucidated on the basis of spectral analysis (IR, NMR and MS spectroscopy). The cytotoxic effects of compounds 1-3 against three human cancer cell lines (MCF-7, MG63 and HepG2) were also evaluated. Compound 3 showed cytotoxic activities with IC50 values of 8.35-39.25 mu M. (c) 2013 The Authors. Published by Elsevier B.V. All rights reserved.
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