Article
Chemistry, Multidisciplinary
Xiaolin Zhang, Xiuli Liu, Luhui Qin, Chao Tang, Yu Huo, Jinbin Wei, Ming Chen, Yutong Gao, Xiaoping Zhang, Yani Wu, Yongxiang Zhao, Renbin Huang, Liping Zhong, Bing Wang
Summary: Liposomes are widely used for drug delivery in tumor treatment due to their ability to enhance anti-tumor efficacy and reduce side effects. This study evaluated the tumor-targeted liposomes HA/TN-DLP for delivering the drug DMDD. HA/TN-DLP showed high stability and controllable drug loading, and exhibited superior cell uptake behavior and inhibition of breast cancer compared to free DMDD. The significantly enhanced anti-tumor effect demonstrated the potential of HA/TN-DLP as a promising tumor-targeting agent.
CHINESE CHEMICAL LETTERS
(2023)
Article
Horticulture
Yulin Hu, Dequan Sun, Huigang Hu, Xuedong Zuo, Tong Xia, Jianghui Xie
Summary: Artificially induced polyploid crops generally exhibit improved agronomic characteristics, such as increased vigor and larger fruit size. However, polyploid plants may show reduced flower numbers and abnormal pollen structures in some cases.
SCIENTIA HORTICULTURAE
(2021)
Article
Horticulture
Ingrid A. de Moraes, Luis J. P. Cruz-Tirado, Douglas Fernandes Barbin
Summary: This study utilized a portable NIR spectrometer combined with chemometrics to assess the physicochemical properties and classify the maturity stage of carambola. Through analysis and modeling of the samples, accurate results were obtained.
SCIENTIA HORTICULTURAE
(2022)
Review
Pharmacology & Pharmacy
Fei Luan, Lixia Peng, Ziqin Lei, Xiyu Jia, Junbo Zou, Yan Yang, Xirui He, Nan Zeng
Summary: Averrhoa carambola L. is a widely cultivated edible fruit in southern China, Southeast Asia, India, and northern South America. It has been traditionally used in Chinese medicine for treating various diseases, especially diabetes. Research has shown that compounds in A. carambola possess bioactivities such as anti-oxidant and anti-inflammatory properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Sultan A. M. Saghir, Mahfoudh A. M. Abdulghani, Reem S. Alruhaimi, Ahmad F. Ahmeda, Naif A. Al-Gabri, Saleh A. M. A. Alomaisi, Amirin Sadikun, Vikneswaran Murugaiyah, Ayman M. Mahmoud
Summary: This study evaluated the toxicity of the methanolic extract of A. carambola leaves (MEAC) in rats. The results showed that MEAC was safe up to a dose of 5000 mg/kg and did not have toxic effects on the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Chengru Li, Na Dong, Liming Shen, Meng Lu, Junwen Zhai, Yamei Zhao, Lei Chen, Zhiting Wan, Zhongjian Liu, Hui Ren, Shasha Wu
Summary: In this study, eight YABBY genes were identified and studied in the star fruit genome. The analysis included their phylogenetic relationships, gene characteristics, chromosome locations, and expression profiles. The results revealed that one of the genes, AcYABBY4, may have a specific role in regulating fruit size. These findings highlight the importance of further investigating the functions of YABBY genes in fruit development.
Review
Food Science & Technology
Kasun Lakmal, Pamodh Yasawardene, Umesh Jayarajah, Suranjith L. Seneviratne
Summary: Star fruit is considered to have various beneficial effects, such as antioxidant, hypoglycemic, hypotensive, hypocholesterolemic, and anti-inflammatory effects. However, overconsumption may lead to nephrotoxicity and neurotoxicity. Factors influencing safe consumption levels include chronic diseases and consumption on an empty stomach. The transition point from beneficial effects to toxicity and the relationship between amount ingested and toxicity severity are still unclear and require further study.
FOOD SCIENCE & NUTRITION
(2021)
Article
Food Science & Technology
Hui-Ling Tan, Pei-Nee Koh, Azhar Mat Easa, Thuan-Chew Tan
Summary: This study evaluated the thermal inactivation kinetics of polyphenol oxidase (PPO) and peroxidase (POD) in starfruit juice. The results showed that PPO has higher heat resistance than POD during thermal processing.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Energy & Fuels
Chandrima Mandal, Monica Jaiswal, S. John Don Bosco, S. Mythili
Summary: The purpose of this study was to improve the extraction process variables for phenolic and flavonoid compounds from freeze-dried Averrhoa carambola fruit powder. The conventional extraction methods were not ideal due to the heat destruction of the compounds, so ultrasound-assisted and microwave-assisted extraction techniques were used. The effects of solvent proportion, duration, and microwave power on the yield of phenolics and flavonoids were investigated and optimized.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Multidisciplinary Sciences
Qihua Lin, Qiuzhen Zhong, Zehuang Zhang
Summary: This study established a gene library from fruits of Averrhoa Carambola L. using RNA sequencing, identifying a total of 99,319 unigenes, including 10 AcSWEET genes. Through qRT-PCR, it was confirmed that AcSWEET2a/2b and AcSWEET16b may play a role in sugar transport during fruit ripening.
Article
Pharmacology & Pharmacy
Maisa Siddiq Abduh, Sultan A. M. Saghir, Amir M. Al Hroob, Albandari Bin-Ammar, Ayat H. Al-Tarawni, Vikneswaran Murugaiyah, Ayman M. Mahmoud
Summary: This study assessed the anti-hyperlipidemic and antioxidant activities of different fractions of the methanolic extract of the star fruit's leaves. The ethyl acetate fraction showed the most effective anti-hyperlipidemic and antioxidant effects. The findings suggest that the leaves of the star fruit can be a safe alternative for individuals with compromised kidney function who are unable to consume the fruit.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Emergency Medicine
Christopher Raciti, Melba Blanzaco, Jeffrey Bernstein
Summary: This case report describes a 74-year-old female with chronic kidney disease and diabetes mellitus who developed intractable hiccups and deteriorated rapidly after consuming starfruit. Despite receiving multiple rounds of hemodialysis, the patient did not survive. This is the first reported fatality due to starfruit ingestion in the U.S., highlighting the need for better understanding and guidelines for the treatment of starfruit toxicity.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Trissa Saha, Mashrafi Bin Mobarak, Md Najem Uddin, Md Saiful Quddus, Mustafizur Rahman Naim, Nigar Sultana Pinky
Summary: In this study, copper (II) oxide nanoparticles (CuO NPs) were synthesized using Averrhoa carambola leaf extract for the first time, in order to meet the demand for green synthesis. The synthesized CuO NPs were characterized using various techniques, including XRD, XPS, FESEM, FTIR, DLS, zeta potential, and UV-Vis spectroscopy. The results showed that the CuO NPs had a monoclinic crystalline phase with a crystallite size of 24.84 nm. The NPs exhibited antibacterial activity against gram positive and gram negative bacteria, with Salmonella typhi and Escherichia coli being the most susceptible strains.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Polymer Science
Karla Deyanira Ayon-Macias, Anely Johanna Castaneda-Andrade, Juan Arturo Ragazzo-Sanchez, Montserrat Calderon-Santoyo
Summary: An antifungal coating made of zein nanofibers and jackfruit leaf extract was successfully prepared using electrospinning. The characteristics of the nanofibers and the encapsulated extract were analyzed using various techniques, including SEM, TGA, and HPLC-MS. The results showed that the encapsulated extract exhibited antimicrobial activity against Cladosporium tenuissimum and Aspergillus sydowii, and the nanofibers provided thermal protection for the compounds in the extract.
Article
Biochemistry & Molecular Biology
Nehal S. Ramadan, Nabil H. El-Sayed, Sayed A. El-Toumy, Doha Abdou Mohamed, Zeinab Abdel Aziz, Mohamed Sobhy Marzouk, Tuba Esatbeyoglu, Mohamed A. Farag, Kuniyoshi Shimizu
Summary: The aqueous methanol leaf extract of Averrhoa carambola L. (CLK) was found to have significant anti-obese activity in an obese rat model. Fourteen compounds were isolated and identified, including new compounds not previously reported in A. carambola L. leaves and compounds isolated for the first time from the Family Oxalidaceae. Flavone glycosides showed potential as antidiabetic agents, while dihydrochalcone glycosides showed weaker activity.
Article
Oncology
Rodrigo C. Zeferino, Nadia S. R. S. Mota, Valdelucia M. A. S. Grinevicius, Karina B. Filipe, Paola M. Sulis, Fatima R. M. B. Silva, Danilo W. Filho, Claus T. Pich, Rozangela C. Pedrosa
INVESTIGATIONAL NEW DRUGS
(2020)
Article
Biochemistry & Molecular Biology
Monica Andressa Wessner do Nascimento, Fernanda Carvalho Cavalari, Vanessa Staldoni de Oliveria, Renata Goncalves, Danusa Menegaz, Eloisa da Silveira Loss, Fatima Regina Mena Barreto Silva
Article
Biochemistry & Molecular Biology
Hemily Batista-Silva, Betina Fernanda Dambros, Keyla Rodrigues, Patricia Acordi Cesconetto, Ariane Zamoner, Kieiv Resende Sousa de Moura, Allisson Jhonatan Gomes Castro, Glen Van der Kraak, Fatima Regina Mena Barreto Silva
Article
Environmental Sciences
Hemily Batista-Silva, Keyla Rodrigues, Kieiv Resende Sousa de Moura, Glen Van der Kraak, Christelle Delalande-Lecapitaine, Fatima Regina Mena Barreto Silva
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Cell Biology
Naira Fernanda Zanchett Schneider, Danusa Menegaz, Andre Luiz Andreotti Dagostin, Lara Persich, Sayonarah C. Rocha, Ana Carolina Pacheco Ramos, Vanessa Faria Cortes, Carlos Frederico Leite Fontes, Rodrigo Maia de Padua, Jennifer Munkert, Wolfgang Kreis, Fernao Castro Braga, Leandro A. Barbosa, Fatima Regina Mena Barreto Silva, Claudia Maria Oliveira Simoes
Summary: Cardiac glycosides have potent cytotoxic and anticancer effects, with the natural cardenolide glucoevatromonoside (GEV) showing short- and long-lasting cytotoxic effects on non-small-cell lung cancer H460 cells. GEV reduced viability, migration, and invasion of H460 cells, induced cell cycle arrest and death, and inhibited Na+,K+-ATPase activity. Additionally, combining GEV with chemotherapeutic drugs exhibited synergistic antiproliferative effects, especially with cisplatin and paclitaxel. The study also revealed a link between Na+,K+-ATPase and Cl- ion channels.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Environmental Sciences
Vanessa Staldoni de Oliveira, Allisson Jhonatan Gomes Castro, Katiuska Marins, Ana Karla Bittencourt Mendes, Gabriel Adan Araujo Leite, Ariane Zamoner, Glen Van der Kraak, Fatima Regina Mena Barreto Silva
Summary: The study revealed that pyriproxyfen can affect the ionic balance in the testis of zebrafish through multiple pathways, leading to oxidative stress and impacting reproductive health. Pyriproxyfen may induce toxicity in the testis by causing calcium overload, increased lipid peroxidation, and diminished antioxidant capacity, thereby affecting spermatogenesis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Toxicology
Vanessa Staldoni de Oliveira, Allisson Jhonatan Gomes Castro, Patricia Acordi Cesconetto, Ariane Zamoner Pacheco de Souza, Jurandir Joaquim Bernardes Junior, Alex Pires de Oliveira Nuner, Carlos Henrique Lemos Soares, Glen Van Der Kraak, Fatima Regina Mena Barreto Silva
Summary: This study compared the effects of pulp and paper mill effluent and betulin on various aspects of testicular physiology in zebrafish, indicating that the alterations may be due to the actions of betulin. Exposure to both effluent and betulin led to decreased lactate and calcium influx, possibly through the activation of the NCX pump. Additionally, betulin treatment resulted in increased ROS, GSH content, GST activity, and a tendency towards decreased CAT activity in the testes.
TOXICOLOGY IN VITRO
(2021)
Article
Reproductive Biology
Hemily Batista-Silva, Keyla Rodrigues, Kieiv Resende Sousa de Moura, Nicolas Elie, Glen Van der Kraak, Christelle Delalande, Fatima Regina Mena Barreto Silva
Summary: The study investigated the effects of Bisphenol A (BPA) on testicular energy metabolism and morphology in zebrafish through in vitro and short-term in vivo experiments. Results showed that BPA exposure decreased lactate and glycogen content, altered enzyme activity, induced apoptosis in testicular cells, and affected spermatogenesis in male zebrafish. Overall, short-term BPA exposure was found to impact energy metabolism and spermatogenesis in zebrafish.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Toxicology
Vanessa Staldoni de Oliveira, Katiuska Marins, Ana Karla Bittecourt Mendes, Ariane Zamoner, Gabriel Adan Araujo Leite, Fatima Regina Mena Barreto Silva
Summary: We studied the effects of pyriproxyfen on zebrafish ovarian morphology and oxidative stress. Exposure to pyriproxyfen resulted in increased generation of reactive oxygen species and decreased glutathione content in the ovaries. Additionally, enzyme activities related to antioxidative defense mechanisms were altered. The histological analysis showed disrupted follicular maturation and various abnormalities in the ovary. These findings suggest that pyriproxyfen acts as an endocrine disruptor and can impair fish reproduction.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ivonne Helena Valderrama, Sandra Milena Echeverry, Diana Patricia Rey, Ingrid Andrea Rodriguez, Fatima Regina Mena Barreto Silva, Geison M. Costa, Luis Fernando Ospina-Giraldo, Diana Marcela Aragon
Summary: This study evaluated the anti-diabetic activity of the butanol fraction from Physalis peruviana in induced type 2 diabetic mice. The results showed that the butanol fraction at a higher dose (100 mg/kg) had better regulation of blood glucose levels in mice, improved lipid metabolism, and protected against oxidative stress.
Article
Biochemistry & Molecular Biology
Paola Miranda Sulis, Ana Karla Bittencourt Mendes, Thais Alves Fernandes, Marisa Jadna Silva Frederico, Diana Patricia Rey, Marcela Aragon, Ketan C. Ruparelia, Regina Mena Barreto Silva
Summary: A chalcone analogue, DMU 101, was synthesized and investigated for its antidiabetic properties. It was found to decrease blood glucose levels, increase glycogen content in skeletal muscle, and reduce serum triacylglycerol and total cholesterol levels. Furthermore, the analogue stimulated glucose uptake and increased insulin secretion through calcium-dependent mechanisms. These findings suggest that this chalcone may have potential for treating diabetes by regulating glucose and lipid metabolism.
Article
Biochemistry & Molecular Biology
Keyla Rodrigues, Hemily Batista-Silva, Kieiv Resende Sousa de Moura, Glen Van Der Kraak, Fatima Regina Mena Barreto Silva
Summary: This study examined the immediate impacts of dibutyl phthalate (DBP) exposure on energy metabolism and gill histology in zebrafish. In vitro exposure to 10 μM DBP for 60 minutes resulted in altered energy supply in the gill tissue, with decreased lactate content and lactate dehydrogenase (LDH) activity. Higher DBP concentrations (100 μM and 1 mM) increased lactate content and LDH activity, blocked glucose uptake, depleted glycogen content, and caused gill injury and liver damage.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Reproductive Biology
Ana Paula Zanatta, Renata Goncalves, Fabiana Ourique da Silva, Rozangela Curi Pedrosa, Leila Zanatta, Helene Bouraima-Lelong, Christelle Delalande, Fatima Regina Mena Barreto Silva
Summary: The study investigated the rapid responses of rat testis to estradiol (E-2) and 1 alpha,25(OH)(2) vitamin D-3 (1,25-D-3), revealing their effects on calcium uptake, estrogen receptors, cyclin expression, and downstream signaling pathways. Both hormones elicited rapid responses at the plasma membrane to regulate gene and protein expression related to cell cycle regulation and spermatogenesis.
Article
Environmental Sciences
Keyla Rodrigues, Hemily Batista-Silva, Kieiv Resende Sousa de Moura, Glen Van der Kraak, Fatima Regina Mena Barreto Silva
Article
Agriculture, Dairy & Animal Science
Vanessa Staldoni de Oliveira, Allisson Jhonatan Gomes Castro, Juliana Tonietto Domingues, Ariane Zamoner Pacheco de Souza, Debora da Luz Scheffer, Alexandra Latini, Carlos Henrique Lemos Soares, Glen Van der Kraak, Fatima Regina Mena Barreto Silva
ANIMAL REPRODUCTION
(2020)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
