期刊
FITOTERAPIA
卷 83, 期 6, 页码 1120-1124出版社
ELSEVIER
DOI: 10.1016/j.fitote.2012.04.023
关键词
Gelsemium elegant; 21-(2-Oxopropyl)-koumine; 11-Methoxygelselegine; Immunosuppressive activity
资金
- key project of the Tropical Characteristic Medical Resources Branch Research Centre of the Chinese Academy of Sciences [KSCX2-YW-R-172]
Bioassay-guided isolation of the stems of Gelsemium elegans has led to the isolation of two new Gelsemium alkaloids, 21-(2-oxopropyl)-koumine (1) and 11-methoxygelselegine (2), and two known alkaloids, koumine (3) and gelselegine (4). The structures of 1-2 were determined by spectroscopic (for both) and single-crystal X-ray diffraction (for 1) analysis. All compounds isolated were evaluated for their potential as immunosuppressive agents and the data suggested that Gelsemium alkaloids of different structural types possibly have potential as immunosuppressive agents. (C) 2012 Elsevier B.V. All rights reserved.
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