期刊
FITOTERAPIA
卷 83, 期 5, 页码 926-931出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2012.04.007
关键词
Schisandra glaucescens; Schisandraceae; Cycloartane triterpenoid; FXR agonistic and antagonistic effects
资金
- NSFC [20802082, 30830115]
- Chinese Academy of Sciences [KSCX2-EW-Q-10, KSCX1-YW-R-24]
- Major State Basic Research Development Program of China [2009CB522303, 2009CB940900]
- Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China
- Natural Science Foundation of Yunnan Province [2005XY04, 2006B0042Q]
Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC50 of 1.50 mu M. (C) 2012 Elsevier B.V. All rights reserved.
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