Article
Polymer Science
Piyachat Chuysinuan, Chalinan Pengsuk, Kriengsak Lirdprapamongkol, Thanyaluck Thanyacharoen, Supanna Techasakul, Jisnuson Svasti, Patcharakamon Nooeaid
Summary: This study developed a wound dressing made of natural- and biowaste-derived biopolymers loaded with turmeric extract, which has antibacterial, antioxidant, and anti-inflammatory activities. The dressing showed inhibitory effects on bacterial growth due to the controlled release of the turmeric extract. It also exhibited antioxidant activity by scavenging radicals and demonstrated anti-inflammatory effects by inhibiting nitric oxide production. This study suggests that the dressing has potential for wound healing.
Article
Biochemistry & Molecular Biology
Weiling Lu, Changchang Kong, Shijunyin Cheng, Xiaodong Xu, Jianfa Zhang
Summary: The study shows that riclin can protect the skin from UVB-induced damage, with antioxidant and anti-inflammatory effects. Riclin increases collagen expression and inhibits oxidation and melanin synthesis. In vivo experiments on mice demonstrate that riclin effectively reduces UVB-induced skin damage and suppresses inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Yaodong Ning, Shi Zhang, Te Zheng, Yao Xu, Song Li, Jianpeng Zhang, Binghua Jiao, Yun Zhang, Zengling Ma, Xiaoling Lu
Summary: The Arctic-derived fungus Eutypella sp. D-1 can produce secondary metabolites with excellent biological activity, some of which exhibit significant anti-inflammatory effects. Seven pimarane-type diterpenes, including three new compounds, were isolated from the fermentation broth of Eutypella sp. D-1. These compounds showed inhibitory effects on cell NO release in vitro and demonstrated anti-inflammatory activity in a zebrafish model.
Article
Biochemistry & Molecular Biology
Daohong He, Huasheng Wu, Huishu Jiang, Zhen Zhang, Chonglong Wang, Dahui Wang, Gongyuan Wei
Summary: This study screened a mutant of Candida utilis SE-172 with high selenite tolerance and glutathione (GSH) biosynthesis capability and investigated its physiological mechanism. Furthermore, the anti-inflammatory and antioxidant activities of this selenized yeast were evaluated in mice with colitis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Solomon Habtemariam
Summary: Carnosic acid (CA) and carnosol (CAR) are major diterpenes found in rosemary plants. They possess phenolic structures and can remove reactive oxygen species (ROS) in cells either directly or by enhancing antioxidant defenses. They also have multiple biological effects and therapeutic potential by modulating various inflammation signaling pathways. These compounds can ameliorate the expression of pro-inflammatory molecules and their mechanisms of action as an anti-inflammatory therapeutics are analyzed.
Review
Biochemistry & Molecular Biology
Won Young Jang, Mi-Yeon Kim, Jae Youl Cho
Summary: Lignans, plant compounds with anti-inflammatory and antioxidant activities, have potential therapeutic value in modulating chronic inflammation and treating various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mohammad Jafar Dehzad, Hamid Ghalandari, Mehran Nouri, Moein Askarpour
Summary: This systematic review and meta-analysis summarized the existing literature on the impact of turmeric and its bioactive compound curcumin on inflammatory and oxidative balance. The results showed that turmeric/curcumin supplementation significantly reduces inflammatory markers and improves antioxidant activity, suggesting its potential as a viable intervention for improving inflammatory/oxidative status.
Article
Chemistry, Medicinal
Chao Wang, Quan-Hao Wei, Zhen-Qiang Xin, Lin -Lin Tian, Jun-Sheng Zhang, Hua Zhang
Summary: This study reported new compounds from the root extract of Morinda officinalis and determined their structures and absolute configurations using spectroscopic analysis and computational methods. These compounds showed moderate inhibitory activity against nitric oxide production in murine macrophage cells, and compound 3b also inhibited the secretion of two inflammatory cytokines.
Article
Biochemistry & Molecular Biology
Barakat M. Alrashdi, Roaya A. Mohamed, Amal H. Mohamed, Feryal A. Samoul, Mazen I. Mohamed, Mohsen M. Moussa, Saad M. Alrashidi, Bassel Dawod, Ola A. Habotta, Ahmed E. Abdel Moneim, Shimaa S. Ramadan
Summary: This study found that turmeric conjugated with selenium nanoparticles effectively counteracted cisplatin-induced renal impairment in mice. Turmeric or turmeric-seNPs therapy significantly reduced renal dysfunction and inflammation, improved oxidative status, and inhibited renal apoptosis in cisplatin-treated mice.
BIOSCIENCE REPORTS
(2023)
Article
Nutrition & Dietetics
Sylvie Morel, Gerald Hugon, Manon Vitou, Marie Vedere, Francoise Fons, Sylvie Rapior, Nathalie Saint, Gilles Carnac
Summary: Research has identified that carnosol in rosemary leaf extracts induces skeletal muscle hypertrophy by repressing the ubiquitin-proteasome system-dependent protein degradation pathway through inhibition of the E3 ubiquitin ligase Muscle RING Finger protein-1.
Article
Chemistry, Medicinal
Yu-Fei Liu, Bao-Chen Yang, Zhi-Min Song, Lin-Qiang Qiao, Rui Peng, Wei-Sheng Feng, Yong-Xian Cheng, Yan-Zhi Wang
Summary: The phytochemical investigation of the ethanol extract from Pinus yunnanensis Franch resin led to the discovery of six new diterpenoids and the determination of their structures using spectroscopic analysis and computational methods. These compounds showed anti-inflammatory effects at certain concentrations.
Article
Biochemistry & Molecular Biology
Zhibin Liang, Pamela Maher
Summary: Alzheimer's disease is a common age-associated disease with no effective treatments. Using phenotypic screening assays, Sterubin from Yerba Santa was identified as a potential drug candidate for AD treatment. Sterubin exhibits neuroprotective and anti-inflammatory effects, and can prevent memory decline.
Review
Biochemistry & Molecular Biology
Stephen T. Sinatra, Drew S. Sinatra, Stephen W. Sinatra (Step), Gaetan Chevalier
Summary: Grounding or earthing is a hidden secret for health and vitality, yet only a small part of the scientific community understands its importance. Once health professionals and others recognize its role in preventing inflammatory diseases, it can have a significant impact on public health. Previous data and testimonials provide evidence of the earth's healing power on the human body.
BIOMEDICAL JOURNAL
(2023)
Review
Plant Sciences
Marcello Nicoletti
Summary: The therapeutic story of European mistletoe has had ups and downs. In ancient times, it was considered a panacea, but recent concerns about its toxicity led to doubts about its medicinal value. However, its selective action on tumor cells has brought back medical interest in mistletoe.
Article
Biochemistry & Molecular Biology
Juliette Cholet, Caroline Decombat, Laetitia Delort, Mael Gainche, Alexandre Berry, Clemence Ogeron, Isabelle Ripoche, Marjolaine Vareille-Delarbre, Marion Vermerie, Didier Fraisse, Catherine Felgines, Adrien Rossary, Edwige Ranouille, Jean-Yves Berthon, Albert Tourrette, Julien Priam, Etienne Saunier, Yves Troin, Francois Senejoux, Pierre Chalard, Florence Caldefie-Chezet
Summary: Luzula sylvatica extract demonstrated antioxidant and anti-inflammatory properties, inhibiting reactive oxygen species production and reducing the secretion of inflammatory mediators. It also decreased PGE2 secretion in synovial fluid and protected cartilage by decreasing the expression of proteases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Cedric Del Rio, Jian Huang, Gregory W. Stull, Remi Allemand, Zhe-Kun Zhou, Tao Su
Summary: The fossil endocarp of the liana genus Iodes from the Oligocene Wenshan flora in southwestern China represents the first Icacinaceae fruit fossil record from Asia, indicating a long-standing presence of the genus in SE Asia, dating back to the Paleogene. Based on the characteristics of the fossil and climate data, it is hypothesized that the region had a subtropical climate during the Oligocene, supporting a rainforest with a mixed regional flora of subtropical and tropical elements.
JOURNAL OF SYSTEMATICS AND EVOLUTION
(2022)
Article
Plant Sciences
Yong-Jiang Huang, Hai Zhu, Tao Su, Robert A. Spicer, Jin-Jin Hu, Lin-Bo Jia, Zhe-Kun Zhou
Summary: The study presents abundant fossil fruits and seeds of herbs from the late Pliocene in the southern Hengduan Mountains region, revealing the rise of herbaceous diversity in the area and the potential key driving forces for the opening of meadow vegetation. This finding provides the first direct evidence of past treeless open vegetation within the HMR, improving our understanding of vegetation evolution in the region.
JOURNAL OF SYSTEMATICS AND EVOLUTION
(2022)
Article
Meteorology & Atmospheric Sciences
Tao Su, Taichen Feng, Bicheng Huang, Zixuan Han, Zhonghua Qian, Guolin Feng, Wei Hou, Wenjie Dong
Summary: The study analyses the temporal variation of actual evapotranspiration (AE) over China during 1980-2015 using an ensemble of six reanalyses and a complementary-relationship-based AE dataset. It reveals significant increase in annual mean AE in China, with major regime shifts occurring around 1998. Climate change and landscape characteristics are identified as the primary causes for changes in AE in different regions of China.
INTERNATIONAL JOURNAL OF CLIMATOLOGY
(2022)
Article
Plant Sciences
Jingjing Yao, Qinghong Shen, Min Huang, Ming Ding, Yajuan Guo, Wenbo Chen, Yuefang Lin, Yaqiu Zheng, Shaofang Yu, Wenxin Yan, Tao Su, Zhongqiu Liu, Linlin Lu
Summary: This study aimed to explore the dominant tumor model and specific target of CM by integrative pharmacology and biological experiments. The most predominant and specific cancer types that are sensitive to CM were screened and identified based on a combination network pharmacology and bioinformatics analysis. The priority target responsible for CM-related anti-tumor efficacy was further validated by molecular docking and in vitro experiments.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Qijia Li, Weiyudong Deng, Torsten Wappler, Torsten Utescher, Natalia Maslova, Yusheng (Christopher) Liu, Hui Jia, Chengyu Song, Tao Su, Cheng Quan
Summary: By studying leaf fossils with arthropod traces collected from the Miocene Huaitoutala flora in the northern Tibetan Plateau, this research provides direct evidence of plant-arthropod interactions, indicating that the Miocene ecosystem in this region was more diverse and dynamic than previously thought.
REVIEW OF PALAEOBOTANY AND PALYNOLOGY
(2022)
Editorial Material
Biodiversity Conservation
Tao Su, Robert A. Spicer, Zhe-Kun Zhou
Article
Biodiversity Conservation
Lin-Bo Jia, Jin-Jin Hu, Shi-Tao Zhang, Tao Su, Robert A. Spicer, Jia Liu, Jiu-Cheng Yang, Pu Zou, Yong-Jiang Huang, Zhe-Kun Zhou
Summary: This article reports the discovery of three Bauhinia fossil species with cuticular preservation from the Paleogene of Puyang Basin, southwestern China, extending the emergence of Bauhinia in Asia to the late Eocene. It also shows that the diversification of Bauhinia in Asia and the phenomenon of a small region harboring multiple Bauhinia species in southwestern China can be traced back to the Paleogene.
Article
Geography, Physical
Mengxiao Wu, Jian Huang, Robert A. Spicer, Shufeng Li, Jiagang Zhao, Weiyudong Deng, Wenna Ding, He Tang, Yaowu Xing, Yimin Tian, Zhekun Zhou, Tao Su
Summary: This study provides insights into the paleoelevation and paleoclimate of the Lithe Basin on the southeastern margin of the Tibetan Plateau during the early Oligocene. The results show that the basin had reached its present elevation at that time and experienced a humid subtropical climate. The findings also suggest that the appearance of the modern flora in this region began during the early Oligocene.
GLOBAL AND PLANETARY CHANGE
(2022)
Article
Plant Sciences
Weiyudong Deng, Dario De Franceschi, Xiaoting Xu, Cedric Del Rio, Shook Ling Low, Zhekun Zhou, Robert A. Spicer, Lili Ren, Raoqiong Yang, Yimin Tian, Mengxiao Wu, Jiucheng Yang, Shuiqing Liang, Torsten Wappler, Tao Su
Summary: Cupressaceae fossil tree stumps from the Oligocene of southwestern China were found to contain abundant quartz-petrified damage traces, and the fossils also revealed arthropods and fungus, filling a gap in the fossil records for insect herbivory in this region. The disappearance of Taxodium supports the changes in the environment at that time.
REVIEW OF PALAEOBOTANY AND PALYNOLOGY
(2022)
Article
Geosciences, Multidisciplinary
Jiagang Zhao, Shufeng Li, Alexander Farnsworth, Paul J. Valdes, Tammo Reichgelt, Linlin Chen, Zhekun Zhou, Tao Su
Summary: The growth of the Qinghai-Tibetan Plateau during the Cenozoic period played a significant role in driving climate change in the region. Both temperature and precipitation showed an overall decline, with the growth of the plateau leading to a gradual decrease in temperature and precipitation in the northeastern part. This research provides insights into environmental change and ecosystem evolution during the Cenozoic period.
SCIENCE CHINA-EARTH SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xinwen Zhang, Uriel Gelin, Robert A. Spicer, Feixiang Wu, Alexander Farnsworth, Peirong Chen, Cedric Del Rio, Shufeng Li, Jia Liu, Jian Huang, Teresa E. Spicer, Kyle W. Tomlinson, Paul J. Valdes, Xiaoting Xu, Shitao Zhang, Tao Deng, Zhekun Zhou, Tao Su
Summary: Spinescence is an important trait for plants to defend against mammalian herbivores. However, the evolution of spinescence remains poorly understood, with most studies focusing on modern ecosystems. Recently discovered well-preserved Eocene plant fossils in the central Tibetan Plateau reveal a diversity of spiny plants and rapid diversification during that time. Regional aridification and expansion of herbivorous mammals may have driven the diversification of spinescence in central Tibetan woodlands.
NATURE COMMUNICATIONS
(2022)
Article
Biodiversity Conservation
Shumei Xiao, Shufeng Li, Xiaojun Wang, Linlin Chen, Tao Su
Summary: This study uses simulation to examine the historical and potential future distribution of Cedrus Trew. It finds that winter precipitation and temperature are the key factors determining the distribution of Cedrus, with summer precipitation playing a more important role in the Mediterranean region. The study also suggests that climate change will have a significant impact on the distribution of Cedrus, highlighting the need for conservation and management efforts.
ECOLOGICAL INDICATORS
(2022)
Article
Entomology
Xiao-Ting Xu, Jacek Szwedo, Di-Ying Huang, Wei-Yu-Dong Deng, Martyna Obroslak, Fei-Xiang Wu, Tao Su
Summary: A new genus and species of spittlebugs from central Tibetan Plateau in China represent a rare fossil find, with its extinction likely linked to regional aridification and changes in plant taxa over the last 33 million years.
Article
Plant Sciences
Ai Song, Jia Liu, Shui-Qing Liang, Truong Van Do, Hung Ba Nguyen, Wei-Yu-Dong Deng, Lin -Bo Jia, Cedric Del Rio, Gaurav Srivastava, Zhuo Feng, Zhe-Kun Zhou, Jian Huang, Tao Su
Summary: Recent paleobotanical investigations in Vietnam have revealed a warm climate in northern Vietnam and nearby areas during the Oligocene. The studies also identified a new species of palm from this period.
Article
Multidisciplinary Sciences
Zhongyu Xiong, Xiaohui Liu, Lin Ding, Alex Farnsworth, Robert A. Spicer, Qiang Xu, Paul Valdes, Songlin He, Deng Zeng, Chao Wang, Zhenyu Li, Xudong Guo, Tao Su, Chenyuan Zhao, Houqi Wang, Yahui Yue
Summary: Studying the Paleogene topography and climate of central Tibet provides insights into collisional tectonic mechanisms and their connection to climate and biodiversity. Evidence suggests that the Lunpola Basin in central Tibet experienced significant surface uplift of at least 2.0 kilometers over the past 38 million years, transforming it into a plateau.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.