Article
Biology
Titiana V. V. Zheleznichenko, Tatiana N. N. Veklich, Vera A. A. Kostikova
Summary: This study successfully achieved micropropagation and morphogenesis initiation of S. pallasii in vitro, and identified some characteristics of its active compounds. This lays the foundation for further biotechnological and phytochemical research on S. pallasii.
Article
Biochemistry & Molecular Biology
Qonita Kurnia Anjani, Emilia Utomo, Juan Dominguez-Robles, Usanee Detamornrat, Ryan F. Donnelly, Eneko Larraneta
Summary: In this study, a HPLC-UV method was developed and validated for the quantification of CUR and DPA in polymer-based wound dressings or creams. The method showed high precision and accuracy, and the CUR and DPA solutions were found to be stable under specific storage conditions. The developed method may be useful in screening formulations for CUR and DPA through in vitro release studies.
Review
Pharmacology & Pharmacy
Mauricio A. Garcia, Felipe Varum, Jozef Al-Gousous, Michael Hofmann, Susanne Page, Peter Langguth
Summary: This article reviews the latest techniques for bio-predictive dissolution testing of colon-targeted products. Conventional methods overlook physiological factors, while bio-predictive testing can accelerate product development and regulatory approval.
Article
Biochemistry & Molecular Biology
Zvezdelina Yaneva, Donika Ivanova, Nikolay Popov
Summary: This study investigated the microencapsulation, in vitro release capacity and efficiency of catechin-rich Acacia catechu extract by Clinosorbent-5 microparticles through detailed analysis and mathematical modelling. The results showed a maximum extent of 32% catechin microencapsulation in acidic medium and 88% maximum release efficiency in simulated enzyme-free gastric medium after 24 hours. The developed bioflavanol/clinoptilolite microcarrier system provided sustained catechin in vitro release behavior without an initial burst effect.
Article
Biochemistry & Molecular Biology
Enkelejda Goci, Entela Haloci, Antonio Di Stefano, Annalisa Chiavaroli, Paola Angelini, Ajkuna Miha, Ivana Cacciatore, Lisa Marinelli
Summary: The study aimed to prepare a pharmaceutical Carbopol-based formulation containing capsaicin and evaluate its in vitro release and antimicrobial and antifungal properties. The results showed that approximately 50% of capsaicin was released within 52 hours from the formulation, and it significantly enhanced the antimicrobial effects of capsaicin against various bacteria and fungi strains.
Article
Biochemical Research Methods
Yee Shan Sim, Zan Yang Chong, Juzaili Azizi, Choon Fu Goh
Summary: This study aimed to develop and validate a gradient HPLC-UV analytical method for determining the skin permeation of mitragynine. The results showed that mitragynine can be delivered through the skin. This study addressed the limitations of current methods and confirmed the potential of mitragynine for transdermal delivery.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Chemistry, Applied
Raffaele Cucciniello, Michele Tomasini, Anna Russo, Laura Falivene, Angelita Gambuti, Martino Forino
Summary: Acetaldehyde plays a crucial role in determining certain properties of wine, and its reaction with flavonoids can significantly impact the color, astringency, and colloidal stability of the wine. A study investigated the reaction between acetaldehyde and catechin, revealing the formation of ethylidene-bridged catechins as initial products, which eventually dissociate to accumulate vinyl-catechins over time.
Article
Biochemical Research Methods
Franziska Wienberg, Marcel Hoevels, Konrad Kosciow, Uwe Deppenmeier
Summary: The article discusses the rapid development of strategies to improve human health by modulating the gut microbiota, with a focus on the use of prebiotics. A method using inulosucrase from Lactobacillus for the synthesis of inulin-FOS was studied, along with the development of a time-saving and resource-efficient HPLC method for rapid analysis of these oligosaccharides.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hafiz Muhammad Ibrahim, Haroon Khalid Syed, Muhammad Affan, Saba Anees, Gabriel Onn Kit Loh, Muhammad Shahid Iqbal, Salah-Ud-Din Khan, Fahad Al-Saikhan
Summary: A RP-HPLC isocratic method for simultaneous estimation of valsartan and amlodipine in pharmaceutical solid dosage preparations has been developed and validated. The method showed good linearity, system suitability, and stability, making it beneficial for routine analysis and simultaneous estimation.
LATIN AMERICAN JOURNAL OF PHARMACY
(2021)
Article
Engineering, Chemical
Qinglin Su, Paul Hermant, Federica Casati, Bhakti Halkude, Wei Wu, Anjana Ramnath, Atul Dubey, Stephen Born, Bayan Takizawa, Salvatore Mascia
Summary: A predictive mathematical model was developed and implemented in a continuous manufacturing pilot plant for tablet dissolution. The model included the mass balance of API solute and the dissolution, diffusion, and population balance of API particles in the swollen tablet. Equivalence was demonstrated through comparison with experimental data, with all sampled tablets showing a similarity factor f(2) > 50. Concluding remarks and industrial perspectives on model predictive in vitro dissolution testing are provided.
Article
Chemistry, Analytical
Melissa Chamon Alves Premazzi, Eduardo da Silva Gomes de Castro
Summary: A simple and fast method using reverse phase High Performance Liquid Chromatography with spectrophotometric detection on UV range (HPLC-UV) was developed and validated for determining recombinant human Erythropoietin (rhEPO) in the presence of human serum albumin (HSA) as a stabilizer in three different presentations. The method demonstrated high efficiency, accuracy, and sensitivity, and its reliability was confirmed through various validation tests.
MICROCHEMICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Daniel Szulczyk, Mateusz Wozinski, Michal Kolinski, Sebastian Kmiecik, Agnieszka Glogowska, Ewa Augustynowicz-Kopec, Michal A. Dobrowolski, Piotr Roszkowski, Marta Struga, Krzesimir Ciura
Summary: This study investigated the antitubercular properties of Ciprofloxacin derivatives conjugated with menthol and thymol moieties. The results showed that these compounds have antitubercular activity and exhibit similar or better activity against drug-resistant strains. Additionally, the increased lipophilicity and affinity to phospholipids of the new derivatives offer advantages for new drug candidates. Further studies are needed to understand their safety, efficacy, and mechanism of action.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Fernando J. Pereira, Aida Rodriguez-Cordero, Roberto Lopez, Luis C. Robles, A. Javier Aller
Summary: A rapid, simple, and sensitive isocratic RP-HPLC method with photodiode array detection was developed for the determination of paracetamol, caffeine, and tramadol in pharmaceutical formulations. An improved procedure for tramadol using a fluorescence detector system was also established.
Article
Pharmacology & Pharmacy
Marco Brugnera, Marta Vicario-de-la-Torre, Vanessa Andres-Guerrero, Irene Bravo-Osuna, Irene Teresa Molina-Martinez, Rocio Herrero-Vanrell
Summary: This paper discusses the development and validation of a rapid method for the quantification of two neuroprotective agents in biodegradable PLGA microspheres. The method allows for the simultaneous determination of the two agents and has potential value in the treatment of glaucoma.
Article
Food Science & Technology
Yu Chang, Qi Wang, Juqing Huang, Xianliang Luo, Yajuan Huang, Yirui Wu, Peng Chen, Yafeng Zheng
Summary: Curcumin has promising applications in functional foods, but its low stability and bioavailability limit its use in the food industry. This study demonstrates that cellulose nanofiber can serve as a low-cost carrier for curcumin, improving its stability and enabling slow release.
Article
Pharmacology & Pharmacy
Ian R. Reid, Jingyuan Wen, Anna Mellar, Mengyang Liu, Amani Jabr, Anne M. Horne
Summary: The aim of this study was to assess the safety and efficacy of two oral zoledronate preparations in postmenopausal women. The results showed that oral zoledronate had a smaller and less sustained anti-resorptive effect compared to intravenous zoledronate. However, oral zoledronate could be a viable option with dosing intervals of weeks to months.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ray Ong, Jillian Cornish, Jingyuan Wen
Summary: Bone and joint infections are a rare but serious problem worldwide. Lactoferrin has antimicrobial and bone-regenerating effects, which may help improve the treatment of bone and joint infections. However, its oral bioavailability in humans is highly variable due to potential degradation in the stomach and small intestine. Encapsulating lactoferrin in nanocarriers can enhance its absorption, stability, and oral bioavailability.
Article
Pharmacology & Pharmacy
Mengyang Liu, Manisha Sharma, Guo-Liang Lu, Zhiwen Zhang, Naibo Yin, Jingyuan Wen
Summary: This study evaluates the solid lipid nanoparticles (SLNs) carrier system for enhancing the skin penetration and stability of L-Glutathione (GSH). The GSH-SLNs showed 3.7-fold improvement in penetration across the skin compared to aqueous GSH, and prolonged antioxidant activity against UVA-induced oxidative stress. SLNs as a carrier system have the potential to improve skin health through enhanced delivery of GSH.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Sanjukta Duarah, Manisha Sharma, Shuo Chen, Thomas K. Proft, Jacelyn Loh, Jingyuan Wen
Summary: A biodegradable microneedle-based transdermal delivery system was developed for sustained and effective delivery of dexamethasone. The microneedle arrays enhanced the permeation of dexamethasone and showed comparable anti-inflammatory efficacy to intravenous injection. This study suggests that microneedle arrays could be a safe, easy, effective and minimally invasive alternative to current delivery methods for dexamethasone.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Yao Wu, Honglei Xie, Yongping Li, Xinyue Bao, Guo-Liang Lu, Jingyuan Wen, Yuan Gao, Yaping Li, Zhiwen Zhang
Summary: The researchers developed a bioinspired lipoprotein system loaded with a glutathione-activated nitric oxide donor (NO-BLP) to improve tumor vasculature normalization and enhance the delivery efficiency of albumin-bound paclitaxel nanoparticles (PAN) in tumors. NO-BLP exhibited superior tumor accumulation and penetration compared to liposomal formulation (NO-Lipo), resulting in significant vascular normalization and a 2.33-fold increase in PAN accumulation. The sequential treatment of NO-BLP with PAN showed an 81.03% inhibition of tumor growth, outperforming monotherapy and the counterpart NO-Lipo plus PAN treatment. Thus, the bioinspired lipoprotein system of NO-BLP provides a promising platform for tumor vessel normalization and efficient intratumor delivery of nanomedicines.
Review
Pharmacology & Pharmacy
Harpinder K. Brar, Jiney Jose, Zimei Wu, Manisha Sharma
Summary: This review explores the potential of targeted therapies, such as tyrosine kinase inhibitors (TKIs), in treating glioblastoma multiforme (GBM). It also analyzes the reasons why TKIs have been unsuccessful in clinical trials for GBM despite their success in treating other cancer types. The main focus is on promising drug delivery strategies, particularly the use of nanocarriers, to enhance the efficacy of TKIs in GBM by overcoming the limitations imposed by the blood-brain barrier.
Article
Pharmacology & Pharmacy
Yu Gao, Andrew N. Shelling, David Porter, Euphemia Leung, Zimei Wu
Summary: This study investigates the structural integrity and long-term stability of trastuzumab under different stress factors in formulation development. Results show that trastuzumab is resistant to mechanical and freeze-and-thaw stress, but unstable under acidic and alkaline environments. Low temperature and low concentration favor long-term stability. This study provides valuable stability information for developing trastuzumab-involved nano-formulation and clinical applications.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Patrick Pan, Darren Svirskis, Geoffrey I. N. Waterhouse, Zimei Wu
Summary: This study developed a simple HPLC method for the simultaneous quantification of hydrophilic benzophenone-4 and lipophilic octocrylene, along with three other commonly used UV filters. The method demonstrated good specificity, linearity, accuracy, and precision, and was able to effectively extract the UV filters from a commercial sunscreen.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Editorial Material
Pharmacology & Pharmacy
Jingyuan Wen, Yuan Huang
Article
Psychology, Clinical
Y. Nina Gao, Brandon Coombes, Euijung Ryu, Vanessa Pazdernik, Gregory Jenkins, Richard Pendegraft, Joanna Biernacka, Mark Olfson
Summary: This study compares patients diagnosed with depression without anxiety, anxiety without depression, or both depression and anxiety, and identifies differences in the clinically observable phenome between these groups. The results show that patients diagnosed with depression only are more likely to have diagnoses of obesity, sleep apnea, and type II diabetes, while patients diagnosed with anxiety only are more likely to have diagnoses of palpitations, benign skin neoplasms, and cardiac dysrhythmias. Patients with comorbid depression and anxiety have higher rates of other mental health disorders, substance use disorders, sleep problems, and gastroesophageal reflux.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Patrick Pan, Darren Svirskis, Geoffrey I. N. Waterhouse, Zimei Wu
Summary: This study examined the properties and interactions of hydrogels containing hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP). The results showed that HPMC played a dominant role in determining the gel properties, while the addition of PVP improved the adhesiveness. Drug release experiments and Fourier transform infrared spectroscopy confirmed the interactions between PVP and the drug.
Article
Pharmacology & Pharmacy
Trusha J. J. Purohit, Satya Amirapu, Zimei Wu, Sara M. M. Hanning
Summary: This study evaluated the rectal bioavailability of hollow-type suppositories (HTS) and the impact of two chemical forms of amoxicillin. The results showed similar rectal bioavailability for both forms of amoxicillin, and neither HTS formulation caused significant irritation to the rectal mucosa following a single dose.
Article
Pharmacology & Pharmacy
Xudong Yao, Craig Bunt, Mengyang Liu, Siew-Young Quek, John Shaw, Jillian Cornish, Jingyuan Wen
Summary: The aim of this study is to enhance the cellular uptake and transport of bovine lactoferrin using pectin- and chitosan-modified solid lipid nanoparticles. Solid lipid particles containing bovine lactoferrin were formulated through the solvent evaporation technique, incorporating stearic acid along with either chitosan or pectin modification. The study evaluated the cellular uptake and transport of bovine lactoferrin-loaded solid lipid particles in vitro using the Caco-2 cell model.
Article
Chemistry, Multidisciplinary
Jianwei Zhu, Yuning Zhang, Zheng Li, Xiaowen Bao, Yanfeng Zhou, Bo Ma, Ying Xie, Peiyu Yan, Zimei Wu, Qi Zhang, Jianhua Zou, Xiaoyuan Chen
Summary: This study designs an intelligent nanosystem that responds to hypoxia for targeted drug delivery, improving therapeutic efficacy and reducing side effects. The system combines hypoxia-activatable tirapazamine (TPZ) with polyethylene glycol to form a pH-sensitive poly-prodrug. Furthermore, the nanosystem can generate reactive oxygen species and has high photothermal conversion efficiency, which destroys tumor blood vessels and activates hypoxia-induced chemotherapy.
MATERIALS HORIZONS
(2023)
Article
Engineering, Biomedical
Ernest Cheah, Mahima Bansal, Linh Nguyen, Anais Chalard, Jenny Malmstrom, Simon J. O'Carroll, Bronwen Connor, Zimei Wu, Darren Svirskis
Summary: Electrically modulated delivery of proteins allows for targeted and dose-tunable delivery to local tissues. This study presents an electrically active composite material, comprising GelMA and a conducting polymer, capable of controlled protein release over 3 weeks. The material exhibits electroactivity, mechanical properties, and cytocompatibility, making it suitable for tissue engineering applications requiring spatio-temporal control of protein delivery.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.