期刊
FITOTERAPIA
卷 82, 期 3, 页码 375-382出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2010.11.012
关键词
Shuang-Huang-Lian; Forsythiae fructus; Forsythoside A; Intestinal absorption; Pharmacokinetics
资金
- Jiangsu Provincial Technology Innovation Team
- Jiangsu Provincial Traditional Chinese Medicine Administration Bureau [HZ07051]
Shuang-Huang-Lian (SHL), a traditional Chinese formula containing Lonicerae japonicae flos (LJF), Scutellariae radix (SR) and Forsythiae fructus (FF), is commonly used to treat acute upper respiratory tract infection, acute bronchitis and light pneumonia. Forsythoside A is one of the main active ingredients in Forsythiae fructus, a key herb in SHL. In the present study, effects of different compositions in SHL on the intestinal absorption of forsythoside A were investigated. The observations from in situ intestinal circulation model showed that A/%(h(-1)) of forsythoside A in FF+LSF, FF+SR and SHL were all reduced greatly compared with that in FF. However, in pharmacokinetics study, C-max and AUC(0) (->) (1440) of forsythoside A all increased and T-1/2 prolonged in SHL, FF+LJF and FF+SR compared with FF. The results indicated that the different compositions of SHL decreased absorption but increased bioavailability of forsythoside A, which may be related to its metabolism inhibited in intestine or liver. (c) 2010 Elsevier B.V. All rights reserved.
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