期刊
FITOTERAPIA
卷 82, 期 7, 页码 964-968出版社
ELSEVIER
DOI: 10.1016/j.fitote.2011.05.012
关键词
Dasymaschalon blumei; Cytotoxicity; Alkaloid; Aristolactam; Oxoaporphine
资金
- Center for Innovation in Chemistry (PERCH-CIC)
- Office of the Higher Education Commission
- Mahidol University under the National Research Universities Initiative
Bioassay-guided fractionation of the cytotoxic ethyl acetate extract from the stems of Dasymaschalon blumei (Annonaceae) led to the isolation of four aristololactam alkaloids, including the hitherto unknown 3,5-dihydroxy-2,4-dimethoxyaristolactam (1), as well as the three known compounds, aristolactam BI, goniopedaline, and griffithinam. Additionally, the cytotoxic extract from the combined leaves and twigs of the same plant yielded three known oxoaporphine alkaloids, oxodiscoguattine, dicentrinone, and duguevalline. The structures of aristolactams and oxoaporphine alkaloids were elucidated on the basis of spectroscopic methods. All isolates were evaluated for cytotoxicity against a panel of mammalian cancer cell lines and a noncancerous human embryonic kidney cell Hek 293. (C) 2011 Elsevier B.V. All rights reserved.
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