Article
Biochemistry & Molecular Biology
Weerasak Songoen, Julia Brunmair, Florian Traxler, Viktoria Chiara Wieser, Witthawat Phanchai, Wanchai Pluempanupat, Lothar Brecker, Johann Schinnerl
Summary: This study conducted a comprehensive phytochemical examination of the yellow twig Nauclea orientalis, identifying 13 tryptamine-derived alkaloids. The analysis showed that strictosamide is the key compound in the overall alkaloid composition, and it may contribute significantly to the yellow color of the wood. The study also analyzed the metabolomics of alkaloids and investigated the enzymatic deglucosylation of strictosamide. Furthermore, anti-feedant assays revealed the potential role of strictosamide in plant defense.
Article
Plant Sciences
Tripetch Kanchanapoom, Poolsak Sahakitpichan, Nitirat Chimnoi, Chaleaw Petchthong, Wassapol Thamniyom, Phonchanok Nangkoed, Somsak Ruchirawat
Summary: Four new monoterpene alkaloid glycosides and 12 known compounds were isolated from the leaves of Nauclea orientalis, and their structures were determined based on physical data and spectroscopic evidence, including 1D and 2D NMR experiments.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Guanghou Wang, Lijuan Hou, Yue Wang, Huan Liu, Jiuzhi Yuan, Huiming Hua, Lixin Sun
Summary: A pair of new compounds and a new alkaloid were isolated from Nauclea officinalis, along with several known compounds. Some of these compounds showed inhibitory activity on nitric oxide production in vitro and moderate cytotoxic activity.
Article
Engineering, Chemical
Sook Yee Liew, Wen Qi Mak, Hin Yee Thew, Kooi Yeong Khaw, Hazrina Hazni, Marc Litaudon, Khalijah Awang
Summary: Phytochemical investigation on the bark of Nauclea officinalis led to the discovery of a new monoterpenoid indole alkaloid, nauclediol. Its structure was identified through extensive spectroscopic analysis. Nauclediol showed cholinesterase-inhibitory activities against AChE and BChE, with IC50 values of 15.429 and 8.756 μM, respectively. Statistical analysis revealed that nauclediol acts as a non-competitive inhibitor for both AChE and BChE. Molecular docking studies showed that nauclediol interacts with the choline-binding site and the catalytic triad of TcAChE and hBChE. This study also demonstrated the neuroprotective potential of nauclediol against amyloid beta-induced cytotoxicity and LPS-induced neuroinflammation activity in a dose-dependent manner.
Article
Chemistry, Applied
Yue Wang, Huan Liu, Lijuan Hou, Jinhong Liao, Peng Zhang, Hao Zhang, Guanghou Wang, Lixin Sun
Summary: Two new indole alkaloids, naucleamide H (1) and (+/-)-19-O-butylangustoline (8), along with seven known alkaloids, were isolated from the water extract of Nauclea officinalis. The structures of these compounds were determined by spectroscopic analysis. The new compound 1 exhibited significant inhibitory activity against HepG-2 cells with an IC50 value of 19.59 μg/mL, and the new compound 8 showed strong inhibitory effects against HepG-2, SKOV3, HeLa, MCF-7, and KB cell lines.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Jie Zhou, Si-Yu Du, Zhong-Ying Fang, Jin-Hong Feng
Summary: Melognine, a novel monoterpenoid indole alkaloid isolated from the stems of Melodinus fusiformis, possesses a unique ring system and exhibits significant cytotoxicity against human breast cancer cells BT549. The mechanism of action involves activation of caspase-3 and p53, as well as downregulation of Bcl-2 to induce apoptosis in BT549 cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Francesca Bonvicini, Alessandra Locatelli, Rita Morigi, Alberto Leoni, Giovanna Angela Gentilomi
Summary: Isatin and its derivatives are important heterocycles with various biological activities and are essential building blocks in organic synthesis. In this study, a small library of 18 isatin hybrids were synthesized and evaluated for antimicrobial potential, with two lead compounds showing inhibitory activity against S. aureus at very low concentrations.
Article
Chemistry, Medicinal
Kun Fan, Lan-Chun Zhang, Wei-Yan Hu, Shi-Yu Deng, Hao Wu, Bang-Yin Tan, Rong-Ping Zhang, Cai-Feng Ding, Hao-Fei Yu
Summary: Tabernaecorymine A, a novel alkaloid compound obtained from the stem bark of Tabernaemontana corymbosa, exhibited significant antibacterial activity against Streptococcus dysgalactiae, with a better performance than the commonly used plant drug berberine.
Article
Chemistry, Applied
Shi-Ying Mai, Yong-Hui Li, Xu-Guang Zhang, Yi-Ran Wang, Jun-Qing Zhang, An Jia
Summary: A new indole alkaloid, naucleofficine H, was isolated from Nauclea officinalis, along with four known alkaloids. These compounds were found to promote HUVEC cell proliferation, with compounds 3 and 5 up-regulating the expression of VEGF and p-ERK in HUVEC cells.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Emmanuel O. Adeyoju, Clement O. Ajayi, Awodayo O. Adepiti, Anthony A. Elujoba
Summary: This study compared the antimalarial activity of methanol and water extracts of MAMA Powder against Plasmodium berghei-infected mice, finding that the water extract exhibited higher efficacy and can be optimized for chloroquine-resistant malaria, aiding in the production of various dosage forms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Guanghou Wang, Hongjin Wang, Huan Liu, Yue Wang, Ziwei Lin, Lixin Sun
Summary: A new method was developed for the simultaneous determination of 12 major alkaloid constituents in N. officinalis, characterized by its rapid, specific, and sensitive nature. Through optimization of the mobile phase and temperature, successful separation of three pairs of epimers was achieved, with good accuracy and stability of the method.
ANALYTICAL METHODS
(2021)
Article
Chemistry, Organic
Xin-Ming Xu, Ming Xie, Jiazhu Li, Mei-Xiang Wang
Summary: A novel catalytic asymmetric tandem reaction of tertiary enamides was developed using a chiral Diph-Pybox/Cu(OTf)(2) complex. The method allows for the expedited synthesis of indolizino[8,7-b]indole derivatives with high yields and excellent enantioselectivity and diastereoselectivity.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Medicinal
Zhilin Huang, Huaishuang Xu, Honggeng Chen, Bohang Sun, Huarong Huang, Hongxia Fan, Junxia Zheng
Summary: Three new pairs of benzyltetrahydroisoquinoline alkaloid epimers, seco-neferine A-F, were isolated and identified, with some compounds showing certain inhibitory effects on breast cancer cells in vitro.
Article
Biochemistry & Molecular Biology
Fernanda Valerio Lopes, Pedro Henrique Fazza Stroppa, Juliane Aparecida Marinho, Roberta Reis Soares, Lara de Azevedo Alves, Priscila Vanessa Zabala Capriles Goliatt, Clarice Abramo, Adilson David da Silva
Summary: This study evaluated the antimalarial activity of triazole derivatives, with compound 5 showing promising potential for further development in antimalarial chemotherapy. In vitro and in vivo studies showed that compound 5 had significant parasitemia suppression and minimal cytotoxicity, making it a leading candidate for future research in antimalarial drug development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Plant Sciences
Ines Carqueijeiro, Konstantinos Koudounas, Thomas Duge de Bernonville, Liuda Johana Sepulveda, Angela Mosquera, Dikki Pedenla Bomzan, Audrey Oudin, Arnaud Lanoue, Sebastien Besseau, Pamela Lemos Cruz, Natalja Kulagina, Emily A. Stander, Sebastien Eymieux, Julien Burlaud-Gaillard, Emmanuelle Blanchard, Marc Clastre, Lucia Atehortua, Benoit St-Pierre, Nathalie Giglioli-Guivarc'h, Nicolas Papon, Dinesh A. Nagegowda, Sarah E. O'Connor, Vincent Courdavault
Summary: Deglycosylation is a crucial step in plant defense mechanisms, catalyzed by enzymes like SGD to produce reactive aglycones. Alternative splicing of the SGD gene in C. roseus leads to the shorter isoform shSGD, which disrupts SGD multimers and inhibits its activity, impacting downstream MIA synthesis. This pseudo-enzyme shSGD acts as a regulator of MIA biosynthesis by interfering with metabolic channeling and recruitment of enzymes.
Article
Chemistry, Applied
Hoang-Vinh-Truong Phan, Thuc-Huy Duong, Duc-Dung Pham, Hoang-Anh Pham, Van-Kieu Nguyen, Thi-Phuong Nguyen, Huu-Hung Nguyen, Ngoc-Hong Nguyen, Pornpat Sam-ang, Kiettipum Phontre, Jirapast Sichaem
Summary: A series of lupeol derivatives were designed and synthesized for their inhibitory activity against alpha-glucosidase and cytotoxic activities. Lupeol analogues 2b and 2e showed the best activity against alpha-glucosidase, while 2d and 3a exhibited weak cytotoxicity against K562 cell line.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Thi-Quynh-Trang Nguyen, Nguyen-Kim-Tuyen Pham, Nguyen Tien Trung, Nguyen Truong An, Dinh-Tri Mai, Jirapast Sichaem, Bui-Linh-Chi Huynh, Nguyen Thi Hong Anh, Ngoc-Hong Nguyen, Thuc-Huy Duong
Summary: In this study, a new hopane-type triterpene, indicuen (1), along with eight known compounds (2-9) were isolated from the lichen Parmotrema indicum Hale. The chemical structures of these compounds were determined by spectroscopic data, DFT-NMR chemical shift calculations, and comparison with literature. Compounds 1, 5, and 7 showed moderate inhibitory activity against alpha-glucosidase.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Lien T. M. Do, Tuyet T. A. Nguyen, Phung K. P. Nguyen, Truong L. Tuong, Toan N. Vo, Jirapast Sichaem
Summary: A previously unreported rotenoid derivative, boeractanone (1), along with four known compounds, was isolated from the aerial part of Boerhavia erecta L. Their structures were elucidated through spectroscopic data analysis and comparison with published NMR data.
CHEMISTRY OF NATURAL COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Huy Truong Nguyen, Thanh-Trung Nguyen, Thuc-Huy Duong, Nguyen-Minh-An Tran, Chuong Hoang Nguyen, Thi-Hong-Anh Nguyen, Jirapast Sichaem
Summary: The novel compound schomburgkianone I and the reported compound guttiferone K exhibited potent inhibition against alpha-glucosidase and showed strong antibacterial activity. These compounds are potential candidates for diabetes treatment.
Article
Biochemistry & Molecular Biology
Thanh-Hung Do, Thuc-Huy Duong, Huy Truong Nguyen, Thi-Hien Nguyen, Jirapast Sichaem, Chuong Hoang Nguyen, Huu-Hung Nguyen, Nguyen Phuoc Long
Summary: Lichen-derived monoaromatic compounds have bioactive properties such as antioxidant, antifungal, antiviral, cytotoxicity, and enzyme inhibition. This study isolated and identified a series of monoaromatic compounds from lichen and evaluated their α-glucosidase inhibition and antimicrobial activity. Compound 4 showed the strongest α-glucosidase inhibition, while compound 9a exhibited remarkable activity against Staphylococcus aureus.
Article
Chemistry, Applied
Thanh-Sang Vo, Huu-Hung Nguyen, Thi-Phuong Nguyen, Thi-Minh-Dinh Tran, Xuan-Hao Bui, Minh-Hiep Dinh, Nguyen-Kim-Tuyen Pham, Jirapast Sichaem, Van-Son Dang, Ngoc-Hong Nguyen, Thuc-Huy Duong
Summary: Two new compounds with anticancer and alpha-glucosidase inhibitory activities were isolated from the leaves of Combretum quadrangulare Kurz.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lien T. M. Do, Jirapast Sichaem
Summary: This study provides new evidence for the medicinal potential of Melodorum fruticosum by isolating new flavonoid derivatives from its stem bark.
Article
Chemistry, Applied
Huu-Hung Nguyen, Thanh-Hung Do, Thi-Hoai-Thu Nguyen, Thuc-Huy Duong, Huu-Canh Vo, Van-Mai Do, Thi-Phuong Nguyen, Jirapast Sichaem, Ngoc-Hong Nguyen, Huy Truong Nguyen
Summary: This study investigated the chemical compounds of Boerhavia erecta collected in Vietnam and identified two new compounds. Compound 1 showed strong inhibition of alpha-glucosidase enzyme and antimicrobial properties against Acinetobacter baumannii.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Hoang-Dung Nguyen, Huy Truong Nguyen, Thi-Hoai-Thu Nguyen, Jirapast Sichaem, Huu-Hung Nguyen, Ngoc-Hong Nguyen, Thuc-Huy Duong
Summary: A phytochemical investigation of Lindera myrrha roots growing in Vietnam led to the discovery of a new eudesmane sesquiterpenoid compound, along with seven known compounds. These compounds exhibited antimicrobial activity against antibiotic-resistant, pathogenic bacteria.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Multidisciplinary Sciences
Rumpa Jutakanoke, Nuttakorn Intaravicha, Purin Charoensuksai, Wuttichai Mhuantong, Jarungwit Boonnorat, Jirapast Sichaem, Wongsakorn Phongsopitanun, Warunya Chakritbudsabong, Sasitorn Rungarunlert
Summary: The highly acid sulfate Rangsit soil series in Thailand has caused major agricultural problems. Water hyacinth can be converted to biochar through pyrolysis and used for acid soil amendment. The suitable ratio of water hyacinth biochar, soil, and sand for water convolvulus cultivation was found to be 50 g, 400 g, and 100 g (1:8:2). This soil mixture significantly improved soil pH and promoted optimal water convolvulus growth. Additionally, biochar amendment positively influenced the soil bacterial community.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Thanh-Hung Do, Thuc-Huy Duong, Tran Nguyen Minh An, Thi-Phi-Giao Vo, Van-Mai Do, Ngoc-Hong Nguyen, Jirapast Sichaem
Summary: A bioactivity-guided investigation of lichen Parmotrema cristiferum led to the discovery and identification of two new depsidones, cristifones A and B. The structures of the isolated compounds were determined using spectroscopic methods and comparison with literature data. Both compounds showed potent alpha-glucosidase inhibitory activity, with compound 2 being a non-competitive inhibitor.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Applied
Thuc-Huy Duong, Tran Nguyen Minh An, Thi-Kim-Dung Le, Thi-Minh-Dinh Tran, Huy Truong Nguyen, Thi Hong Anh Nguyen, Ngoc-Hong Nguyen, Jirapast Sichaem
Summary: A new depsidone, parmoferone A (1), along with three known compounds, parmosidone K (2), albifolione (3), and 4-chloroorcinol (4), were isolated from the lichen Parmotrema cristiferum. The structures of the compounds were determined through spectroscopic analysis and comparison with literature. The inhibitory activity of compounds 1-4 against alpha-glucosidase was evaluated, and compound 1 exhibited potent non-competitive inhibition with an IC50 value of 18.1 μM.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Medicinal
Nguyen Thi Le Thuy, Bui Thanh Tung, Truong Nguyen Nhu Trang, Nguyen Kim Phi Phung, Jirapast Sichaem
CHEMISTRY OF NATURAL COMPOUNDS
(2023)
Article
Chemistry, Applied
Phan-Si-Nguyen Dong, Hoang-Vinh-Truong Phan, Jirapast Sichaem, Hoai-Vu Nguyen-Si, Thanh-Nha Tran, Le-Thuy-Thuy-Trang Hoang, Thi-Minh-Suong Huynh, Huong Thi Thu Le, Dinh-Tri Mai, Tung-Lam Ngo, Tien-Dung Le, Van-Kieu Nguyen
Summary: A new spiroterpenoid named tinctorin (1), along with a known compound called norreticulatin (2), was isolated from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale. Their structures were determined through extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. The absolute configuration of compound 2 was established for the first time. Compound 1 showed no inhibitory activity against α-glucosidase.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biology
Jetsada Ruangsuriya, Jirapast Sichaem, Apichat Tantraworasin, Somcharoen Saeteng, Phanchaporn Wongmaneerung, Angkhana Inta, Neal M. M. Davies, Kewalin Inthanon
Summary: The extract from Calophyllum inophyllum has notable antioxidant activity and exhibits significant antiproliferative, anti-migratory, and anti-invasive effects on cancer cells, which may be attributed to its ability to reduce cellular reactive oxygen species (ROS) levels.
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.
